Podophyllotoxin external-use formulation prescription for treating pointed condyloma and herpes genitalis, dosage form series and preparation method
A technology for podophyllotoxin and a preparation process, which is applied in the field of pharmacy, can solve the problems that the drug cannot be absorbed quickly, is inconvenient to use, and affects the medication, and achieves the effects of prolonging the action time of the drug, improving the compliance, and reducing irritation.
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Embodiment 1
[0040] Embodiment 1: Podophyllotoxin topical spray
[0041] 1. Prescription: 100mL The mass or volume of each ingredient in this prescription is:
[0042] Podophyllotoxin 0.5g
[0043] Azone 2.5mL
[0044] Propylene glycol 20mL
[0045] 2-Hydroxypropyl-β-cyclodextrin 2.5g
[0046] Glyceryl triacetate 77.5mL
[0047] Ethylparaben 0.03g
[0048] 2. Preparation method:
[0049] According to the above prescription of podophyllotoxin topical spray, weigh each component for later use, first take the prescribed amount of azone, propylene glycol, 2-hydroxypropyl-β-cyclodextrin, ethyl paraben, and add appropriate glycerol triacetate After the ester is fully dissolved and mixed evenly, add the prescribed amount of podophyllotoxin and stir to dissolve, and finally add the remaining triacetin, and stir evenly to obtain the medicinal solution. The above-mentioned medicinal liquid can be filled into the packaging container of the spray to obtain the external-use spray of podophylloto...
Embodiment 2
[0050] Embodiment 2: Podophyllotoxin topical spray
[0051] 1. Prescription: 100mL The mass or volume of each ingredient in this prescription is:
[0052] Podophyllotoxin 0.5g
[0053] Azone 2.5mL
[0054] Propylene glycol 40mL
[0055] Methyl-β-cyclodextrin 2.5g
[0056] Triacetin 57.5mL
[0057] Ethylparaben 0.03g
[0058] 2. Preparation method:
[0059] According to the above-mentioned prescription of podophyllotoxin topical spray, weigh each component for later use, first take the prescribed amount of azone, propylene glycol, methyl-β-cyclodextrin, ethylparaben, add an appropriate amount of glycerol triacetate, fully After dissolving and mixing evenly, add the prescribed amount of podophyllotoxin and stir to dissolve, and finally add the rest of glycerol triacetate and stir evenly to obtain the medicinal solution. The above-mentioned medicinal liquid can be filled into the packaging container of the spray to obtain the external-use spray of podophyllotoxin.
Embodiment 3
[0060] Embodiment 3: Podophyllotoxin topical spray
[0061] 1. Prescription: 100mL The mass or volume of each ingredient in this prescription is:
[0062] Podophyllotoxin 0.5g
[0063] Azone 2.5mL
[0064] Propylene glycol 60mL
[0065] Dimethyl-β-cyclodextrin 2.5g
[0066] Triacetin 37.5mL
[0067] Ethylparaben 0.03g
[0068] 2. Preparation method:
[0069] According to the above-mentioned prescription of podophyllotoxin topical spray, weigh each component for later use, first take the prescribed amount of azone, propylene glycol, dimethyl-β-cyclodextrin, ethylparaben, add an appropriate amount of glycerol triacetate, After fully dissolving and mixing evenly, add the prescribed amount of podophyllotoxin and stir to dissolve, and finally add the rest of glycerol triacetate and stir evenly to obtain the liquid medicine. The above-mentioned medicinal liquid can be filled into the packaging container of the spray to obtain the external-use spray of podophyllotoxin.
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