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Method for improving adhesion property of polyacrylamide hydrogel, and resulting polyacrylamide hydrogel

A technology of polyacrylamide and acrylamide, which is applied in the field of biomedical materials and can solve problems such as lack of adhesion properties

Active Publication Date: 2019-04-19
JIANGHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the self-healing hydrogels currently reported require certain external stimuli to complete, and they still lack certain adhesion properties, so other means are needed to achieve the adhesion effect.

Method used

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  • Method for improving adhesion property of polyacrylamide hydrogel, and resulting polyacrylamide hydrogel
  • Method for improving adhesion property of polyacrylamide hydrogel, and resulting polyacrylamide hydrogel
  • Method for improving adhesion property of polyacrylamide hydrogel, and resulting polyacrylamide hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Prepare 0.01mol / L PBS buffer solution (1L)

[0063] Add 800mL of deionized water, 7.9g of sodium chloride, 0.2g of potassium chloride, 0.24g of potassium dihydrogen phosphate and 1.8g of dipotassium hydrogen phosphate into a 1L volumetric flask in sequence, and dissolve with magnetic stirring at room temperature. Adjust the pH of the solution to 7.2-7.4 with HCl, and finally add distilled water to make it up to 1L to obtain a 0.01mol / L PBS buffer solution. After the solution is prepared, store it in a refrigerator at 4°C.

[0064] Preparation of dopamine-modified sodium hyaluronate (HAC)

[0065] 1. At room temperature, weigh 1g of sodium hyaluronate, put it into a three-necked flask, then add 100mL of 1mol / L PBS buffer solution and a suitable magnet, stir until it is completely dissolved, adjust the pH of the solution to 5, and then Add catalyst 0.476g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) and 0.286g of N-hydroxysuccinimide (NHS), fully stir and disso...

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Abstract

The invention provides a method for improving the adhesion property of a polyacrylamide hydrogel, and resulting polyacrylamide hydrogel. The method comprises the following steps: (1) uniformly mixingdopamine grafted and modified hyaluronic acid or hyaluronate and a soluble tetraborate in deionized water to form a first crosslinked network; and (2) adding acrylamide and a crosslinking agent, thenadding an initiator and tetramethylethylenediamine under ice bath conditions, performing uniform mixing, and then polymerizing the obtained mixture at 0-4 DEG C to obtain the polyacrylamide hydrogel,wherein in step (1), the dopamine graft rate of the above modified product is 30-32%, and a mass ratio of the modified product to the tetraborate is 5:(2-1); and a mass ratio of the acrylamide added in step (2) to the modified product in the step (1) is (18-20):1, and the hyaluronate is a potassium salt or a sodium salt. The method greatly improves the adhesion property of the prepared polyacrylamide hydrogel.

Description

technical field [0001] The invention relates to biomedical materials, in particular to a method for improving the adhesion performance of polyacrylamide hydrogel and the obtained polyacrylamide hydrogel. Background technique [0002] Self-healing hydrogels are a class of hydrogel materials that can quickly self-heal the fracture interface and restore the original properties after the structure is damaged. Due to its good self-healing properties, it can not only prolong the service life of the material, but also improve the safety performance of the material, so it is widely used in the fields of biosensing, bionic electronic skin and wearable electronic devices. [0003] Most of the self-healing hydrogels reported so far require certain external stimuli to complete, and they still lack certain adhesion properties, so other means are needed to achieve the adhesion effect. Studies have shown that the podocytes of marine mussels can secrete a kind of silk with adhesive propert...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/08C08L33/26C08F220/56C08F222/38C08B37/08
CPCC08B37/0072C08F220/56C08J3/075C08J2305/08C08J2433/26C08F222/385
Inventor 曹一平贝中武黄园尤庆亮
Owner JIANGHAN UNIVERSITY
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