261 results about "Allergic asthma" patented technology

The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.

The present invention relates to novel human antibodies specifically directed against human immunoglobulin E (anti-IgE). The present invention also relates to pharmaceutical compositions and methods for treating asthma, in particular allergic asthma, as well as other IgE-mediated disorders including allergic rhinitis and food allergies.

The invention relates to compounds of general formula (I):wherein R1, R2, R3, R4 and R5 are as defined hereinfor the treatment of allergic conditions, wherein the treatment is by pulsed therapy which comprises a first period during which the compound is administered to the patient and a second period of at least seven days during which the compound is administered to the patient in a reduced amount. The invention also relates to compounds of general formula (I) for desensitizing the immune system of a subject to allergens, thus preventing or reducing the symptoms of allergic conditions such as allergic asthma, allergic rhinitis, or atopic dermatitis.

The invention discloses a method for developing a novel indoor acaricide. The novel acaricide uses clove and other Chinese medicinal materials as raw materials, the main active component thereof is eugenic acid, and the novel acaricide is a pure natural chemical substance, has no notable harms to human bodies and other organic bodies, has no potential hazards to the environment too, and can be widely applied to killing, preventing and controlling various dust mites of dermatophagoides pteronyssinus, dermatophagoides farinae and the like in various regions and various indoor environments. The novel acaricide can effectively control the number of the dust mites in the living environments of people, greatly reduce the density of dust mite allergens in the indoor environments, and significantly reduce the disease incidence of dust mite anaphylactic diseases. Besides, the novel acaricide has outstanding effects of preventing and performing adjuvant therapy on various anaphylactic diseases taking the dust mites as the allergens, such as allelgic asthma, rhinitis and the like.

The present invention relates to an herbal composition which is non-alcoholic, non-sedating and non-freezing in nature for the treatment of chronic respiratory disorders such as cold, cough, allergic asthma, seasonal allergic rhinitis, pharyngitis, laryngitis and the like and a process for preparing the same. The process comprises procuring, cleaning, grading of specified herbal plants per the standard specification, disintegrating and pulverizing separately to form coarse powder, then macerating individual powders separately with aqueous solution of preservatives, then extracting, filtering, concentrating and spray drying to make dry extract powder or semisolid soft extract. Further dissolving each of the extracts separately in aqueous solution containing preservatives and then allowing to maturate after mixing. Then adding filtered extracts to the sugar syrup containing preservatives, glycerin and appropriate excipients to obtain a homogenous cough syrup.

The present invention relates to anti IL13 antibodies that hind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.

The invention relates to the technical field of antibodies, and especially relates to a human thymus stromal lymphopoietin monoclonal antibody and an application thereof. The TSLP antibody can be specifically combined with hTSLP, has high affinity, and can effectively inhibit the combination of TSLP and a receptor thereof so as to inhibit activation of a downstream signal path and activation of immune cells by TSLP. The TSLP antibody has great significance in detection of the content of hTSLP and allergic asthma, and diagnosis, treatment and prognosis of inflammatory or allergic inflammatory diseases such as chronic obstructive pulmonary disease, allergic dermatitis, allergic rhinitis, allergic nasosinusitis, eosinophilic granulocytic esophagitis, allergic conjunctivitis, inflammatory bowel disease or atopic dermatitis.

The present invention relates to a histaminase of vegetable origin to be used in the treatment of allergic and septic shock and inallergic asthma. The invention also regards the preparation of the histaminase for pharmaceutical use and the corresponding pharmaceutical compositions.

The invention discloses a Chinese medicinal preparation for treating allergic rhinitis, allergic asthma and urticaria and a preparation method thereof. The Chinese medicinal preparation comprises the following main raw material medicaments in part by weight: 4 to 36 parts of bupleurum, 5 to 30 parts of root of red-rooted salvia, 4 to 28 parts of paniculate swallowwort root, 4 to 28 parts of cicada slough, 6 to 32 parts of dry rehmannia root and 4 to 28 parts of ligusticum sinense oliver. The preparation method comprises the following steps of: 1, cleaning the medicinal materials with water; 2, drying the medicinal materials, crushing into medicinal powder of 100 to 200 meshes, uniformly mixing, soaking, decocting twice, filtering out, and mixing to obtain an active extract; when filtrate becomes thick paste with the concentration density of between 1.30 and 1.35, drying, and crushing into medicinal powder of 100 to 200 meshes to obtain powder; and 3, adding auxiliary materials, and preparing into capsules, tablets and the like. The Chinese medicinal preparation has the effects of resisting inflammation, resisting allergy and improving microcirculation, improves allergic body diathesis, improves resisting capability of a human body to allergens, and has obvious effects on the allergic rhinitis, the allergic asthma and the urticaria, short treatment cycle and low recurrence rate.

The present invention relates to immunoglobulin single variable domain sequences that are directed against (as de-fined herein) OX40L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such immunoglobulin single variable domain sequences. In particular these immunoglobulin single variable domain sequences can block binding of OX40L to OX40. The immunoglobulin single variable domains, compounds and constructs can be used for prophylactic, therapeutic or diagnostic purposes, such as for the treatment of inflammatory disease and / or disorder such as e.g. asthma, allergic asthma, chronic colitis, Crohn's disease, inflammatory bowel disease, and / or arthrosclerosis.

The invention provides an artemisia pollen allergen vaccine, and a preparation method and application thereof. The artemisia pollen allergen vaccine comprises an artemisia sieversiana pollen allergen, an artemisia annua pollen allergen and an artemisia argyi pollen allergen. Compared with a single artemisia pollen allergen vaccine, the combined vaccine has the advantages that the effectiveness of treatment is improved while the safety can be ensured; and the artemisia pollen allergen vaccine can be used for treating allergic dermatitis, chronic urticaria, allergic rhinitis and allergic asthma which are caused by allergy to multiple artemisia pollens.

The present invention relates to novel human antibodies specifically directed against human immunoglobulin E (anti-IgE). The present invention also relates to pharmaceutical compositions and methods for treating asthma, in particular allergic asthma, as well as other IgE-mediated disorders including allergic rhinitis and food allergies.

The present invention is based on the discovery that biological peptide-based mimotopes of mannose-containing cell-wall compounds of Mycobacterium tuberculosis, specifically, ManLAM, have an anti-inflammatory effect and immunoregulator effect in animal models of inflammation. Such models include animal models of allergic peritonitis, allergic asthma and septic shock model (mice injected with LPS) and in Crohn's disease model (TNBS-induced colitis). Thus, the present invention concerns the use a molecule, particularly, an amino acid based molecule for the production of a pharmaceutical composition for the treatment of an inflammatory condition, the amino acid comprising one or more peptides characterized in that it can bind to ManLAM binding antibodies; and / or it can elicit an immune response in a subject inoculated therewith, giving rise to production of ManLAM-binding antibodies. The invention also provides pharmaceutical compositions for treating inflammatory conditions and comprising the amino acid-based molecule, as well as to methods of treatment of such conditions by administering to a subject an amount of the amino-acid based molecules.

The invention belongs to the technical field of biology, and relates to an allergic asthma model, in particular to application of chitosan serving as immuno-adjuvant in preparing a mouse allergic asthma model. According to the application, the mouse allergic asthma model prepared by applying chitosan serving as immuno-adjuvant is subjected to airway responsiveness, lung tissue pathological examination and inflammation marker inspection, and results indicate that the mouse allergic asthma model prepared by applying chitosan serving as immuno-adjuvant is remarkably superior to a conventional immuno-adjuvant prepared asthma model in airway eosinophilic inflammation, airway responsiveness and airway inflammatory cytolines and other aspects. The chitosan has low price and rich sources; and the mouse asthma model by using chitosan as immuno-adjuvant is remarkably superior to a traditional adjuvant, and has the advantages of simple method, low cost, good reproducibility and the like.

The present invention relates to method of preparing dust mite allergen vaccine with nanometer particle as carrier. Dust mite is one of the main allergen causing allergic diseases. The present invention applies biodegradable nanometer PLGA particle as the allergen carrier to coat recombinant dust mite allergen Der p2 / Der f2 in preparing nanometer level dust mite allergen vaccine. Specifically, by means of gene engineering technology, recombinant Der p2 / Der f2 protein is prepared through cloning and expression in colibacillus and PLGA coated nanometer particle is prepared through re-emulsifying and solvent volatizing process. The form, average size, coating rate, medicine carrying amount and extracorporeal accumulation and release curve of the nanometer particle are obtained, and test shows that Der p2 / Der f2-PLGA nanometer particle has certain curative effect on allergic asthma.

The invention discloses a medicine for treating cough. The medicine adopts Cortex Mori, Radix Panacis Quinquefolii, Bulbus Fritillariae Unibracteatae, Cordyceps, Radix Scutellariae, Radix Saposhnikoviae, Fructus Forsythiae, Radix Aucklandiae, Cortex Magnoliae Officinalis, Radix Platycodi, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Astragali, Flos Lonicerae, Endothelium Corneum Gigeriae Galli, Rhizoma Atractylodis Macrocephalae, Herba Ephedrae, Poria and Roasted Radix Glycyrrhizae as the raw materials. The drugs are dried, crushed and prepared into power or capsules. The invention is used for treating chronic bronchitis, allelgic asthma, emphysema, pulmonary heart disease and high blood pressure and has the advantages of quick relieving cough, eliminating phlegm and relieving asthma, enhancing appetite, promoting digestion, the most remarkable characteristic of both temporary solution and permanent cure, good long term effect.

The present invention relates to methods and pharmaceutical composition for the treatment of T-helper type 2 (Th2)-mediated diseases. More particularly, the present invention relates to an inhibitor of the Suv39h1-HP1a silencing pathway for use in the treatment of a T-helper type 2 (Th2)-mediated disease, in particular allergic asthma.

The present invention provides a method of inhibiting at least one of allergic asthma, allergic rhinitis and atopic. The present invention further provides a method for the reduction, prevention or treatment of allergy like symptoms in a subject.

The invention provides strategies for treating and preventing airway hyperreactivity and non-allergic asthma comprising antagonizing IL-17 activity and / or production by iNKT cells. Provided herein is a method of diagnosing non-allergic asthma and airway hyperreactivity comprising neutrophils quantification in sputum.

The present invention relates to novel humanized anti-IL-4 and IL-13 antibodies and fragments thereof and novel bispecific antibodies and fragments thereof that specifically bind to IL-4 and IL-13. The invention also includes uses of the antibodies to treat or prevent IL-4 and / or IL-13 mediated diseases or disorders, including allergic asthma and dermatitis.

The invention discloses a closed bacterium polysaccharide and a preparing method; application of preparing cure allergic rhinitis medicine through closed bacterium polysaccharide and allergic asthma medicine and application of preparing cure adult respiratory distress syndrome medicine; which is characterized by the following parts: (1) the component of closed bacterium polysaccharide are more definite and the action of inhibit sensitized big rat antigen attack back lung acidophilia inflammation and can be developed to new medicine or functional food or health products be used to treat allergic rhinitis and allergic asthma; (2) the polysaccharides through PEG deposition polysaccharides to produce the closed bacterium polysaccharides are much more higher than polysaccharides preparing through alcohol deposition; and quantity of PEG is about one twentieth of alcohol.

The invention relates to the biotechnology field, and more specifically, the invention discloses a human monoclonal antibody against IgE, a preparation method and a purpose thereof. According to the invention, a natural human phage antibody library of large capacity is constructed;; a human antibody 2E19 strain against IgE is obtained through screening from the library; an amino acid sequence of a heavy chain variable region is expressed as SEQ ID NO: 6; and the amino acid sequence of a light chain variable region is expressed as SEQ ID NO: 8. Besides, the invention also discloses the preparation method of the antibody 2E19, as well as a nucleotide sequence for encoding the antibody 2E19 and an expression vector and a host cell comprising the nucleotide sequence. The antibody 2E19 of the invention has a higher antibody affinity, so as to be able to obviously inhibit degranulation caused by the combination of IgE and FC epsilon RI on a cell surface, and the antibody 2E19 does not combine with the IgE combined with the FC epsilon RI on the cell surface. The antibody 2E19 of the invention could be used for the preparation of a medicine for treating hypersensitivity diseases, especially for treating allergic asthma.

The invention discloses lactobacillus reuteri capable of alleviating allergic asthma and application thereof and belongs to the technical field of medicines. The lactobacillus reuteri has an effect ofrelieving allergic asthma, which is embodied by: (1) significantly reducing lung inflammation in mice with allergic asthma; (2) significantly inhibiting the generation of dust mite specific immunoglobulin IgG1 in serum of allergic asthma mice; (3) significantly reduced the contents of IL-5 and IL-13 in alveolar lavage fluid of mice with allergic asthma; (4) significantly reducing the content of IL-17A in alveolar lavage fluid of mice with allergic asthma, and thus the lactobacillus reuteri has great application prospects in the preparation of products for preventing and / or treating allergic asthma.

The invention relates to a compound composition containing intal and statins claritin. The compound composition consists of the following components: a) a certain amount of intal; b) a certain amount of one of olopatadine hydrochloride, ioratadine, desloratadine, degreasing ioratadine, desloratadine, rupatadine and betahistine; c) other medicinal excipients. The compound composition can be made into external preparations such as eye drops, nose drops, aerosol, spray, inhalant, gelata, eye ointments, ointments or patch and the like. The compound composition can be used for curing the diseases such as anaphylactic eye diseases, anaphylactic rhinitis, skin urtication, urticaria, allergic asthma and the like, can significantly improve allergic symptoms, and has the characteristics of high efficiency, stability, safety, low adverse reaction rate, convenient use and the like.

Methods of treatment of allergic asthma with IgE antagonists, including anti-IgE antibodies, IgE variants, peptide antagonists, peptidomimetics and other small molecules, are described.

The invention discloses a loratadine oral quickly-soluble film and a preparation method thereof. By controlling parameters such as particle size of a loratadine drug, proportion of a film-forming material, content of water of a film product and the like, the product dissolution is improved, the bioavailability can be improved, the preparation can effectively prevent and cure such as allergic rhinitis, chronic idiopathic urticaria, allergic asthma, atopic dermatitis and associated symptoms caused by allergy such as skin diseases (eczema, dermatitis, pruritus cutanea), and the drug effect can be sufficiently realized. The loratadine oral quickly-soluble film does not need water, can be rapidly dissolved in the oral cavity and is convenient to take by patients and particularly suitable for the old people and children patients; moreover, the loratadine oral quickly-soluble film has characteristics of high dispersity, rapidness in absorption, fastness in effect, favorability for improving the bioavailability, and the like.

The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and / or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).

The invention relates to an application to preparing a medicine for treating a disease caused by immunity imbalance of a mammal with a tumulosic acid compound K2-1 or other pharmaceutically acceptable salt thereof as an active ingredient, wherein the disease caused by immunity imbalance is allergy, and the allergy is allergic asthma; and the tumulosic acid compound K2-1 is of a structure represented by a chemical formula shown in the specification, wherein R2=OH.

The invention discloses a vaccine for preventing and / or treating allergic asthma. The active ingredients of the vaccine for preventing and / or treating allelgic asthma is as the following: the compound consisting the proteantigen causing allergic asthma or epitope peptides and the recombinant eukaryotic cell expression carrier which inserts proteantigen causing allergic asthma or epitope peptides coding gene thereof in the multiple cloning site. The vaccine can induce to produce immune regulatory T cell, can restrain the activity of allergic T cell of immune animals, thus preventing and / or treating allergic asthma effectively.