42 results about "Urolithin" patented technology

The subject invention is drawn to ellagitannin metabolites (e.g., urolithin) that find use in treating or preventing a neoplastic disease in a subject.

Provided are compositions comprising compounds or precursors to compounds which may be used for a variety of therapeutic applications including, for example, treating and / or preventing a disease or disorder related to reduced or inadequate mitochondrial activity, including aging or stress, diabetes, obesity, and neurodegenerative diseases. The compounds relate generally to urolithins and precursors thereof, including but not limited to ellagitannins and urolithin A. In certain embodiments the compositions are presented in or as food products or nutritional supplements. These same compounds and compositions can also be used advantageously in generally healthy individuals to increase or maintain metabolic rate, decrease percent body fat, increase or maintain muscle mass, manage body weight, improve or maintain mental performance (including memory), improve or maintain muscle performance, improve or maintain mood, and manage stress.

The invention provides compositions comprising a medium chain triglyceride and a urolithin. The invention also provides uses and methods associated with, or making use of the compositions, such as a medicament, dietary supplement, functional food or medical food and in the treatment and / or prophylaxis of a muscle-related pathological condition.

The present invention addresses the problem of providing a method for eliminating the hydroxyl group at the 9-position of an urolithin in order to produce another urolithin. This problem is solved bya method for producing second urolithin, the method including a step (a) for causing a microorganism, which is capable of producing a second urolithin from a first urolithin, to produce the second urolithin from the first urolithin, in a solution containing the first urolithin.

Provided are compositions comprising compounds or precursors to compounds which may be used for a variety of therapeutic applications including, for example, treating and / or preventing a disease or disorder related to reduced or inadequate mitochondrial activity, including aging or stress, diabetes, obesity, and neurodegenerative diseases. The compounds relate generally to urolithins and precursors thereof, including but not limited to ellagitannins and urolithin A. In certain embodiments the compositions are presented in or as food products or nutritional supplements. These same compounds and compositions can also be used advantageously in generally healthy individuals to increase or maintain metabolic rate, decrease percent body fat, increase or maintain muscle mass, manage body weight, improve or maintain mental performance (including memory), improve or maintain muscle performance, improve or maintain mood, and manage stress.

The invention discloses an application of urolithin A in prevention and treatment of allergic rhinitis and allergic asthma, and the urolithin A is used for treating allergic airway diseases by adjusting lung tissue TXNIP / NLRP3 pathway related proteins. The inventor finds that the urolithin A can significantly improve multiple inflammatory indexes of mice with allergic airway diseases, and compared with ellagic acid, the urolithin A has the effects of improving the nose scratching frequency of the mice in a disease model group, reducing the levels of IL-5, IL-4 and IL-18 in BALF, and improving the inflammatory index of the mice with allergic airway diseases. The traditional Chinese medicine composition has better effects on relieving lung eosinophilic granulocyte infiltration and goblet cell hyperplasia, reducing pathological scores of bronchial and perivascular inflammatory cell infiltration degrees, increasing the level of anti-oxidation factors GSH of lung tissues, reducing TXNIP, ASC and IL-1beta protein expression of the lung tissues and reducing the proportion of NLRP3 and TXNIP positive cells.

The present invention addresses the problem of providing an effective and highly safe osteoclast differentiation inhibitor and a food or beverage, a medicine, a supplement, and a cosmetic exhibiting an osteoclast differentiation-inhibiting effect. The problem is solved by an osteoclast differentiation inhibitor containing an urolithin.

The invention relates to the compound urolithin A and its compositions for topical use in inflammatory skin conditions of various etiologies. Anti-inflammatory activity has been demonstrated in vivo in a model of inflammation of the ear caused by infiltration with dinitrochlorobenzene in rats. Topical application of an ointment containing 0.2 and 1.0% urolithin A resulted in a decrease in ear edema and scratching frequency, which was associated with a decrease in the number of immune cells responsible for the progression of inflammation. The results obtained indicate the possibility of using a composition containing urolithin A in local therapy of skin inflammations, in treatment of which hydrocortisone or other steroids are currently used.

Disclosed are compounds for use in raising an immune response to an antigen and / or enhancing, modulating or augmenting an immune response to an antigen. Particularly the use of urolithins. The invention also relates to immune enhancers comprising urolithins, methods of using such immune enhancers and processes for the preparation of such immune enhancers. The invention also relates to the use of urolithins in methods for modulating stem cell function, for example, enhancing stem cell numbers, promoting stem cell regeneration and promoting stem cell differentiation.

The invention discloses a benzo [c] benzopyrone derivative and application thereof. A series of chemical derivatives containing a Uro B skeleton (benzo [c] benzopyrone) as shown in a formula (I) are designed and synthesized by introducing different N-terminal end groups into a urolith derivative through a 1, 3-dibromopropane bridge chain. The invention can be applied to preparation of various anti-tumor drugs and is especially suitable for bladder cancer.

The present invention addresses the issue of providing: a novel microorganism having a high capability to produce urolithins; and a method of producing urolithins using the same, and the issue is solved by a microorganism that belongs to the genus Eggerthella and produces urolithins.

A urolithin-containing aqueous solution containing urolithin and collagen, a dried solid composition thereof, methods for producing these, and a stabilization method for urolithin.

The invention provides compounds of formula (I) or salts thereof:wherein:A, B, C, D, W, X, Y and Z are as defined in the specification, and at least one of A, B, C, D, W, X, Y and Z is OR1; each R1 being independently H or C(═O)R2, and at least one R1 group being C(═O)R2; where each R2 is selected from:CHR3NHR4, where R4 is H and R3 is a group selected from CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, CH2Ph, CH2-3-(1H-indole), CH2CH2SCH3, CH2OH, CHOHCH3, CH2SH, CH2SeH and CH2PhpOH,wherein said R3 group can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORA or C1-C4 alkyl;or R3 and R4 together with the C and N atoms to which they are attached form a 5-membered heteroalkyl ring, wherein said heteroalkyl ring can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORA or C1-C3 alkyl,wherein RA is C1-C4 alkyl optionally substituted with one or more halogen, cyano or nitro groups.The compounds are effective pro-drugs for urolithins and they enable the ready delivery of urolithins to the site in the digestive tract where they can be absorbed into the body.

An object of the present invention is to provide a method for eliminating the hydroxyl group at the 8-position of a urolithin to produce another kind of urolithin, and this object is achieved by a method for producing a second urolithin, comprising the Step (a): allowing, in a solution. containing a first urolithin, a microorganism having an ability to produce the second urolithin from the first urolithin to produce the second urolithin from the first urolithin.

A composition comprising: a) nicotinamide riboside and b) a urolithin which is a compound of formula (I) or a salt thereof: formula (I) wherein: A, B, C and D are each independently selected from H and OH; W, X, and Y are each independently selected from H and OH; and Z is selected from H and OH. Said composition is suitable for use as a medicament, for example for the treatment of pathological conditions related to muscles, neurodegenerative diseases and / or mitochondrial diseases.

The application discloses the application of ellagic acid metabolite Urolithin A in the technical field of pharmaceutical preparations in the preparation of anti-enterovirus drugs, especially the application in the preparation of drugs for preventing and treating enterovirus 71 (Enterovirus 71, EV71). The present invention shows that Urolithin A can inhibit the replication of EV71 at gene and protein levels through the influence of UroA on EV71 virus titer and EV71 protein expression. It is proved that the Urolithin A has obvious anti-EV71 effect and can be used to prepare anti-EV71 medicine.

The invention discloses an environment-friendly long-acting metal antirust agent, and relates to the technical field of urolithin, in particular to an environment-friendly long-acting metal antirust agent. The environment-friendly long-acting metal antirust agent is prepared from the components in percentage by weight: 15-25% of sulfuric acid, 20-35% of citric acid, 3-10% of ethylene glycol, 1-3%of ethylenediamine tetraacetic acid, 0.1-0.5% of polyvinylpyrrolidone and the balance of water. According to the environment-friendly long-acting metal antirust agent, the sulfuric acid is an inorganic strong acid, has good dispersity, can be completely ionized in a solution, and is beneficial to improving the conductivity, the dispersing capacity and the anode current efficiency of a polishing solution, so that the surface of stainless steel is polished uniformly; and the citric acid is low in acidity and large in viscosity, can achieve a dissolving effect and form a passivation film on the surface of the stainless steel in the polishing process, and prevents over-corrosion of the stainless steel; and the ethylene glycol is adsorbed on the surface of an anode, is beneficial to promoting formation of a diffusion layer, can form a thin film on the surface of the stainless steel together with the citric acid, prevents over-corrosion of the stainless steel, and makes the surface of the polished stainless steel be bright and fine.

The present disclosure provides nanoparticle compositions comprising i) a polymeric nanoparticle, ii) one or more ligands conjugated to the polymeric nanoparticle, and iii) urolithin A. The disclosure also provides methods and pharmaceutical compositions comprising the nanoparticle compositions for use in treating patients with various disease states.