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Product for treating skin diseases caused by Malassezia

A technology for skin diseases and Malassezia, applied in skin diseases, skin care preparations, cosmetic preparations, etc., can solve problems such as inability to obtain good therapeutic effects, achieve good Malassezia reproduction, and inhibit Malassezia Bacteria reproduction, cholesterol-lowering effects

Active Publication Date: 2012-10-24
晟薇药业(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the antifungal agents that are widely used and have good antifungal activity against Malassezia are limited to several types such as ketoconazole and itraconazole, but there are reports in the literature that these antifungal agents will relapse after treatment, so Unable to achieve good therapeutic effect

Method used

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  • Product for treating skin diseases caused by Malassezia
  • Product for treating skin diseases caused by Malassezia
  • Product for treating skin diseases caused by Malassezia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: Honokiol inhibiting product inhibits Malassezia experiment

[0024] Inhibition zone test:

[0025] Experimental strain: Malassezia furfur (Malassezia furfur, ATCC44344)

[0026] Medium: Malassezia solid medium: glucose 40g / L, agar 14g / L, peptone 10g / L, dissolved in distilled water, adjusted to pH 6.8~7.0, autoclaved at 115°C for 20 min

[0027] Malassezia liquid medium: glucose 40 g / L, dissolved in distilled water, adjusted to pH 6.8-7.0, autoclaved at 115°C for 20 min

[0028] The honokiol is purified from the plant Magnolia officinalis by the prior art, which can be the crude extract containing magnolol, or the refined honokiol obtained by purification. Or honokiol is obtained by chemical synthesis.

[0029] Experimental method: After the test bacteria were subcultured on the Malassezia solid medium, to ensure the purification and viability of the colony, pick a single clone into 50 ml Malassezia liquid medium, culture it at 30°C for 24 h, and use ...

Embodiment 2

[0043] Embodiment 2: the preparation of the hair conditioner containing honokiol medicine

[0044] Main ingredients: 4.50wt% cetearyl alcohol, 3.50wt% behenyltrimethylammonium chloride, 3.50wt% glyceryl stearate, 2.00wt% cyclopentasiloxane, dimethicone and Dimethiconol 1.00wt%, Dioctyl Carbonate 1.00wt%, Honokiol 0.20wt%, Propylene Glycol 2.00wt%, Methylparaben 0.10wt%, Cathone 0.07wt%, appropriate amount of essence, The rest is deionized water.

[0045] The main components and mass percentages in this example are shown in Table 3.

[0046] Table 3 The main components and mass percentages of hair conditioner prepared in Example 2

[0047]

[0048]

[0049] Cetearyl Alcohol, Behenyltrimonium Chloride, Glyceryl Stearate, Cyclopentasiloxane, Simethicone and Dimethiconol Blend, Dicapryl Carbonate, and Magnolol is mixed as phase A; propylene glycol, methylparaben, and deionized water are mixed as phase B; the rest is used as phase C. Raise the temperature of phases A an...

Embodiment 3

[0050] Embodiment 3: the preparation of the shampoo containing honokiol medicine

[0051] Main ingredients: Guar Gum Hydroxypropyltrimethylammonium Chloride 0.10wt%, 10% Citric Acid Aqueous Solution, Polyquaternium-10 0.20wt%, Methylparaben 0.10wt%, EDTA Disodium Salt 0.05wt %, ammonium lauryl ether sulfate 15.00wt%, ammonium lauryl sulfate 5.00wt%, coconut oil monoethanolamide 1.00wt%, cocamidopropyl betaine 4.00wt%, cetearyl alcohol 0.80 wt%, ethylene glycol stearate 1.50wt%, acrylic (ester) copolymer 1.50wt%, dimethylsiloxane and aminodimethylsiloxane (and) dimethylsiloxane alcohol 1.00wt%, polydimethylsiloxane and cocamidopropyl betaine 1.50wt%, honokiol 0.50wt%, kasone 0.08wt%, appropriate amount of NaCl, appropriate amount of essence, appropriate amount of 10% citric acid aqueous solution, The balance is deionized water.

[0052] Add guar gum hydroxypropyltrimethylammonium chloride to water, add citric acid to adjust to transparent, then add polyquaternium-10, methyl...

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Abstract

The invention provides a product for treating skin diseases caused by Malassezia, and medicines and daily chemical products of honokiol, wherein the product treats honokiol or its derivative as an active component; and the medicines and the daily chemical products are prepared through dispersing the honokiol or its derivative in medicine carriers. Above medicaments provided by the invention can effectively inhibit the breeding of the Malassezia, have the advantages of low toxicity and high medicine effect efficiency, and have wide application prospects.

Description

technical field [0001] The invention relates to a product for treating skin diseases, in particular to medicines, daily chemical products and the like which can treat skin diseases caused by Malassezia fungus, with honokiol or its derivatives as active ingredients. Background technique [0002] Dandruff, seborrheic dermatitis, atopic dermatitis, and psoriasis are all very common skin diseases, which not only affect the health of patients, but also bring a lot of inconvenience to the lives of patients. There are many causes of skin diseases, fungal diseases, bacterial skin diseases, viral skin diseases, skin diseases caused by arthropods, allergic skin diseases, neurological dysfunction skin diseases, pigmentary disorder skin diseases, parasitic skin diseases etc. [0003] Different types of skin diseases require targeted treatment, such as the treatment device and method disclosed in patent WO2006 / 125092A2, which are used to treat acne and papules caused by bacterial and fu...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P31/10A61P17/08A61P17/06A61P17/00A61K8/891A61K8/33A61Q5/02A61Q5/12A61Q19/00A61Q19/10
Inventor 孙常磊翟春涛朱丽平
Owner 晟薇药业(上海)有限公司
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