178 results about "Hyaluronates" patented technology

A medical device and methods to relieve joint pain and adapted for knee joint repair, replacement and augmentation. The invention discloses joint lubricant, particularly hyaluronate compositions and methods for treatment of osteoarthritis.

The invention discloses a method for preparing oligomeric hyalurate by a digestion method, and the oligomeric hyalurate and an application thereof. Bacillus hyaluronidase obtained through fermental cultivation of Bacillus sp. A50 CGMCC NO.5744 is used for degrading hyaluronic acid or a salt thereof, and the method comprises the steps of preparing the hyaluronic acid or the salt thereof, enzymolysis, inactivation, filtering, settling, dewatering and drying. According to the method, the hyaluronidase produced by the Bacillus is used for degrading the hyaluronic acid or the salt thereof, and the oligomeric hyalurate is prepared through dezymotizing, alcohol or ketone settling and dewatering and drying. The method is simple to operate and mild in condition, has no destroy on the product structure and no environmental pollution, the hyaluronidase for fermentation is low in cost and is suitable for large-scale industrial production, the prepared oligomeric hyalurate has the advantages of good percutaneous absorption capability, high purity, no cytotoxicity, strong oxidation resistance and the like, and can be used in fields such as cosmetics, foods and medicines.

Eye diseases such as glaucoma can be treated using a composition containing cross-linked hyaluronic acid or a cross-linked salt of hyaluronic acid such as sodium hyalurate. The composition can be a monophasic gel. The composition can include a cross-linking agent such as 1,4-butanediol diglycidylether. The composition can contains about 2.25% (w / w) of the salt of hyaluronic acid. The composition can have a cross-linking rate of about 0.5 to 50%.