894 results about "Skin repair" patented technology

The present invention provides tissues derived from animals, which lack any expression of functional alpha 1,3 galactosyltransferase (alpha-1,3-GT). Such tissues can be used in the field of xenotransplantation, such as orthopedic reconstruction and repair, skin repair and internal tissue repair or as medical devices.

Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.

The invention relates to the technical field of cosmetics, and discloses a nona-oligopeptide composition for skin repairing and application thereof. The nona-oligopeptide composition is prepared from, by weight, 1-30 parts of palmitoyl-tripeptide-1, 1-30 parts of tripeptide-1 copper, 1-50 parts of palmitoyl-tripeptide, 1-30 parts of carnosine, 1-30 parts of acetyl tetrapeptide-5, 1-30 parts of palmitoyl-tetrapeptide-7, 0.1-30 parts of acetyl hexapeptide-8, 0.1-30 parts of nonapeptide-1, and 1-30 parts of nisin. The nona-oligopeptide composition has the effect of a cell factor sample, affects the growth of skin flora, is applied to dermatology and skin beautifying, and has the effects of repairing skin lesion, adjusting metabolism and inhibiting skin condition conditioned pathogen growth.

The invention discloses a skin burn repair material and a preparing method thereof, and belongs to the field of biomedicine. A functional loading substance is added into a polymer to prepare the repair material through the coaxial electrostatic spinning process, and the upper surface layer micro-nano structure is adjusted so that the repair material can resist adhesion of outside microorganisms and bacteria. The prepared repair material containing the functional loading substance with antibacterial, antiphlogistic and repair promoting functions repairs the skin burn area in a targeted mode based on the characteristics of different stages of the burnt skin repair process. The adopted base material has high biocompatibility, secondary damage to the wound region of traditional medical gauze when fresh dressing is changed for a wound is avoided, and secondary infection caused by external factors can be effectively resisted. The skin burn repair material and the preparing method thereof can be effectively applied to biomedicine related fields and have the possibility of extensive clinic application.

The invention relates to hydrogel as well as a preparation method and a purpose of the hydrogel. The hydrogel is prepared through electron beam or Gamma-ray radiation on natural polymers or derivates of the natural polymers after the medicine active ingredient loading in oxygen-free environment. The hydrogel has good biocompatibility and use safety, the biological effects of the natural polymers or the derivates of the natural polymers on the wound healing and the skin repair protection can be permanently and fully exerted in local parts in the hydrogel mode, good medicine slow release functions of the hydrogel are also fully utilized, the required medicine active ingredients are specifically added, good efficiencies and wide purposes are given to the hydrogel, and the hydrogel can be used in the fields of skin, mucosa and cornea wound dressings, filling materials, tissue engineering materials, cell culture media and the like, and can also be used in the field of daily use articles such as skin care products and cosmetics.

The invention discloses a protein skin care product having the function of skin repair and care, which contains a protein composition with 0.3% to 5% of mass fraction, wherein the protein composition is composed of keratin and collagen with the mass ratio of the keratin to the collagen being 1: 0.2 to 2. The protein skin care product of the invention having the function of skin repair and care includes mask liquid, cream and cleansing emulsion.

The invention provides compound polypeptide nanometer vesicles with a skin repair function, and belongs to the technical field of cosmetics. The compound polypeptide nanometer vesicles are prepared from, by weight, 0.01-1 part of regenerated repairing active peptide, 0.01-1 part of antioxidant active peptide, 0.1-5 parts of natural moisturizing active factors, 0.01-1 part of microcirculation-promoting active ingredients, 5-20 parts of lipoid wall materials, 0.1-5 parts of cholesterol, 10-45 parts of polyhydric alcohols and 30-98 parts of water. According to the compound polypeptide nanometer vesicles, repairing components acting on different target spots are provided aiming at different repair mechanisms of the skin barrier; meanwhile, the nanometer vesicles are adopted for covering various hydrophilic and lipophilic active ingredients, a unique closed lipid bilayer structure of the vesicles is utilized, the stability of the repairing compound is significantly improved, the skin penetration amount is increased, slow release of the active ingredients is effectively controlled, and the repairing effect is improved.

The invention relates to the technical field of masks, and particularly relates to a Dendrobium officinale moisturizing and repair sleeping mask and a preparation method thereof. The mask comprises a phase A component and a phase B component, wherein the phase A component comprises moisturizer, emulsifier, sodium hyaluronate A and water; the phase B component comprises Dendrobium officinale extracting solution, Crocus sativus extract, ganoderma lucidum extract, agilawood extract, sodium hyaluronate B and cosolvent. The mask is prepared from Crocus sativus, ganoderma lucidum, agilawood and Dendrobium officinale, wherein the Crocus sativus achieves the main effect of activating blood circulation to dissipate blood stasis; the ganoderma lucidum and the agilawood respectively achieve the auxiliary effects of invigorating qi and calming the nerves, and promoting circulation of qi to relieve pain; the Dendrobium officinale achieves the adjuvant effect of nourishing yin and promoting salivation; and the whole composition achieves the effects of promoting flow of qi and blood circulation, dispersing blood stasis and nourishing the kidney-yin. Besides, since the Dendrobium officinale extracting solution contains abundant colloid, the loss of moisture and collagen in the skin can be supplemented, elastic fibers can be repaired, and cell tissues can be reformed, so that the original elasticity and gloss of the skin are recovered, the remarkable freckle removal effect is achieved; and under the condition of ensuring that the skin is sufficiently moisturized, the mask has a greatly improved skin repair function.

The invention relates to a use of a mesenchymal stem cell conditioned culture medium for cosmetics, preferably a use for skin repair and regeneration, whitening, wrinkle resisting and oxidation resisting, and is characterized in that the mesenchymal stem cell conditioned culture medium is prepared by the following method: (1) obtaining mesenchymal stem cells; (2) culturing the mesenchymal stem cells obtained in the step (1) in a complete culture medium; (3) culturing the mesenchymal stem cells obtained in the step (2) in a base culture medium; and (4) centrifuging to remove the mesenchymal stem cells, taking a supernatant, and filtering the supernatant, to obtain the filtrate which is the mesenchymal stem cell conditioned culture medium.

The invention discloses a skin barrier repairing preparation. The preparation is prepared from the following components: deionized water, sucrose stearate, phytosteryl isostearate, vitamin E, glycerinum, butylene glycol, 1,2-pentylene glycol, octyldodecanol, polydimethylsiloxane, hydrogenated polyisobutene, oleic acid, linoleic acid, ceramide 2, ceramide 3, ceramide 6II, sodium hyaluronate, xanthan gum, disodium EDTA, acrylates C10-30 alkyl acrylate crosslinked polymer, allantoin and sorbitan caprylate. The invention further provides a method for preparing the skin barrier repairing preparation. According to the preparation method, the problem of dissolving compound ceramide can be solved, the impact of ceramide crystallization on stability under a low-temperature condition can be reduced, the stability of the preparation can be improved, and other skin repairing components can be added and compounded with the compound ceramide. The skin barrier repairing preparation has an excellent product formula stability and a multiple repairing effect on the skin barrier.

The invention provides a composition containing hyaluronic acid substances and ectoine substances. The composition comprises the two substances according to a mass ratio of 50:1 to 1:50, and the masspercentage of the composition is 0.001% to 100%. The hyaluronic acid salt includes but not limited to sodium salt, potassium salt, calcium salt, zinc slat or magnesium salt, and the molecular weight is smaller than 106Da; the ectoine substance is ectoine or salt or / and ester acceptable in cosmetic or medicine field, hydroxyl ectoine or salt or / and ester acceptable in cosmetic or medicine field, and the combination thereof. The composition can be used as whitening, anti-inflammatory, moisturizing, and after-sun injured skin repair components in cosmetics or medicines. The composition can reachsynergistic function in moisturizing, whitening, inflammation diminishing, sun screening, and after-sun injured skin repair.

The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles.

A skin augmentation composition comprises a therapeutically effective amount of a combination of a gingerol and a curcumin and a cosmetically or pharmaceutically acceptable carrier. Methods for enhancing the repair of damaged skin and the prevention of developing wounds in a subject having damaged skin comprises administering to a portion of damaged skin, a composition comprising a therapeutically effective amount of a combination of a gingerol and a curcumin and a cosmetically or pharmaceutically acceptable carrier.

The invention provides a novel skin anti-allergy and repair composition, and also provides skin repair cream containing the skin anti-allergy and repair composition, and a preparation method of the skin repair cream. An anti-allergy and anti-inflammatory traditional Chinese medicine composition extract aiming at sensitive or damaged skin multi-dermatitis is adopted, meanwhile, other component rawmaterials are supplemented, and after compounding, the skin repair cream has synergetic effects of clearing heat, detoxifying and cooling blood, and can be beneficial to diminishing inflammation, sterilizing, astringing, repairing, improving skin resistance, eliminating scytitis, astringing, moistening, lustring skins, repairing damaged parts, and recovering elasticity and luster of the skins. Theskin repair cream can be used for eliminating carbuncle swell, cleansing, lustring, nourishing and protecting the skins, and is suitable for skin types with skin allergy, pruritus, desquamation, inflammation and the like caused by misusing cosmetics.

The invention belongs to the field of skin repair and provides mesenchymal stem cell factor freeze-dried powder as well as a preparation method and application thereof. The mesenchymal stem cell factor freeze-dried powder prepared by the method provided by the invention is high in purity, injuries of foreign additives on the human body and skin can be avoided, and potential hazards of skin allergy are avoided. The prepared freeze-dried powder product is stable in property, so that the biological activity of the mesenchymal stem cell factor freeze-dried powder is achieved for a long time.

The invention discloses a preparation method of a polypeptide silk facial mask, which comprises the steps of fully mixing polypeptide powder and silk protein nutrient solution and cooling. Polypeptide powder is mainly composed of aloe vera, carnosine, oligopeptide, soluble collagen, 2‑o‑ethyl ascorbic acid, betaine, trehalose, niacinamide, allantoin; the protein nutrient solution of silk is mainly composed of water, glycerin, Propylene glycol, butylene glycol, malto-oligosaccharide glucoside, hydrogenated starch hydrolyzate, glycerol polymethacrylate, PVM / MA copolymer, carbomer, sodium hyaluronate triethanolamine, baobab pulp extract, tranexamic acid , Centella asiatica extract, dipotassium glycyrrhizate and other skin conditioners or moisturizers. Through the combination of polypeptide powder and silk protein liquid, it can effectively give fresh nutrition to the skin, promote the skin repair process, strengthen the nutrient absorption capacity, deeply nourish, smooth and rejuvenate the skin, and make the skin elastic.

The invention discloses a novel anti-allergy repairing composition for skin. The anti-allergy repairing composition comprises the following components by weight percent: 5%-12% of moisturizing agent, 0.1%-3.0% of thickener, 1%-4% of skin repairing agent, 0.1%-1.5% of preservative, and the balance of water. The invention also discloses a preparation method of the skin repairing agent. The anti-allergy repairing composition for skin can be prepared into cream or water aqua, can be directly smeared at the infected part and has no toxicity or harm to human skin. The skin repairing composite component has strong effects of clearing heat and detoxifying, being anti-allergy, repairing skin, diminishing inflammation and astringing; other auxiliary additive components are selected from the moisturizing agent, preservative and thickener and the like which can keep the skin tender and smooth and moisturize the skin and are mild and non-irritant to skin. The anti-allergy repairing composition is convenient to use, achieves the purposes of moisturizing, diminishing inflammation and relieving itching and repairing damaged skin, and is applicable to sensitive skin and skin allergy, pruritus, desquamation, red and swollen skin and couperose skin that are caused by misuse of cosmetics.

The invention relates to a porous bacterial cellulose skin repair material with a density structure and a preparation method thereof. The porous bacterial cellulose skin repair material with the 'upper dense and lower loose' structure similar to human skin is prepared by controlling the culture condition of bacterial cellulose and adding sustained-release microspheres in the culture process. A loose layer is tightly combined with a dense layer, so that obvious physical layering is avoided, and the structural continuity is good; and gradient changes of the structures are produced in the loose layer and the dense layer, and multiple pores distributed uniformly are formed in the loose layer, so that the upper dense and lower loose gradient structure of the human skin is simulated to the utmost degree. Cells easily enter the material, the healing period of a wound is obviously shortened, and proliferation of healed scars is effectively reduced; and good air permeability and water holding property of the bacterial cellulose are kept, the wound surface can be kept in a wet environment, and healing of the wound surface is facilitated. The forming process is simple, the culture period is short, the preparation process is environment-friendly, simple, convenient and quick, and the preparation cost is low.

The invention discloses an anti-aging skin care composition containing multiple natural extracts and biological active polypeptide, an anti-aging skin care mask essence and a preparation method thereof. The anti-aging skin care mask essence has the advantages that the characteristic of compounding combination in the traditional Chinese herbal medicines is utilized, and a moisturizer is combined with the biological active polypeptide and the multiple natural extracts according to a proper ratio of usage amount to form the mask essence; the multiple functions of moisturizing, water supplementing, inflammation diminishing, anti-oxidizing, skin repair and the like are combined; while the skin nutrient metabolism is improved and the skin elasticity is maintained, the tissues of surface skin arerepaired, so as to realize multiple effects of moisturizing, wrinkle resisting and aging resisting.

The invention discloses a preparation method of self-adhesive skin repairing hydrogel. The preparation method includes subjecting natural chitosan to quaternary amine modification to enable the natural chitosan to have excellent bactericidal performance; preparing BSA (bull serum albumin) nano-particles embedded with growth factors promoting skin regeneration through desolvation; grafting dopamine into a natural gelatin material; crosslinking the quaternary amine modified chitosan, the growth factor embedded BAS nano-particles and the dopamine grafted gelatin to form a hydrogel material. The hydrogel material has multiple functions of adhesion, bacteria inhibition and skin wound healing promotion, thereby being used for skin repairing.

The invention relates to the technical field of cosmetics, in particular to a moisturizing composition and application of the same in preparation of the cosmetics. According to the composition, betaine, amino acid, allantoin, oat beta-glucan, oligomerized hyaluronic acid, nicotinamide, ceramide, repairing bioactive peptide and D-panthenol are compounded reasonably. Through triple barrier repairing of skin corium layers, basilar membranes and skin cuticulae, the composition can have good effect of increasing skin moisture content and reducing skin moisture loss. The effect is improved remarkably as compared with the effect of the individually-used components or conventional moisturizing compositions. In a proper ratio, the synergistic effect is achieved through compounding of the components, and accordingly, the moisturizing effect is improved. Experiments show that the moisturizing composition can increase the skin moisture content to 98.19% within 30 minutes, and the skin moisture content can be kept increased by above 70% after two hours.

The invention relates to an acne-removing, oil-controlling and whitening cosmetic composition and an application thereof, belonging to the technical field of cosmetics. A cosmetic composition for acne control, oil control and whitening, the cosmetic composition includes the following components calculated by weight percentage: 3-8% of nano-pearl powder, 0.5-0.8% of Bletilla striata extract, 0.6-1.2% of coix seed extract %, cactus extract 1.3-1.5%, tea tree essential oil 0.01-0.03%, rice oil 0.5-1.0%, rutin extract 0.5-1.0%, grape seed extract 1-2%, skin repair solution 40-60% , and the balance is water. The cosmetic composition of the present invention is compounded with a variety of natural plant extracts and skin repairing liquids, which can produce significant acne-removing and acne-removing effects, can reduce swelling and promote the disappearance of skin inflammation, improve, dilute and remove acne marks, and at the same time Play a role in whitening the skin and preventing pigmentation plaques.

The invention discloses a donkey-hide gelatin drink and a preparation method thereof, belonging to the technical field of drinks. The donkey-hide gelatin health care drink comprises the main raw materials of donkey-hide gelatin, red dates, brown sugar, high fructose corn syrup, citric acid, vitamin C, stabilizer and purified water, and is prepared by the steps of dissolving, filtrating, mixing, homogenizing, sterilizing, tinning and the like. The donkey-hide gelatin drink has the effects of beautifying human skin, enriching the blood, soothing the nerves, preventing cold and flu and the like, wherein the donkey-hide gelatin drink contains a special amino acid-hydroxyproline which is a purified collagen protein and is the best way of ensuring the collagen synthesis of skin regeneration, therefore, the donkey-hide gelatin drink has the effects of moisture preservation, anti-wrinkle, skin repair, hair moisturizing and the like; meanwhile, because of containing the red dates and the brown sugar, the donkey-hide gelatin drink not only has the nutrition of the red dates and the brown sugar, but also has the pleasant aroma of the red dates and the sweet aroma of the brown sugar; the donkey-hide gelatin drink has a taste and an aroma which can not be blended out by food additives; and the donkey-hide gelatin drink has better beautifying effect by the complement of the skin whitening function of the brown sugar and the beautifying skin effect of the donkey-hide gelatin.

The present invention provides tissues derived from animals, which lack any expression of functional alpha 1,3 galactosyltransferase (alpha-1,3.GT). Such tissues can be used in the field of xenotransplantation, such as orthopedic reconstruction and repair, skin repair and internal tissue repair or as medical devices.

The invention discloses skin barrier repairing lotion. The skin barrier repairing lotion is prepared from the following raw materials: water, a humectant, a skin conditioning agent, an emulsifier, a thickening agent, an antioxidant, plant extract and a skin repairing agent, wherein the skin repairing agent is prepared from palmitoyl tripeptide-5, acetyl tetrapeptide-2, acetyl hexapeptide-8, oligopeptide-1, ceramide 3, ceramide 6II and ceramide 1. According to the skin barrier repairing lotion, the ceramide and polypeptide are prepared into a ceramide-polypeptide skin repairing agent with a net-shaped structure; when the ceramide-polypeptide skin repairing agent is used, a protection film can be formed on the surface of skin, the protection time on the skin is prolonged and the effect of askin barrier is realized; the ceramide-polypeptide skin repairing agent is prepared into nano-gel microcapsules and the ceramide-polypeptide skin repairing agent is protected, so that the stability isenhanced and the ceramide-polypeptide skin repairing agent effectively acts on skin cells and has a skin repairing effect.

The invention discloses an anti-aging composition with various hyaluronates, which comprises, by weight, 1-10% of butylene glycol, 1-5% of hydrolyzed hyaluronic acid, 1-5% of sodium acetylated hyaluronate, 0.1-5% of sodium hyaluronate, 0.1-5% of a sodium hyaluronate crosslinked polymer, 0.1-5% of hydroxypropyl trimethyl ammonium chloride hyaluronic acid, 0.1-1% of oligopeptide-1, 0.01-1% of blackend swallowwort root extract, 0.1-0.5% of PEG-60 hydrogenated castor oil, 0.1-0.5% of p-hydroxyacetophenone, 0.1-1% of octanohydroxamic acid, and the balance of deionized water, adding up to 100%. Theanti-aging composition has extended functions, provides both moisturizing and skin repairing and soothing; since the anti-aging composition is water soluble, the anti-aging composition is not limitedto product forms and is addable to liquids, milks, creams, essences and the like.

The invention discloses a cosmetic composition containing gold collagen. The cosmetic composition consists of nano-gold particles, collagen hydrolysate, phospholipids, 1,3-butanediol, hexanediol, pentanediol, ethylhexyl glycerin and a skin conditioning component. On one hand, nano-gold plays roles of activating superoxide dismutase, eliminating hydroxyl free radicals, promoting the proliferation of human epidermal cells and resisting decrepitude; on the other hand, the nano-gold particles, collagen hydrolysate and phospholipids are uniformly dispersed according to a microjet technology, interact and are combined through a charge or other ways; the nano-gold particles and the phospholipids have excellent affinity on skin cells and interact to promote the percutaneous absorption of small-molecule collagen hydrolysate, replenish collagen as well as related polypeptides and amino acids, promote skin repairing and collagen synthesis, so as to achieve skin repair effects of delaying skin aging and improving skin health.

The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles.

The invention provides a freeze-dried powder for repairing skin. The freeze-dried powder is prepared according to the following steps: placing mannite, sodium hyaluronate and oligopeptides-1 into water; placing a mixture into a stirring device for stirring at a constant rate; stirring for 10min at the rotation rate of 600r / min, thereby forming a mixing solution A; standing by the mixed solution A for 24 hours and then placing into the stirring device for stirring at the constant rate; and stirring for 20 minutes at the rotation rate of 1200r / min. The freeze-dried powder can multiple repair the skin injured by acnes, can promote skin microcirculation, can relieve acne marks, can recover the skin to healthy state and can moisten skin; in the invention, the preparation method is simple, the operation is easy, the prepared product acts on the skin surface, no injection is required and the effect is obvious; a freeze-drying technique is adopted by the invention, so that the cosmetics can be effectively kept for a long time under the condition of no preservative and the side effect of the cosmetics to the skin caused by the stimulation of the preservative can be thoroughly removed; a freeze-drying preparation method is vacuum and sterile, has the highest safety and can keep biological activity for a long time.