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128results about How to "Avoid unfolding" patented technology

Bifunctional stapled polypeptides and uses thereof

The invention relates to bifunctional stapled or stiched peptides comprising a targeting domain, a linker moiety, and an effector domain, that can be used to tether, or to bring into close proximity, at least two cellular entities (e.g., proteins). Certain aspects relate to bifunctional stapled or stiched peptides that bind to an effector biomolecule through the effector domain and bind to a target biomolecule through the targeting domain. Polypeptides and / or polypeptide complexes that are tethered by the bifunctional stapled or stiched peptides of the invention, where the effector polypeptide bound to the effector domain of the bifunctional stapled or stiched peptide modifies or alters the target polypeptide bound to the targeting domain of the bifunctional peptide. Uses of the inventive bifunctional stapled or stiched peptides including methods for treatment of disease (e.g., cancer, inflammatory diseases) are also provided.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE

Articulated inflatable structure and robot arm comprising such a structure

An articulated structure having a tubular inflatable casing that contains a fluid under pressure and that has a central axis along which there are defined at least one fixed-geometry segment and at least one variable-geometry segment, the arm including a deformation mechanism for deforming the variable-geometry segment, the casing and the deformation mechanism arranged so as to generate curvature of the variable-geometry segment in such a manner that the variable-geometry segment conserves a volume that is substantially constant. A robot arm including such a structure.
Owner:COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Beta-catenin targeting peptides and uses thereof

The invention relates to β-catenin targeting peptides comprising an α-helical segment that are optionally stapled or stitched, and pharmaceutical compositions thereof. Uses of the inventive β-catenin targeting polypeptides including methods for treatment of disease, such as diseases associated with aberrant Wnt signaling, including cancer, are also provided.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE

Toilet paper dispenser

The present invention provides ease of installation of toilet paper rolls on a vertical spindle sitting on a plate that prevents the unrolling of the paper. The floor free standing unit has a provision to store spare rolls on the pole, the spindle supports a decorative plate for decoration. A second unit is a wall mounted unit with a flex arm that could move the plate and spindle from right to left. A third is a wall mounted fixed unit. All three units are built with the same basic elements, plate and spindle. Each units' spindle supports a decorative plate.
Owner:GUAY LAMBERT +1

Brick carrying handcart with tension force adjusting function

The present invention provides a brick carrying handcart with a tension force adjusting function. The handcart comprises wheels, a brick accommodating part which is formed by a rear wall and two side walls; two bottom plate structures for closing or opening a brick supporting area; a movement part for opening the bottom plate structures to the two sides, wherein the movement part comprises a pair of rotating shafts passing through a support and a pair of connecting parts; a movement rod, the lower end of which is connected with an inner side of the connecting part through a first connecting ring; a movement lever arranged on the upper part of the movement rod and linked with the movement rod, the free end is provided with a handle, the connecting end is rotatingly connected with a first supporting part fixed on the rear wall plate; and a locking part provided with a locking device. Through adopting the handcart, bricks can be orderly entrucked, the bricks can be prevented from being damaged when unloading, the whole state of entrucking can be kept when unloading the bricks, the space flexible use and working can be enhanced, and beneficial effects can be realized.
Owner:李长燮

Vent for electrochemical cell

An electrochemical cell includes a housing having a first end and a vent located at the first end that is configured to deploy from the housing to allow the expulsion of gases from within the cell. The electrochemical cell also includes at least one projection extending outward from the first end adjacent the vent. The at least one projection is configured to prevent accidental deployment of the vent.
Owner:柯锐世高级解决方案有限公司
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