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36 results about "Systemic immunity" patented technology
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Systemic immunity. Systemic acquired resistance (SAR) provides enhanced, long-lasting systemic immunity to secondary infection by a range of biotrophic, hemibiotrophic and necrotrophic pathogens that have diverse modes of infection.
Preparation method for chicken-mouth litchi ferment
InactiveCN104187483ASimple manufacturing methodUnique tasteFood ingredient functionsFood preparationAmnesiaWhole body
The invention discloses a preparation method for chicken-mouth litchi ferment. Whole chicken-mouth litchis are air-dried and are mixed with momordica grosvenori and dry lotus seeds; dry rose petals, dry lotus petals and dry acacia petals are added for seasoning; after twice fermentation, harmful substances such as methyl alcohol and nitrite are removed through alkalescent resin and decompression distillation. According to the preparation method disclosed by the invention, by virtue of normal temperature and normal pressure production, the technology is simple, the operation is convenient, pollution is avoided, energy consumption is low, and the preparation method is easy to popularize. The chicken-mouth litchi ferment prepared by the preparation method has the effects of tonifying qi, enriching blood, tonifying the spleen, reinforcing the stomach, astringing the intestines, securing essence and tranquilizing by nourishing the heart, can enhance the whole-body immunity and obviously improve the symptoms such as sleeplessness, amnesia and exhausting, can be directly made into oral liquid, powder, tablets or capsules, and can be also used as a functional additive added into relevant food, beverage or feed and fertilizer.
Owner:北海市东雨农业科技有限公司
Novel prime-boost combinations of attenuated mycobacterium
InactiveUS20090304750A1Effective protectionOrganic active ingredientsBacterial antigen ingredientsPrime boostMucosal vaccine
The present invention provides vaccine compositions for effective induction of both mucosal and systemic immunity to pathogenic Mycobacterium species. Vaccination protocols are provided in which both parenteral and mucosal vaccine formulations are administered to a host. The parenteral and mucosal formulations comprise live, attenuated Mycobacteria.
Owner:HONE DAVID +1
Non-specific complex polysaccharide immunity milk and preparation method thereof
InactiveCN101336661AExpand the connotationExtended epitaxyMilk preparationFood preparationBiotechnologyDisease
This invention discloses a nonspecific compound polysaccharides immune milk,which is formulated from the following raw materials, by weight,0.3 to 60 parts of fungi polysaccharides, 0.9 to 15 parts of plant polysaccharides, 35 to 1000 parts of functional oligosaccharides, 8000 to 10000 parts of skim cow milk or skim sheep milk. This invention extends the connotation and the extension of immune milk, solves some problems of immune milk produced by local immunity and / or systemic immunity, such as high cost, high operational difficulty, long period and anaphylaxis, has the obvious function of immune regulation, promotes the body resistance to diseases, has good health effect to the people who is weak and liable to have cold. The nonspecific compound polysaccharides immune milk of this invention has a steady character, no risk of anaphylaxis, simple processing technology,is easy to produce on a large scale and has great developmental prospect.
Owner:NORTHWEST A & F UNIV
Hiv/siv vaccines for the generation of mucosal and systemic immunity
Compositions of genetically engineered, secreted gp96 (gp69-Ig) induced strong mucosal and systemic immune responses and CD8 expansion that was independent of CD4 help. Immunization of patients with gp96-Ig immunization is especially attractive for induction of mucosal and systemic immunity to SIV / HIV and other diseases.
Owner:UNIV OF MIAMI
Methods and compositions for intranasal delivery
ActiveUS20130129781A1Improve liquidityLow hygroscopicitySsRNA viruses negative-senseAntibacterial agentsVaccine deliveryWhole body
Provided herein are methods for generating dry vaccine powder formulations. Dry vaccine powder formulations can be used for intranasal delivery. Also provided are methods for stimulating local mucosal and systemic immunity by intranasal vaccine delivery.
Owner:KM BIOLOGICS CO LTD +1
Methods and compositions for intranasal delivery
ActiveUS20130273120A1Improve liquidityLow hygroscopicityAntibacterial agentsSsRNA viruses negative-senseVaccine deliveryWhole body
Owner:SHIN NIPPON BIOMEDICAL LAB
Interferon alpha and antisense K-ras RNA combination gene therapy
InactiveUS20050260167A1Increased cell deathEasy to solveBiocideSugar derivativesAbnormal tissue growthWhole body
An antiproliferative effect of IFN-α gene transduction in pancreatic cancer cells. The invention relates to expression of IFN-α to effectively induce growth suppression and cell death in pancreatic cancer cells, an effect which appeared to be more prominent when compared with other types of cancers and normal cells. Another aspect of the invention relates to targeting the characteristic genetic aberration, K-ras point mutation, in pancreatic cancer, and that the expression of antisense K-ras RNA significantly suppresses the growth of pancreatic cancer cells. When these two gene therapy strategies are combined, the expression of antisense K-ras RNA significantly enhanced IFN-α-induced cell death (1.3-3.5 fold), and suppressed subcutaneous growth of pancreatic cancer cells in mice. The invention also relates to a method of suppressing pancreatic cancer cells using double strand RNA formed by antisense and endogeneous K-ras RNA in combination with the anti-tumor activity of IFN-α. The invention relates to the combination of IFN-α and antisense K-ras RNA as an effective gene therapy strategy against pancreatic cancer. The invention also relates to a method of treating pancreatic cancer cells disseminated throughout the body by administering the inventive combination to localized pancreatic cancer cell tumor. The invention also relates to inducing indirect immunological antitumor activity to provide systemic immunity against pancreatic cancer cells.
Owner:HEALTH SCI TECH TRANSFER CENT JAPAN HEALTH SCI FOUND
Novel prime-boost combinations of attenuated mycobacterium
The present invention provides vaccine compositions for effective induction of both mucosal and systemic immunity to pathogenic Mycobacterium species. Vaccination protocols are provided in which both parenteral and mucosal vaccine formulations are administered to a host. The parenteral and mucosal formulations comprise live, attenuated Mycobacteria.
Owner:AERAS GLOBAL TB VACCINE FOUND
Mucosally targeted immunization
InactiveUS20010021384A1Bacterial antigen ingredientsViral antigen ingredientsWhole bodySpecific immunity
The invention concerns the use of an immunogen specific of a pathogenic agent with a gateway in the buccal mucous membrane region, for producing a vaccine composition to be administered in the floor of the mouth in a human being so as to develop directly a local response in IgA antibodies and in B cells secreting IgA in the buccal mucous membrane, saliva and ganglions draining said mucous membrane. The invention also concerns a vaccine composition capable of being applied in the floor of the mouth in a human being to induce local and systemic immunity in IgA antibodies, substantially consisting of a material adhering or not to the buccal mucous membrane and containing an immunogen specific of the pathogenic agent with a gateway into the buccal mucous membrane.
Owner:AVENTIS PASTUER LTD
Nasal cavity spraying inactivated influenza virus vaccine and its prepn process
InactiveCN1810291AImprove effectivenessExtended stayAerosol deliveryAntiviralsNasal cavityLocal immunity
The nasal cavity spraying inactivated influenza virus vaccine contains the following components: cell immunizing factor, natural polysaccharide and influenza virus antigen. The effective synergistic reaction of IL-2 and natural polysaccharide raises the permeating of the influenza virus antigen in nasal cavity, avoids the degradation of enzyme on the antigen and raises the effectiveness of the medicine obviously. It is revealed that the vaccine composing scheme may be well applied in inoculating macro biomolecule to nasal cavity to produce excellent protection effect while stimulating body to generate local immunity reaction and systemic immunity reaction.
Owner:侯云德
Influenza nanovaccine
Immunogenic compositions and methods of using them include a biodegradable or bioerodible polyanhydride nanoparticle comprising 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) and 1,6-bis(p-carboxyphenoxy)hexane (CPH) copolymers, an immunogenic protein of an Influenza Virus and an adjuvant entrapped within an interior of the nanoparticle, and an excipient. The immunogenic composition may be administered to a subject to confer both local and systemic immunity to the Influenza Virus.
Owner:IOWA STATE UNIV RES FOUND +1
Spleen-tonifying and stomach-nourishing health-care tea and preparation method thereof
InactiveCN107889907AEnsure safetyLow costVitamin food ingredientsPre-extraction tea treatmentMorinda parvifoliaApple peel
Owner:GUIZHOU FENGGANG COUNTY QIANYUZHI ECO TEA IND
Hiv/siv vaccines for the generation of mucosal and systemic immunity
Compositions of genetically engineered, secreted gp96 (gp69-Ig) induced strong mucosal and systemic immune responses and CD8 expansion that was independent of CD4 help. Immunization of patients with gp96-Ig immunization is especially attractive for induction of mucosal and systemic immunity to SIV / HIV and other diseases.
Owner:UNIV OF MIAMI
Dairy product capable of improving body immunity and preparation method thereof
ActiveCN113142301AImprove immunityMilk preparationAgainst vector-borne diseasesBiotechnologyImmunocompetence
The invention provides a dairy product capable of improving body immunity and a preparation method thereof, bifidobacterium lactis TY-S01 and / or lactobacillus paracasei L9 are / is inoculated in the dairy product, and the dairy product forms comprise yoghourt and lactobacillus beverage. A dairy product added with the bifidobacterium lactis TY-S01 and / or the lactobacillus paracasei L9 is used as a raw material, after mice are fed, the phagocytic ability of macrophages to chicken erythrocytes, the killing ability of NK cells, the multiplication ability of splenic lymphocytes and the concentration of serum IgG are measured to study the influence of the product on mouse systemic immunity. Results show that the immune function of mice fed with high fat is remarkably reduced compared with that of the mice fed with feed, the bifidobacterium lactis TY-S01 can enhance the systemic immune ability of a body from the aspect of the innate immune function, and the lactobacillus paracasei L9 can enhance the systemic immune ability of the body from both aspects of the innate immune function and the acquired immune function.
Owner:CHONGQING TIANYOU DAIRY CO LTD
Immune checkpoint blocking polypeptide prodrug nano-micelle, preparation method and application
InactiveCN111956609AEnhanced Blocking Healing EffectsImprove bioavailabilityOrganic active ingredientsPharmaceutical non-active ingredientsPolythylene glycolChemo therapy
The invention discloses an immune checkpoint blocking polypeptide prodrug nano-micelle, a preparation method and application. The nano-micelle takes a hydrophobic anti-tumor drug as a core, and the core is independently connected with immune checkpoint blocking polypeptide and polyethylene glycol through a matrix metalloproteinase sensitive connection peptide, wherein the immune checkpoint blocking polypeptide and the polyethylene glycol form a shell layer. The nano-micelle disclosed by the invention has a tumor microenvironment enzyme response, and can responsively release the immune checkpoint blocking polypeptide under a function of matrix metalloproteinase under a tumor microenvironment, and avoids systemic immunity related adverse reaction caused by tumor off-target releasing of an immune checkpoint blocking drug. Through a chemotherapy killing function of an anti-tumor drug and a blocking function of the immune checkpoint, while nano-micelle blood circulation time is prolonged, the accumulation of the anti-tumor drug in a tumor focus can be enhanced, drug bioavailability is improved, the systemic immunity related adverse reaction caused by the tumor off-target releasing of the immune checkpoint blocking drug can be avoided, and a synergetic anti-tumor function of chemotherapy killing and the immune checkpoint blocking is realized.
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Transmucosal administration of aggregated antigens
Owner:ENZO THERAPEUTICS
Chinese-Western compound medicine preparation for treating pseudomembranous enteritis
InactiveCN105148277APromote reproductive growthInhibition of reproductionAntibacterial agentsHeavy metal active ingredientsOreas martianaSyzygium buxifolium
The invention discloses a Chinese-Western compound medicine preparation for treating pseudomembranous enteritis. The Chinese-Western compound medicine preparation comprises traditional Chinese medicine components and Western medicine components, wherein the traditional Chinese medicine components are prepared by mainly extracting the following components: papilionaceae mucuna cochinchinensis, phoenix dactylifera, brassica caulorapa, tofieldia divergens, syzygium buxifolium, corn cob, flower of potentilla fruticosa, oreas martiana, glycine max, bidens tripartita, herb of marsh orchis, tofieldia divergens, polytrchum commune, boschniakia himalaica, denseflower blumea herb, rhynchelytrum repens, polycarpaea corymbosa, myriaceis nepalensis, vaccinium fragile and boenninghausenia albiflora; the Western medicine components comprise pectinesterase, magnesium chloride, vitamin k, antibiotic constituents, iron, thiamine, pancreatic enzyme, ceftriaxone sodium and probiotics. According to the Chinese-Western compound medicine preparation, the traditional Chinese medicine therapy and the Western medicine therapy are combined, the effects of warming the middle, tonifying qi, invigorating the spleen for eliminating dampness, nourishing yin, clearing away heat, warming the kidney, tonifying deficiency, clearing heat, removing toxicity, diminishing inflammation, and relieving pain are achieved, harmful bacteria in intestinal tract can be eliminated, the action of bacterial toxin is weakened, the growth of normal flora in intestinal tract is facilitated, the digestion function is improved, the immunity of the whole body is adjusted, the curative effect to the pseudomembranous enteritis is definite, and the Chinese-Western compound medicine preparation takes effect quickly.
Owner:王羲笛
Nutrient tablet taking giant spiny frog peptide powder as matrix
PendingCN114680341AEnhance systemic immunityLower blood fatTransportation and packagingRotary stirring mixersBiotechnologyDisease
The nutritional tablet taking the giant spiny frog peptide powder as the matrix comprises the following raw materials: the giant spiny frog peptide powder, astaxanthin oil, soya bean lecithin, astragalus membranaceus powder and beta-cyclodextrin, the raw material composition of the nutritional tablet is limited, the giant spiny frog peptide powder is taken as the matrix, and the astaxanthin oil, the soya bean lecithin and the astragalus membranaceus powder are compounded, so that the prepared nutritional tablet has the effects of enhancing the immunity of the whole body, improving the immunity of the whole body and improving the immunity of the whole body; therefore, the effects of preventing and treating diseases such as hypertension, cerebral thrombosis, coronary heart disease, myocardial infarction and the like are achieved.
Owner:福建省健丰生物科技有限公司
A kind of granular adjuvant and its preparation method and application
ActiveCN108324938BAchieving a double activation effectBreak natural physiological barriersPharmaceutical non-active ingredientsImmunological disordersAntigenAdjuvant
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI
Parenteral Nutrition Formulation
ActiveUS20210378998A1Improve Gut HealthMaintaining or amelioratingAntipyreticAnalgesicsPediatric patientLocal immunity
The present disclosure relates to parenteral nutrition formulations, including ready-to-use parenteral nutrition formulations which are reconstituted from multi-chamber containers and amino acid formulations. More particularly, the present disclosure is directed to formulations comprising butyrate derivatives, specifically arginine butyrate, for use with adult or pediatric patients. The disclosure further provides for methods of reducing or preventing systemic and local inflammation of patients receiving parenteral nutrition, and methods of maintaining or ameliorating their systemic immunity and local immunity, as well as the patients' gut barrier functions.
Owner:BAXTER INT INC +1
Delivery vehicle composition and methods for delivering antigens and other drugs
ActiveUS7767197B2Increase viscosity of compositionPromote prolonged releaseBiocideBacterial antigen ingredientsAntigenDelivery vehicle
The present invention provides an immunogen composition and methods for using the same for the development of immunity, and particularly at mucosal sites in a mammal, thereby providing immunity at the site of entry for many major pathogenic organisms and also systemic immunity. The immunogen composition includes an antigen, a biocompatible polymer, and a liquid vehicle, with the biocompatible polymer and liquid vehicle being present in such proportions and interacting in such a way that the immunogen composition exhibits reverse-thermal viscosity behaviour. A delivery vehicle composition including a drug other than an antigen is also provided. Methods are provided for delivering the compositions of the invention to a host.
Owner:ENDO PHARMA COLORADO
A kind of preparation method of chicken mouth lychee enzyme
InactiveCN104187483BAvoid generatingFully retain nutrientsFood ingredient functionsAmnesiaDistillation
The invention discloses a preparation method for chicken-mouth litchi ferment. Whole chicken-mouth litchis are air-dried and are mixed with momordica grosvenori and dry lotus seeds; dry rose petals, dry lotus petals and dry acacia petals are added for seasoning; after twice fermentation, harmful substances such as methyl alcohol and nitrite are removed through alkalescent resin and decompression distillation. According to the preparation method disclosed by the invention, by virtue of normal temperature and normal pressure production, the technology is simple, the operation is convenient, pollution is avoided, energy consumption is low, and the preparation method is easy to popularize. The chicken-mouth litchi ferment prepared by the preparation method has the effects of tonifying qi, enriching blood, tonifying the spleen, reinforcing the stomach, astringing the intestines, securing essence and tranquilizing by nourishing the heart, can enhance the whole-body immunity and obviously improve the symptoms such as sleeplessness, amnesia and exhausting, can be directly made into oral liquid, powder, tablets or capsules, and can be also used as a functional additive added into relevant food, beverage or feed and fertilizer.
Owner:北海市东雨农业科技有限公司
A kind of chitosan-modified nano-enzyme mucosal immune adjuvant and influenza mucosal vaccine and preparation method thereof
ActiveCN111617241BEasy to retouchEasy to prepare in large batchesSsRNA viruses negative-senseViral antigen ingredientsDendritic cellMucosal adjuvant
Owner:YANGZHOU UNIV
Tooth-strengthening and odontogeny-preventing element and preparation method thereof
InactiveCN102641216APromote phagocytosisEasy to killCosmetic preparationsToilet preparationsOral diseaseOral ulcers
The invention relates to a tooth-strengthening and odontogeny-preventing element and a preparation method thereof. The preparation method comprises the following steps: adding a composite acid-proof anti-sensitive material serving as a water-soluble material in a toothpaste matrix; adding bovine colostrums immunoglubin when water is added to reach constant volume at last, wherein bovine colostrums immunoglubin accounts for 0.01-10.0wt% of the toothpaste matrix, the composite acid-proof anti-sensitive material contains 0.1-5% of potassium nitrate, 0.1-10% of strontium chloride or strontium acetate, and 0.01-0.5% of sanshoamides; and finally homogenizing, degassing and filling according to the process of the common toothpaste. The tooth-strengthening and odontogeny-preventing element has the benefits of promoting the restoration of oral mucosas, effectively preventing pathogens from being adhered to oral mucosa cells, neutralizing virus and ectotoxin, effectively preventing series of oral diseases such as oral ulcer, decayed tooth and periodontal disease; and the tooth-strengthening and odontogeny-preventing element also can promote the improvement of systemic immunity of human bodies after long-time use.
Owner:湖北华冠中科生物药业有限公司
Combination Immunogene Therapy
InactiveUS20100316603A1Improving immunogenicityPeptide/protein ingredientsVirus peptidesHuman tumorTumor response
The present invention provides to immunogene therapy protocols for the treatment of tumors. In particular, the present invention provides combinations of immune-modulating proteins that induce systemic immunity against tumors. In addition, the present invention provides humanized animal models suitable for the evaluation of anti-human tumor immunity and permit the identification of combinations of immune-modulating genes which when delivered to human tumor cells induce an effective anti-tumor response, including a systemic anti-tumor response.
Owner:RADIENT PHARMA
A kind of preparation method and application of chickpea watercress polypeptide
ActiveCN107988301BRetain biological activityImprove immunityAntibacterial agentsAntimycoticsFood additiveNeutral protease
The invention relates to a preparation method and application of chickpea watercress polypeptide. In the method, chickpea watercress oil components are fully degreased, extracted with phosphate buffer solution, neutral protease, alkaline protease, trypsin or papain Enzymatic hydrolysis, using ultrafiltration membrane technology to prepare peptides with molecular weights of 6‑10kDa, 3.5‑6kDa, 1‑3.5kDa, and then refining them by spray drying or freeze drying. The peptide powder has been verified to have anti-bacterial and fungal activity, has a wide range of anti-microbial activities, and has the function of enhancing humoral immunity and systemic immunity. It is rich in pure natural plant-derived peptides and proteins that are easily digested and absorbed by the human body. The feature of the protein is that it not only retains the original biological activity of chickpea, but also realizes the purpose of turning waste into wealth and making full use of resources; the protein can be used as a natural antibacterial agent, food additive or medicine, and can be used in the food and pharmaceutical industries .
Owner:XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
A kind of preparation method and application of camel milk antioxidant polypeptide
ActiveCN109180788BEnhance humoral immunityFunction increasePeptide preparation methodsDepsipeptidesAntioxidantUltrafiltration
The present invention relates to a preparation method and application of camel milk antioxidant polypeptide. The method uses fresh camel milk as raw material, centrifuges at 4°C to remove butter, adopts traditional isoelectric point method for precipitation, dialysis bag, concentration and freezing The total casein was obtained by drying, hydrolyzed with trypsin, refined by freeze-drying to obtain antioxidant peptides, and then separated and purified by ultrafiltration membrane, gel column and high-performance liquid phase to obtain three kinds of camel milk with relatively strong antioxidant activity Antioxidant peptides. Its amino acid primary deconstruction was identified as three polypeptides by combining high-resolution mass spectrometry and liquid chromatography-tandem chromatography: RLDGQGRPRVWLGR (1665.94Da), TPDNIDIWLGGIAEPQVKR (2122.13Da) and VAYSDDGENWTEYRDQGAVEGK (2489.09 Da). The polypeptide has the function of enhancing humoral immunity and systemic immunity. It is rich in pure natural protein and 18 kinds of amino acids that are easily digested and absorbed by the human body. It is more suitable as an ideal dairy product for the elderly and infants.
Owner:XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
Chinese and western medicine composition for treating acute peritonitis and preparation method
InactiveCN107913400ADefinite curative effectQuick resultsOrganic active ingredientsPeptide/protein ingredientsGinger GrassWhole body
The invention relates to a Chinese and Western medicine composition for treating acute peritonitis and a preparation method thereof. The raw materials for making the active ingredients of the Chinese and Western medicine composition are composed of: white calamus, long stem orchid, ginger grass, cup chrysanthemum, ground loquat, Rattan, sour rattan wood, citronella, orange peel, camphor root, ginger, black cortex root, lysozyme, mebrobenatezine; the Chinese and Western medicine composition of the present invention combines traditional Chinese medicine and Western medicine, and has the functions of sterilizing, reducing inflammation, clearing away heat Detoxification, expelling wind and dampness, nourishing the spleen and stomach, dispelling cold and relieving the exterior, warming the middle and relieving pain, eliminating filth and harmonizing the middle, and can eliminate harmful bacteria in the intestinal tract, contribute to the growth of normal intestinal flora, improve digestive function, regulate Systemic immunity has definite curative effect on acute peritonitis, and the effect is quick. In terms of prescription selection, the present invention has certain innovativeness for treating acute peritonitis and has certain social and economic value.
Owner:周雷
Oral compound strain fermentation product and application thereof
PendingCN114304513AEffectively adjust the balancePromote proliferationMicroorganism based processesFermentationBiotechnologyMicroorganism
The invention relates to the technical field of IPC A61K, in particular to an oral compound strain fermentation product and application thereof. A preparation process of the fermentation product comprises the following steps: S1, preparing a fermentation base material; s2, inoculating a compound strain into the fermentation base material, and performing fermentation culture to obtain a fermentation product stock solution; and S3, carrying out post-treatment on the fermentation product stock solution to obtain a fermentation product finished product. The oral compound strain fermentation product provided by the invention can act on the intestinal tract-oral cavity-skin axis of a human body, effectively regulate the balance of microorganisms in an ecological system of the human body and promote the proliferation of probiotics; lesions such as inflammation and acne can be effectively relieved, and intestinal homeostasis and systemic immunity are regulated; body energy consumption and lipid oxidation can be enhanced, and weight management is achieved; meanwhile, conversion of emotion restoration neurotransmitters can be promoted, and emotion regulation is helped; the preparation process of the fermentation product is simple and convenient, the obtained product is good in stability, and the formula compatibility is high when the fermentation product is applied to downstream products.
Owner:仙婷(广州)科技研发有限公司
Nasal cavity spraying inactivated influenza virus vaccine and its prepn process
InactiveCN100425288CImprove effectivenessExtended stayAerosol deliveryAntiviralsNasal cavityLocal immunity
The nasal cavity spraying inactivated influenza virus vaccine contains the following components: cell immunizing factor, natural polysaccharide and influenza virus antigen. The effective synergistic reaction of IL-2 and natural polysaccharide raises the permeating of the influenza virus antigen in nasal cavity, avoids the degradation of enzyme on the antigen and raises the effectiveness of the medicine obviously. It is revealed that the vaccine composing scheme may be well applied in inoculating macro biomolecule to nasal cavity to produce excellent protection effect while stimulating body to generate local immunity reaction and systemic immunity reaction.
Owner:侯云德
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