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Veterinary product

A technology of animal mites and allergens, applied in purified animal allergen extracts, more especially dog ​​allergies, treatment of mammals, house dust mite allergies, and can solve sensitivity and other problems

Pending Publication Date: 2020-05-08
莱蒂个人实验室
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One problem with treating dogs with allergen extracts developed and characterized for human immunotherapy is that dogs are likely to be sensitized to previously innocuous allergens such as Der f 1 and Der f 2

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0085] The source material (which may also be referred to as starting material) for the production of the extract is a mite culture with >80% D. farinae bodies grown by Laboratorios LETI and is commercially available. The three animal extracts were prepared according to the following methods:

[0086] A. Extract I

[0087] ●Weigh the raw material to be extracted and record the weight;

[0088] ● Calculate the volume of extractant (PBS 0.01M-NaCl 0.15M) required using the following formula:

[0089] Raw material (g) x 20=ml extractant;

[0090] - Place the raw material in a container containing half the extractant volume (calculated in the previous step) and extract for 4 hours at 3°C-5°C with magnetic stirring:

[0091] ml extractant (total volume) ÷ 2=ml extractant (volume 1);

[0092] Centrifuge the mixture at 10,000 rpm for at least 30 minutes at 5°C;

[0093] - Then recover the supernatant and record the volume. The supernatant was kept at 3°C-5°C in a labeled airt...

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Abstract

The present invention relates to a purified veterinary allergen extract enriched. In particular, the invention relates to a purified veterinary allergen extract enriched with Der f 15 and Der f 18. The invention further relates to use of the allergen extract as a veterinary product, and its use in treating allergy, in particular house dust mite allergy in mammals, more particularly, dogs.

Description

technical field [0001] The present invention relates to enriched purified animal allergen extracts. In particular, the present invention relates to purified animal allergen extracts enriched in Der f 15 and Der f 18. The present invention further relates to the use of said allergen extract as a veterinary product, and its use in the treatment of allergies, especially house dust mite allergies, in mammals, more particularly dogs. Background technique [0002] Atopic dermatitis is a pruritic allergic skin disease that affects approximately 10% of dogs and is associated with the production of IgE antibodies to environmental allergens. The main cause of non-seasonal allergies in dogs is house dust mites (HDM), specifically the species Dermatophagoides farinae. Allergic dogs are treated with medications that control symptoms, but alternative treatments include specific immunotherapy (SIT), which involves the administration of increasingly larger doses of allergen extracts with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P37/00A61K39/35A61K38/17C07K1/14A61K39/00
CPCA61K38/1767A61K39/35C07K1/145A61K2039/54A61K2039/577A61P37/00A61K38/17A61K39/00C07K1/14A61K2039/552
Inventor J·C·桑切斯R·M·罗伯L·R·勒奇P·B·考贝特A·P·罗德里格斯
Owner 莱蒂个人实验室
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