170 results about "Polyacrylamide Hydrogel" patented technology

A hydrogel for use as a prosthetic device for supplementing, augmenting or replacing cartilage in the intra-articular cavity of a joint and for treatment or prevention of arthritis. The hydrogel may be a polyacrylamide hydrogel obtained by combining acrylamide and methylene bis-acrylamide. A prosthetic device comprising the polyacrylamide hydrogel is also disclosed.

The invention discloses graphene aerogel and a hybrid composite material thereof as well as a preparation method and application of the of graphene aerogel. The preparation method comprises the following steps: 1) mixing graphene oxide, a reducing agent, acrylamide, N,N-methylene-bisacrylamide and potassium persulfate and reacting to obtain partially-reduced graphene/polyacrylamide hydrogel; 2) carrying out pre-freezing and reduction on the partially-reduced graphene/polyacrylamide hydrogel in sequence to obtain graphene/polyacrylamide hydrogel; 3) dialyzing and drying the graphene/polyacrylamide hydrogel in sequence to obtain the graphene aerogel. The graphene aerogel has the characteristics of uniform cellular structure and light weight, excellent resilience, relatively high mechanical strength and good solvent resistance; a preparation process is simple, rapid and low in cost; the graphene aerogel can also be used for preparing polymer/graphene composite aerogel, nanoparticle/graphene composite aerogel and polymer/graphene composite materials and the like, so that application of the graphene aerogel is expanded.

The present invention relates to a mammary prosthesis made of polyacrylamide hydrogel. Said prosthesis include a shell which is made of medical high polymer elastic material, such as silicone, and said shell have a round curved surface. The shell is filled with polyacrylamide hydrogel, or with hydrogel powder, and the weight of the filled powder is matched with the volume of the circular shell, that is to say, each 100 ml volumes of the shell could be filled with about 2.5–5 g hydrogel powder.

A hydrogel is obtained by combining acrylamide and methylene based-acrylamide, radical initiation and washing with pyrogen-free water or saline solution to give less than 3.5% by weight polyacrylamide, based on the total weight of the hydrogel. The hydrogel may be used as a soft tissue filler endoprosthesis. Also disclosed is a method of filling a soft tissue in a mammal using the endoprosthesis, and a prosthetic device comprising the polyacrylamide hydrogel.

The invention discloses prussian blue nano-scale hollow olivary microballoons, and belongs to the technical field of prussian blue materials. A preparation method of the prussian blue nano-scale hollow olivary microballoons comprises the following steps that 1, acrylamide as a monomer, N,N'-methylenebisacrylamide as a cross-linking agent, ammonium persulfate as an initiator and ethanol as a solvent are prepared into crosslinked polyacrylamide hydrogel microballoons by a dispersion polymerization technology; 2, hydrogel microballoon/ethanol suspending liquid is added with a Fe<3+> salt aqueoussolution; 3 the mixed solution obtained by the step 2 is stirred violently for one night so that the crosslinked polyacrylamide hydrogel microballoons swelled by Fe<3+> deform; 4, a potassium ferrocyanide aqueous solution is added dropwisely into the mixed solution treated by the step 3 to form prussian blue shells; and 5, the solvent is removed so that the prussian blue nano-scale hollow olivarymicroballoons are obtained. The preparation method of the prussian blue nano-scale hollow olivary microballoons has the advantages of simple operation, low cost, good adaptability for large-scale production, and controllability of microballoon sizes. The prussian blue nano-scale hollow olivary microballoons have nano-scale short axis sizes and micron-scale long axis sizes, and can be utilized widely for drug slow release, sensors, electrode materials and the like.

The invention discloses a hydrogel antifouling fiber, a preparation method of hydrogel antifouling fiber and a preparation method of an implanted type high-strength hydrogel antiflouling coating layer, and relates to antiflouling materials, preparation methods of the antiflouling materials, and preparation methods of vessel antifouling coating layers, for mainly solving the technical problems that the conventional PVA (Polyvinyl Acetate) fiber implanted type vessel antiflouling coating layer is poor in antifouling effect and short in service life. The hydrogel antifouling fiber disclosed by the invention is a fiber with a core-shell structure, the shell layer of the fiber is made of polyacrylamide, and the core layer is made of carbon nano tube modified polyacrylamide. The preparation method comprises the following steps: 1, preparing polyacrylamide hydrogel, 2, preparing a core layer spinning dope, 3, preparing a shell layer spinning dope, 4, spinning by using a wet method to obtain the hydrogel antifouling fiber. The preparation of the antifouling coating layer comprises the following steps: spraying implantation gel onto a substrate, further implanting the hydrogel antifouling fiber into the substrate through a high-pressure static implantation technique, and drying to obtain the implanted type high-strength hydrogel antifouling coating layer. The coating layer is not changed when being soaked in seawater or industrial water for 6 months, so that the coating layer can be applied to vessel antifouling.

The present invention relates to a method for preparing a natural or synthetic polymer hydrogel loading graphene oxide or graphene, and to the selective and high-capacity adsorption and loading of the hydrogel with respect to a low-molecular weight material or a high-molecular weight material. More specifically, an alginate or polyacrylamide hydrogel loading graphene and a graphene derivative is prepared, wherein the hydrogel can be controlled to enable selective absorption according to the characteristics of an adsorbate by adjusting the reduction degree of graphene oxide, exhibits high adsorption capacity, and is easy to handle as a hydrate. These characteristics can significantly improve the adsorption efficiency with respect to a material in water or an organic phase material, compared with existing hydrogels.

The invention discloses a chitosan polyacrylamide hydrogel base material and a preparation method thereof. The chitosan polyacrylamide hydrogel base material is composed of an acrylamide solution, a methylene diacrylamide solution, H2O, an ammonium persulfate solution, tetramethyl ethylenediamine and a chitosan solution. The preparation method of the chitosan polyacrylamide hydrogel base material comprises a step of mixing and stirring, a step of transferring to a glass clamping plate for reacting, and a step of immersion. The chitosan polyacrylamide hydrogel base material has a simple technology and allows hydrogels having different hardnesses to be obtained, and the obtained hydrogels have the advantages of non-toxicity, easy adherence growth of cells, reduction of the reaching complexity of the cytomechanics, benefiting for the researches on the mechanical properties of the cells, and reduction of the researching cost.

The invention relates to a preparation method of a composite carboxymethyl chitosan/graphene oxide/polyacrylamide hydrogel. The preparation method includes the steps of adding CMCTs (carboxymethyl chitosan) in a GO (graphene oxide) solution, stirring, adding AM (acrylamide), and stirring to obtain a CMCTs/GO/AM dispersion solution; under the conditions of stirring and ice-water bath, adding an initiator solution and an accelerating agent into the dispersion solution, and stirring to obtain a mixed solution; placing the mixed solution in a container, vacuumizing, inflating nitrogen, sealing, and reacting at a room temperature for 8-12 hours to obtain the composite carboxymethyl chitosan/graphene oxide/polyacrylamide hydrogel. The preparation method is simple in preparing process, easy to operate and beneficial to industrial production; the prepared composite carboxymethyl chitosan/graphene oxide/polyacrylamide hydrogel is high in biocompatibility, mechanical property and toughness, can be used for artificial skin, artificial ligament and the like and has a potential application value in histological engineering.

The invention relates to preparation and application of high strength anti-tear magnetic hydrogel. The preparation is as below: dissolving acrylamide monomer and a sodium alginate powder in a sodium alginate@Fe3O4 magnetic fluid, adding a crosslinking agent and an initiator to obtain a polyacrylamide hydrogel penetrated by a sodium alginate@Fe3O4 polymer chain and a free sodium alginate polymer chain; immersing the obtained hydrogel in an aqueous solution containing Mn<+> multivalent cations to diffuse Mn<+> into the hydrogel, crosslinking the sodium alginate@Fe3O4 and free sodium alginate polymer chain by electrostatic interaction to obtain the Fe3O4@(M-sodium alginate/polyacrylamide)magnetic hydrogel, which has high mechanical properties (tensile strength up to 1.0MPa, the maximum elongation at break of up to 11 times, compressive strength of up to 5.0MPa, and the maximum energy to break up to 2800J/m<2>), and is insensitive to the crack (the maximum elongation at break of the sample containing cracks up to 9 times). The high strength anti-tear magnetic hydrogel can be applied to magnetic medical catheters.

The invention provides a method for improving the adhesion property of a polyacrylamide hydrogel, and resulting polyacrylamide hydrogel. The method comprises the following steps: (1) uniformly mixingdopamine grafted and modified hyaluronic acid or hyaluronate and a soluble tetraborate in deionized water to form a first crosslinked network; and (2) adding acrylamide and a crosslinking agent, thenadding an initiator and tetramethylethylenediamine under ice bath conditions, performing uniform mixing, and then polymerizing the obtained mixture at 0-4 DEG C to obtain the polyacrylamide hydrogel,wherein in step (1), the dopamine graft rate of the above modified product is 30-32%, and a mass ratio of the modified product to the tetraborate is 5:(2-1); and a mass ratio of the acrylamide added in step (2) to the modified product in the step (1) is (18-20):1, and the hyaluronate is a potassium salt or a sodium salt. The method greatly improves the adhesion property of the prepared polyacrylamide hydrogel.

The invention discloses a small-caliber bionic blood vessel with a three-layer structure and a manufacturing method thereof. Knitted silk fiber is adopted as an inner layer of the bionic blood vesselto simulate the structure and properties of human body blood vessel collagen, electrostatic spun polyurethane fiber serves as an outer layer to simulate the structure and properties of blood vessel elastin. In addition, polyacrylamide hydrophilic gel is also adopted as a middle layer to further improve the elasticity of the bionic blood vessel, meanwhile improve the bursting pressure of the bionicblood vessel and prevent blood permeation in the use process. The microcosmic three-layer structure of the human blood vessel can be simulated, and the special nonlinear mechanical properties of thehuman blood vessel can be also simulated. In addition, the raw materials for the bionic blood vessel have good cytocompatibility, are degradable and are suitable for blood vessel repair and regeneration in tissue engineering. Therefore, the small-caliber bionic blood vessel with the three-layer structure has a high potential practical value.