80results about How to "Anti-inflammatory effect" patented technology

An implantable stimulation electrode for use with an implantable tissue stimulator, especially a pacemaker, a defibrillator, a bone stimulator or a neurostimulator includes a metal base body, optionally one or more intermediate layers disposed on the base body and a coating covering the base body and, optionally, intermediate layers in order to increase tissue compatibility. The coating should prevent tissue irritations after implantation and more particularly increase the stimulus threshold associated therewith, have very high biocompatibility and also has an anti-inflammatory effect. An increase in tissue compatibility is achieved by virtue of the fact that the coating has a polysaccharide layer made of hyaluronic acid and / or hyaluronic acid derivatives.

An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. Finally, the neurostimulator includes an integrated leadless heart rate sensor configured to sense heart rate and to record the sensed heart rate as data into a memory.

An implantable device (11) for evaluating autonomic cardiovascular drive in a patient (10) suffering from chronic cardiac dysfunction is provided. A stimulation therapy lead (13) includes helical electrodes (14) configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins (28) electrically connected to the helical electrodes (14). A neurostimulator (12) includes an electrical receptacle (25) into which the connector pins (28) are securely and electrically coupled. The neurostimulator (12) also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes (14) in alternating cycles of stimuli application and stimuli inhibition (90) that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. The neurostimulator (12) includes a recordable memory (29) storing a baseline heart rate. The neurostimulator (12) includes an integrated leadless heart rate sensor (31) configured to continually monitor heart rate in light of the baseline heart rate.

The present invention relates to American goldenrod herb total flavone extract and its preparation process and use. The American goldenrod herb total flavone extract contains quercetin, quercetin-3-O-beta-D-heteroside, kaempferol-3-O-alpha-L-rhamnoside, chlorogenic acid, etc. capable of preventing and treating senile dementia, various inflammatory respiratory diseases, esophagus cancer, etc. The preparation process is simple, high extracting rate, and the extract has high pharmacological effect, stable property, low toxicity and controllable quality.

The invention discloses a Chinese medicinal preparation for relieving pains caused by various chronic diseases and wounds, wherein the raw material include the following constituents (by weight ratio): cattail pollen 10-50, trogopterus dung 10-50, rhizoma corydalis 10-50, curcuma root 10-50, sandalwood 10-25, notoginseng 10-50, radix salvia miltiorrhiza 10-50, curcuma longa 10-30, rhizome of Sichuan lovage 10-30, amber 10-30 and borneol 1-10.

An implantable device (11) for evaluating autonomic cardiovascular drive in a patient (10) suffering from chronic cardiac dysfunction is provided. A stimulation therapy lead (13) includes helical electrodes (14) configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins (28) electrically connected to the helical electrodes (14). A neurostimulator (12) includes an electrical receptacle (25) into which the connector pins (28) are securely and electrically coupled. The neurostimulator (12) also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes (14) in alternating cycles of stimuli application and stimuli inhibition (90) that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. The neurostimulator (12) includes a recordable memory (29) storing a baseline heart rate.

The present invention is new total plumepoppy alkaloid salt and its preparation and application. The total plumepoppy alkaloid salts of organic acid and boric acid have the content of 50-90 % accounting in the organic acid salt and boric acid salt of sanguinarine and chelirubine. The total plumepoppy alkaloid salts of organic acid and boric acid have the antibacterial and antiphlogistic activity superior to that of total plumepoppy alkaloid sulfate and hydrochloride. The present invention also relates to the antibacterial and antiphlogistic application of medicines and daily use articles containing total plumepoppy alkaloid salts of organic acid and boric acid for human and animal.

The present invention is in the field of prevention and treatment of atherosclerosis and atherosclerosis-related clinical conditions. In particular, the present invention relates to the use of sphingolipids, more preferably phytosphingosine, sphingosine, sphinganine, ceramide, cerebroside lyso-sphingomyelin and / or sphingomyelin for prevention and treatment of inflammatory processes associated with atherosclerosis, psoriasis, colitis or auto-immune diseases in a subject.

The present invention relates to a method for treating dermal inflammation and dermal diseases by local or systemic delivery, in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of Formyl peptide receptor 2 (FPR2).

The present invention discloses the use of Fritillaria fricarifolia alkaloid compounds represented by general formula I in the preparation of antitussive, expectorant and / or anti-inflammatory drugs, wherein R1 is: =O or R2 is: H; R3 is: H; R4 is H or OH; R5 is: O or none. Among them, Sibetine, Tribenidone, Sibetine Nitrogen Oxides, Isofibesine, Isofibesine Nitrogen Oxides and 10 times the amount of codeine phosphate have similar antitussive effects, and the 5 The antitussive and anti-inflammatory effects of this monomer are also superior to peiminine and peiminine; among them, peiminine, peiminine, sibenetine, sibemine nitrogen oxide, and isobeamine Nitrogen oxides have a good expectorant effect. The invention also discloses the total alkaloid extract of Fritillaria wabu and its preparation method and application. Formula I

A composition is provided that includes a fish spawn protein isolate. A natural product extract is also present that includes unsaturated fatty acids and sterols. An emulsifier is provided to form a mixture of the isolate and the extract. A composition is also provided that includes an egg hatching protein isolate and at least one biocide protective of isolate activity. An emulsifier forms a mixture with the isolate that has an aqueous phase buffered to a pH of between 5.6 and 7.9. A process of producing such a cosmetic has an emulsion or an aqueous phase that is buffered to a pH of between 5.5 and 7.9 prior to the addition of isolate to the emulsion. A process of improving skin appearance is provided that includes the application of the cosmetic to the skin at least three times per week to achieve the improvement of the skin appearance.

Symptoms, including biochemical correlates, of multiple sclerosis (MS) in a mammal are beneficially affected by administering to the mammal small doses of bodies, such as liposomes, of a size resembling that of mammalian cells, the bodies having phosphate glycerol head groups presented exteriorly on their surfaces. Preferred are liposomes comprised of 50-100% phosphatidylglycerol, with the phospho glycerol headgroups thereof exteriorly presented.

The invention discloses a traditional Chinese medicinal preparation for treating gout and a preparation method thereof. The traditional Chinese medicine is prepared from the following raw materials in part by weight: 1 to 30 parts of longhairy antenoron herb, 1 to 20 parts of clematis root, 1 to 20 parts of piper wallichii, 1 to 20 parts of lysimachia trientaloides hemsl, 1 to 20 parts of siphonostegia chinensis, 1 to 20 parts of oriental waterplantain rhizome and 1 to 10 parts of plantain herb. The traditional Chinese medicinal preparation is prepared from seven natural Chinese medicinal herbs, has the effects of clearing heat and eliminating stagnation and eliminating blood stasis and removing pain, has obvious anti-inflammatory effect and analgesic activity, and has good effects of treating acute gouty arthritis and various diseases during critical gout, difficult recurrence, and no obvious toxic or side effect or untoward effect.

The invention relates to organic fertilizer, in particular to jonquil planting organic fertilizer .The invention further relates to a preparation method of the jonquil planting organic fertilizer .The jonquil planting organic fertilizer is prepared from, by mass, 30-50 parts of arenaceous soil, 13-19 parts of closterium powder, 10-15 parts of chicken manure, 10-15 parts of decumbent bugle herb, 7-15 parts of pomegranate peel, 10-20 parts of acalypha australis, 8-16 parts of a water-retaining agent, 9-18 parts of hedyotis diffusa residues, 7-15 parts of radix isatidis residues, 1-5 parts of urea, 2-6 parts of calcium superphosphate and 2-5 parts of multiple microorganisms .The jonquil planting organic fertilizer can be prepared and directly applied, the preparation process is simple, and the utilization rate is high.

The invention discloses a preparation method of hydrogel dressing containing honeysuckle flower and Chinese wolfberry fruit extracts. The synergistic effect of the Chinese wolfberry fruit and honeysuckle flower extracts and nanometer zinc oxide is utilized; on one hand, the extracts are wrapped at the periphery of the nanometer zinc oxide, so that the extracts can stably exist; on the other hand,Chinese wolfberry fruits and honeysuckle flowers have the effects of protecting cells and promoting cell multiplication; the obvious antibacterial activity and anti-inflammatory effects are realized;meanwhile, the pharmacological actions of regulating the blood sugar, reducing the lipid, resisting the mutagenesis, resisting the senility, resisting the anoxia, regulating the endocrine hormone andthe like are achieved; when being applied to application dressing, the extracts can be synergistic with the nanometer zinc oxide; the antibacterial effect of the hydrogel dressing is enhanced; meanwhile, the wound healing is promoted, and the anti-inflammatory effect is achieved; when the nanometer zinc oxide is used for modifying a chitosan solution, the mechanical performance of the hydrogel dressing is improved; meanwhile, the antibacterial effect is enhanced.

The present invention relates to a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity comprising a polypeptide comprising a bee venom-PLA2 amino acid sequence exclusive of a leader sequence as an active ingredient. The secretory bee venom-phospholipase A2 of the present invention activates a regulatory T cell and suppress a differentiation of Th1 / Th7. Therefore, the present polypeptide can be used as a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity, i.e. autoimmune diseases, allergic diseases, or neurodegenerative diseases.

The invention discloses children anti-caries toothpaste containing natural antibacterial components, and a preparation technology of the children anti-caries toothpaste. The children anti-caries toothpaste comprises the following ingredient compositions in parts by weight: 5-15% of silicon dioxide, 0.2-0.9% of xanthan gum, 0.1-0.8% of carrageenan, 30-50% of sorbitol (70% solution), 10-20% of glycerin, 0.5-2.5% of sodium polyphosphate, 0.5-2% of polyethylene glycol, 0.5-2.5% of lauryl sodium sulfate, 0.05-0.5% of Olaflur, 0.1-5.0% of isomaltooligosaccharide, 1.0-6.0% of xylitol, 0.001-0.1% of polylysine, 0.001-0.2% of glycine, 0.05-1.5% of eugenol, 0.06-2.8% of pineapple enzyme, 0.05-2.5% of folium isatidis extract, 0.001-0.025% of pigment, 0.1-1% of essence and the balance of purified water. The children toothpaste can clean teeth and also can perform the functions of inhibiting bacteria, resisting inflammation, stopping bleeding, accelerating a wound to heal, and efficiently preventing caries.

The invention discloses a rapid hemostatic sponge and a preparation method thereof, the rapid hemostatic sponge comprises gelatin, a polysaccharide compound and a cross-linking agent, and the polysaccharide compound is prepared by physically cross-linking a hydrophobic modified polysaccharide compound and a hydrophilic modified polysaccharide compound. The polysaccharide complex in the components of the rapid hemostatic sponge has both hydrophilic groups and hydrophobic groups, so that the hydrophilic and hydrophobic synergistic effect is achieved, the whole components of blood are promoted to be rapidly gelatinized within 10-30 s, and the hemostatic effect of the sponge is greatly enhanced; according to the process, a polysaccharide compound and gelatin are uniformly mixed in a manner of cross-linking, mixing and freeze-drying, so that the technical problem that chitosan in the existing chitosan gelatin foam is easy to infiltrate and is not uniformly released is solved; tannic acid is adopted as a cross-linking agent, the anti-inflammatory effect can be achieved on the premise that the biological safety of the sponge is guaranteed, the tannic acid and chitosan can achieve a synergistic effect in the hemostasis function, and the effect is better compared with that of common chitosan gelatin sponge.

Provided is a new anti-inflammatory drug that produces an anti-inflammatory effect by modulating macrophage function. Specifically, a new anti-inflammatory drug that produces an anti-inflammatory effect through induction of M2 macrophages using activin species is provided.

The invention relates to compound sulfachloropyridazine sodium powder, and aims to provide a method for preparing compound sulfachloropyridazine sodium powder for preventing and treating livestock pasteurella infection. The method includes dispensing from 60 to 65 parts of sulfachloropyridazine sodium, from 2 to 4 parts of indometacin potassium, from 10 to 25 parts of suspending agents, from 2 to 4 parts of flavoring agents and the balance acceptable carriers; and then respectively mixing and grinding the components and mixing the components together to obtain the compound sulfachloropyridazine sodium powder. The compound sulfachloropyridazine sodium powder has an exact curative effect for various animals with pasteurellosis and is suitable to be popularized and used in animal husbandary. The sulfachloropyridazine sodium and the indometacin potassium are used compatibly, the indometacin potassium is used as an antibacterial synergist while realizing antibacterial and anti-inflammation effects, and drug effects of a main drug can be strengthened under a synergetic effect. The compound sulfachloropyridazine sodium powder can be orally taken, fed in a mixed manner and absorbed with drinking water effectively, is not easy to cause drug resistance, is safe in long-term healthcare and prevention and treatment, and has good palatability, flowability and suspension water-solubility, and various clinical administration modes of the product and convenience in administration of the product are guaranteed.

The invention discloses children allergic rhinitis oil and a preparation method thereof. The child allergic rhinitis oil is prepared from the following raw materials in parts by mass: 20-40 parts of flos magnoliae liliflorae, 10-30 parts of cocklebur fruits, 10-20 parts of fructus liquidambaris, 10-20 parts of licorice roots, 10-20 parts of rhizoma acori graminei, 60-80 parts of sesame oil, 10-50parts of olive oil, 5-10 parts of tea tree essential oil, 5-10 parts of honeysuckle flowers, 7-15 parts of Chinese azalea flowers, 6-15 parts of herba ephedrae, 2-5 parts of radix arnebiae seu lithospermi, 4-6 parts of radix scutellariae, 10-15 parts of herba houttuyniae, 8-12 parts of walnut kernels, 10-20 parts of radix astragali, 10-20 parts of periostracum cicada, 1-5 parts of herba schizonepetae, 1-6 parts of radix pseudostellariae, 6-10 parts of stiff silkworm, 6-10 parts of rhizoma pinelliae preparata, 3-7 parts of carapax eretmochelyos, 5-15 parts of bighead atractylodes rhizome, 1-11parts of radix bupleuri, 0.02-2 parts of a vitamin composition, 0.4-4 parts of an amino acid composition and 0.3-3 parts of adjuvant materials. The children allergic rhinitis oil has the beneficial effects of being beneficial to children and obvious in antiallergic and anti-inflammatory effects.

The invention relates to the compound urolithin A and its compositions for topical use in inflammatory skin conditions of various etiologies. Anti-inflammatory activity has been demonstrated in vivo in a model of inflammation of the ear caused by infiltration with dinitrochlorobenzene in rats. Topical application of an ointment containing 0.2 and 1.0% urolithin A resulted in a decrease in ear edema and scratching frequency, which was associated with a decrease in the number of immune cells responsible for the progression of inflammation. The results obtained indicate the possibility of using a composition containing urolithin A in local therapy of skin inflammations, in treatment of which hydrocortisone or other steroids are currently used.

The present invention relates to a compound for use in a method of treating a disease selected from cystic fibrosis, ulcerative colitis, and irritable bowel syndrome, wherein said compound is an inhibitor of a TMEM16 protein, preferably of TMEM16A and / or TMEM16F.

The invention discloses a skin care composition and a preparation method thereof. The skin care composition comprises an industrial hemp flower and leaf extract and a glycyrrhiza glabra extract, and the mass ratio of the industrial hemp flower and leaf extract to the glycyrrhiza glabra extract is (1.5-16): 1. Specifically, the skin care composition can be composed of the following components in percentages by weight: 1% to 20% of an emollient, 0.05% to 1% of a thickening agent, 0.5% to 5% of an emulsifying agent, 0.15% to 0.5% of a hemp flower and leaf extract, 0.03% to 0.1% of a glycyrrhiza glabra extract, 0.1% to 1.0% of a preservative, 0.5% to 15% of polyhydric alcohol, 0.02% to 0.2% of an additive and the balance of pure water. According to the skin care composition disclosed by the invention, the industrial hemp flower and leaf extract and the glycyrrhiza glabra extract have a synergistic effect, so that multiple skin care effects of whitening, removing freckles, removing wrinkles, diminishing inflammation, brightening the skin color, homogenizing the skin color and the like are achieved.

A composition for treating inflammation and pain, including a hydrogen-generating compound in an amount that increases the amount of hydrogen in an individual and has an anti-inflammatory effect. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A method of treating inflammation and pain, by administering a composition comprising a hydrogen-generating compound to an individual in an amount that increases the amount of hydrogen in the individual and has an anti-inflammatory effect.

The invention provides a formula of facial mask powder with effects of maintaining beauty and keeping young and belongs to the field of beauty maintaining and young keeping. The facial mask powder comprises raw materials in parts by weight as follows: 5-10 parts of radix codonopsis, 5-10 parts of venenum bufonis, 5-10 parts of lavender, 10-20 parts of mung bean, 5-10 parts of flos lonicerae, 5-10 parts of flos chrysanthemi, 3-8 parts of radix sophorae flavescentis, 3-8 parts of periostracum cicadae, 10-20 parts of lotus root, 5-10 parts of rhizoma bletillae, 5-10 parts of radix angelicae sinensis, 5-10 parts of rhizoma ligustici, 5-10 parts of cuttlebone, 5-10 parts of feaces vespetilio, 10-15 parts of green tea, 10-20 parts of orange peel and 10-20 parts of pearl powder. The invention further discloses a preparation method and an application method of the facial mask powder with the effects of maintaining beauty and keeping young. The facial mask powder with the effects of maintaining beauty and keeping young is prepared from Chinese herbal medicines, treat skin deeply, achieves the purposes of inflammation diminishing and beauty maintaining, has remarkable effect and is safe and free of side effects.

The invention discloses Moringa oil facial mask and a making method thereof. The Moringa oil facial mask is made with butanediol, Aesculus hippocastanum flower water, Hypericum perforatum flower extract, glycereth-26, glycerol polymethacrylate, oat peptides, beta-glucose, 1,2-pentanediol, ellagic acid, tranexamic acid, yeast ferment extract, panthenol, Radix Pulsatillae extract, white willow barkextract, PET-10 phytosterol, C12-13 pareth-9, Moringa oil, carbomer, triethanolamine, xanthan gum, phenoxyethanol, sodium hyaluronate and the balance of water. The technical problem that domestic Moringa oil facial mask with good skin-care effect is absent in China is solved. The self-researched domestic Moringa oil facial mask is provided, which has the effects of whitening and moisturizing, wrinkle resisting and speckle removing, skin firming, and age defying, is good in safety and nonirritating and is suitable for beauty-loving people of all ages.

The invention discloses a preparation method of novel bi-crosslinked antibacterial hydrogel for repairing wound surfaces of burns and scalds, which specifically comprises the following steps: firstly, preparing polyhexamethylene biguanide-loaded ZIF-8 nanoparticles, grafting 3-aminophenylboronic acid to human-like collagen to obtain modified human-like collagen, activating sodium alginate by using EDC and NHS, and finally, performing composite crosslinking on sodium alginate, the ZIF-8 nanoparticles and the modified human-like collagen to form double-network hydrogel with a stable space structure, and performing Co60 irradiation sterilization to obtain the novel double-crosslinking antibacterial hydrogel for repairing wound surfaces of burns and scalds. The preparation method is simple and easy to implement and good in reproducibility, wherein the prepared bi-crosslinking antibacterial hydrogel has long-acting slow-release antibacterial capacity and good epithelial cell growth promoting capacity, has ideal performance in the aspect of burn and scald wound repair and is wide in application prospect.

The invention discloses a quick-acting hemostatic sponge and a preparation method thereof, the polysaccharide-based hemostatic sponge comprises gelatin, a polysaccharide conjugate and a cross-linking agent, and the polysaccharide conjugate is prepared by a hydrophilic and hydrophobic co-grafting process. Compared with a mixing scheme of a hydrophilic modified polysaccharide conjugate and a hydrophobic modified polysaccharide conjugate, the polysaccharide conjugate is more uniform in group distribution and more stable in property; the sponge can generate physical and chemical effects with all components of blood through a hydrophilic and hydrophobic synergistic effect, so that the all components of the blood are quickly gelatinized within 10-30 seconds, and the hemostatic effect of the sponge is greatly enhanced; according to the process, a polysaccharide conjugate and gelatin mixed freeze-drying mode is adopted, and the polysaccharide conjugate and the gelatin are uniformly mixed, so that the technical problem that chitosan in existing chitosan gelatin foam is easy to infiltrate so as to cause non-uniform release is solved; tannic acid is adopted as a cross-linking agent, the anti-inflammatory effect can be achieved on the premise that the biological safety of the sponge is guaranteed, the tannic acid and chitosan can achieve a synergistic effect in the hemostasis function, and the effect is better compared with that of common chitosan gelatin sponge.

The invention discloses allergic rhinitis oil for adults and a preparation method thereof. The allergic rhinitis oil for adults is prepared from the following raw materials in parts by mass: 20-30 parts of radix angelicae, 10-20 parts of fructus liquidambaris, 60-80 parts of sesame oil, 10-50 parts of olive oil, 5-10 parts of tea tree essential oil, 5-10 parts of flos lonicerae, 10-15 parts of herba taraxaci, 6-10 parts of radix notoginseng, 2-3 parts of cortex mori radicis, 1-2 parts of herba asari, 10-15 parts of herba centipedae, 8-12 parts of rhizoma cimicifugae, 5-15 parts of rhizoma chuanxiong, 5-15 parts of radix codonopsis, 1-6 parts of folium perillae, 1-5 parts of fructus arctii, 5-9 parts of semen armeniacae amarum, 10-15 parts of radix platycodi, 3-7 parts of pangolin scales, 10-16 parts of radix astragali, 5-15 parts of radix saposhnikoviae, 5-15 parts of cortex moutan, 1-11 parts of fructus mume, 0.02-2 parts of vitamin compositions, 0.4-4 parts of amino acid compositionsand 0.3-3 parts of accessories. The allergic rhinitis oil for adults has the benefits that the allergic rhinitis oil is capable of effectively treating allergic rhinitis, is remarkable in effect, andis small in side effects.