78 results about "Malassezia" patented technology

Dandruff and symptoms of dandruff can be treated using lipophilic agents or lipid precursor and / or promoters to strengthen the scalp. The lipophilic agents or lipid precursor and / or promoters are preferably used in conjunction with an antifungal agent which has activity against Malassezia spp, particularly Malassezia furfur. Suitable antifungal agents include those conventionally used for the treatment of dandruff including, for example, zinc pyrithrone (ZnPTO), octopirox and azole antifungal agents such as climbazole and ketocanazole. The antifungal agents may be used singularly or as a mixture of one or more antifungal agents.

The invention relates to a scouring bath additive derived from plant, in particular to a traditional Chinese medicine additive which is used for bath lotion and has the efficacy of antibacterium and bacteriostasis. The traditional Chinese medicine additive comprises the raw materials based on the weight ratio: 10-15% of lightyellow sophora root, 15-25% of goldthread root, 15-20% of artemisia leaf, 20-30% of ginger, 15-20% of peppermint, 20-30% of baikal skullcap root, 10-15% of chili, 15-20% of cacumen platycladi, 15-20% of phellodendron, 25-30% of smallanthus sonchifolius leaves and 25-35% of liquorice. The additive can be used for the bath lotion including shampoo, bath milk, facial cleanser and liquid soap, and can replace chemical bacteriostatic agent for killing and inhibiting conventional bacteria such as excrement colon bacillus, staphylococcus aureus, pseudomonas aeruginosa and the like as well as dermatophyte such as malassezia. After being added into the bath lotion, the bath lotion has the functions of relieving itching, sterilizing, removing scurf and protecting the skin, causes no stimulation and toxic side effect for the skin, and has the advantages of low cost and no environmental pollution.

The invention provides a product for treating skin diseases caused by Malassezia, and medicines and daily chemical products of honokiol, wherein the product treats honokiol or its derivative as an active component; and the medicines and the daily chemical products are prepared through dispersing the honokiol or its derivative in medicine carriers. Above medicaments provided by the invention can effectively inhibit the breeding of the Malassezia, have the advantages of low toxicity and high medicine effect efficiency, and have wide application prospects.

The invention provides a shampoo containing snake gall, olive oil and Chinese herbs, which is characterized in that original snake gall, the olive oil and extract of specific Chinese herbs (coptis, cortex moutan radicis and the like) in a specific ratio are added to a basic shampoo formulation; the original snake gall has the function of inhibiting bacterial growth; the olive oil has the function of moisturizing hair; the extract of coptis, cortex moutan radicis and other Chinese herbs has the function of inhibiting the growth of malassezia; and the shampoo simultaneously added with the original snake gall, the olive oil and the extract of specific Chinese herbs has the characteristics of obvious effect of inhibiting the growth of bacteria and fungi, removing dandruff and relieving itching, reduces the irritation of chemical additives to scalp, and removes dandruff safely. In addition, the shampoo has the characteristics of ensuring good combing property, gloss and softness of washed hair, along with abundant foam and comprehensive conditioning performance superior to that of domestic / foreign mainstream shampoo products.

The present invention relates to an anti-dandruff composition comprising 1-acetoxychavicol acetate (I). Furthermore, the present invention relates to a method for preparing said anti-dandruff composition and the use of said anti-dandruff composition for treating or preventing Malassezia induced dandruff formation. Moreover, the present invention relates to a method for preparing an Alpinia galanga extract and an extract obtainable or obtained by said method as well as the use of this extract for treating Malassezia induced dandruff formation comprising applying an anti-dandruff composition comprising said extract.

The invention discloses an application of tea saponin used as a malassezia inhibitor, and in particular relates to an application for preparing drugs for treating skin diseases caused by malassezia. The invention further discloses an external preparation and daily cosmetics containing the tea saponin.

The invention belongs to the field of pharmaceuticals, and relates to the new use of an usnic acid and derivatives of the usnic acid, specifically to the use of the usnic acid and the derivatives of the usnic acid for the preparation of medicaments for treating skin diseases caused by malassezia, in particular to the use of the usnic acid and the derivatives of the usnic acid for the preparation of medicaments for treating overmuch scurf, seborrheic dermatitis, atopic dermatitis and psoriasis caused by the malassezia. Inhibition test results show that an average diameter value of an inhibition zone is 20mm and the usnic acid can remarkably inhibit the growth of the malassezia; and a measurement result of a minimal inhibitory concentration (MIC) value of a sodium usnic acid for the inhibition of the malassezia shows that the growth of the malassezia is inhibited along with the rise of a medicinal concentration gradient of the usnic acid and the derivatives of the usnic acid. The usnic acid and the derivatives of the usnic acid disclosed by the invention can be used for preparing the medicaments for treating the skin diseases caused by the malassezia, and can also be used for preparing household chemicals and external preparations for preventing and treating the skin diseases.

The invention belongs to the technical field of traditional Chinese medicine or cosmetics, and relates to a fructus forsythia-containing preservative and a preparation method thereof. The preservativeconsists of the following components: a fructus forsythia extract, sophocarpidine, bamboo water, a synergist and ascorbyl glucoside. The low-toxicity, low-irritation and high-effect natural preservative is obtained by compounding natural plant active components, and is applied to the fields of cosmetics and the like. The natural, low-toxicity and no-irritation preservative is prepared by compounding the fructus forsythia extract, the sophocarpidine and the bamboo water, has good preservative effect on 5 common microorganisms in the cosmetics, has certain inhibition effect on scalp fungi malassezia fufur, and can serve as a formula component of natural skin-care products and anti-dangdruff products.

The invention relates to a plant anti-dandruff shampoo, and a preparation method thereof. The plant anti-dandruff shampoo comprises, by weight, 5 to 20 parts of Maca root extract, 5 to 10 parts of cocamidopropyl betaine, 10 to 15 parts of fatty alcohol polyoxyethylene ether sodium sulphate, 1 to 3 parts of cetearyl glucoside, 3 to 5 parts of sodium cocoamphoacetate, 1 to 3 parts of a plant anti-dandruff ingredient, and the balance water. The preparation method comprises following steps: water is heated to 72 to 75 DEG C; cocamidopropyl betaine, fatty alcohol polyoxyethylene ether sodium sulphate, cetearyl glucoside, and sodium cocoamphoacetate are added, and stirring and uniform mixing are carried out; an obtained product is cooled to about 40 DEG C, the Maca root extract and the plant anti-dandruff ingredient are added, and an obtained mixed product is stirred to be uniform. The synergistic effect of the effective components in Maca is capable of adjusting head skin sebum secretion balance, inhibiting abnormal breeding of malassezia, and removing dandruff; the plant anti-dandruff ingredient is added, so that inhibition and killing of pathogenic bacteria are realized, and a two-pronged approaches is adopted to remove dandruff.

The invention relates to a traditional Chinese medicine extracting solution capable of resisting bacteria, removing acnes and treating blebs as well as application thereof and skin-care lotion prepared from the traditional Chinese medicine extracting solution and belongs to the technical field of cosmetics. The traditional Chinese medicine extracting solution is prepared from the following components: mulberry twig / or mulberry root extract, dandelion extract and chamomile extract; the extracting solution contains a plurality of types of active and effective components, can be used for effectively inhibiting or killing coryneform bacteria on surfaces of the acnes, and acne propionibacterium, staphylococcus epidermidis and malassezia fufur of pathogenic bacteria in the acnes, and has the effect of removing the acnes on faces and backs, thus treating both symptoms and root causes; meanwhile, bleb viruses are inhibited or killed, so that the skin-care lotion prepared from the traditional Chinese medicine extracting solution can be used for resisting the bacteria, removing the acnes and effectively inhibiting the bleb viruses; and the skin-care lotion has a good curative effect and a lasting effect, does not bounce and the like and has no skin irritation effect and other side effects.

The invention discloses an application of melaleuca alternifolia oil as a malassezia inhibitor, and in particular relates to an application in preparing drugs for treating skin diseases caused by malassezia. The invention further discloses an external preparation and daily cosmetics containing the melaleuca alternifolia oil.

The invention belongs to the field of daily chemicals, and relates to an anti-dandruff and itching-relieving shampoo composition as well as a preparation method and application thereof, and the composition comprises the following components in percentage by weight: 0.1-5% of hydrolyzed chitosan, 0.001-2% of sophocarpidine and 0.01-2% of pyridoxine hydrochloride. In the composition, the natural and mild anti-dandruff agent hydrolyzed chitosan is selected to be compounded with a low-dose natural low-irritation bactericide matrine to inhibit malassezia, inflammation can be inhibited, and itching in head can be relieved; the hydrolyzed chitosan can effectively enhance scalp moisturizing, and pyridoxine hydrochloride is compounded to moisturize and regulate scalp grease, so that scalp moisture and grease are kept balanced, the scalp health state is maintained, and a better anti-dandruff effect is achieved.

The subject invention is directed to the treatment of infections caused by fungi which are resistant to standard antifungal drugs such as fluconazole. The treatment method involves administering to the sufferer an effective amount of an agent that suppresses the activity of the fungal (H+)-ATPase pump (Pma1p). Such agents may take the form of: a) 2-phenyl-1,2-benzisoselenazol-3(2H)-one, commonly referred to as ebselen and depicted by Formula I, or b) 2-phenyl-1,2-benzisoselenazol-3(2H)-one 1-oxide, commonly referred to as ebselen se-oxide and depicted by Formula II, or pharmaceutically acceptable salts thereof. Opportunistic fungal infections include those which are systemic and those which are superficial and are caused by species of fungi belonging to the genus Candida, Aspergillus, Pneumocystis, Tinea, Blastomyces, Cryptococcus, Histoplasma, Sporotrichum, Malassezia, Hansenula, Rhodotorula, Trichosporon, as well as others.

The invention discloses an anti-hair-loss hair-care composition and application thereof, and aims to provide a composition capable of effectively inhibiting the activity of 5alpha-reductase, reducingthe proliferation of malassezia fufur, and promoting the proliferation of dermal papilla cells. The composition is applied to toiletries, has a remarkable improvement effect on seborrheic alopecia, and is prepared from, by weight, 1-6 parts of a spiraea ulmaria extract, 3-9 parts of a guava fruit extract, 2.5-7 parts of a turmeric root extract, 2-5 parts of a magnolia bark extract and 5-10 parts of a tea extract. The invention belongs to the technical field of daily necessities.

The invention discloses amino acid shampoo having functions of restraining bacteria, relieving itching, protecting hair and repairing damaged hair. The amino acid shampoo comprises the following components in percentage by mass of 0.1-5% of a scarlet kadsura root extract, 3-8% of an amino acid surfactant, 3-8% of glycerine, 2-6% of sorbitol, 0.1-0.5% of ethylenediaminetetraacetic acid disodium, 1-3% of oat kernel oil, 2-6% of an olive leaf extract, 0.1-0.5% of citric acid, 0.1-0.5% of PEG-120 methyl glucose dioleate, 1-5% of polyquaternary ammonium salt-7 and 0.3-0.9% of phenoxyethanol. According to the amino acid shampoo disclosed by the invention, the effects of the scarlet kadsura root extract for resisting oxidation, restraining inflammation and restraining bacteria are utilized, and the scarlet kadsura root extract, the oat kernel oil and the olive leaf extract are compounded in a specific proportion, so that the amino acid shampoo can restrain the production of dandruff caused byexcessive proliferation of scalp cells caused by propagation of malassezia, restrain itching caused by seborrheic dermatitis, restrain the production of the dandruff caused by oxidization stress of the scalp cells, besides, nourish the scalp and promote scalp health.

The invention provides application of a fungal microbiome as a marker in preparation, treatment, screening and lung cancer diagnosis. By constructing a fungal microbiome DNA enrichment and extractionmethod, fungal microbiome DNA is extracted from tissues, feces and alveolar lavage fluid, and ITS sequencing and metagenome sequencing are applied to fungal microbiome and gene function analysis, wherein aspergillus polyangius is enriched in tumor tissues, candida albicans is enriched in tumor tissues and para-carcinoma tissues, and malassezia is enriched in alveolar lavage fluid; by detecting these target strains or molecular markers, lung cancer can be found and intervened as early as possible, and the target strains or molecular markers are expected to be used as important indicators for lung cancer screening; and in addition, the characteristics of the type and quantity of fungi are obtained through DNA sequencing results of fungal florae in feces, tissues and alveolar lavage fluid samples of different parts of lung adenocarcinoma patients, and the lung cancer is more accurately screened and diagnosed in an assisted mode based on the quantity and ratio characteristics of the fungispecifically enriched in the lung cancer.

The invention discloses a primer group and kit for simultaneously detecting various pathogenic fungi. The primer group comprises 14 pairs of primers, and the primers can perform specific multiplex amplification on DNA sequences of 14 target fungi, wherein the target fungi comprise candida albicans, candida tropicalis, candida glabrata, candida parapsilosis, candida krusei, aspergillus fumigatus, aspergillus terreus, trichophyton mentagrophytes, trichophyton rubrum, epidermophytom floccosum, sporothrix schenckii, microsporum caninum, fonsecaea pedrosoi and malassezia fufur. The kit adopts a multiple fluorescence labeling PCR amplification technology for multiplex amplification, multiple common pathogenic fungi can be identified at the same time through a one-time reaction, the detection efficiency is high, the speed is high, and the cost is low; in addition, interspecific and intraspecific comparison can be performed on sequences in a fungus ITS or beta-tubulin database, an intraspecific conserved region is selected to design an amplification primer, and very strong species specificity is achieved. The whole detection process can be completed within 2-3 hours, the detection speed ishigh, and the requirement for rapid detection of clinical samples can be met.

The invention provides a method for detecting scalp malassezia, and belongs to the technical field of microbiological detection. The method comprises the following steps: 1) adhering a dandruff samplefrom a fixed point on the scalp by using a transparent adhesive tape, and adhering the transparent adhesive tape with the adhered dandruff sample on a hollow glass slide; and 2) dyeing the dandruff sample with a KOH gentian violet solution, cleaning the residual dye liquor, and performing microscopic examination. By adopting the method provided by the invention, the natural state of skin lesionscan be intuitively reflected, and the relative bacterial amount per unit area is judged. In the method provided by the invention, the transparent adhesive tape with the adhered dandruff sample is adhered on the hollow glass slide to facilitate the dyeing and the microscopic examination, furthermore, the adhesive tape has high transparency, flat surface and good refractive index of microscopic examination, which is convenient for moving observation and searching for related fields during the microscopic examination. By adopting the method provided by the invention, the scalp malassezia can be detected effectively, conveniently and quickly.

The invention relates to the field of skin care products, and particularly discloses a plant anti-dandruff and itching-relieving composition, a plant anti-dandruff and itching-relieving shampoo and a preparation method of the plant anti-dandruff and itching-relieving shampoo. The plant anti-dandruff and itching-relieving composition is prepared from the following components in percentage by mass: 40.0-60.0% of a bamboo hat leaf extract and 40.0-60.0% of an oat kernel extract. The plant anti-dandruff and itching-relieving composition is obtained by reasonably matching the bamboo hat leaf extract and the oat kernel extract according to a specific proportion, and is applied to hair care products. The bamboo hat-shaped bamboo hat leaf extract can effectively inhibit the growth of malassezia, maintain the healthy environment of scalp and reduce scurf. The oat kernel extract can inhibit the activation of an important transcriptional regulatory factor NF-kB expressed by proinflammatory protein, and efficiently diminish inflammation and relieve itching. The oat kernel extract can effectively relieve irritation of the environment to the scalp, and the anti-dandruff effect of the bamboo hat leaf extract is enhanced.

The invention belongs to the field of cosmetics, and particularly relates to a shampoo type composition having the efficacy of removing dandruff, and a preparation method of the shampoo type composition. The shampoo type composition comprises the following components in parts by weight of 1-3 parts of sodium hyaluronate, 0.1-0.5 part of guar gum, 0.3-1 part of piroctone olamine, 0.1-0.5 part of anoat kernel extract and 0.5-1.5 parts of a calendula flower extract. According to the shampoo type composition disclosed by the invention, mainly the growth of malassezia is restrained through the piroctone olamine , and production of the dandruff is reduced; besides, the sodium hyaluronate has similar structure to the composition structure of stratum corneum of the skin of a human body, and moisturizing factors higher in substantivity bring high watery and moistening sense for skin and muscle; and finally, the oat kernel extract and the calendula flower extract, having the efficacy of resisting bacteria and resisting inflammation are added, so that the sensitivity resisting capacity of sebum is reinforced, and stimulation and invasion of external environment to skin and muscle are reduced.

The invention relates to the technical field of bacterium prevention of microorganisms, in particular to application of polyphyllin in products for resisting malassezia fufur and candida albicans. Itis discovered that in-vitro drug sensitivity tests by an inventor that polyphyllin has an inhibition effect on malassezia fufur and candida albicans. The weight fraction of polyphyllin I, VI and VII and MIC, with an inhibition effect on malassezia fufur, of rhizoma paridis total saponin is 2 mug / mL, 19 mug / mL, 39 mug / mL and 0.5 mug / mL; The weight fraction of polyphyllin I, II, VI and VII and MIC,with an inhibition effect on candida albicans, of rhizoma paridis total saponin is 0.125 mug / mL, 0.03125 mug / mL, 78 mug / mL, 0.625 g / L and 0.5 g / L. Compared with an existing bacteriostat, polyphyllin has small MIC value on malassezia fufur and candida albicans and has good antimicrobial activity. Polyphyllin can be used as an antimicrobial active component and added to external medicine, oral medicine, a disinfectant, a washing agent and an antimicrobial coating and has the functions of inhibiting growth of malassezia fufur and candida albicans.

The subject invention is directed to the treatment of infections caused by fungi which are resistant to standard antifungal drugs such as fluconazole. The treatment method involves administering to the sufferer an effective amount of an agent that suppresses the activity of the fungal (H+)-ATPase pump (Pma1p). Such agents may take the form of: a) 2-phenyl-1,2-benzisoselenazol-3(2H)-one, commonly referred to as ebselen and depicted by Formula I, or b) 2-phenyl-1,2-benzisoselenazol-3(2H)-one 1-oxide, commonly referred to as ebselen se-oxide and depicted by Formula II, or pharmaceutically acceptable salts thereof. Opportunistic fungal infections include those which are systemic and those which are superficial and are caused by species of fungi belonging to the genus Candida, Aspergillus, Pneumocystis, Tinea, Blastomyces, Cryptococcus, Histoplasma, Sporotrichum, Malassezia, Hansenula, Rhodotorula, Trichosporon, as well as others.

The present invention discloses a malassezia inhibitor. Results of in vitro microorganism-inhibiting tests show that an extract of stachys sieboldii has a significant inhibitory effect on malassezia and is an excellent malassezia inhibitor. The malassezia inhibitor can be used to treat skin diseases of tinea versicolor, folliculitis, seborrheic dermatitis, etc., can also be developed into anti-dandruff daily chemical products or cosmetics, has a wide range of application potentials, and also has very high safety due to being derived from natural plants.

The invention provides selenium sulfide composite powder for hair washing. Selenium sulfide is uniformly dispersed on the surfaces of nano microspheres in a nano form, can be directly mixed with a hair washing composition for use, is not easy to settle and separate in the composition, does not need to be mixed with a shampoo during use, and is simple and convenient. Carbon sphere particles can be used as an active carbon shampoo additive, can reduce generation of scurf and reduce grease secretion, and have an obvious inhibition effect on malassezia.

The invention belongs to the technical field of medicine preparation and particularly relates to application of rose aqueous extracts to preparing malassezia-prevention medicine or soap. According to the application of the rose aqueous extracts to preparing the malassezia-prevention medicine or soap, a preparation process of the rose aqueous extracts includes the steps that roses are obtained and decocted for 0.5-4 h with 2-12 folds of water, the extraction solution is concentrated, and the rose aqueous extracts are obtained. Compared with the prior art, the rose aqueous extracts are applied to preparing the malassezia-prevention medicine or soap, the skin care functions of wrinkle prevention, cold injury prevention, face beautifying and the like of roses can be achieved, malassezia can be effectively inhibited, and accordingly a series of skin diseases caused by malassezia are treated. The obtained product is environmentally friendly and natural and conforms to popular consumption concept.

The invention belongs to the field of daily chemicals, and relates to an anti-dandruff shampoo composition and a preparation method and application thereof. The anti-dandruff shampoo composition provided by the invention comprises the following components: PCA sodium, nicotinamide, and undecylenyl hydrolyzed wheat protein potassium. The invention also provides the preparation method of the scalp care composition, and an application of the scalp care composition in cosmetics. According to the composition disclosed by the invention, the milder anti-dandruff agent undecylenyl hydrolyzed wheat protein potassium is selected to inhibit malassezia, meanwhile, the powerful humectant PCA sodium is matched to prevent scalp dryness, and further nicotinamide is compounded to repair a scalp barrier torestore the scalp to a healthy state, so that better anti-dandruff effects are achieved.

The invention provides anti-dandruff shampoo containing rose fermentation liquor. The rose fermentation liquor is rich in polysaccharides, flavones and amino acids. The flavones contained in the shampoo acts on scalp microorganisms, malassezia and staphylococcus can be selectively inhibited, growth of propionibacterium is not inhibited, and therefore scalp flora is balanced. The polysaccharides contained in the shampoo can keep scalp moist, and the amino acids can enhance scalp barrier. Therefore, the shampoo can adjust scalp micro-ecology, improve scalp health from multiple dimensions and achieve the effects of removing dandruff and nourishing scalp. In a preferred scheme, three auxiliary surfactants including sodium cocoyl methyl taurate, cocamidopropyl betaine and cocamidopropyl hydroxysultaine are added into the anti-dandruff shampoo, so that the anti-dandruff shampoo generates most foam and is high in foam durability.