The invention relates to two types of isoquinoline compounds and application thereof to preparing anti-cancer medicaments. The compounds have obvious growth suppression and activity killing effects on various human cancer cells. The two types of isoquinoline compounds have the molecular structural characteristics shown in the specification respectively, wherein R1, R2, R3, R4, R5, R7, R8, R9, R10, R11 and R12 are same or different hydrogen, alkyl group, naphthenic group, alkenyl group, alkine group, unsaturated monocyclic alkyl group, alkoxy group, halogen, hydroxyl group, nitryl group, cyano group, trifluoromethyl group, heterocyclic substituent, carboxyl group, ester group, amido group, acryl group or aldehyde group; R6 is an aliphatic hydrocarbon group or aryl group; R13 is cyano (-CH) or alkoxy (RO-); and X- is sulfate radical, halogen anion, carbonate, bicarbonate radical, phosphate radical, hydrogen phosphate radical, fatty acid radical, sulfonic acid radical or tetraphenyl borate radical.