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61 results about "Active Vitamin D" patented technology
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Vitamin D3, also known as cholecalciferol, is the most biologically active form of vitamin D found in humans and animals. When sunlight hits the skin, it converts cholesterol into an active form of vitamin D3.
Treatment of lung cancer with active vitamin D compounds in combination with other treatments
InactiveUS20060172014A1Reduced hypercalcemicIncrease doseBiocideHeavy metal active ingredientsHigh dosesCompound (substance)
The present invention relates to a method for treating or ameliorating lung cancer in an animal by administering to the animal active vitamin D compounds or mimics thereof by high dose pulse administration in combination with one or more chemotherapeutic agents or radiotherapeutic agents / treatments.
Owner:NOVACEA INC
Pharmaceutical compositions comprising active vitamin D compounds
Disclosed are pharmaceutical compositions comprising an active vitamin D compound in emulsion pre-concentrate formulations, as well as emulsions and sub-micron droplet emulsions produced therefrom. The compositions comprise a lipophilic phase component, one or more surfactants, and an active vitamin D compound. The compositions may optionally further comprise a hydrophilic phase component.
Owner:CHEN ANDREW X +3
Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
InactiveUS20060003950A1Reduce incidenceReduce riskBiocideCarbohydrate active ingredientsAnticarcinogenActive Vitamin D
The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the prostate, e.g., prostatic cancer and prostatic hyperplasia, which includes administering to a patient in need thereof an active vitamin D analogue and another anticancer agent. Cell differentiation is promoted, induced or enhanced without causing to the patient dose-limiting hypercalcemia and hypercalciuria.
Owner:BONE CARE INT
Pharmaceutical compositions comprising phosphate binder, calcium receptor-active compound and/or active vitamin d
InactiveUS20130085121A1Maintain good propertiesImprove bioavailabilityOrganic active ingredientsBiocideMineral bone diseaseCalcium Binder
The present invention is an oral solid pharmaceutical compositions for the treatment of kidney diseases and mineral bone disorder including a phosphate binder, a calcium receptor-active compound and at least one pharmaceutically acceptable excipient, the invention further including a method for preparing the pharmaceutical compositions including the steps of granulating cinacalcet and / or sevelamer and / or vitamin D by one of a wet and a dry granulation process, each with at least one pharmaceutically acceptable excipient to form cinacalcet granules and / or sevelamer granules and / or vitamin D granules, mixing at least two of the cinacalcet granules, sevelamer granules and vitamin D granules to form a granules mixture and compressing the granules mixture to tablets or encapsulating the granules mixture into capsules or pulverizing the granules mixture into a dispersion powder.
Owner:WEIFANG SYNERPHARM
Pharmaceutical compositions comprising active vitamin D compounds
InactiveUS20050020546A1Shorter TmaxOvercome disadvantagesBiocideOrganic active ingredientsEmulsionCompound (substance)
Disclosed are pharmaceutical compositions comprising an active vitamin D compound in emulsion pre-concentrate formulations, as well as emulsions and sub-micron droplet emulsions produced therefrom. The compositions comprise a lipophilic phase component, one or more surfactants, and an active vitamin D compound. The compositions may optionally further comprise a hydrophilic phase component.
Owner:NOVACEA INC
Soft capsules
InactiveUS6893658B1Easily discriminatedImprove securityOrganic active ingredientsBiocideRed Ferric OxideMedicine
An object of the present invention is to provide soft capsule formulations of active vitamins D, well-suited to practical production with easy discrimination of active ingredient levels, in which stability of the active vitamins D3 to light and heat is ensured, and which material is highly safe to the human body. According to the present invention, soft capsule formulations of active vitamins D3 can be obtained-wherein the capsule shell contains a white pigment and yellow iron oxide and / or red iron oxide, or titanium oxide and caramel, or yellow iron oxide.
Owner:CHUGAI PHARMA CO LTD
Method of treating breast cancer using a combination of vitamin D analogues and other agents
ActiveUS7094775B2Good treatment effectReduce in quantityHeavy metal active ingredientsBiocideIncreased calciumActive Vitamin D
The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the breast, e.g., breast cancer, which includes administering to a patient in need thereof an active vitamin D analogue and another anticancer agent. Cell differentiation is promoted, induced or enhanced without causing to the patient dose-limiting hypercalcemia and hypercalciuria.
Owner:BONE CARE INT
Treatment of cancer with active vitamin D compounds in combination with radiotherapeutic agents and treatments
InactiveUS20060177374A1Treating and ameliorating cancerReduced hypercalcemicBiocideOrganic active ingredientsCompound (substance)Treated animal
The present invention relates to a method for treating cancer in an animal by administering to the animal an active vitamin D compound or a mimic thereof in combination with a radiotherapeutic agent or treatment.
Owner:NOVACEA INC
Treatment of liver disease with active vitamin D compounds
InactiveUS20050009793A1Treating and ameliorating and preventing liver diseaseReduced hypercalcemic effectBiocideOrganic active ingredientsDiseaseCompound (substance)
The present invention relates to a method for treating liver disease in a animal by administering to the animal an active vitamin D compound, preferably one that accumulates in the liver.
Owner:NOVACEA INC
Pharmaceutical compositions comprising active vitamin D compounds
InactiveUS20050026877A1Shorter TmaxOvercome disadvantagesBiocideOrganic active ingredientsEmulsionCompound (substance)
Disclosed are pharmaceutical compositions comprising an active vitamin D compound in emulsion pre-concentrate formulations, as well as emulsions and sub-micron droplet emulsions produced therefrom. The compositions comprise a lipophilic phase component, one or more surfactants, and an active vitamin D compound. The compositions may optionally further comprise a hydrophilic phase component.
Owner:NOVACEA INC
Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
InactiveUS6858595B2Relieve symptomsAvoid symptomsOrganic active ingredientsBiocideInflammatory bowel diseaseActive Vitamin D
Methods of treating inflammatory bowel disease are described, and in particular the prevention and treatment of inflammatory bowel disease in humans as well as other animals. These methods involve the administration of biologically active vitamin D compounds, and therapeutic compositions thereof, so that the symptoms of Inflammatory Bowel Disease are reduced or relieved.
Owner:WISCONSIN ALUMNI RES FOUND
Pharmaceutical compositions comprising active vitamin D compounds
InactiveUS20060189586A1Shorter TmaxOvercome disadvantagesBiocideOrganic active ingredientsEmulsionActive Vitamin D
Disclosed are pharmaceutical compositions comprising an active vitamin D compound in emulsion pre-concentrate formulations, as well as emulsions and sub-micron droplet emulsions produced therefrom. The compositions comprise a lipophilic phase component, one or more surfactants, and an active vitamin D compound. The compositions may optionally further comprise a hydrophilic phase component.
Owner:NOVACEA INC
Treatment of immune-mediated disorders with active vitamin D compounds alone or in combination with other therapeutic agents
InactiveUS20060178351A1Treating, ameliorating, or preventing an immune-mediated disorderReduced hypercalcemicAntibacterial agentsBiocideDiseaseTreated animal
The present invention relates to a method for treating, ameliorating, or preventing immune-mediated disorders in an animal by administering to the animal active vitamin D compounds or mimics thereof The invention further relates to a method for treating, ameliorating, or preventing immune-mediated disorders in an animal by administering to the animal active vitamin D compounds or mimics thereof in combination with other therapeutic agents.
Owner:NOVACEA INC
Method for treating and preventing hyperparathyroidism
InactiveUS20090137536A1Good curative effectInherent toxicityOrganic active ingredientsBiocidePhysiologyHyperparathyroidism
This invention relates to a method for treating or preventing hyperthyroidism associated with aging and / or with Aging-Related Vitamin D Deficiency (ARVDD) syndrome by administering a sufficient amount of an active vitamin D compound utilizing a variety of effective treatment protocols. The invention further relates to treating or preventing one or more of the following conditions, e.g., (1) primary vitamin D deficiency, (2) 1,25-(OH)2D3 deficiency, and (3) 1,25-(OH)2D3 resistance included within the syndrome of ARVDD.
Owner:MAZESS RICHARD B +2
Prevention of Arterial Restenosis with Active Vitamin D Compounds
InactiveUS20070148205A1Reduced hypercalcemic effectPreventing, treating, or ameliorating arterial restenosisBiocideOrganic active ingredientsPercent Diameter StenosisCompound (substance)
Owner:WHITEHOUSE MARTHA J +1
Prevention of arterial restenosis with active vitamin d compounds
InactiveUS20070142339A1Reduced hypercalcemic effectPreventing, treating, or ameliorating arterial restenosisBiocideOrganic active ingredientsPercent Diameter StenosisVitamin
The present invention relates to a method for preventing, treating, or ameliorating arterial restenosis after angioplasty in an animal by administering to the animal active vitamin D compounds. The invention further relates to a method for preventing, treating, or ameliorating restenosis after angioplasty in an animal by administering to the animal active vitamin D compounds in combination with other therapeutic agents. A further aspect of the invention is a method for preventing, treating, or ameliorating stenosis within and / or around an arterial bypass graft in an animal comprising administering to the animal an active vitamin D compound.
Owner:NOVACEA INC
Pharmaceutical compositions comprising active vitamin D compounds
Disclosed are pharmaceutical compositions comprising an active vitamin D compound in emulsion pre-concentrate formulations, as well as emulsions and sub-micron droplet emulsions produced therefrom. The compositions comprise a lipophilic phase component, one or more surfactants, and an active vitamin D compound. The compositions may optionally further comprise a hydrophilic phase component.
Owner:LAIDLAW BARBARA +1
Treatment of pancreatic cancer with active vitamin d compounds in combination with other treatments
InactiveUS20070275934A1Reduced hypercalcemic effectIncrease doseBiocideOrganic active ingredientsHigh dosesActive Vitamin D
The present invention relates to a method for treating or ameliorating pancreatic cancer in an animal by administering to the animal active vitamin D compounds by high dose pulse administration in combination with one or more chemotherapeutic agents or radiotherapeutic agents / treatments.
Owner:CURD JOHN G
Method for identifying altered vitamin D metabolism
InactiveUS20070207488A1Generate as much of a calcemic responseNervous disorderMicrobiological testing/measurementVitamin D metabolismActive Vitamin D
A method is provided for identifying an individual as having altered vitamin D metabolism comprising analyzing a biological sample from the individual for the presence of CYP24 SNPs and / or aberrantly spliced CYP24 mRNA. The presence of the SNPs and / or the aberrantly spliced CYP24 mRNA indicates that the individual has altered vitamin D metabolism. Also provided are methods for customizing dosages of biologically active vitamin D compounds for individuals who are determined to have altered vitamin D metabolism.
Owner:HEALTH RES INC
Multi-use vessels for vitamin D formulations
This invention relates to multi-use dispensing vessels containing pharmaceutical formulations of active vitamin D compounds, and also to plastic blow fill containers containing active vitamin D formulations.
Owner:BONE CARE INT
Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
InactiveUS20020128241A1Relieve symptomsAvoid symptomsOrganic active ingredientsBiocideInflammatory bowel diseaseActive Vitamin D
Methods of treating inflammatory bowel disease are described, and in particular the prevention and treatment of inflammatory bowel disease in humans as well as other animals. These methods involve the administration of biologically active vitamin D compounds, and therapeutic compositions thereof, so that the symptoms of Inflammatory Bowel Disease are reduced or relieved.
Owner:WISCONSIN ALUMNI RES FOUND
Ophthalmic composition containing active vitamin D
An ophthalmic composition comprises active vitamin D as an effective component and is used for preventing deterioration of the optical transparency, occurrence of high intraocular pressure diseases or defective sight, observed after an ophthalmic operation, due to hyperplasia of the anterior ocular cells in the tissues damaged by the ophthalmic operation, which are in course of a healing process, and / or excess production of cellular materials.The ophthalmic composition can be dropped in the eye after operations such as those for cataract, for transplantation of intraocular lenses and for cornea to maintain the intraocular transparency of the anterior ocular region, to control the hyperplasia of the anterior ocular cells in the tissues damaged by the ophthalmic operation, which are in course of a healing process, and / or excess production of cellular materials and to thus prevent any reduction of visual acuity.
Owner:MUKAI KATSUHIKO
Pharmaceutical spray composition comprising a vitamin d analogue and a corticosteroid
ActiveUS20130123720A1Improve permeabilityMaintain good propertiesOrganic active ingredientsDispensing apparatusLipid formationDisease
The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative and a corticosteroid, and its use in the treatment of dermal diseases and conditions. The spray comprises especially a propellant selected from the group consisting of dimethyl ether, diethyl ether and methylethyl ether or a mixture thereof and further a pharmaceutically acceptable lipid carrier solubilised or suspended in said propellant.
Owner:LEO PHARMA AS
Nutrition liquid for chronic nephropathy and preparation method thereof
InactiveCN1840171AFood safetyReasonable configurationHeavy metal active ingredientsPeptide/protein ingredientsNutritional statusVitamin C
Disclosed is a nutrient solution for treating chronic kidney diseases and its preparing process, wherein each 500ml of the nutrient solution contains carbohydrate compound 55-65g, saturated fatty acid 10-12g, mono-saturated fatty acids 20-24g, protein 6-10g, zinc 5-10mg, ferrum 10-15mg, calcium 0.2-0.5g, cellulose 3-3.5g, complex vitamin B 10-30mg, active vitamin D 0.5-0.8ug, folic acid 1-2mg, vitamin C 50-100mg, pantothenic acid 3-5mg, yeast 10-15g, and probiotic 210-250mg.
Owner:SUZHOU UNIV
Prevention of Thrombotic Disorders with Active Vitamin D Compounds or Mimics Thereof
InactiveUS20080069814A1Reduce and avoid unwantedReduce and avoid and adverse effectOrganic active ingredientsBiocideDiseaseMedicine
The present invention relates to a method for preventing, treating, or ameliorating thrombotic disorders in an animal comprising administering to the animal an active vitamin D compound or a mimic thereof. According to the invention, the active vitamin D compound or the mimic thereof may be administered by HDPA so that high doses of the active vitamin D compound or the mimic thereof can be administered to an animal without inducing severe symptomatic hypercalcemia. The invention also relates a method for preventing, treating, or ameliorating thrombotic disorders in an animal comprising administering to the animal an active vitamin D compound or a mimic thereof in combination with one or more other therapeutic agents.
Owner:NOVACEA INC
Preparation method of activated vitamin D3 drug CD ring intermediate
ActiveCN107098799AHigh yieldThe process steps are simpleGroup 4/14 element organic compoundsPreparation by halogen introductionIodineDiol
The invention relates to a preparation method of an activated vitamin D3 drug CD ring intermediate. The preparation method comprises the following steps: carrying out iodine substitution on a diol derivative 2 to obtain a compound 3, carrying out hydroxyl reaction on the compound 3 to obtain a compound 4, carrying out Michael addition reaction on the compound 4 to obtain a compound 5, carrying out nucleophilic addition reaction on the compound 5 to obtain a compound 6, carrying out deprotection reaction on the compound 6 to obtain a compound 7, and carrying out oxidation reaction on the compound 7 to obtain a compound 1, namely, the activated vitamin D3 drug CD ring intermediate (25-hydroxy Grundmann's one). The preparation method provided by the invention has the advantages that the steps are simple, the product yield is high, and massive 25-hydroxy Grundmann's one can be prepared.
Owner:SHANDONG UNIV
Medicine for preventing and treating sicca syndrome and composition thereof
ActiveCN107007606AChemically stableUnique o-benzoquinone structureOrganic active ingredientsSenses disorderDiseaseVitamin C
The invention relates to pyrroloquinoline quinine, derivatives and / or salts thereof and application to preparation of medicines for treating and / or preventing primary sicca syndrome, secondary sicca syndrome and mouth dryness, eye dryness and damage of multiple systems caused by fatigue of other exocrine glands and other organs outside glands thereof as well as a medicine composition of PQQ or PQQ combined active vitamins d, NAC, resveratrol, epigallocatechin gallate, curcumin, anthocyanin, vitamin E, vitamin C or vitamin D and the like. The medicine and the medicine composition can be used for treating sicca syndrome and adaptation diseases related to the sicca syndrome. The medicine and the medicine composition are capable of removing excess oxygen radicals in the body, inhibiting NF-kB activation caused by oxidative stress and inhibiting autoimmunity so as to reduce the inflammatory response of the sicca syndrome.
Owner:NANJING SHUPENG BIOTECH CO LTD
New application of vitamin D
PendingCN105087463AEnhance in vitro proliferative abilityInhibition of clonogenicityOrganic active ingredientsVertebrate cellsPhysiologyNude mouse
The invention relates to a method for slowing down ovarian surface epithelial cell vicious transformation. During ovarian surface epithelial cell vicious transformation, active vitamin D (1,25(OH)2D3) is added through each passage and after each culture medium replacement so as to slow down the ovarian surface epithelial cell vicious transformation. The invention further provides application of the vitamin D in the preparation of medicine for treating ovarian cancer. By the long-term use of low dosage of vitamin D, 25-hydroxyvitamin D or active vitamin D, the tumorigenic ability of ovarian surface epithelial cells in the body of a nude mouse can be weakened effectively.
Owner:SUZHOU UNIV
Method of treating and preventing hyperparathyroidism with active vitamin d analogs
InactiveUS20100087404A1Suppress parathyroid activityLower levelBiocideInorganic boron active ingredientsHyperparathyroidismEffective treatment
This invention relates to a method for treating or preventing hyperthyroidism secondary to chronic kidney disease by administering a sufficient amount of an active vitamin D analog utilizing a variety of effective treatment protocols.
Owner:GENZYME CORP
Pharmaceutical composition comprising solvent mixture and a vitamin D derivative or analogue
A substantially anhydrous, topical pharmaceutical composition comprising a non not alcoholic three-component solvent mixture and a biologically active vitamin D derivative or analogue dissolved therein as well as a pharmaceutically acceptable carrier may be used in the treatment of dermal conditions.
Owner:LEO PHARMA AS
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