31 results about "Allergen extract" patented technology

The invention discloses a method for standardizing allergen extract with respect to the contents of major as well as minor allergens. The method comprises determining relative amounts of allergens in a given extract, followed by an adjustment of the contents of major an minor allergens so as to meet predefined limitations. Also disclosed is an anti-allergy kit comprising means for profiling an allergic subject and an extract or series of extracts prepared according to the invention.

The present invention relates to a process for producing an allergen extract from a biological allergen source material comprising the steps ofa) contacting the source material with a liquid extraction agent to produce a allergen extract mixture containing allergens dissolved in a liquid phase and a solid phase consisting of source material residues,b) subjecting the allergen extract mixture to a first separation step to remove the solid phase to produce a crude allergen extract,c) subjecting the crude allergen extract to a low molecular fraction removal step to remove molecules having a molecular size of less than 10 kDa, andd) carrying out step c) until the allergen extract has conductivity of below 2000 μS / cm at 25° C. to obtain a purified allergen extract.

The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and / or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).

The present invention discloses processes for producing native, depigmented and polymerized allergen extracts. The invention further discloses extracts produced via the processes, and pharmaceutical and vaccine compositions comprising the extracts, for diagnosis and treatment of allergy.

The invention relates to a ginkgo leaf extract powder injection, which contains 1 weight part of ginkgo leaf extract, 1-4 weight parts of hydroxypropyl beta cyclodextrin, and 0.02- 0.08 parts by weight. Its preparation method is: take ginkgo biloba extract, add hydroxypropyl beta cyclodextrin and mix in proportion, add acid-base regulator, filter, and the filtrate is ultrafiltered through a 50000-150000 Dalton ultrafiltration membrane, ultrafiltration The liquid is directly aseptically freeze-dried or aseptically spray-dried to form a powder for injection. On the basis of fully retaining the active ingredients, the preparation effectively removes impurities such as macromolecules, pyrogens, particles (including resin exfoliation), microorganisms, etc. in the original extract, and the safety and stability of the preparation are significantly improved.

The invention discloses an anaphylactic disease allergen colloidal gold diagnostic test strip. The test strip comprises a sample hole, a colloidal gold pad, a film strip, an absorbent pad and a PVC board, wherein the film strip is coated with inhalation group allergen I, inhalation group allergen II, a food group allergen and a mouse anti-goat IgG antibody, so as to form three detecting strips and one quality control strip. Each allergen energy included in the test strip can represent allergen molecules of 80 percent of patients, and on the detecting film strip, a symbolic allergen coated molecule replaces an allergen extract, so that the purpose of quickly diagnosing the anaphylactic disease technically is achieved. The time for detecting by using the test strip lasts for 5 to 30 minutes, the specificity is high, the sensitivity is high, the testing is simple and quick, on-site detecting is achieved, special training for operators is not required, operation can be finished according to specification, and quick diagnosis to anaphylactic diseases can be achieved.

The present invention provides the present invention relates to an infusion solution of allergen of C. chinensis pollen, an infusion solution thereof and a preparation method thereof. The allergen extract of C. chinensis pollen contains the amino acid sequence of C. chinensis pollen allergen protein as shown in SEQ ID NO.4. The infusion solution is prepared by the process of collecting, drying, defatting, extracting, ultrafiltration concentration, freeze-drying, redissolving and the like of C. chinensis pollen, and its main components are C. chinensis pollen allergen, glycerin, sodium chloride, phenol, etc. . The allergen infusion solution of C. chinensis pollen has the characteristics of high specificity, sufficient extraction of allergenic protein components of C. chinensis, stable total biological titer, long validity period and good aseptic effect; the original solution can be effectively used for the treatment of allergic diseases. The skin prick test can be used in the diagnosis of in vitro basophil activation test and specific immunotherapy after appropriate dilution.

The invention relates to novel immunogenic polypeptides identified in house dust mites and storage mites, which have the potential to be used in allergy immunotherapy, for diagnostic purposes, eventually via production of antibodies binding the polypeptide or for characterising allergen extracts of house dust mites and storage mites.

Pro-toothpaste compositions formulated to receive a volume of allergen solution to provide toothpastes that exhibit efficacy for oral mucosal immunotherapy (OMIT) and acceptable consumer and product stability properties, along with kits of pro-toothpaste, allergen / extracts of allergens, and optionally compounding means and / or specialized toothbrushes are provided. Toothpastes suitable and effective for OMIT and methods for managing allergic symptoms and for reducing risk of allergy in people without symptoms employing the pro-toothpastes, toothpastes and kits of the invention are also disclosed.

The invention discloses a filter screen antianaphylaxis detection method, which is used for detecting antianaphylaxis of a filter screen in an air purification apparatus. The method comprises the following steps: S100: cutting the filter screen into a sample sheet A with a diameter of 50 mm; S200: respectively sterilizing the sample sheet A, a sample sheet B and a sample sheet C; S300: placing the sample sheet A into a 250ml sterile triangular flask A; S400: respectively dropwise adding and dyeing a dilute solution of an allergen solution onto the sample sheet A and the sample sheet B; S500: standing the sterile triangular flask A, a sterile triangular flask B and a sterile triangular flask C in a space with an ambient temperature of 25 DEG C for one hour; and S600: respectively adding 10ml of allergen extract liquid into the sterile triangular flask A, the sterile triangular flask B and the sterile triangular flask C. The invention also provides a filter screen antianaphylaxis detection apparatus. A nonwoven fabric is used as a comparison reference, so that the antianaphylaxis of the sample filter screen and a comparison result with the nonwoven fabric can be detected.

The present invention provides a periplaneta americana allergen preparation production method, which comprises: (1) inactivating periplaneta americana in a refrigerator, removing intestinal tracts, washing with 75% ethanol, carrying out air-drying, and placing in the refrigerator so as to be spare; (2) taking an appropriate amount of the frozen periplaneta americana, and grinding into powder in liquid nitrogen; (3) degreasing with acetone, placing into the refrigerator to freeze, and carrying out freeze-drying in a vacuum freeze dryer to obtain powder; (4) weighing the periplaneta americana powder, adding an extraction solution, carrying out centrifugation, and sucking the supernatant, wherein the supernatant is a periplaneta americana allergen extract; (5) adopting specific antibodies to identify the content and the proportion of the main allergen in the periplaneta americana allergen crude extract; and (6) according to the identification result in the step (5), adding recombinant protein expressed by yeast or insects. With the periplaneta americana allergen crude extract extracted by using the method, the main allergen protein of the periplaneta americana can be obtained to the maximal degree, the extract has good repeatability, and the error is less than 30%.

The invention relates to processes for producing semi-purified and purified allergen extracts and pharmaceutical compositions and vaccines for use in the diagnosis and treatment of allergy. In one aspect of the invention, a process for producing a depigmented allergen extract is provided, the process comprising: a) basifying a native allergen extract; and b) removing molecules having a molecular size of less than 3.5 kDa; and c) adjusting the pH to neutrality; thereby to produce a depigmented allergen extract.