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Compound composition of intal and Statins

A technology of sodium cromoglycate and its composition, which is applied in the field of compound composition and can solve the problems of systemic adverse reactions such as irritation

Inactive Publication Date: 2010-07-07
北京华禧联合科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purpose is to provide a practical, convenient and reliable preparation form for the clinic, so as to solve the problem of systemic adverse reactions easily caused by oral preparations in the treatment of allergic diseases and the strong irritation of a single local drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: inhalation powder mist

[0024] Sodium Cromoglycate 20g

[0025] Olopatadine 1g

[0026] Lactose 20g

[0027]

[0028] Total 41g

[0029] Preparation process: Mix cromolyn sodium and olopatadine evenly to make a very fine powder, fully mix with the prescribed amount of lactose and evenly distribute them into hard gelatin capsules, so that each capsule contains 20 mg of cromolyn sodium and 1 mg of olopatadine , that is.

Embodiment 2

[0030] Embodiment 2: Aerosol

[0031] Sodium Cromoglycate 70g

[0032] Olopatadine 10g

[0033] Ethanol 30ml

[0034] Dichlorodifluoromethane 150g

[0035] Vitamin C 7.5g

[0036]

[0037] Add sterile distilled water to 1000ml

[0038] Preparation process: dissolve the prescribed amount of sodium cromoglycate, olopatadine, and vitamin C in a mixture of sterile distilled water and ethanol, filter through a funnel with a sand core, add sterile distilled water to 1000ml, fill in divided doses, and seal Dosage valve system, pressurize and inject nitrogen respectively, that is to say.

Embodiment 3

[0039] Embodiment 3: ointment

[0040] Sodium Cromoglycate 0.6g

[0041] Olopatadine 0.3g

[0042] Isopropyl myristate 1.3g

[0043] White Vaseline 1.8g

[0044]

[0045] Total 4.0g

[0046] Preparation process: Thoroughly mix sodium cromoglycate, olopatadine, isopropyl myristate and white petrolatum to obtain the product.

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PUM

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Abstract

The invention relates to a compound composition containing intal and statins claritin. The compound composition consists of the following components: a) a certain amount of intal; b) a certain amount of one of olopatadine hydrochloride, ioratadine, desloratadine, degreasing ioratadine, desloratadine, rupatadine and betahistine; c) other medicinal excipients. The compound composition can be made into external preparations such as eye drops, nose drops, aerosol, spray, inhalant, gelata, eye ointments, ointments or patch and the like. The compound composition can be used for curing the diseases such as anaphylactic eye diseases, anaphylactic rhinitis, skin urtication, urticaria, allergic asthma and the like, can significantly improve allergic symptoms, and has the characteristics of high efficiency, stability, safety, low adverse reaction rate, convenient use and the like.

Description

technical field [0001] The invention relates to a compound composition comprising sodium cromolyn and stadines, which can be used for treating allergic diseases such as allergic conjunctivitis, allergic rhinitis, itchy skin, urticaria and allergic asthma. The composition can be made into external preparations such as eye drops, nasal drops, aerosol, spray, inhalation, gel, eye ointment, ointment or patch. Background technique [0002] According to WHO data: At present, 250 million people in the world suffer from allergic diseases, and the incidence rate is showing a rapid upward trend. Ordinary oral preparations are used to treat allergic eye diseases, allergic rhinitis, skin allergic diseases and allergic asthma. They are mainly absorbed through the gastrointestinal tract, and then distributed in the dermal tissue of the skin through blood circulation, so as to exert the anti-allergic effect of the drug. effect. There may be a risk of serious systemic adverse reactions in...

Claims

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Application Information

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IPC IPC(8): A61K31/4545A61K31/352A61K31/335A61P27/14A61P37/08A61P11/02A61P17/04A61P11/06
Inventor 王艳皎王建航张志芳
Owner 北京华禧联合科技发展有限公司
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