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10637results about "Liquid separation" patented technology
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Apparatus for manipulating droplets by electrowetting-based techniques
InactiveUS6911132B2Improve controllabilityImprove accuracyBurnersElectrostatic separatorsElectricityControl manner
An apparatus is provided for manipulating droplets. The apparatus is a single-sided electrode design in which all conductive elements are contained on one surface on which droplets are manipulated. An additional surface can be provided parallel with the first surface for the purpose of containing the droplets to be manipulated. Droplets are manipulated by performing electrowetting-based techniques in which electrodes contained on or embedded in the first surface are sequentially energized and de-energized in a controlled manner. The apparatus enables a number of droplet manipulation processes, including merging and mixing two droplets together, splitting a droplet into two or more droplets, sampling a continuous liquid flow by forming from the flow individually controllable droplets, and iterative binary or digital mixing of droplets to obtain a desired mixing ratio.
Owner:DUKE UNIV
Microfabricated crossflow devices and methods
InactiveUS7294503B2Increase sensitivityHigh numberSludge treatmentFixed microstructural devicesMain channelEnzyme
A microfluidic device for analyzing and / or sorting biological materials (e.g., molecules such as polynucleotides and polypeptides, including proteins and enzymes; viruses and cells) and methods for its use are provided. The device and methods of the invention are useful for sorting particles, e.g. virions. The invention is also useful for high throughput screening, e.g. combinatorial screening. The microfluidic device comprises a main channel and an inlet region in communication with the main channel at a droplet extrusion region. Droplets of solution containing the biological material are deposited into the main channel through the droplet extrusion region. A fluid different from and incompatible with the solution containing the biological material flows through the main channel so that the droplets containing the biological material do not diffuse or mix. Biological material within the droplets can be analyzed and / or sorted by detecting a predetermined characteristic of the biological sample in each droplet and sorting the droplet accordingly.
Owner:CALIFORNIA INST OF TECH
Electrophoretic displays containing magnetic particles
InactiveUS6870661B2Easy to fallImprove stabilitySludge treatmentStatic indicating devicesElectrophoresisDisplay device
An electrophoretic medium comprises a plurality of one or more types of particles suspended in a suspending fluid. The particles include at least one electrically charged, electrophoretically mobile particle capable of translating through the suspending fluid upon application of an electric field to the medium and at least one magnetic particle. A magnet is disposed adjacent the electrophoretic medium to introduce a threshold resistance to magnetic particle movement.
Owner:E INK CORPORATION
Acrylic microchannels and their use in electrophoretic applications
Microchannels having at least an acrylic inner surface and methods of their use in electrophoretic applications are provided. The subject microchannels may be in the form of a variety of configurations suitable for holding an electrophoretic medium. The subject microchannels give rise to substantially reduced EOF and / or adsorption as compared to fused silica under conditions of electrophoresis and find use in a variety of electrophoretic applications in which charged entities are moved through a medium under the influence of the an applied electric field.
Owner:MONOGRAM BIOSCIENCES
Small object moving on printed circuit board
A printed circuit board based digital or droplet microfluidic system and method for producing such microfluidic system are disclosed. The digital microfluidic device comprises a printed circuit board having a substrate and a plurality of electrode pads disposed on the top surface of the substrate in a rectangular array. A via extends from each electrode pad through the substrate to other locations on the substrate . A dielectric layer is disposed on the electrode pads. Droplets may be manipulated using electrowetting principles and others by applying a voltage to the desired electrodes. Each electrode pad can be controlled directly and independently from the other electrode pads to modify the surface wettability of the dielectric layer in the vicinity of the electrode pad by applying a voltage to the desired electrode pad(s). In this way, droplets may be formed, moved, mixed, and / or divided or other small objects manipulated while in air or immersed in a liquid on the dielectric surface.
Owner:RGT UNIV OF CALIFORNIA
Treating produced waters
InactiveUS20070102359A1Complicate purificationIncrease ratingsUltrafiltrationTreatment involving filtrationEmulsionUnit operation
The present invention is directed to various sets of unit operations for treating aqueous effluents and logic for designing and effecting the treatment. The unit operations include stabilization of subterranean waters, sequential oxidation steps to alter selected target materials, oxidation to break up emulsions prior to removal of the emulsion components, and intense oxidation to break up difficult-to-remove organic target materials.
Owner:HW PROCESS TECH
Construction of electrophoretic displays
An electrophoretic display (100) comprises a front light-transmissive substrate (112), a rear substrate (116) spaced from the front substrate (112) so as to leave a cavity, and an electrophoretic medium (102) in the cavity, the electrophoretic medium (102) comprising a liquid external phase (120) and a plurality of capsules (104) suspended in the liquid external phase (120), each of the capsules comprising a capsule wall, a suspending fluid (106) held within the capsule wall and at least one electrically charged particle (108, 110) suspended in the suspending fluid (106).
Owner:E INK CORPORATION
Droplet-based particle sorting
InactiveUS20080053205A1Large facilityEasy to testSludge treatmentVolume/mass flow measurementChemical physicsParticle sorting
Owner:ADVANCED LIQUID LOGIC
Systems and methods for optical actuation of microfluidics based on opto-electrowetting
InactiveUS6958132B2Improve performanceSludge treatmentMaterial analysis by electric/magnetic meansElectricityMicrofluidics
Owner:RGT UNIV OF CALIFORNIA
Miniature support for thin films containing single channels or nanopores and methods for using same
Single-channel thin film devices and methods for using the same are provided. The subject devices comprise cis and trans chambers connected by an electrical communication means. At the cis end of the electrical communication means is a horizontal conical aperture sealed with a thin film that includes a single nanopore or channel. The devices further include a means for applying an electric field between the cis and trans chambers. The subject devices find use in applications in which the ionic current through a nanopore or channel is monitored where such applications include the characterization of naturally occurring ion channels, the characterization of polymeric compounds, and the like.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE +1
Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip
A device for generating droplets includes a substrate comprising a reservoir site configured to hold a liquid and including a first electrode, a droplet creation site including a second electrode, and droplet separation site disposed between the reservoir site and the droplet creation site and containing an electrode. The device includes control circuitry operatively coupled to the first, second, and third electrodes. The control circuitry is configured to measure the fluid volume on the electrodes and independently adjust an applied voltage to increase / decrease the quantity of fluid. The device can move fluid onto the creation site or back onto to the reservoir site. When the fluid volume is at the desired value or range, a driving voltage is delivered to the first and second electrodes to form a new droplet. The device may generate droplets having a uniform or user-defined size smaller than the electrode.
Owner:RGT UNIV OF CALIFORNIA
Inline-injection microdevice and microfabricated integrated DNA analysis system using same
InactiveUS20090035770A1Sludge treatmentVolume/mass flow measurementCapillary electrophoresisElectrophoresis
Methods and microfluidic circuitry for inline injection of nucleic acids for capillary electrophoresis analysis are provided. According to various embodiments, microfabricated structures including affinity-based capture matrixes inline with separation channels are provided. The affinity-based capture matrixes provide inline sample plug formation and injection into a capillary electrophoresis channel. Also provided are methods and apparatuses for a microbead-based inline injection system for DNA sequencing.
Owner:RGT UNIV OF CALIFORNIA
Droplet-based nucleic acid amplification device, system, and method
InactiveUS20080038810A1Reduces and eliminates build-upImprove efficiencyElectrostatic separatorsSludge treatmentTemperature controlBiology
The present invention relates to a droplet-based nucleic acid amplification device, system, and method. According to one embodiment, a droplet microactuator is provided and includes: (a) a substrate comprising electrodes for conducting droplet operations; and (b) one or more temperature control means arranged in proximity with one or more of the electrodes for heating and / or cooling a region of the droplet microactuator and arranged such that a droplet can be transported on the electrodes into the region for heating.
Owner:DUKE UNIV +1
Electrophoretic media containing specularly reflective particles
ActiveUS20040094422A1Good flexibilityImprove uniformitySludge treatmentStatic indicating devicesElectrophoresisSpecular reflection
An electrophoretic medium (100) comprises at least one type of particle (108) suspended in a suspending fluid (106) and capable of moving therethrough on application of an electric field to the medium, the particles (108) including at least one electrophoretically mobile specularly reflective particle.
Owner:E INK CORPORATION
Electrophoretic media containing specularly reflective particles
ActiveUS7312916B2Improve reflectivityReduces backplane scatteringSludge treatmentStatic indicating devicesElectrophoresisSpecular reflection
An electrophoretic medium (100) comprises at least one type of particle (108) suspended in a suspending fluid (106) and capable of moving therethrough on application of an electric field to the medium, the particles (108) including at least one electrophoretically mobile specularly reflective particle.
Owner:E INK CORPORATION
Method and Apparatus Using Electric Field for Improved Biological Assays
ActiveUS20090032401A1Avoid corrosionIncrease electric fieldElectrostatic separatorsSludge treatmentPresent methodEngineering
Disclosed are a method and apparatus that use an electric field for improved biological assays. The electric field is applied across a device having wells, which receive reactants, which carry a charge. The device thus uses a controllable voltage source between the first and second electrodes, which is controllable to provide a positive charge and a negative charge to a given electrode. By controlled use of the electric field charged species in a fluid in a fluid channel are directed into or out of the well by an electric field between the electrodes. The present method involves the transport of fluids, as in a microfluidic device, and the electric field-induced movement of reactive species according to various assay procedures, such as DNA sequencing, synthesis or the like.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Methods for manipulating droplets by electrowetting-based techniques
InactiveUS20060054503A1Improve controllabilityImprove accuracySludge treatmentShaking/oscillating/vibrating mixersElectricityEngineering
Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. The methods further include activating the first and second electrodes to spread at least a portion of the droplet across the second electrode and deactivating the first electrode to move the droplet from the first electrode to the second electrode.
Owner:DUKE UNIV
Liquid transfer device
InactiveUS20090321262A1Reduce in quantityEasy to controlSludge treatmentTransportation and packagingSpherical shapedEngineering
Provided is a liquid transfer device which controls electrically liquid position. The surface of the liquid transfer device is provided with unevenness in order to solve a problem of having a large number of electrodes for controlling voltage. The number of electrodes for controlling voltage can be halved by utilization of restoring force of liquid to a spherical shape by surface tension, in addition to electrical force.
Owner:HITACHI HIGH-TECH CORP
Electrophoretic particles and processes for the production thereof
In electrophoretic media, it is advantageous to use pigment particles having about 1 to 15 percent by weight of a polymer chemically bonded to, or cross-linked around, the pigment particles. The polymer desirably has a branched chain structure with side chains extending from a main chain. Charged or chargeable groups can be incorporated into the polymer or can be bonded to the particles separately from the polymer. The polymer-coated particles can be prepared by first attaching a polymerizable or polymerization-initiating group to the particle and then reacting the particle with one or more polymerizable monomers or oligomers.
Owner:E INK CORPORATION
Systems and Methods for Controlling the Position of a Charged Polymer Inside a Nanopore
Techniques for controlling the position of a charged polymer inside a nanopore are provided. For example, one technique includes using electrostatic control to position a linear charged polymer inside a nanopore, and creating an electrostatic potential well inside the nanopore, wherein the electrostatic potential well controls a position of the linear charged polymer inside the nanopore.
Owner:GLOBALFOUNDRIES US INC
Microfluidic devices for methods development
InactiveUS6880576B2Material nanotechnologySludge treatmentChromatographic separationFlow resistivity
Microfluidic devices with multiple fluid process regions for subjecting similar samples to different process conditions in parallel are provided. One or more common fluid inputs may be provided to minimize the number of external fluid supply components. Solid materials such as chromatographic separation media or catalyst media is preferably provided in each fluid process region. Solid materials may be supplied to the devices in the form of slurry, with particles retained by porous elements or frits. Different fluid process regions may having different effective lengths, different solid material types or amounts, or may receive different ratios of common fluids supplied to the device. The flow resistances of dissimilar fluid process regions may be balanced passively with the addition of impedance elements in series with each fluid process region.
Owner:AGILENT TECH INC
Electrochemical device for moving particles covered with protein
InactiveUS6972080B1Efficient disposalElectrostatic separatorsSludge treatmentBlood componentElectrolysis
An electrochemical device for moving particles covered with a protein is provided. The device includes at least two electrodes that are in contact with a liquid containing the protein-covered particles and a circuit that generates a potential difference in a range that does not cause electrolysis of the liquid between the electrodes. The particles are moved by electrophoresis in the direction of the arrangement of the electrodes. The invention provided herein has numerous applications, including use in a microorganism concentration condensing device, a blood component induction device, and / or a blood component induction method, and / or an electric appliance that decreases the concentration of microorganisms present on the surface of a heat exchanger.
Owner:PANASONIC CORP
Microfluidic devices with thick-film electrochemical detection
InactiveUS6878255B1Reduce usageCost advantageSludge treatmentVolume/mass flow measurementAnalyteMicrofluidic channel
An apparatus for conducting a microfluidic process and analysis, including at least one elongated microfluidic channel, fluidic transport means for transport of fluids through the microfluidic channel, and at least one thick-film electrode in fluidic connection with the outlet end of the microfluidic channel. The present invention includes an integrated on-chip combination reaction, separation and thick-film electrochemical detection microsystem, for use in detection of a wide range of analytes, and methods for the use thereof.
Owner:ARROWHEAD CENT
Sample Processing Droplet Actuator, System and Method
InactiveUS20080230386A1Easy to useFacilitates of propertySequential/parallel process reactionsSludge treatmentInterior spaceEngineering
Sample processing droplet actuators, systems and methods are provided. According to one embodiment, a stamping device including a droplet microactuator is provided and includes: (a) a first plate including a path or network of control electrodes for transporting droplets on a surface thereof; (b) a second plate mounted in a substantially parallel orientation with respect to the first plate providing an interior volume between the plates, the second plate including one or more stamping ports for transporting some portion or all of a droplet from the interior volume to an exterior location; (c) a port for introducing fluid into the interior volume between the plates; and (d) a path or network of reference electrodes corresponding to the path or network of control electrodes. Associated systems and methods including the stamping device are also provided.
Owner:ADVANCED LIQUID LOGIC +1
Optoelectronic tweezers for microparticle and cell manipulation
ActiveUS7612355B2Easy to operateEasy to createElectrostatic separatorsSludge treatmentMicroparticleOpto electronic
An optical image-driven light induced dielectrophoresis (DEP) apparatus and method are described which provide for the manipulation of particles or cells with a diameter on the order of 100 μm or less. The apparatus is referred to as optoelectric tweezers (OET) and provides a number of advantages over conventional optical tweezers, in particular the ability to perform operations in parallel and over a large area without damage to living cells. The OET device generally comprises a planar liquid-filled structure having one or more portions which are photoconductive to convert incoming light to a change in the electric field pattern. The light patterns are dynamically generated to provide a number of manipulation structures that can manipulate single particles and cells or groups of particles / cells. The OET preferably includes a microscopic imaging means to provide feedback for the optical manipulation, such as detecting position and characteristics wherein the light patterns are modulated accordingly.
Owner:RGT UNIV OF CALIFORNIA
Method of using actuators for microfluidics without moving parts
InactiveUS7255780B2Maximize area overlapEffectively converting the surface into more hydrophilicSludge treatmentFlow mixersElectricityMicrofluidics
A series of microactuators for manipulating small quantities of liquids, and methods of using these for manipulating liquids, are disclosed. The microactuators are based on the phenomenon of electrowetting and contain no moving parts. The force acting on the liquid is a potential-dependent gradient of adhesion energy between the liquid and a solid insulating surface.
Owner:ADVANCED LIQUID LOGIC
Method and apparatus for the manipulation of particles by means of dielectrophoresis
InactiveUS6942776B2Increase rangeAvoid the needElectrostatic separatorsSludge treatmentPlanar substrateEngineering
An apparatus and method for establishing closed dielectrophoretic potential cages and precise displacement thereof comprising a first array of selectively addressable electrodes, lying on a substantially planar substrate and facing toward a second array comprising one electrode. The arrays define the upper and lower bounds of a micro-chamber where particles are placed in liquid suspension. By applying in-phase and counter-phase periodic signals to electrodes, one or more independent potential cages are established which cause particles to be attracted to or repelled from cages according to signal frequency and the dielectric characteristics of the particles and suspending medium. By properly applying voltage signal patterns into arrays, cages may trap one or more particles, thus permitting them to levitate steadily and / or move. In the preferred embodiment, where one array is integrated on a semiconductor substrate, displacement of particles can be monitored by embedded sensors.
Owner:SILICON BIOSYSTEMS SPA +1
Microfluidic control using dielectric pumping
InactiveUS6949176B2High-performance operationImprove reliabilityElectrostatic separatorsSludge treatmentMiniaturizationEngineering
Devices and methods utilizing dielectric pumping and variable dielectric pumping to move fluids through microchannels. Two fluids having dissimilar dielectric constants form an interface that is positioned between two electrodes in order to move the interface and therefore the fluids. Dielectric pumping and variable dielectric pumping may be used to move fluids in miniaturized analytical packages containing microchannels in which forces created by surface tension predominate over the gravitational force.
Owner:NEOPHOTONICS CORP
Device and method for separating components of a fluid sample
A device and method is provided for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising at least two components and more particularly an elastic portion and a plug member. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the elastic portion of the separator to deform so that the separator migrates into the fluid sample and stabilizes between the heavier and lighter fractions of the fluid sample. The elastic portion of the separator will resiliently return to its initial configuration upon termination of the centrifugal load such that the elastic portion sealingly engages the container and separates the heavier and lighter fractions of the fluid sample.
Owner:BECTON DICKINSON & CO
Solid state molecular probe device
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE
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