394 results about "Bacillus acnes" patented technology

An acne treatment system, device and method includes optical visualization means for identifying areas of skin colonized by the P. acnes bacteria, and further comprises methods, techniques and apparatus for the reduction or elimination of such colonies through the use of light of a power density and wavelength configured to be absorbed by porphyrins produced by the bacteria, resulting in a quenching. Various alternative embodiments are disclosed, including eye safe embodiments, embodiments in which a treatment regimen is provided on a disposable cartridge, embodiments in which the authenticity of the cartridge is verified to ensure proper operation, as well as others.

The present invention relates to a devices and methods for killing and / or debilitating pathogenic microorganisms in or on a patient's body, such as light-sensitive bacteria including helicobacter pylori and / or propionibacterium acnes. A chemiluminescent light source provides electromagnetic radiation having predetermined wavelengths in the visible spectrum. The light wavelengths are selected for absorption by naturally-occurring photosensitive chemicals produced by the patient's body.

The present invention relates to methods for treating and preventing acne or P. acnes infection in a subject comprising topically administering to the subject in need thereof an anti-acne nanoemulsion composition.

Methods are provided for improved immunization against coccidiosis and other bacterial, viral, or parasitic diseases in poultry. One method includes administering a solution of Propionibacterium acnes suspended in normal saline to a chick at age day one, following hatching. An anticoccidial vaccine and / or other vaccine is then administered to the chick such as by oral administration. Alternatively the method includes the steps of aseptically injecting Propionibacterium acnes in ovo at about day 18 in development, followed by post-hatching vaccination with an anticoccidial vaccine and / or other vaccine. Alternatively, either method can be utilized without the subsequent vaccination step for stimulating non-specific cell-mediated immune responses in poultry.

The subject matter of the present invention is a bacteria or mix of bacteria having an antagonistic activity with respect to stains of S. aureus, P. aeruginosa, Streptococcus pyogenes, Enterococcus faecium, Enterobacter cloacae, Proteus mirabilis, Bacteroides fragilis Staphylococcus epidermidis, Propionibacterium acnes, Candida albicans and / or Malassezia furfur as well as the use thereof in the treatment and / or prevention of infections or colonisations related to those pathogens. The invention pertains to care products containing one or more non-pathogenic antagonistic strains intended to prevent and / or treat infections or colonisations on skin, wounds, mucous membranes and appendages.

The invention belongs to the field of cosmetics and skin care products and discloses an acne-removing composition, a skin care product and a preparation method thereof. The acne-removing composition comprises mangosteen peel, thyme and fructus aurantii. Bacteriostatic experiments of propionibacterium acnes prove that the traditional Chinese medicine composition is good in inhibitory effect on the propionibacterium acnes, the three medicinal materials of the composition have a synergic anti-inflammation effect, and the composition is fast to become effective and good in effect. The acne-removing skin care product comprises the acne-removing composition, oldenlandia diffusa, salviae miltiorrhizae, honeysuckle stem, Chinese honey locust seed, tea tree essential oil and the like. The acne-removing skin care product does not contain ethanol and is safe and mild. Experiments prove that the skin care product is evident in acne treating effect, high in cure rate, natural and mild and capable of being used for a long time. The preparation method of the skin care product is simple to operate and suitable for large-scale production.

The invention belongs to the technical field of cosmetics, and particularly relates to acne treatment essence cream and a preparing method thereof. The essence cream contains aluminum starch octenylsuccinate, salicylic acid, PCA zinc, zinc gluconate, nicotinamide, tangerine orange pericarp extract, amur corktree bark extract and retinyl palmitate. The acne treatment constituents in the essence cream are obtained through screening. The new acne treatment constituents in the essence cream can effectively restrain propionibacterium acnes. Experimental studies prove that a good acne treatment effect can be realized by adding the acne treatment constituents to the essence cream. Stability studies show that the essence cream has higher stability.

The invention belongs to the technical field of cosmetics, and in particular relates to mild, oil-controlled and acne-removing essence. The multi-effect mild, oil-controlled and acne-removing essencefor men mainly comprises the following components: water, glycerinum, propylene glycol, EDTA disodium, xanthan gum, acryloyl dimethyl taurine / VP copolymer, allantoin, panthenol, a peony foot extract,p-hydroxyacetophenone, phenoxyethanol, ethylhexylglycerin, sodium benzoate, citric acid, o-cymene-5-alcohol, a phellodendron bark extract, butanediol, 10-hydroxydecanoate, a witchhazel extract, a lactic acid bacteria / mungbean seed extract fermented product filtrate, quaternary ammonium salt-73, PET-40 hydrogenated castor oil and essence. The mild, oil-controlled and acne-removing essence can effectively balance oil, reduce skin hyperkeratosis and minimize pores, can inhibit the growth of propionibacterium acnes and reduce skin inflammation such as acne, is mild and non-irritant and achieves the oil-controlling and acne-removing effects.

The invention discloses a polypeptide composition capable of effectively improving acne and repairing skin damage. The polypeptide composition comprises antibacterial polypeptides, polypeptides capable of inhibiting inflammatory response and / or polypeptides capable of promoting collagen and keratin regeneration and repairing acne marks. The polypeptide composition has the advantages that the growth and propagation of propionibacterium acnes and staphylococcus aureus can be inhibited, inflammatory response can be inhibited, edema and couperose skin can be prevented, corium layer collagen synthesis is increased, the regeneration and reinforcing of dermal-epidermis junction (DEJ) area structure tissue can be promoted, epidermis cell differentiation and maturation can be promoted, acne marks can be effectively repaired, and effective acne improving and skin damage repairing can be achieved.

The invention relates to application of a photosensitizer for treating acne. The photosensitizer is amino acid zinc phthalocyanine or a derivative thereof or organic or inorganic salt thereof which is used as the photosensitizer in photodynamic therapy for treating acne. The photosensitizer is of targeting and targeting aggressivity to target germs. Photons with special energy excite target molecules of the photosensitizer, the target molecules of the photosensitizer can transfer energy to oxygen molecules, and high energy oxygen molecules kill adjacent target germs: propionibacterium acnes, escherichia coli and staphylococcus aureus to treat acne. The photosensitizer provided by the invention used to treat acne is good in effect, free from antibiotics and hormone and tolerance, less in side effect, safe and nontoxic and economic and practical; can efficiently and quickly kill propionibacterium acnes, escherichia coli and staphylococcus aureus which induce acne to treat acne and restore skins without damaging normal cells; and is small in use level of effect medicines, and strong in effect of killing acne pathogenic bacteria.

An improved method, formulation and kit for the treatment of acne vulgaris are disclosed. The formulation is effective in inhibiting or killing the Proprionibacterium microorganism without utilizing antibiotics A preferred formulation alleviates the four pathogenic factors involved in the development of acne a) the putative pathogen of acne, Proprionibacterium acnes, b) abnormal desquamation of sebaceous-follicle epithelium (comedogenesis), c) the androgen-induced excessive sebum production, and d) the follicular reactivity (inflammation). The formulations are preferably applied as a cream, lotion or an emulsion.

The present invention belongs to the technical field of cosmetics, and particularly relates to an acne removing and skin beautifying essence liquid and a preparation method thereof, wherein the essence liquid comprises an acne removing component, and the acne removing component comprises a phellodendron amurense tree bark extract and a rosa multiflora fruit extract. According to the present invention, the acne removing component is obtained through screening; the new acne removing component can effectively inhibit Propionibacterium acnes, and the test research results show that the product provides a good acne treating effect and a good whitening effect after the acne removing component is added to the essence liquid; and the stability research results show that the essence liquid has good stability.

The invention relates to an oil control and acne removal composition and an application thereof. The oil control and acne removal composition comprises, by weight, 2-25 parts of water-soluble polyurethane, 5-25 parts of kaolin, 1-5 parts of titanium dioxide, 3-10 parts of dipropylene glycol, 0.1-1 part of zinc pyrrolidone carboxylate and 1-5 parts of an anti-acne active substance. A polyurethane-containing mud film is produced by adopting the aqueous polyurethane as a film forming component and selecting the dipropylene glycol as a film forming assistant, the kaolin controls oil through externally adsorbing the oil, and octanoylglycine, sarcosine, Cinnamomum zeylanicum bark extract and zinc salt of strong acid of pyrrolidone can inhibit the oil secretion through inhibiting 5alpha-reductase, so the composition can effectively inhibit acne propionibacteria of acne skins and effectively restore acnes on oily skins.

The invention discloses an acne-removing composition and a preparation method thereof. The acne-removing composition can be absorbed by skins faster compared with an emulsion preparation so as to take the function to the maximum extent. The function of comprehensively removing acnes is achieved by means of improving the moisturizing effect of the skins, adjusting the grease balance of the skins, inhibiting hypersecretion of sebum and inhibiting reproduction of propionibacterium acnes as well as by virtue of interaction of anti-inflammatory action and acne removal. The pH of the acne-removing composition is 4.5-5.5 (10% aqueous solution) which is faintly acid, and the acne-removing composition is mild in property and does not irritate the skins, and meanwhile, the effects of macromolecular salicylic acid and a composite plant acne-removing preparation are more obvious.

The invention discloses an acne-removing cream containing Chinese herbal medicine extracts and a preparation method thereof, and aims to provide the acne-removing cream having stronger inhibitory effect on propionibacterium acnes, having good acne-removing effect, being safe and gentle and having no irritation on human bodies. The technical key point comprises that the acne-removing cream is prepared from the following components by the mass percentage: 6-10% of an emulsifier, 2-3% of a coemulsifier, 10-14% of grease, 0.4-0.6% of an antioxidant, 1.6-2.4% of an absorption enhancer, 5-7.5% of an acne-removing composition, 1.6-2.4% of an emulsifier thickener, 8-12% of a moisturizer, 0.2-1% of a preservative, and the balance water. With the total mass of the acne-removing composition as 100%, the acne-removing composition comprises the components by the mass percentage: 6-10% of camphor, 6-10% of menthol, 12-20% of a peony root extract, 28-40% of a rheum palmatum root extract, 20-30% of a Chinese gall extract and 8-12% of a cortex phellodendri amurensis extract. The acne-removing cream belongs to the technical field of skin care products.

The invention discloses an apple enzyme and a preparation method. The preparation method comprises the following steps: juicing apples, uniformly mixing apple juice with pure water, adding glucose which accounts for 1-5% of the total weight of the obtained raw material mixture into the raw material mixture that the volume percentage of the apple juice is 5-20%, adjusting the pH value to 5.0-7.0, sterilizing, preparing mixed bacteria from the obtained raw material liquid and a pichia pastoris bacterial liquid and a lactobacillus plantarum bacterial liquid in a volume ratio of 1:(1-5), controlling the temperature to 25-35 DEG C, performing primary fermentation for 12-48 hours, controlling the temperature of the obtained primary fermentation solution to 25-35 DEG C by using an acetic bacterial liquid, performing secondary fermentation for 12-36 hours, and sterilizing, thereby obtaining a finished product of the apple enzyme. Compared with a finished product of natural fermentation, the finished product of the apple enzyme disclosed by the invention has a remarkable antibacterial effect on propionibacterium acnes, and the removal rate IC50 of the apple enzyme on DPPH is 0.43%.

The invention discloses a mung bean fermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy. The mung bean fermentation broth comprises a wall-broken filtrate obtained after fermentation of mung bean sprouts via lactic acid bacteria, wherein the solid content of the filtrate is 1 to 20%. The invention also discloses a preparation method for the mung beanfermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy. The preparation method comprises the following steps: 1) germination of mung beans; 2) breeding of lactic acid bacteria; 3) liquid homogenization of mung bean sprouts, addition of milk and trace elements, steam sterilization and cooling; 4) inoculation of the lactic acid bacteria for fermentation; 5) high-pressure homogenization and wall breaking; 6) freeze concentration and coarse filtration; and 7) membrane filtration and degerming. According to the invention, mung bean seeds are subjected topreliminary germination at first and then to fermentation via lactic acid bacteria, and the obtained wall-broken filtrate is safe and free of any irritation during external application, and can substantially inhibit hyaluronidase, rapidly eliminate Bacillus acnes, reduce hyperpigmentation and inhibit the formation of acne scars.

Methods of treating acne are disclosed comprising applying a benzoyl peroxide solution in one or more solvents to the skin of a user and applying a sealer thereto. The methods are useful to improve the penetration of active drug into the skin in need thereof, and are highly effective in treating P. Acne.

The invention relates to the technical field of cosmetics, in particular to a graphene mask and a preparation method thereof. Each 100 weight parts of the graphene mask is composed of: 0.1-8 parts ofgraphene, 0.05-5.2 parts of chitosan, 0-0.7 part of salicylic acid, 0.9-8.8 parts of gel, 0.1-2.9 parts of a honeysuckle extract, 0.1-3.5 parts of a dandelion extract, 0.1-2.5 parts of a salvia miltiorrhiza extract, 0.01-0.1 part of spice, and the balance water. According to the invention, graphene cooperates with chitosan, the honeysuckle extract, the dandelion extract and the salvia miltiorrhizaextract to serve as the main raw materials, the raw materials cooperate with each other for deep repair and treatment on skin comprehensively from the aspects of permeability, adsorption, antibacterial properties, oxidation resistance, repairability and the like, the graphene mask realizes quick and thorough elimination of propionibacterium acnes and thorough purification of pores, and is particularly effective on treatment of acne.

The invention discloses a botanical medicine composition with an acne removing effect and application. The botanical medicine composition is prepared from radix salviae miltiorrhizae, pomegranate bark, spreading hedyotis herb, rhizoma curcumae and licorice roots. The botanical materials are smashed, screened and mixed, the mixture is added into an extraction solvent and then soaked, room-temperature extraction is carried out with a high-pressure homogenization extraction machine, extraction liquor is subjected to centrifugal separation and then concentrated with a membrane, concentrated liquor is adsorbed with macroporous resin and then eluted repeatedly with ethanol, elution liquor is collected, butanediol is added for dissolution after membrane concentration, filtering is carried out, and the botanical medicine composition is obtained, wherein water or ethanol or an ethanol aqueous solution serves as the extraction solvent. The botanical medicine composition can inhibit secretion of skin grease, effectively inhibit propionibacterium acnes and achieve a good acne removing effect, and can enhance skin immunity, improve skin nature and make skin permeable, clean, smooth and fine when used for a long term.

The invention provides a preparation method of a probiotic and aloe mask, which is characterized by preparing a fermentation stock solution from aloe vera raw juice, glucose and water according to certain proportions and adding probiotics for performing co-fermentation. By setting different temperature gradients and pH gradients, after viable count, optimal fermentation conditions are determined; an aloe and probiotic fermentation solution is adopted to carry out an antibacterial test so as to determine an antibacterial effect, such as propionibacterium acnes; and meanwhile, by determining an antioxidant index, the antioxidant ability of the aloe and probiotic fermentation solution is determined, such as determination of DPPH radical scavenging ability, determination of iron ion chelating ability and determination of total reducing force. According to the product, the aloe and probiotic fermentation solution is mixed with cosmetic auxiliary materials in proportion so as to be processed into a pasty mask, and after sensory index testing, skin irritation testing and trial effect testing, the safety and functionality of the product are determined, so that the aims of skin protection and health care are achieved.

The present invention relates to a composition for preventing and treating acne, comprising a material which has excellent antibacterial activity against Propionibacterium acnes known as acne-causing bacteria and which shows strong antibacterial activity against skin floras that enlarge the site of inflammation to worsen acne, in which the material also helps to regenerate skin cells damaged by acne. The composition comprises bee venom (collected from Apis meliffera) and is used the form of soap, cosmetic products, and medical products for skin application such as ointments, bands and dressings, which are used to fundamentally prevent and treat acne.

The invention relates to a recombinant yeast strain capable of producing conjugated linoleic acid and an application thereof. In the invention, codon optimization is carried out on linoleate isomerase in propionibacterium acnes (PAI) gene to obtain an optimized gene opai, recombinant expression plasmid and recombinant Yarrowia lipolytica bacterium which contain the opai gene are prepared, and therecombinant Yarrowia lipolytica bacterium which expresses the opai gene is utilized to produce conjugated linoleic acid.

Provided herein are ketolide derivatives, which can be used as antibacterial agents. Compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae, Propionibacterium acnes or any combination thereof. Also provided are processes for preparation of compounds described herein, pharmaceutical compositions thereof, and methods of treating bacterial infections.

The invention discloses acne-removing cream. The acne-removing cream is prepared from hexamidine diisethionate, a hydroxypropyl-beta-cyclodextrin inclusion compound of azelaic acid, a hydroxypropyl-beta-cyclodextrin inclusion compound of salicylic acid and oat alkaloid derivatives. Permeation and stripping effects of salicylic acid in the hydroxypropyl-beta-cyclodextrin inclusion compound of salicylic acid is beneficial to permeation of other components into the skin basal layer, and the hexamidine diisethionate, a hydroxypropyl-beta-cyclodextrin inclusion compound of azelaic acid are enabledto more effectively kill propionibacterium acnes to fundamentally treat acnes, and great acne removing effects are achieved. By the hydroxypropyl-beta-cyclodextrin inclusion compound of azelaic acid,oil secretion and chromatosis can be evidently reduced while antibacterial acne-removing effects are achieved, water-oil balance is effectively regulated, and acne reduction and acne mark fading are realized; by the oat alkaloid derivatives, skin irritation symptoms such as allergy and stabbing pain caused by other components can be alleviated, and swelling, itching and pains of acne affected parts can be alleviated.

The invention discloses a sterilization composition for regulating skin microorganism floras and an application of the sterilization composition. The sterilization composition consists of a lactobacilli fermentation lysis product, quaternary ammonium salt-73, and a mangosteen peel extract. For the composition, the lactobacilli fermentation lysis product and the mangosteen peel extract can reduce killing rate of beneficial bacteria or symbiotic bacteria when other small pox removing components (such as the quaternary ammonium salt-73) are used for killing Propionibacterium acnes, and unbalanceof different degrees of floras caused by individual difference is balanced. In addition, the collocation use of the lactobacilli fermentation lysis product and the mangosteen peel extract can also effectively reduce stimulation or damage of conventional preservatives to faces of acne patients, and can reduce generation of allergic reaction situations that faces are itching, painful and swollen caused by preservatives.

The invention provides a polypeptide having the molecular weight of 3321.6 Da and having an amino acid sequence as shown in SEQ ID NO.1. The invention also provides six derivatives of the polypeptide. The polypeptide and the derivatives thereof provided by the invention have efficient broad-spectrum bacteriostatic effect on gram positive bacteria and gram negative bacteria (especially having good killing effect on anti-clindamycin anaerobic propionibacterium acnes), fungi and yeasts, and have high activity (the concentration for killing the propionibacterium acnes in vitro can be only 0.125 mg / L). The polypeptide and the derivatives thereof can be applied in preparation of microbial bacterial and fungal infection-controlling and anti-inflammatory products, wherein the products include externally-applied disinfectants, anti-bacterial agents, wound-protection or infection-prevention dressings, acne treating drugs, skin care products, cosmetics and the like. The polypeptide is designed and synthesized based on a tryptophan bromide-containing fragment of a marine biological sea urchin, has stronger bacteria inhibiting or killing and anti-inflammatory effects and better stability, and can be used as an antibiotic substitute.

The present invention relates to a slow-released preparation of antibiotic for local application, it is slow-released injection or slow-released implant preparation. The injection is composed of slow-released microspheres and solvent, the slow-released microsphere contains slow-released auxiliary material and beta-lactamase inhibitor or tetracyclines, the solvent is a special solvent containing suspension adjuvant of sodium cellulose glycollate, etc. its viscosity is 100 cp -3000 cp (20-30 deg.C), the slow-released auxiliary material is selected from EVAc, PLA, PLGA, sebacic acid copolymer, albumin glue and gelatin. The slow-released implant preparation is prepared by using slow-released microspheres or adopting melting process. Said invention also provides its application range.

The invention discloses a traditional Chinese medicine composition for removing acne and an application thereof. The pharmaceutical composition comprises the following components: an extract product of Centella asiatica, an extract product of scutellaria roots, vitamin E, clove oil, an extract product of licorice, an extract product of flavescent sophora, hydrolyzed pearl, and borneol, and the materials and a proper amount of matrix are used for preparing a preparation for external use. The traditional Chinese medicine composition has efficacies for clearing heat and draining dampness, detoxifying, and dispersing the swelling; the composition has multiple efficacies for better inhibiting growth of Propionibacterium acnes without generation of drug resistance, resisting hyperplasia of scar, resisting chromatosis, resisting inflammation, easing pain, preserving moisture, adjusting balance of oil and fat, and the like; the product has obvious anti-acne effects, and can be used for thoroughly eradicating acne without recurrence after healing; the product does not have toxic and side-effects, and acne removal does not leave marks. Total effective rate of the traditional Chinese medicine composition for treating acne in four weeks is 100%, and acne of healed patients does not recur. After acne is treated, total effective rate for resisting chromatosis reaches 85.71%, the curative effects are better than the effects of Tretinoin cream, and obvious adverse reactions are not observed.