58 results about "Compound K" patented technology

The invention pertains to the technical field of biology and medicine, and relates to a bacterial strain of streptomyces fradiae NTGA-334 with a preseravation no. of CGMCC No.2074, and a process for using the bacterial strain to ferment and transform Compound K in glycol group in various notoginsenosides so as to prepare 20-O-beta-D-glucopyranoside-20 (S)-protopanaxadiol. The culture media are Gause's no.1, ISP2, corroding acid (HSG culture medium) and asparagine culture medium. During the fermentation, the dosing proportions of various notoginsenosides are 0.1-10% (w / v), fermenting temperature is 18-50 DEG C, dynamically adjusted pH value of 0.1-35%(w / v) aqueous ammonia is 0.1-30% (w / v). The invention transforms and ferments in a scaled way various notoginsenosides, prepares Compound K, provides a streptomycete stain that is of steady condition, simple nutrition requirement and good growth, and provides a process for fermenting and separating by a simple and easy fully automatic fermenting tank. Using this bacterial strain and process to produce Compound K, the production cost is low, the foreign matter is less, and the yield rate is high.

A lead-free piezoelectric ceramic composition wherein a suitable amount of Cu is contained in a perovskite compound of a non-stoichiometric composition represented by a formula (KxA1-x)y(Nb1-zBz)O3, wherein “A” represents at least one of Na and Bi, while “B” represents at least one of Ta and Ti, and wherein 0<x≦1, 0<y<1, and 0≦z≦1, so that by-products such as KaCubNbcOd and KaCubTacOd are produced as a result of reaction of (Nb1-zBz) with Cu in the process of calcination of a starting material, and the by-products restrict melting and abnormal grain growth of (KxNa1-x)(Nb1-zTaz) O3 during firing of a calcined body, thereby improving sinterability of the fired body, while restricting volatilization of alkali components and melting of KNbO3, thereby increasing the density and improving the piezoelectric properties of the fired body. The ceramic composition is prepared by firing a starting composition including the perovskite composition as a primary component, and a secondary component in the form of at least one of compounds KaCubNbcOd, KeCufTagOh and KiCujTikOl.

The invention relates to a method for separating and purifying a panaxoside compound-K from microorganism zymocyte by applying macroporous resin for preparing a raw medicine. The purifying yield reaches more than 72 percent, and the content of the panaxoside compound-K in a product is more than 96 percent. The method mainly comprises the following steps of: adding ethanol into zymocyte for extracting and concentrating; decoloring by active carbon and filtering; after adding water into filter liquor for diluting, leading the filter liquor to pass through a macroporous resin chromatographic column; washing by a low-concentration organic solvent aqueous solution for removing pigment and high-polarity saponin; eluting by a high-concentration organic solvent aqueous solution to obtain a panaxoside compound-K component; and finally crystallizing to obtain the panaxoside compound-K raw medicine with the content of more than 96 percent. The invention can provide a great amount of qualified raw medicine samples for the pharmaceutical development of the panaxoside compound-K.

The invention discloses a method for preparing ginseng rare anti-cancer saponin Compound K from composite bacteria, and belongs to the fields of functional food and pharmacy. According to the method, RB1 or ginseng, American ginseng and panax notoginseng serve as raw materials, 1 to 5 percent of sugar and milk powder are added, preferable saccharomycetes for producing beta-glucosaccharase, lactic acid bacteria and bifidobacterium are adopted, fermentation is conducted at 30 to 37 DEG C for 5 to 14 days, microbial transformation of the compound bacteria is conducted, and the rare ginseng containing saponin C-K is obtained. The obtained fermented ginseng powder and panax notoginseng powder have strong and attractive fragrance and good taste, and the health-care effect and the nutritional value of ginseng and panax notoginseng are greatly improved.

The present invention relates to a series of dicarboxylic acid ester derivatives of ginsenosides such as succinate and glutarate derivatives of 20-O-β-D-glucopyranosyl-protopanaxadiol (compound K, abbreviated as CK), preparation thereof and pharmaceutical uses thereof. The dicarboxylic acid ester derivatives of ginsenosides of the present invention can be used to form pharmaceutical acceptable salts thereof having a high water solubility or can be directly dissolved in an aqueous solution of metal salt, and retain the pharmaceutical activities of ginsenosides such as tumor growth inhibition and cancer preventive cytotoxicity. The dicarboxylic acid ester derivatives of ginsenosides of the present invention are thus suitable for use in the manufactures of various pharmaceutically and cosmetically acceptable dosage forms of preparations, such as peripheral, oral, and topical dosage forms.

The invention provides a high-performance liquid chromatography (HPLC) method for simultaneously determining 16 ginseng saponin monomers, such as Rg1, Re, Rf, Rb1, Rg2, Rc, Rb2, Rb3, F1, Rd, F2, Rg3, protopanaxatriol, Compound K, Rh2 and protopanaxadiol. The determination range comprises medicinal plants such as ginseng and American ginseng containing more than one saponin monomer, and preparations thereof. Compared with the prior art, the HPLC method has the advantages that the variety of the ginseng saponin monomers simultaneously determined by the method can be up to 16, and the efficiency is improved. Only are acetonitrile and water used as mobile phases, so that the problems that phosphate is large in loss on a chromatographic column, the system is troublesome to clean and the like are solved. The built HPLC method is wide in linearity range, accurate in method, good in reproducibility, fast and convenient, stable and reliable. A theoretical basis is provided for quality control of the medicinal plants, such as ginseng and American ginseng, and the preparations thereof.

Disclosed herein is nanoemulsion prepared by emulsifying main metabolites of ginseng saponin obtained by conversion of glucose, i.e. compound K (20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol), ginsenoside F1 (20-O-β-D-glucopyranosyl-20(S)-protopanaxatriol) and compound Y (20-O-[α-L-arabinopyranosyl(1→6)-β-D-glucopyranosyl]-20(S)-protopanaxadiol); and admixture-thereof, in fine emulsion or liposome with dermotropic emulsifier by nano-emulsification; and having enhanced skin penetration, so to be effective in promoting proliferation of fibroblast and biosynthesis of collagen.

The invention relates to the field of daily chemicals and plant extracts, in particular to a ginseng flower composite fermentation product and an application thereof. A ginseng flower extract is fermented by yeast and lactic acid bacteria successively, and the contents of rare ginsenosides s-Rg2, R-Rg2, S-Rg3, R-Rg3, PPT, F4, Rh4, Rg5 and Compound K in the ginseng flower composite fermentation product contained in a supernatant of the fermentation product are all increased. The ginseng flower composite fermentation product can promote human keratinocyte proliferation, inhibit tyrosinase activity, limit melanin generation, improve skin pigmentation, and has whitening effect. Therefore, the ginseng flower composite fermentation product can be used for preparing skin external preparations, and can be used as an active ingredient for skin repair, improvement of pigmentation or whitening.

The invention provides a mixture of monomer and liquid crystal to improve a uneven concentration case of a polymer / liquid crystal composite material. Thus, the invention provides a liquid crystal element, which is made of the polymer / liquid crystal composite material obtained by polymerizing the mixture of monomer and liquid crystal. The mixture of monomer and liquid crystal is characterized in that: the polymer / liquid crystal composite material is obtained by mixing more than one kind of polymerized monomer represented by a general formula (1) into an optical isotropic liquid crystal compositions containing a non-Chiral liquid crystal component A and a chiral compound k. In the formula (1), such as Ra represents straight chain alkyl with 1~30 carbon atoms, Rb represents straight chain subalkyl with 1~30 carbon atoms, ring A1 represents 1,4-phenylene, X1 represents -O-,P1 represents acryloyl.

The invention provides a composite solid-state electrolyte and a preparation method thereof. The composite solid-state electrolyte comprises a solid-state substrate and an electrolyte mixed into the substrate, wherein the electrolyte comprises zinc salts; the solid-state substrate is formed by compounding K type carrageenan and paper. According to the preparation method provided by the invention,the K type carrageenan and the paper are compounded into a composite solid-state electrolyte substrate, and the formed solid-state electrolyte has high ionic conductivity, and can be used as an electrolyte material for an all-solid-state zinc ion battery. The composite solid-state electrolyte provided by the invention has high ionic conductivity, so that the specific capacity and the rate performance of a battery are favorably improved. The composite solid-state electrolyte can inhibit the growth of negative electrode zinc dendrite, so that the battery cycle performance is favorably improved.The invention also provides a solid-state zinc ion battery comprising the K type carrageenan / paper solid-state electrolyte, and good application and development prospects are realized in the aspects of portable foldable flexible electronics and energy source devices. The preparation method provided by the invention is simple, and helps reduce the cost.

The invention discloses high-moisture-retention fountain solution compounded by k-carrageenan and konjac glucomannan. The fountain solution consists of the following raw materials in parts by weight: 70-85 parts of deionized water, 10-15 parts of k-carrageenan, 6-10 parts of konjac glucomannan, 3-6 parts of tea polyphenol, 2-5 parts of Turkey red oil, 1-3 parts of sorbitol, 3-6 parts of pH modifier, 1-3 parts of coconut oil fatty acid diethanolamide, and 1-3 parts of wetting agent. The fountain solution serves as a hydrophilic film-forming agent through compounding k-carrageenan with konjac glucomannan, improves durability of a water film, and is excellent in wettability and permeability in use.

The invention discloses a method for synthesizing rare ginsenoside CK (compound K) through biotransformation of natural saponins. According to the method, Ganoderma sinensis is used as a fermentation bacterium for fermentation culture, the natural saponins are added to fermentation broth for continuous fermentation after fermentation is performed for at least three days, and the rare ginsenoside CK is obtained. The rare ginsenoside CK is obtained through fermentation of Ganoderma sinensis used as the fermentation strain and the natural saponins used as a substrate, the transformation rate is high, and the rare ginsenoside CK is safe and non-toxic; compared with other microorganisms, the medicinal and edible fungus is higher in safety and can produce more bioactive substances in the process of synthesis through biotransformation, and product popularization is easy.

The invention discloses a corrosion-resistant mildew-proof fountain solution containing compounded k-carrageenan-konjak gum. The fountain solution is composed of the following raw materials in parts by weight: 70-85 parts of deionized water, 10-15 parts of k-carrageenan, 6-10 parts of konjak gum, 3-6 parts of tea polyphenol, 2-5 parts of Turkey red oil, 1-3 parts of sorbitol, 3-6 parts of a pH adjustor, 1-3 parts of a corrosion-resistant bactericide, 1-3 parts of tributyl phosphate and 1-3 parts of alkylphenol polyoxyethylene. The fountain solution, by compounding the k-carrageenan and the konjak gum, is taken as a hydrophilic film-forming agent, and improves the durability of a water film, so that the fountain solution disclosed by the invention has good wetting and permeating properties if being used.

There are provided a promoter containing ginsenoside compound K for the production of hyaluronic acid, and more particularly, a new efficacy of 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (compound K), a chief metabolite of ginseng saponin, to increase the expression of hyaluronic acid synthase gene in human cell and thereby to promote the production of hyaluronic acid, and an anti-aging agent containing the promoter for the production of hyaluronic acid as an effective ingredient.

The present invention relates to an inhibitor for the biosynthesis of gelatinase comprising ginsenoside F1 (20-O-beta-D-glucopyranosyl-20(S)-protopanaxatriol) or compound K (20-0-beta-D-glucopyranosyl-20(S)-protopanaxadiol), which is a chief metabolite of ginseng saponin, as an active ingredient; and a cosmetic / medical composition for the prevention of skin-aging comprising the same which is superior in inhibiting the decomposition of epidermal-dermal junction and also in accelerating the generation thereof.

The invention provides a preparation method of sodium avibactam. The method comprises that sodium 2-ethylhexanoate reacts with an intermediate compound K, so that the sodium avibactam is obtained. Theinvention also provides a preparation method of the intermediate compound K. The preparation method comprises the following steps: (1) carrying out reaction on a compound J with ammonium formate, formic acid and triethylamine in presence of a catalyst, and removing benzyl, so that a compound K1 is obtained; (2) adding an acid binding agent, a sulfonation reagent and water into the K1 reaction liquid obtained in the step (1), and reacting; and (3) adding tetrabutylammonium acetate aqueous solution into the reaction liquid obtained in the step (2), stirring and reacting, then adding an extraction solvent, separating out an organic phase, drying, then distilling off the solvent, adding a crystallization solvent, stirring, and crystallizing, so that the compound K is obtained. The preparationmethods provided by the invention are low in cost, avoid a high-risk preparation method for debenzylation through hydrogenation, are high in safety performance, easy to operate and applicable to industrial production and have greater application value.

The invention relates to the field of biology, and discloses an enzyme, an encoding gene thereof, application of the enzyme and the encoding gene, and a method for preparing a ginseng saponin compound K. The invention particularly provides the enzyme, the encoding gene thereof, a recombinant carrier, expression box, transgenic cell line or recombinant bacterium containing the encoding gene, a composition with the enzyme as the active component, and application of the enzyme to degradation of a glycoside compound, and provides a method for preparing the ginseng saponin compound K. When used for degrading ginsenoside Rb3 and gynostemma saponin IX in notoginseng leaf total saponin, the enzyme probably can also hydrolyze glucose at the C3 site by acting on the xylose glycoside structure at the C20 site in ginsenoside Rb3 and gynostemma saponin IX, and therefore ginseng saponin CK is obtained, and the conversion rate of ginseng saponin CK is 84% or above.

The invention belongs to the technical field of medical technology, relates to a preparation method for increasing CK (Compound K) yield of ginsenoside, and in particular relates to a preparation method for increasing the CK yield of ginsenoside by increasing the yield of a converted product through adjustment and control in a microbial conversion process. According to the preparation method, the yield of the converted product and the concentration of a primer are improved through metabolic regulation. The preparation method comprises the steps of: reconstructing ultraviolet mutagenesis of a parental strain, culturing in a high-concentration pseudo-ginseng stem and leave saponin culture medium, sieving in a directional manner to obtain a strain resisting to 1-5% of the total saponins of the pseudo-ginseng stems and leaves. Through the strain mutagenesis and the metabolic regulation, the concentration of the primer and the yield of the converted product are improved obviously, the final conversion rate is up to 43.63%, and the yield of the Compound K of the ginsenoside is improved by more than 80%. The preparation method for increasing CK yield of ginsenoside has practical significance for the industrial application of the microbial conversion.

The invention provides a method for synthesizing a nano-hollow silicon sphere supported noble metal catalyst by a micro-emulsion method. The method comprises the following steps: slowly adding a surfactant A into a solvent B to form a solution C; adding a co-surfactant D into the solution C to form a solution E; uniformly mixing a silicate compound F and a saline reagent G to form a precursor solution, and dropwise adding the precursor solution into the solution E to form a solution H; dropwise adding deionized water into the solution H to form a solution I; dropwise adding ammonia water into the solution I to form a solution J so as to form an organic SiO2(o) sphere; adding a silicate compound K into the solution J to form a solution M so as to form a SiO2(o)@SiO2(i) structure; adding a precipitant N into the solution M, standing to obtain precipitate, washing for 1-2 times with O, and dispersing into the deionized water to form a solution P; etching the SiO2(o) layer by a hydrofluoric acid aqueous solution to obtain an SiO2 hollow sphere, centrifugally washing, and drying; reducing the SiO2 hollow sphere into an Si hollow sphere by magnesium powder; supporting noble metal particles Q to the Si hollow sphere to obtain the nano-hollow silicon sphere supported noble metal effective photo-catalyst, and centrifugally drying.

The present invention relates to a pharmaceutical composition and a health functional food composition for preventing and treating non-alcoholic fatty liver disease, which comprises red ginseng concentrate having enhanced Compound K as an effective ingredient by using an enzyme conversion technique.

The invention relates to the technical field of medicines, in particular to a lentinan capsule with an anti-tumor effect and a preparation method thereof. According to the lentinan capsule with the anti-tumor effect, lucid ganoderma bioactive substances capable of improving body immunity and an anti-aging effect and lentinan with the anti-tumor effect are also used for promoting proliferation anddifferentiation of organism stem cells, improving body immunity and the anti-aging effect and further enhancing the anti-tumor curative effect of the capsule. A capsule shell adopts pure plant raw materials, a capsule shell prepared by compounding K-type carrageenan and xanthan gum is also used, and the capsule is good in mechanical property, resistant to high temperature and antibacterial and solves the technical problems that a large quantity of chemical components exist in animal gelatin and cause severe pollution to air and the water environment.

The present specification provides a composition for preventing skin aging, containing, as active ingredients: dehydrogenated abietic acid, a stereoisomer thereof, a salt thereof, a hydrate thereof, or a solvate thereof; and compound K represented by chemical formula (2), a stereoisomer thereof, a salt thereof, a hydrate thereof, or a solvate thereof, thereby having excellent skin cell proliferation effects, collagen production promotion effects, and Lipofuscin accumulation inhibition effects, while not causing any skin side effects.

Disclosed herein is nanoemulsion prepared by emulsifying main metabolites of ginseng saponin obtained by conversion of glucose, i.e. compound K (20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol), ginsenoside F1 (20-O-β-D-glucopyranosyl-20(S)-protopanaxatriol) and compound Y (20-O-[α-L-arabinopyranosyl(1→6)-β-D-glucopyranosyl]-20(S)-protopanaxadiol); and admixture thereof, in fine emulsion or liposome with dermotropic emulsifier by nano-emulsification; and having enhanced skin penetration, so to be effective in promoting proliferation of fibroblast and biosynthesis of collagen.

The invention discloses a fatty acid ester compounds of ginsenoside secondary glycoside compound K and method for preparing same, wherein the compound includes two derivatized compounds OM1 and SM1 having the structural formula disclosed in the specification, wherein R is oleoyl or stearoyl, and they are all esters formed by compound K with aliphatic acid. The invention also provides the method for synthesizing compound K and aliphatic acid, the pharmaceutical composition using the compositions as active composition, and the use of the compounds and pharmaceutical composition in preparing medicament for treating tumor.

The present invention relates to processed ginseng containing honey ingredients and a method for preparing the same. The method according to the present invention comprises the steps of: preparing a first mixture material comprising ginseng and honey; steam-heating the first mixture material; cooling the first mixture material; separating ginseng and honey from the first mixture material; coolingthe separated ginseng at a low temperature; cooling the separated honey at room temperature; forming a second mixture material by mixing the ginseng cooled at a low temperature and the honey cooled atroom temperature; aging the second mixture material at a low temperature; and obtaining ginseng from the second mixture material. According to the present invention, hydrolysis for high molecular weight ginsenoside of ginseng is induced by honey ingredients such that the amounts of low molecular weight ginsenosides, such as Rg5+Rk1, Rg3, Rh2 and Compound K, which have high in vivo absorption rates, are increased.

Disclosed are uses of ginseng saponin, which contains at least 90% of a compound K, Rd, F2, and Rg3 as a main ingredient and has effects in extending the lifespan of the cell, promoting the cell differentiation, increasing the number of red blood cells, and reducing the triglycerides by extracting, heat-treating, and enzyme-converting the ginseng saponin to prepare active saponins Rd, F2, and Rg3 including a compound K.

The invention provides a method for promoting conversion of ginsenoside by paenibacillus polymyxa through Cu<2+> ions. The content of ginsenoside monomers Rg1, Re, Rf, Rb1, Rg2, Rb2, Rb3, Rd, Rh4, Rg3, protopanaxatriol, Compound K, Rg5, Rh2 and protopanoxadiol in ginseng products converted by the paenibacillus polymyxa is increased. The efficient production of ginsenoside monomers is facilitated;further, the medicinal value of the ginseng is improved. The method is simple and convenient; the cost is low; the industrialized large-scale production is facilitated.

The present invention relates to a pharmaceutical composition and a health functional food composition for preventing and treating non-alcoholic fatty liver disease, which comprises red ginseng concentrate having enhanced Compound K as an effective ingredient by using an enzyme conversion technique.