1491results about How to "Convenient length" patented technology

The retention of oral drug dosage forms in the stomach is improved by using swellable dosage forms that are shaped in a manner that will prevent them from inadvertently passing through the pylorus as a result of being in a particular orientation. The planar projection of the shape is one that has two orthogonal axes of different lengths, the longer being short enough to permit easy swallowing prior to swelling while the shorter is long enough within one-half hour of swelling to prevent passage through the pylorus.

The invention relates to bifunctional stapled or stiched peptides comprising a targeting domain, a linker moiety, and an effector domain, that can be used to tether, or to bring into close proximity, at least two cellular entities (e.g., proteins). Certain aspects relate to bifunctional stapled or stiched peptides that bind to an effector biomolecule through the effector domain and bind to a target biomolecule through the targeting domain. Polypeptides and / or polypeptide complexes that are tethered by the bifunctional stapled or stiched peptides of the invention, where the effector polypeptide bound to the effector domain of the bifunctional stapled or stiched peptide modifies or alters the target polypeptide bound to the targeting domain of the bifunctional peptide. Uses of the inventive bifunctional stapled or stiched peptides including methods for treatment of disease (e.g., cancer, inflammatory diseases) are also provided.

Uplink traffic channel allocation is realized by utilizing a dedicated control channel in which a prescribed portion of the control channel resource, for example, frequency, time slot or the like, is reserved for transporting the uplink traffic channel requests. Both the base station and the particular mobile unit know the prescribed portion of the control channel resource a priori. Consequently, when the particular mobile unit transmits an uplink traffic channel request via the prescribed portion of the control channel resource there is no need for adding any control header information, thereby minimizing overhead. Furthermore, the length of the uplink traffic channel requests can be optimally chosen without constraints imposed by other control message schemes. Reduced overhead coupled with the prescribed portion of the control channel resource arriving quite frequently reduces latency in the particular mobile unit acquiring an uplink traffic channel. In one example, delivery of adequate uplink traffic channel request information to the base station, while minimizing the adverse impact of losing requests, is ensured by persistently transmitting the requests. Specifically, after the mobile unit transmits a first request, it transmits a second or even a third request instead of waiting to receive a response message from the base station and / or waiting for a timer to time out. By the mobile unit using such a persistent request transmission scheme, the base station can readily determine the true value of the received request by eliminating the transmission loop delay effect, thereby allowing a sensible assignment decision to be made.