2486 results about "Sample processing" patented technology

Disclosed are methods, devices and systems for biological and chemical sample processing using microfluidic chips. The disclosed microfluidic chips contain at least two detection zones for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens to determine their presence in the sample. Systems are also described comprising a cassette having at least one port and a sample inlet in fluid communication with a detection zone for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens, or mixtures thereof, if present, in a sample. Methods for concurrent testing of at least two of RNA, DNA, antibody, and antigen in a sample are also described, as are methods for testing for pre-selected pathogens and microfluidic methods.

This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.

A novel and useful whitening matched filter (WMF) for use in a communications receiver. The WMF is constructed by cascading a matched filter and a noise-whitening filter. The response of the matched filter is derived from the time reversed complex conjugate of the channel impulse response. The whitening filter is derived by extracting the minimum phase portion of the mixed phase channel impulse response using homomorphic deconvolution. The whitening filter is implemented using either an FIR or IIR filter adapted to process the data received before and after the training sequence using a minimum phase system in a direction in time opposite to that of the direction of corresponding data sample processing performed by the equalizer.

Flexible pouch and flexible cartridge devices for fluid sample processing, related methods of making and using, related manufacturing systems and related instrumentation systems are described. Flexible pouches provide broad advantage in a wide variety of fields by overcoming the need for complex instrumentation, dedicated devices, and relatively high cost in conventional fluid sample devices. Flexible cartridge devices are particularly advantageous in control of fluid handling, rapid adaptation to a number of configurations by the end user, multiple uses for a single configuration, and in cost and ease of manufacture.

The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and / or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.

Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.

In accordance with an embodiment of a system for handling and processing chemical and / or biological samples, a MicroChamber comprises a substrate, a reservoir formed on the substrate for receiving a chemical and / or biological sample, and an encoder such as a barcode or other suitable device. The encoder encodes information describing at least one characteristic of the substrate and / or reservoir.

Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.

A cassette for containment, storage and processing of material samples, having a top member that is slideably attachable to and detachable from the base member with minimal force and relaxed requirement for precision in the alignment operation. The top member is hingeably connected to the base member when attached and is positively locked to the base member in the attached closed position. The top member is easily opened and closed with one hand when attached to the base member, and facilitates high volume sample processing, e.g., of tissue samples for the purpose of histological determinations.

An automated staining apparatus and a method for treating samples arranged on a carrier is disclosed, in which portions of two or more selected reagents from a first station containing the reagents are collected individually by a robot arm handling a probe and dispensed in a mixing station of the apparatus. After mixing the reagents in the mixing station, e.g. by shaking or rotating the mixing cup containing the reagents, the reagent mixture is applied to selected samples by the robot arm and a probe.

Sample processing systems and methods of using those systems for processing sample materials located in devices that are separate from the system are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include connection apparatus that allow for rapid and easy removal and / or replacement of base plates.

Systems and methods are provided for collecting, preparing, and / or analyzing a biological sample. A sample collection site may be utilized with one or more sample processing device. The sample processing device may be configured to accept a sample from a subject. The sample processing device may perform one or more sample preparation step and / or chemical reaction involving the sample. Data related to the sample may be sent from the device to a laboratory. The laboratory may be a certified laboratory that may generate a report that is transmitted to a health care professional. The health care professional may rely on the report for diagnosing, treating, and / or preventing a disease in the subject.

The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

The invention provides an integrated sample-processing system and components thereof for preparing and / or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.

The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.

The present invention provides a method and device for collecting treating and analysis of biological or chemical material by introducing a source material into a specimen container, transferring the source material to a processing device and thermally, chemically and / or mechanically treating the source material to alter at least one constitutive characteristic of the source material and to release or create a target material from the source material.

The invention provides an automatic extraction device and an automatic extraction method of a nucleic acid based on nano magnetic beads. The device comprises a base (1), as well as a motor, a magnetic bar (6), a magnetic bar clamping mechanism (3), a stirring sleeve (5), a stirring sleeve clamping mechanism (10), a deep hole plate (2), a control circuit and an upper computer which are arranged on the base (1). According to the device and the method which are provided by the invention, the nucleic acid is combined with the nano magnetic beads; and then, the nucleic acid is extracted from a nucleic acid cracking liquid under the attraction of the magnetic bar (6). Thus, the consistency of sample treatment is guaranteed to a great extent; the human interference is reduced; and the cross interference risk is decreased. The device and the method provided by the invention are suitable for the pretreatment of sample inspection in the medicinal field, the biological field, the agricultural field and the like.

A sample processing tubule may include at least three segments. Each segment may be defined by the tubule, may be fluidly isolated, at least in part by a breakable seal, may be so expandable as to receive a volume of fluid expelled from another segment, and may be so compressible as to contain substantially no fluid when so compressed. At least one segment may contain at least a control reagent. At least one segment may contain at least one of a nucleic acid amplification reagent and a detection reagent.

Microfluidic sample processing disks with a plurality of fluid structures formed therein are disclosed. Each of the fluid structures preferably includes an input well and one or more process chambers connected to the input well by one or more delivery channels. The process chambers may be arranged in a compliant annular processing ring that is adapted to conform to the shape of an underlying thermal transfer surface under pressure. That compliance may be delivered in the disks of the present invention by locating the process chambers in an annular processing ring in which a majority of the volume is occupied by the process chambers. Compliance within the annular processing ring may alternatively be provided by a composite structure within the annular processing ring that includes covers attached to a body using pressure sensitive adhesive.

Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.

A system and method for conditioning of very low pressure gas samples extracted from a source, heating the samples, boosting the pressure to a level appropriate for analysis, regulating the gas sample temperature and pressure to prevent dew-point dropout from Joules Thompson condensation, and passing the gas sample to an a remotely located analyzer or analyzer array where the electrical power for the pressurizing pump and heated regulator is provided by heat tracing.

The invention discloses a full automatic biochip detection system belonging to the clinical detection field of multi-marker biochips. The system adopts modular structure and comprises an automatic sample processing module, a reaction washing module, a detection module, a Tip head storage module, a reagent storage module, a biochip storage module, a sample storage module, a system base, an electric control box and a computer, the electric control box and all the modules are operated under the control of software, so as to realize the automatic sampling, the sample adding, the reaction, the washing, the detection and other processes. All the modules can work independently and can also be combined together and matched for work. The full automatic biochip detection system can overcome the shortcomings of the existing biochip detector and reduce the errors caused by human operation, and has stable and reliable detection result and good flexibility, so that the full automatic biochip detection system can not only greatly improve the detection efficiency, but also can be conductive to the accuracy of the detection result; the system has simple operation, therefore, the system is not only applicable to the scientific research and the applications of laboratories and hospitals, but also can be used for large-scale sample screening of large-scale hospitals and blood stations.

Disclosed is a sample analysis device provided with: a first sample processing portion which is disposed in a first layer and performs some of a plurality of processes on a sample in a container; a second sample processing portion which is disposed in a second layer located above or under the first layer and performs at least some other processes among the plurality of processes on the sample in the container, the some of the plurality of processes having been performed on the sample; and a container transfer portion which transfers the container, which contains the sample on which the some of the processes have been performed, from the first layer to the second layer.

An automated sample processing system and methods are disclosed where sample(s) are arranged on a carrier element and a process operation control system automatically processes the sample(s) perhaps robotically according to protocol and according to a scheduling system. The processing may include and be enhanced by a vibration of the sample via a vibrator disposed in or upon a sample carrier or a sample cover. Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities may be accomplished to determine an enhanced sequence for processing.

A capture and purification apparatus is configured as a stand-alone apparatus or as part of a larger system. The capture and purification apparatus can be configured as a microfluidic cartridge that includes microfluidic circuitry and individually controlled valves. The microfluidic cartridge can be configured to function independently, or can be configured to be coupled to a separate instrument that provides the actuation to perform the capture and purification process. The capture and purification apparatus is configured as a volume-driven system that applies single-direction valves, a single fluid driving device, and fluid lines to control and discretely direct fluid flow within a full-loaded fluidic system. Such control enables various fluid sample processing techniques to be performed including, but not limited to, lysis, thermal cycling, and / or target analyte capture and purification, for example using a combination of ion-exchange chromatography and size-exclusion chromatography (SEC).