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Water-containing liquid allergic reaction bacterin preparation for mouth mucosa drug administration

A technology of oral mucosa, water liquid, applied in the field of vial or ampoule and prevention or treatment of allergic diseases, sublingual administration

Inactive Publication Date: 2010-08-04
ALK ABELLO SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] Aqueous liquid formulations containing allergen extracts of mugwort species pollen and protein stabilizers, and the use of such formulations for oromucosal administration, to the best of the inventors' knowledge, have not been disclosed in the scientific literature so far

Method used

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  • Water-containing liquid allergic reaction bacterin preparation for mouth mucosa drug administration

Examples

Experimental program
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Effect test

Embodiment 2

[0141] Prepare vials or ampoules for dose escalation phases

[0142] The pollen allergen extract obtained in Example 1 was further diluted with a solution containing glycerin (0.5ml / ml), sodium chloride (9mg / ml), phenol (3mg / ml) and water to obtain a set of vials, Include:

[0143] One or more vials (1), each containing 1 / 5 of the maintenance dose per 0.2ml

[0144] One or more vials (2), each containing 1 / 25 of the maintenance dose per 0.2ml

[0145] One or more vials (3), each containing 1 / 125th of the maintenance dose per 0.2ml, optionally

[0146] One or more vials (4), each containing 1 / 625 of the maintenance dose per 0.2 ml.

[0147] An appropriate maintenance dose is 60 μg of Art v 1.

[0148] Alternatively, the allergen extract obtained in Example 1 was further diluted with a solution containing glycerol (0.5ml / ml), sodium chloride (9mg / ml), phenol (3mg / ml) and water to obtain a set of Vial contains:

[0149] One or more vials (1), each containing 1 / 10 of the mai...

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PUM

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Abstract

The invention relates to a water-containing liquid bacterin preparation and the purpose thereof for treating and preventing allergic reaction. The preparation contains an allergen extract which exists in water-containing liquid or suspension containing a protein stabilizer and derives from one or more kinds of artemisia plant pollen.

Description

[0001] Field of technology [0002] The present invention relates to an aqueous liquid allergy vaccine formulation containing one or more allergen extracts of plants of the genus Artemisia, for oromucosal administration, in particular sublingual administration. Background of the invention [0003] Allergies are an important health problem in countries adopting a western lifestyle. Moreover, the prevalence of allergic diseases is increasing in these countries. Although in general, allergies are not considered a life-threatening disease, asthma is responsible for a large number of deaths each year. The abnormal prevalence of approximately 30% among adolescents results in significant loss of quality of life, workdays and money, and constitutes a major health problem in the world. [0004] Allergy is a complex disease. A variety of factors contribute to sensitization events. These include an individual's susceptibility determined by the not-well-understood interplay of several...

Claims

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Application Information

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IPC IPC(8): A61K39/36A61K9/08A61P37/08A61K47/36A61K47/26A61K47/34A61K47/18A61K47/10
Inventor M·斯庞夫特D·B·赫南德斯
Owner ALK ABELLO SA
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