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Podophyllotoxin external-use formulation prescription for treating pointed condyloma and herpes genitalis, dosage form series and preparation method

A technology for podophyllotoxin and a preparation process, which is applied in the field of pharmacy, can solve the problems that the drug cannot be absorbed quickly, is inconvenient to use, and affects the medication, and achieves the effects of prolonging the action time of the drug, improving the compliance, and reducing irritation.

Active Publication Date: 2012-07-04
BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Podophyllotoxin has stable physical and chemical properties, but is insoluble in water. The main solvent used in the tincture is high-concentration ethanol, which causes the preparation to have strong irritation to the vulva mucosa, which not only brings pain to the patient, but also directly affects the medication. And there are safety problems in production and transportation
Ointment is mainly inconvenient to use, and the drug cannot be absorbed quickly after application. After a certain period of administration, the drug matrix attached to the surface of the mucous membrane must be washed off, and it also has certain mucous membrane irritation.

Method used

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  • Podophyllotoxin external-use formulation prescription for treating pointed condyloma and herpes genitalis, dosage form series and preparation method
  • Podophyllotoxin external-use formulation prescription for treating pointed condyloma and herpes genitalis, dosage form series and preparation method
  • Podophyllotoxin external-use formulation prescription for treating pointed condyloma and herpes genitalis, dosage form series and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: Podophyllotoxin topical spray

[0041] 1. Prescription: 100mL The mass or volume of each ingredient in this prescription is:

[0042] Podophyllotoxin 0.5g

[0043] Azone 2.5mL

[0044] Propylene glycol 20mL

[0045] 2-Hydroxypropyl-β-cyclodextrin 2.5g

[0046] Glyceryl triacetate 77.5mL

[0047] Ethylparaben 0.03g

[0048] 2. Preparation method:

[0049] According to the above prescription of podophyllotoxin topical spray, weigh each component for later use, first take the prescribed amount of azone, propylene glycol, 2-hydroxypropyl-β-cyclodextrin, ethyl paraben, and add appropriate glycerol triacetate After the ester is fully dissolved and mixed evenly, add the prescribed amount of podophyllotoxin and stir to dissolve, and finally add the remaining triacetin, and stir evenly to obtain the medicinal solution. The above-mentioned medicinal liquid can be filled into the packaging container of the spray to obtain the external-use spray of podophylloto...

Embodiment 2

[0050] Embodiment 2: Podophyllotoxin topical spray

[0051] 1. Prescription: 100mL The mass or volume of each ingredient in this prescription is:

[0052] Podophyllotoxin 0.5g

[0053] Azone 2.5mL

[0054] Propylene glycol 40mL

[0055] Methyl-β-cyclodextrin 2.5g

[0056] Triacetin 57.5mL

[0057] Ethylparaben 0.03g

[0058] 2. Preparation method:

[0059] According to the above-mentioned prescription of podophyllotoxin topical spray, weigh each component for later use, first take the prescribed amount of azone, propylene glycol, methyl-β-cyclodextrin, ethylparaben, add an appropriate amount of glycerol triacetate, fully After dissolving and mixing evenly, add the prescribed amount of podophyllotoxin and stir to dissolve, and finally add the rest of glycerol triacetate and stir evenly to obtain the medicinal solution. The above-mentioned medicinal liquid can be filled into the packaging container of the spray to obtain the external-use spray of podophyllotoxin.

Embodiment 3

[0060] Embodiment 3: Podophyllotoxin topical spray

[0061] 1. Prescription: 100mL The mass or volume of each ingredient in this prescription is:

[0062] Podophyllotoxin 0.5g

[0063] Azone 2.5mL

[0064] Propylene glycol 60mL

[0065] Dimethyl-β-cyclodextrin 2.5g

[0066] Triacetin 37.5mL

[0067] Ethylparaben 0.03g

[0068] 2. Preparation method:

[0069] According to the above-mentioned prescription of podophyllotoxin topical spray, weigh each component for later use, first take the prescribed amount of azone, propylene glycol, dimethyl-β-cyclodextrin, ethylparaben, add an appropriate amount of glycerol triacetate, After fully dissolving and mixing evenly, add the prescribed amount of podophyllotoxin and stir to dissolve, and finally add the rest of glycerol triacetate and stir evenly to obtain the liquid medicine. The above-mentioned medicinal liquid can be filled into the packaging container of the spray to obtain the external-use spray of podophyllotoxin.

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PUM

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Abstract

The invention discloses a podophyllotoxin preparation formula for external use for the treatment of condyloma acuminatum and genital herpes, a series of formulations and a preparation method, and belongs to the field of pharmacy. The weights or the volumes of all the ingredients of the formula of 100ml of the podophyllotoxin preparation for external use are as follows: 0.5g of podophyllotoxin, 20ml-80ml of main solvent, 1ml-3ml of penetration enhancer 1, 0.5g-2.5g of penetration enhancer 2, 20ml-80ml of cosolvent and 0.03-0.5g of preservative. The podophyllotoxin preparation for external use has the advantages that the types and the amount of excipients and the proportion of main drugs are reasonable, the drug administration is carried out by a liniment, a spray or other formulations which are applicable to the external use, the main drug can be rapidly absorbed by the horny layer and the epidermis, the efficacy is significant, the local toxicity or side effects are small, the skin acute toxicity is very low, and the podophyllotoxin preparation has no irritation and weak allergy and does not hinder the skin normal functions; the podophyllotoxin preparation has no systemic toxicityor side effects, thereby being safe and effective. The preparation prepared by the formula has the advantages of good appearance, moderate viscosity, easy coating, spraying drug administration, feasible process, controllable quality, simple preparation process, and suitability for industrial batch production.

Description

technical field [0001] The invention relates to a prescription, a series of dosage forms and a preparation method of podophyllotoxin external preparations for treating condyloma acuminata and genital herpes, specifically, a preparation prescription, a series of external dosage forms and preparations for treating condyloma acuminatum and genital herpes with podophyllotoxin as an active ingredient The method belongs to the field of pharmacy. Background technique [0002] Genital warts are genital venereal diseases caused by human papillomavirus (HPV) infection. The number of patients with genital warts has increased nearly 10 times in the past 15 years. According to my country's sexually transmitted disease detection report, the genital HPV detection rate is 30.69 / 100,000, and its incidence rate ranks second in sexually transmitted diseases, second only to gonorrhea (Xu Wenyan. Prevention and treatment of sexually transmitted diseases. Shanghai: Second Military Medical Univer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K9/12A61K47/34A61K47/40A61P31/14A61P31/22A61K47/10
Inventor 高永良王慧桃李劲彤王东兴
Owner BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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