48 results about "Topical spray" patented technology

A topical spray or foam, methods of making the formulation, and methods of use thereof, has been developed. In one preferred embodiment, the composition includes one or more active agents and exhibits both antibacterial activity and antifungal activity. Excipients such as chemical disinfectants, anti-pruritic agents to minimize itching, and skin protective compounds may be added. The composition may be formulated to be dispensed as a spray or foam and the spray or foam may be administered either by a hand pump or by an aerosolizing propellant. A second single phase formulation has also been developed. The formulation comprises a first drug which is water soluble or hydrophilic and a second drug which is lipid soluble or hydrophobic, wherein at least one of the drugs is bound to an ion-exchange resin. The use of binding resins, such as ion-exchange resins, allows drugs with incompatible solvent requirements to be prepared in a single-phase formulation.

A topical, medicinal spray composition is provided comprising a drug or combination of drugs in a carrier which, when sprayed on a surface, forms a film. The composition comprises at least one medicament, at least one film former and at least one vehicle. The composition of the invention may further comprise at least one permeation enhancer, at least one solubilizer, at least one plasticizer, and at least one water soluble additive. A metered dose of the composition can be sprayed on a topical site to form a stable, breathable film, preferably over a fixed surface area. A wide range of medicaments for human and veterinary use may be present that act locally or transdermally.

This invention relates to a topical spray preparation for burn treatment and microbial infections on human being or animals. This non-aerosol preparation contains an antimicrobial drug, i.e., silver sulfadiazine, as is dispersed or solubilized in a cream or lotion base matrix which can be sprayed directly from a common trigger spray device. The key component of the matrix can be characterized by it having a suitable molecular weight polymer of cross-linked acrylic acid, such as Carbomers or non-ionic surfactants such as polyoxyethylene alkyl ethers, or any combination of the above materials.

The application provides formulations for the topical administration of an active agent comprising at least one steroid, in the form of topical sprays that are propellant-free, and / or substantially non-foaming, and / or alcohol-free. The present application also provides processes for preparing such compositions and methods of using them in management of skin diseases or disorders such as psoriasis, dermatoses, and other associated skin diseases or disorders.

A pharmaceutical topical spray composition of corticosteroid, an alcohol, a propellant, and botanic seed oils having a blend of black raspberry seed oil, black cumin seed oil, and red raspberry seed oil prepared according to a cold press method. A method for treating an inflammatory skin condition using the administration to the skin of a mammal of the pharmaceutical composition. The pharmaceutical composition is effective in the treatment of inflammatory skin conditions without the need for zinc pyrithione, undecylenic acid, or a detergent.

Disclosed herein are methods of controlling insect pests which infest crop plants, in particular Spodoptera frugiperda (fall armyworm), Lygus hesperus (western tarnished plant bug), Euschistus heros (neotropical brown stink bug), and Plutella xylostella (diamondback moth), and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and plants with improved resistance to infestation by these insects. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of these insect pests.

An exterior-applied urotropine spray for treating hand and foot hyperhidrosis and hircus is prepared from urotropine, alcohol, cosolvent, deodorant, antibacterial agent, antioxidizing agent, surfactant and water through proportional dissolving, stirring, regulating pH value to 4-11, filtering and loading in spray bottles.

The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative and a corticosteroid, and its use in the treatment of dermal diseases and conditions. The spray comprises especially a propellant selected from the group consisting of dimethyl ether, diethyl ether and methylethyl ether or a mixture thereof and further a pharmaceutically acceptable lipid carrier solubilised or suspended in said propellant.

Compositions for the topical administration of an active agent comprising a corticosteroid and a fatty alcohol as skin penetration enhancer, in the form of topical sprays. Processes for preparing such compositions and methods of using them in management of skin diseases or disorders such as psoriasis, dermatoses, and other associated skin diseases or disorders.

A topical spray composition and a system for containing and applying the composition is described. The composition has liquid emulsifiers that unexpectedly result in a superior product suitable to be applied homogeneously.

The invention discloses a preparation method of drug-resistant pseudomonas aeruginosa broad-host range phage, which relates to a preparation method of phage and solves the problem of poor separation and purification effect in the traditional separation method of the pseudomonas aeruginosa phage. The method comprises the following steps: 1, selecting a sewage sample; 2, preparing a lysis solution; 3, carrying out mixed cultivation on the lysis solution and a pseudomonas aeruginosa host cell suspension to obtain a mixed solution; 4, preparing a single phage plaque; and 5, inoculating the phage into a pseudomonas aeruginosa-containing culture medium, culturing until the pseudomonas aeruginosa is completely dissolved, and finally filtering. The preparation method of pseudomonas aeruginosa phage has the advantages of simple operation, good separation and purification effect and no phage breakage. The prepared drug-resistant pseudomonas aeruginosa broad-host range phage can be used for manufacturing autoimmune (vaccines) biological agents for treating diseases caused by the infection of drug-resistant pseudomonas aeruginosa, can be especially used as a topical spray for treating epidermal infectious diseases, and can avoid the drug-resistant pseudomonas aeruginosa produced by the use of antibiotics.

The application provides formulations for the topical administration of an active agent comprising at least one steroid, in the form of topical sprays that are propellant-free, and / or substantially non-foaming, and / or alcohol-free. The present application also provides processes for preparing such compositions and methods of using them in management of skin diseases or disorders such as psoriasis, dermatoses, and other associated skin diseases or disorders.

The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative and a corticosteroid, and its use in the treatment of dermal diseases and conditions. The spray comprises especially a propellant selected from the group consisting of dimethyl ether, diethyl ether and methylethyl ether or a mixture thereof and further a pharmaceutically acceptable lipid carrier solubilised or suspended in said propellant.

Compositions for the topical administration of an active agent comprise a corticosteroid and a fatty alcohol as a skin penetration enhancer, in the form of topical sprays. Processes for preparing such compositions and methods of using them in management of skin diseases or disorders such as psoriasis, dermatoses, and other associated skin diseases or disorders, are described.

A polymeric bio-adhesive film forming topical spray formulation providing a modified, pulsatile (e.g., biphasic) release of the active agent(s) once the solvent evaporates and the film sets, e.g., onhuman skin is disclosed. In certain embodiments, the active agent is bupivacaine hydrochloride.

A polymeric bio-adhesive film forming topical spray formulation providing a modified, pulsatile (e.g., biphasic) release of the active agent(s) once the solvent evaporates and the film sets, e.g., on human skin is disclosed. In certain embodiments, the active agent is bupivacaine hydrochloride.

The invention relates to a spray for external use and for treating dermatopathy of dogs and cats and a preparing method thereof. The spray comprises following components by weight: 2-6 parts of cortex dictamni, 1-5 parts of rhizoma coptidis, 1-5 parts of fructus cnidii, 1-5 parts of white mulberry root-bark, 1-5 parts of stemona root, 2-6 parts of mint and 3-7 parts of herba houttuyniae. The spray has good effects for treating dermatopathy of pet dogs and cats and can prevent dermatopathy for healthy dogs and cats.

A pharmaceutical topical spray composition including a topical corticosteroid, an alcohol, a propellant, isopropyl myristate, and a blend of botanic seed oils is described. The blend of botanic seed oils may include three or more botanic seed oils prepared using a cold press method. A method for treating an inflammatory skin condition by administering the pharmaceutical topical spray composition to the skin of a mammal is also described. The pharmaceutical composition is effective in the treatment of inflammatory skin conditions without the need for zinc pyrithione, undecylenic acid, or a detergent.

A Chinese medicine in the form of external-applied spray for treating cardiovascular and cerebrovascular stagnant diseases is prepared from 11 Chinese-medicinal materials including saffron, pilose asicbell root, wolfberry fruit, notoginseng, etc through immersing, mixing, and stirring.

A sanitizing system is provided which includes an antibacterial liquid composition formulated to sanitize and deodorize the hands, feet, and other areas of the body. The antibacterial liquid composition is adapted to be dispensed from a pump dispenser as a topical spray.

The present invention relates to a touch-free topical spray of halobetasol comprising a composition which is delivered through a dispensing system, wherein the composition comprises from about 0.01% w / w to about 0.5% w / w of halobetasol based on the total weight of the composition for the treatment of skin disorders, wherein the dispensing system comprises a metered valve assembly comprising a metered valve having a stem connected to an actuator, wherein the actuator is provided with an insert having an orifice diameter in a range of about 0.2 mm to about 1.5 mm, and wherein no rubbing-in is required when said composition is applied to affected skin. Said topical spray compositions offer ease of application leading to enhanced patient compliance. Further, said compositions are delivered from a dispensing system in metered doses. It also relates to processes for the preparation of the touch-free topical spray compositions.

The invention belongs to the field of pharmaceutical preparations, relates to a pharmaceutical preparation containing desonide, and specifically relates to a topical spraying agent containing the desonide. A drug contained in the topical desonide spraying agent is a stable-quality desonide drug containing desonide micro powder, and the desonide drug comprises, by weight, 0.05%-0.2% of the desonide micro powder and balance of pharmaceutically acceptable excipients. The topical desonide spraying agent is sprayed directly on a site of action, and is uniform to distribute, the effect is fast to take, in addition, by use of a direct spray method, contact with microorganism is reduced, by use of a closed dark storage container, contact with water and oxygen in the air can be avoided, and the drug stability can be improved.

A Chinese medicine in the form of external-applied spray for treating cancer is prepared from 14 Chinese-medicinal materials including liquor, wolfberry fruit, ginseng, musk, ganoderma, etc through immersing, mixing, and stirring.

The invention discloses medicine preparation for treating dermatoses of helcosis and solar dermatitis and the preparation process of the spraying agent thereof. The spraying agent for external use for preventing and treating the dermatoses of helcosis and solar dermatitis is produced by applying high ester type catechin, matching three kinds of natural medicines of Asian puccoon, peppermint and syers woad leaves to compose compound, and adopting a plurality of advanced preparation technology. The process has the concrete steps that after being pulverized, the Asian puccoon and the peppermint are extracted through reflux with ethyl alcohol, the gruffs are mixed with the pulverized syers woad leaves, the mixture is boiled by adding water and is extracted for three times, the water extracting solution in the three times is combined together, filtered, and mixed with the ethyl alcohol extracting solution of the Asian puccoon and the peppermint after filter liquid is concentrated, then the high ester type catechin is added, separate packaging and spray can charging are performed, and thereby the spraying agent is produced. The medicine preparation has the advantages of high efficiency and non toxicity. The medicine effect is exerted rapidly, the raw materials mentioned in the invention are cheap and available, and have low cost.

The invention discloses a topical spray for treating intractable skin ulcer. The topical spray is prepared from puerarin, sophora flavescens, golden cypress, golden larch bark, oldenlandia diffusa, gallnut, divaricate saposhnikovia roots, borneol and recombinant human basic fibroblast growth factor powder. The topical spray is prepared by the following steps of firstly crushing the raw materials and then adding 95% ethanol for percolation to prepare a traditional Chinese medicine extract solution; adding the recombinant human basic fibroblast growth factor powder for mixing evenly; dissolving taken menthol by using 75% ethanol to serve as a corrigent; and adding tween-80 for solubilizing and then mixing evenly to obtain a finished product spray. An advanced modern medicine preparation technology is used, new components are scientifically added on the basis of reserving effective components of a traditional Chinese medicine preparation, traditional dosage and ratios of the raw materials are changed, the new components are matched with the added oldenlandia diffusa, gallnut, divaricate saposhnikovia roots and the like, so that the therapeutic effects of resisting bacteria, relieving pain, clearing heat and dry dampness of the topical spray are strengthened; and meanwhile, western medicine components are added, so that the prepared topical spray is more convenient to use, fast to take effect and more lasting in medicinal effect.

The invention discloses a spray formula for the muscle injury and a manufacturing process of the spray formula, relates to the field of medical and health services, and particularly relates to a medicinal spray formula for treating the symptoms of muscle fatigue, bruise and strain and the manufacturing process of the spray formula. The medicinal spray formula for treating the muscle injury comprises the following raw medicinal materials of safflower carthamus, a cyperus rotundus powder, radix cyathulae, ligusticum wallichii, anise, radix angelicae, myrrh, moutan bark, borneol, radix clematidis, divaricate saposhnikovia root, and mint oil; the manufacturing process comprises the following steps: 1, drying in the sum; 2, stirring and screening the materials (not including mint oil) by a 30-mesh sieve; 3, soaking and fermenting; 4, filtering a dreg by using a filter screen, taking a medicinal liquid of the filtered medicines; 5, mixing the mint oil into the medicinal liquid, stirring, sealing, and standing for 1 hour; and 6, bottling. The spray formula is an external-use spray prepared from the pure traditional Chinese medicines, reaches the focus of infection through the outer skin,and achieves a better treatment effect; the pain is alleviated after the spray formula is used for 5-10 minutes, and the patient can normally move and work after one day.