The invention discloses a large rib and cotton slipper molding treatment process, and belongs to the technical field of cotton slippers, wherein the raw materials comprise: 40-60 parts of a goose downfiller, 4-6 parts of a deodorant, 1-2 parts of an antioxidant, 1-3 parts of a flame retardant, 6-12 parts of bamboo charcoal fiber, 5-10 parts of calcium carbonate, 3-5 parts of amomum kravanh, 4-8 parts of agastache rugosus, 10-20 parts of honeysuckle, 8-14 parts of liquorice, 2-6 parts of clove, 5-7 parts of toner and 3-5 parts of a cross-linking agent. The process comprises the following steps: a, feeding; b, stirring; c, injecting into a mold; d, air blowing; and e, detection. According to the invention, the cotton slippers prepared by the invention have good antibacterial and deodorant properties, are not easy to age and have a warm-keeping property; bamboo charcoal fibers can adsorb indoor peculiar smell and generate negative ions, and the negative ions can effectively purify air and remove harmful toxins generated by microorganisms; goose down as a main raw material can improve, the warmth retention property of the cotton slippers and the use comfort of people; and the manufacturing process is simple, and materials are easy to obtain.