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Methods of purifying allergen extract

A technology for allergens and extracts, applied in the field of purifying allergen extracts, can solve the problems of allergic reactions or allergies of sensitized patients by injection of allergens

Pending Publication Date: 2021-12-21
莱蒂生物制药公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] One of the risks of immunotherapy is that injecting allergens into sensitized patients can cause anaphylaxis, or anaphylaxis

Method used

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  • Methods of purifying allergen extract
  • Methods of purifying allergen extract
  • Methods of purifying allergen extract

Examples

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Embodiment Construction

[0032] The allergen extracts of the present invention are derived from any source material comprising natural allergens known to elicit an IgE-mediated immune response in an individual. Such allergens may include airborne allergens (such as pollens from grasses, trees, herbs and weeds, dust mites, fungi and molds), food allergens (such as peanuts), insect allergens (such as from cockroaches and fleas, and bee and hornwort venoms) and epithelial allergens (animal hair and animal dander, such as cat and dog dander).

[0033] The source material can be any allergen, including food allergens (such as peanuts), airborne allergens (such as pollen (such as tree pollen, weed pollen, grass pollen, and cereal pollen), dust mites, fungi, and molds), epithelial allergens (animal hair and animal dander, eg, cat hair and dander and dog hair and dander), and insect allergens (eg, from cockroaches and fleas, and bee and wasp venom).

[0034] Pollen allergens from trees, grasses and weeds are...

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Abstract

The invention relates to processes for producing semi-purified and purified allergen extracts and pharmaceutical compositions and vaccines for use in the diagnosis and treatment of allergy. In one aspect of the invention, a process for producing a depigmented allergen extract is provided, the process comprising: a) basifying a native allergen extract; and b) removing molecules having a molecular size of less than 3.5 kDa; and c) adjusting the pH to neutrality; thereby to produce a depigmented allergen extract.

Description

technical field [0001] The present invention relates to methods for the production of semi-purified and purified allergen extracts as well as pharmaceutical compositions and vaccines for the diagnosis and treatment of allergies. Background technique [0002] Allergies are acquired hypersensitivity disorders of the immune system and are triggered by exposure to innocuous environmental substances called allergens. Type I hypersensitivity is the hallmark of allergic reactions and results in the production of excess IgE antibodies, which activate basophils and mast cells, causing an inflammatory response. Effects may be systemic, such as vasodilation, mucus secretion, nerve stimulation, or smooth muscle contraction, leading to an allergic reaction, or effects may be limited to specific areas of the body, such as the respiratory system. [0003] Phleum pratense [0004] Grass allergy is one of the most common and prevalent forms of allergy affecting sensitive people during cert...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/35A61K35/646A61K35/36A61K35/68
CPCA61K35/35A61K35/36A61K35/646A61K35/68A61K36/63A61K36/899
Inventor M·罗曼·埃斯库蒂亚M·莫拉莱斯M·T·加列戈J·卡内尔·桑切斯
Owner 莱蒂生物制药公司
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