334results about How to "Improve compound" patented technology

Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.

Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.

A method for fabricating a semiconductor substrate includes epitaxially growing an elemental semiconductor layer on a compound semiconductor substrate. An insulating layer is deposited on top of the elemental semiconductor layer, so as to form a first substrate. The first substrate is wafer bonded onto a monocrystalline Si substrate, such that the insulating layer bonds with the monocrystalline Si substrate. A semiconductor device includes a monocrystalline substrate, and a dielectric layer formed on the monocrystalline substrate. A semiconductor compound is formed on the dielectric layer and an elemental semiconductor material formed in proximity of the semiconductor compound and lattice-matched to the semiconductor compound.

This invention discloses a method for preparing rubber compositions that exhibit unique combinations of properties that are desirable for tire tread applications for enhanced snow / ice and wet traction, low rolling resistance and increased treadwear performance in comparison with conventional silica compounds. Specifically, a high reactively silane coupling agent, such as a mercaptosilane, is used in combination with a silane coupling typically used for silica tread compounds such as bis(triethoxylsilylpropyl)disulfide to treat silica pellets in a hydrocarbon solvent at elevated temperatures. The treated silica is then blended with solution elastomer cement in a hydrocarbon solvent. The deposited reactive silanes partially react with the elastomer molecules forming a layer of polymer grafted on the silica surfaced. This structure significantly improves the silica retention during the steam stripping operation. Almost 100% (99+%) silica retention has been achieved by this invention. After solvent removal from steam stripping, the treated silica / elastomer mixer is dewatered and dried using conventional equipment such as shaker screens, expellers and expanders to form a well-dispersed silica masterbatch. This technique results in silica compounds with excellent silica dispersion and increased filler-polymer interaction, hence enhanced compound performance such as better physical properties, more desirable dynamic properties (low hysteresis at high temperatures and high hysteresis at low temperatures) and increased abrasion resistance.

An adsorbent-catalyst for removal of sulphur compounds from sulfur compound contaminated gas and liquid feed streams, wherein the adsorbent-catalyst is a synthetic X or Y faujasite with a silica to alumina ratio from 1.8:1 to about 5:1 and wherein 40 to 90% of the cations of the faujasite include transition metals of Groups IB, IIB and VIIB with the balance of the cations being alkali or alkaline earth metals.

A method for removing speckle noise from ultrasound images includes providing a plurality of digitized ultrasound (US) images, each image comprising a plurality of intensities corresponding to a domain of points on a 2-dimensional grid, initializing an initial gain associated with each of said plurality of US images, estimating a signal sub-space by averaging over each US image divided by its associated gain, and estimating an updated gain by projecting its associated image into said signal sub-space. If an absolute difference of said updated gain and said initial gain is less than a pre-determined quantity, obtaining an averaged image from said signal sub-space, estimating an optimal Wiener filter from said plurality of US images and said averaged image, and filtering said averaged image with said Wiener filter, wherein said speckle noise is substantially minimized.

The invention relates to ligands that comprise a moiety (e.g., a dAb) that has a binding site with binding specificity for an endogenous target compound but do not substantially inhibit the activity of said endogenous target compound. Preferably, the ligand does not bind to the active site of an endogenous target compound. The invention relates to the use of such a ligand for the manufacture of a medicament for increasing the half-life, bioavailability, activity or amount of an endogenous target compound to which the ligand binds.

The invention relates to bifunctional stapled or stitched peptides comprising a targeting domain, a linker moiety, and an effector domain, that can be used to tether, or to bring into close proximity, at least two cellular entities (e.g., proteins). Certain aspects relate to bifunctional stapled or stitched peptides that bind to an effector biomolecule through the effector domain and bind to a target biomolecule through the targeting domain. Polypeptides and / or polypeptide complexes that are tethered by the bifunctional stapled or stitched peptides of the invention, where the effector polypeptide bound to the effector domain of the bifunctional stapled or stitched peptide modifies or alters the target polypeptide bound to the targeting domain of the bifunctional peptide. Uses of the inventive bifunctional stapled or stitched peptides including methods for treatment of disease (e.g., cancer, inflammatory diseases) are also provided.

The invention discloses an alternating current drive OLED (Organic Light Emitting Diode) circuit, a driving method and a display device in the technical field of display. The alternating current drive OLED circuit comprises a light emission control unit, a charging unit, a driving unit, a first storage unit, a second storage unit, a first light emitting unit, a second light emitting unit, a first voltage control unit and a second voltage control unit. Reversely connected first light emitting unit and second light emitting unit are used for alternatively emitting light in two adjacent time frames through the first light emitting unit and the second light emitting unit, only one light emitting unit emits and displays light in the same frame time, the other light emitting unit is offset reversely, and the two light emitting units are exchanged at the next frame; alternating current drive of the light emitting units is realized, and the utilization rate of energy is improved; the ageing incentive of the light emitting units is completely eliminated, the service lives of the light emitting units are greatly prolonged, the effect of internal circuit resistance on the light emitting current is eliminated, and the image display quality is perfected.

Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, subcutaneous, and intravenous forms of the compounds and conjugates may be prepared as treatments and / or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the natriuretic compound are also disclosed, having an amino acid sequence that is other than the native sequence.