2098 results about "Ionic polymerization" patented technology

A three dimensional object includes (a) a light polymerized first component; and (b) a second solidified component different from the first component. The object is preferably of a polymer blend formed from the first component and the second component, with the polymer blend as an interpenetrating polymer network, a semi-interpenetrating polymer network, or a sequential interpenetrating polymer network. In some preferred embodiments, the second component does not contain a cationic polymerization photoinitiator. In some preferred embodiments, the three dimensional object is produced by the process of continuous liquid interface production.

The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used. In a more preferred embodiment, the average molecular weight is about 40,000 to 500,000 Daltons. The present invention provides compositions and methods to inhibit fibrosis and scarring associated with surgery. The invention further provides compositions and methods to inhibit glial cell invasion, detrimental bone growth and neurite outgrowth. In a preferred embodiment, the inhibitory compositions further comprise an adhesive protein.

These objects and others may be accomplished with the present invention, the first embodiment of which provides an oil-in-water nanoemulsion, which includes:an oily phase dispersed in an aqueous phase;(i) at least one amphiphilic lipid selected from the group including nonionic amphiphilic lipids, anionic amphiphilic lipids, and combinations thereof; and(ii) at least one water-soluble nonionic polymer selected from the group including homopolymers and copolymers of ethylene oxide; polyvinyl alcohols; homopolymers and copolymers of vinylpyrrolidone; homopolymers and copolymers of vinylcaprolactam; homopolymers and copolymers of polyvinyl methyl ether; neutral acrylic homopolymers and copolymers; C1–C2 alkyl celluloses and their derivatives; C1–C3 alkyl guar; C1–C3 hydroxyalkyl guar; and combinations thereof;wherein a ratio of the weight of the oily phase to the weight of the amphiphilic lipid (i) ranges from 1.2 to 10;and wherein the oily phase includes oil globules having a number-average size of less than 100 nm. The nanoemulsion obtained is preferably transparent and stable on storage. It may form a composition for topical, preferably cosmetic or dermatological compositions, pharmaceutical compositions and ophthalmological compositions.