The invention relates to a method for detecting four tobacco-specific nitrosamines (TSNAs) in lateral
exhaust gas of cigarettes by virtue of
gas chromatography-
tandem mass spectrometry. The method is characterized by comprising the steps of capturing the lateral
exhaust gas of the cigarettes by virtue of a lateral fishtail cover preprocessed by an
ascorbic acid solution and a Cambridge filter preprocessed by an
ascorbic acid saturated
methanol solution, washing the lateral fishtail cover with a
hydrochloric acid solution, adding the washed
hydrochloric acid solution and an TSNAs
internal standard solution into a container in which the Cambridge filter is collected, extracting the Cambridge filter,
processing extraction solution by virtue of a
solid phase extraction column to obtain an eluate,
drying the eluate with
nitrogen, redissolving by virtue of
dichloromethane to obtain a sample, and analyzing the sample by virtue of the
gas chromatography-
tandem mass spectrometry (GC-MS / MS). According to the method, the disadvantages of tedious preprocessing process, low detection sensitivity and strong matrix effect in an existing method are overcome, the preprocessing step of the sample is simplified, and the consumption of organic solvents is reduced; the method has the advantages that the detection is accurate, the sensitivity is high, and the
repeatability is good.