109 results about "Horny layer" patented technology

The invention discloses a method for cultivating algam Dendrobium nobile in group in water. Since the blades of algam Dendrobium nobile before output bottle will not form complete horny layer to process effective photosynthesis, according to the growth and physiological characters, the algam Dendrobium nobile output bottle is cultivated by water cultivate device, to be cultivated for 30 days at right condition, therefore, cultivated seeds can be transplanted into large field. The invention can effectively resolve the problems as low survival rate and improve survival rate to 95%.

[Problems] A composition curable with active energy beams for use in skin patches is provided, which is liquid at ordinary temperature, has a practical crosslinking property or curability in the absence of photopolymerization initiators even when irradiated with visible or ultraviolet light, and provides cured films that are not discolored and excellent in various pressure-sensitive adhesive performances and have appropriate pressure-sensitive adhesiveness so as not to cause pain or damage to the horny layer in the patch-applied area even when patches are repeatedly applied and peeled off, as well as excellent water resistance. [Means for solving problems] The composition curable with active energy beams for use in skin patches is liquid at ordinary temperature and comprises (A) a compound having two or more maleimide groups and (B) an oil component, or water or a water-soluble compound.

An electro-tactile display includes an electrode substrate provided with a plurality of stimulation electrodes, a conductive gel layer positioned between the stimulation electrodes and the skin of a wearer, a switching circuit section electrically connected to the stimulation electrodes, a stimulation pattern generating section electrically connected to the switching circuit, and means for alleviating a sensation experienced by the wearer as a result of the stimulation electrodes. In one aspect, the means for alleviating a sensation is configured from the conductive gel layer. The conductive gel layer has a resistance value equivalent to that of the horny layer of the skin. In another aspect, the means for alleviating a sensation is configured from the stimulation determination means and the threshold value adjustment means.

The invention discloses a microneedle array flexible chip which comprises a flexible substrate and two or more microneedles arranged on the flexible substrate at intervals. Each microneedle comprises a needle rod and a tip arranged at the top end of the needle rod, and the microneedle is fixed on the flexible substrate through the lower part of the needle rod. By organically combining a microneedle array and the flexible substrate, the invention can enable medicine or facial skin care products to pass through horny layers and enter epidermal layers and dermis layers quickly, thereby significantly improving the medicine effect or the effect of facial beautifying and nursing; in addition, the invention takes advantage of a mature process to realize the low-cost high-yield high-repetitiveness production in batch.

Disclosed herein are chemically crosslinked hyaluronic acid nanoparticles and a method for preparing the same. More specifically, the chemically crosslinked hyaluronic acid nanoparticles are prepared by mixing an oil phase containing a surfactant dissolved therein with a water phase, containing hyaluronic acid and a water-soluble crosslinker, dissolved in an aqueous basic solution, so as to form a w / o emulsion, and crosslinking the hyaluronic acid in the w / o emulsion, are uniformly absorbed and dispersed in the horny layer of the skin when they are applied on the skin, thus showing improved ability to be absorbed into skin, and show high water-swelling ability when they are dispersed in water.

The invention discloses a composition with a skin whitening effect, and application thereof to cosmetics. The composition is prepared from the following ingredients in percentage by mass: 0.01 percent to 10 percent of 1-methylhydantoin-2-imide, 0.01 percent to 20 percent of nicotinamide, 0.01 percent to 20 percent of thyme extracts, 0.01 percent to 20 percent of orange peel extracts, 0.001 to 0.5 percent of fullerenes and the balance auxiliary materials and water. The composition has the advantages that the composition is safe and achieves the skin whitening effect; the irritability is low; free radicals can be effectively cleared away; efficient oxidation resistance is realized; the composition with the skin whitening effect is provided; the composition has different action mechanisms of inhibiting the tyrosinase activity, resisting oxidization, clearing away free radicals, brightening skin, holding moisture, accelerating the metabolism function of skin cells, and the like; the composition acts on the epidermal layer, the horny layer and the corium layer, so that the synergistic skin whitening effect is achieved; the irritation and the irritability are low.

The object of the present invention is to provide a face wash which effectively removes pore stains and aged horny layers of the skin and gives whitening effect but has lesser stimulant feel. The present invention solves the object by providing a face wash comprising a protein-degrading enzyme, lipid-degrading enzyme, trehalose, D-glucose, and ascorbic acid and / or a derivative thereof as effective ingredients.

The invention is a horny layer remover with simple and sanitary structure to be easily made and to prevent the damage of skin and effectively remove the horny layers according to the hardness of the horny layer. The invention includes at least one blade in the shape of circle, curve or closed loop on one or both side of the body. And the blade is integrally formed with the body by means of injection molding.

The present invention discloses one kind of epidermal needle and its making process and application. The epidermal needle consists of sheet support and needle array on the support, and the needles have length of penetrating through the skin horny layer and not penetrating into the dermal layer. The epidermal needle may be made through etching metal material, and is used in improving the transdermal absorption of macromolecular beautifying cosmetic and in speeding the transdermal administration of macromolecular biological medicine. The present invention has simple production process and low cost, and is suitable for large scale production and durable. The present invention is especially suitable for transdermal release of beautifying cosmetic, diagnosis reagent, vaccine, macromolecular biological medicine, etc.

The invention relates to a resistance chromatography imager based on micro electrode, and relative micro-cut measurement, wherein it uses micro electrode to span the horny layer with high resistance; it can replace traditional surface electrode, to be used as current activator and sensor to sense voltage signal; the measured signal via magnification and filter is input into PC to be processed and displayed via gray diagram or colorful diagram, to represent the resistance distribution. The invention can reduce the effect of skin resistance in current activation and voltage signal collection, with high signal-noise ratio and reduced error, to improve the calculation accuracy and image resolution.

The invention relates to the medical technical field, in particular to a paeonol micro-emulsion preparation and a preparation method thereof. The paeonol micro-emulsion preparation consists of components with the weight percentage as follows: 0.1 percent to 2 percent of paeonol, 10 percent to 25 percent of surfactant, 5 percent to 30 percent of cosurfactant, 5 percent to 15 percent of oil phase and 40 percent to 70 percent of deionized water. The mouse percutaneous experiment in vitro shows that the paeonol micro-emulsion prepared by the invention has obviously higher capacity of penetrating through the horny layer than the saturated aqueous solution of paeonol (p is less than 0.05), and the paeonol micro-emulsion can penetrate into the skin deeply to take curative effect within a short time and also has certain sustained and controlled release function. At the same time, the paeonol micro-emulsion improves the solubility of the paeonol obviously, increases the drug loading quantity of the preparation and reduces the drug administration times and the dosage. The paeonol micro-emulsion preparation has simple preparation method and uniform grain diameter of the preparation, has the advantages of being safe, stable and efficient and, can be used for preparing dermal medication preparation or cosmetic.

The invention relates to a mask composition. The mask composition comprises the following components according to the preparation ratio: 25% of citric acid, 20% of calcium sulfate, 15% of active carbon, 5% of sodium pyrophosphate, 20% of magnesium silicate adsorbent, 3% of plasticizer, 2% of setting agent and 10% of deionized water. The citric acid, calcium sulfate, active carbon, sodium pyrophosphate and magnesium silicate adsorbent are fully mixed according to proportion, the deionized water is added for mixing, 200-mesh sieve is adopted for sieving, and the plasticizer and setting agent are added and mixed for 15 minutes. The mask composition can accelerate horny layer renewing, and can help remove melanin in skin, thin pores and dissolve blackhead.

The present invention relates to a microneedle and a microneedle array. More specifically, it relates to a microneedle and a microneedle array capable of injecting a drug into the surface layer or horny layer of the skin easily, safely and efficiently.

The invention relates to a method for removing a surface horny layer of a sea cucumber, which comprises the following steps: 1, treatment of raw materials: removing the internal organs of a fresh cucumber, soaking and cleaning the sea cucumber for stander by services; or boiling a dried unsalted or salted sea cucumber in water at a temperature of between 80 and 100 DEG C for 1 to 30 minutes; 2, enzyme treatment: adding the cleaned standby seam cucumber into 0.5 to 3 folds of quality of water, and adding dices and pulps of pineapple or pawpaw to the mixture simultaneously with the addition being 0.1 to 10 percent of that of the sea cucumber; heating the mixture to a temperature of between 40 an 80 DEG C for 5 to 30 minutes, and then deactivating the mixture; or adding 1 to 3 types kinds of bromelain, papain and neutral protease with the addition being 0.005 to 2 percent of that of the sea cucumber; and heating the mixture to a temperature of between 40 and 70 DE C for 5 to 30 minutes, and then deactivating the mixture; and 3, removal of horny substances: cleaning the sea cucumber thoroughly when the horny layer of the sea cucumber is quite easy to remove. The method keeps the appearance of the sea cucumber smooth and the surface thereof undamaged without scratches, and the prepared water soaked sea cucumber does not drop a residue with a clear solution.

The invention provides a method for two-dimensional evaluation of the nature of horny layer oxidized protein on a horny layer, the method comprising specific fluorescent labeling of the carbonyl groups of the oxidized protein in a horny layer specimen taken from skin, and detection of the fluorescence for evaluation, as well as a kit used to carry out the method and a method for screening of agents which inhibit increase in oxidized protein. The invention further provides a method for detecting the oxidized form of a cornified envelope consisting of the water-insoluble substances in a skin-derived horny layer specimen, the method comprising specific fluorescent labeling of the carbonyl groups in a cornified envelope in the oxidized form and detection of the fluorescence thereof for evaluation.

A regime or regimen for promoting cohesion and / or organization of the epidermal horny layer, notably for promoting homogeneity and / or clarity of the complexion, for improving the homogeneity and / or the staying power of makeup compositions on the skin or the lips, for preventing impairment of the horny layer induced by a cosmetic or dermatological active agent, or for promoting cohesion of the horny layer in the preparation of reconstructed epidermis and / or reconstructed skin, entails administering to an individual in need of such treatment, for such period of time as required to elicit the desired effect, a cosmetic / dermatological composition which contains up to 8% by weight of 8-hexadecene-1,16-dicarboxylic acid, formulated into a physiologically acceptable medium therefor.

The invention discloses a method for improving the germination rate and the survival rate of sophora alopecuroide seeds of wild medicinal plants and sophora alopecuroide seeds and belongs to the technical field of seed culture. The method comprises the following steps that: firstly 80-98% sulfuric acid is adopted to soak the seeds for 1-1.5 hours, then more than 95% alcohol is adopted to soak the seeds for 18-30 seconds, and then a sodium hypochlorite solution with the active chlorine content of being 3-6% is adopted to soak the seeds for 3-8 minutes; and the concentrations and the treating time of reagents among all the treating steps have influences on the germination rate, the germination uniformity and the survival rate of the seeds respectively. The method disclosed by the invention has the beneficial effects that firstly the treatment with concentrated sulfuric acid is carried out to break and remove tissue structures of horny layers of outer skin layers and palisade layers of middle skin layers of the seeds, due to coverage to seed holes of mature seeds, the structures have influences on water absorption and oxygen entering into the seeds; and next, the alcohol is used for eliminating polar substances in the skin layer corroded by the sulfuric acid, so that the sodium hypochlorite solution is easy to be used for fully soaking the seed coats in the next step and kill microorganisms on / in the skin layer.

The invention provides a pressure-sensitive adhesive for the skin excellent in pressure-sensitive adhesiveness to the human skin and repeelability therefrom, which does not cause the horny layer to be torn away in peeling and is lowly irritant to the skin; and tapes or sheets made by using the same. The pressure-sensitive adhesive is characterized by comprising (a) 100 parts by weight of a copolymer which is prepared from an olefinic macromonomer and a vinyl monomer and whose molecular weight (in terms of polystyrene and as determined by gel permeation chromatography (GPC)) has a two-peak distribution (with the proviso that when the copolymer is to be post-cured, the distribution is one as determined before the post cure) and (b) 20 to 250 parts by weight of a softener which is compatible with the copolymer and liquid or pasty at room temperature and has a boiling point of 250 or above (with the proviso that when the content of the softener (b) exceeds 80 parts by weight, the copolymer must be post-cured).

It is intended to provide a method of evaluating the transparency and moisture retention of the horny layer by using oxidized protein in the horny layer as an indication.

A technology for delivering a ceramide across the horny layer of skin to sufficiently exert the effects of the ceramide is disclosed. Specifically, an external preparation for skin containing a ceramide delivers the ceramide across the horny layer to near the dermis when the skin preparation is applied on the skin surface. The described skin external preparation contains a ceramide, an organically modified clay mineral, a diester of N-acylglutamic acid, and a phytosterol as components in the form of water-in-oil emulsion.

The invention relates to a skin care cosmetic, in particular to a skin care cosmetic containing liposome recombinant human growth hormone. The cosmetic comprises polyoxyethylene fatty alcohol ether, polysorbate 60, monolaurin, hexadecanol, liquid paraffin, glycerol, sodium polyacrylate, polyvinylpyrrolidone K30, alpha-lipoic acid, perfume, preservative, ionized water, liposome human growth hormone. A surface active agent is introduced in the preparation process of liposome so that the encapsulation rate of the liposome human growth hormone is obviously improved. The invention can emulsify a product by a production technology of micro-emulsion to prepare millimicro-emulsion with the grain diameter of 100-200mm, thereby improving the local penetrability of the cosmetic on the skin, enabling an active substance to directly act on the horny layer to be uniformly distributed and showing more favorable effects of aging resistance, facial care, and the like and being more suitable for sensitive skin.

The invention discloses a podophyllotoxin preparation formula for external use for the treatment of condyloma acuminatum and genital herpes, a series of formulations and a preparation method, and belongs to the field of pharmacy. The weights or the volumes of all the ingredients of the formula of 100ml of the podophyllotoxin preparation for external use are as follows: 0.5g of podophyllotoxin, 20ml-80ml of main solvent, 1ml-3ml of penetration enhancer 1, 0.5g-2.5g of penetration enhancer 2, 20ml-80ml of cosolvent and 0.03-0.5g of preservative. The podophyllotoxin preparation for external use has the advantages that the types and the amount of excipients and the proportion of main drugs are reasonable, the drug administration is carried out by a liniment, a spray or other formulations which are applicable to the external use, the main drug can be rapidly absorbed by the horny layer and the epidermis, the efficacy is significant, the local toxicity or side effects are small, the skin acute toxicity is very low, and the podophyllotoxin preparation has no irritation and weak allergy and does not hinder the skin normal functions; the podophyllotoxin preparation has no systemic toxicity or side effects, thereby being safe and effective. The preparation prepared by the formula has the advantages of good appearance, moderate viscosity, easy coating, spraying drug administration, feasible process, controllable quality, simple preparation process, and suitability for industrial batch production.

A nail and / or skin patch for preventing or treating mycoses is provided that is able to maintain a drug concentration in the nails and / or skin horny layer at a high concentration for a long period of time without adding a dissolving agent that prevents precipitation of drug crystals or permeation enhancer that promotes penetration of drug into the nails and / or skin, retains superior adhesion even when adhered for a long period of time and has causes little skin irritation.A nail and / or skin patch for preventing or treating mycoses, which contains an antimycotic, having an octanol / water partition coefficient in the form of a logKo / w value of 4 or more, in a dissolved state in an acrylic-based pressure-sensitive adhesive layer or silicone-based pressure-sensitive adhesive layer.

The invention discloses an anti-alopecia shampoo, which contains 3-10% by mass of an anti-alopecia active component, wherein the anti-alopecia active component comprises a grape seed extract, a Hamamelis mollis extract, a camellia extract and a chamomile extract, the grape seed extract accounts for 30-50% of the mass of the anti-alopecia active component, and a mass ratio of the Hamamelis mollis extract to the camellia extract to the chamomile extract is (4-9):(3-7):(6-11). According to the present invention, the anti-alopecia shampoo can fundamentally alleviate the problem of excessive alopecia, promote the metabolism of scalp horny layer, strengthen the hair root nutrient absorption, consolidate the hair root growth, reduce hair loss and hair breaking, and further has characteristics ofsignificant anti-alopecia effect, safety, no toxicity, excellent hair cleaning ability and environmental protection, and fine, mild and non-irritating foam.