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389results about How to "Type of reduction" patented technology

5' triphosphate oligonucleotide with blunt end and uses thereof

The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells expressing RIG-I. The present invention further provides an oligonucleotide which is capable of activating RIG-I and which has target gene-silencing activity. The oligonucleotide of the present invention has a double-stranded section of at least 19, preferably at least 21 bp, at least one 5′ triphosphate, and at least one blunt end which bears a 5′ triphosphate. The present invention further provides the use said oligonucleotide for inducing an anti-viral, in particular, an IFN, response in vitro and in vivo. The present invention additionally provides the use of said oligonucleotide for preventing and / or treating diseases or conditions such as infections, tumors / cancers, and immune disorders.
Owner:UNIVERSITY OF BONN

Automated mobile positional social media method and system

A method, system, and / or apparatus for automatically tracking a mobile user using the user's mobile device. This invention is particularly useful in the field of social media, such as for detecting and tracking the location and activity of a user and her community. The method or implementing software application uses or relies upon location information available on the mobile device from any source, such as cell phone usage and / or other device applications. The social media system automatically determines a location type and / or user activity from context information. The context information can include current and past location and user and / or community information, time-dependent information, and third party information. The location activities can be presented to the community using pictograms selected to represent user activities.
Owner:AURA HOME INC

Gene expression profile biomarkers and therapeutic targets for brain aging and age-related cognitive impairment

A statistical and functional correlation strategy to identify changes in cellular pathways specifically linked to impaired cognitive function with aging. Analyses using the strategy identified multiple groups of genes expressed in the hippocampi of mammals, where the genes were expressed at different levels for several ages. The aging changes in expression began before mid-life. Many of the genes were involved in specific neuronal and glial pathways with previously unrecognized relationships to aging and/or cognitive decline. The processes identified by the strategy suggest a new hypothesis of brain aging in which initially decreased neuronal activity and/or oxidative metabolism trigger separate but parallel genomic cascades in neurons and glia. In neurons, the cascade results in elevations in calcium signaling and reductions of immediate early gene signaling, biosynthesis, synaptogenesis and neurite remodeling. In contrast, glia undergo increased lipid metabolism and mediate a cycle of demyelination and remyelination that induces antigen presentation, inflammation, oxidative stress and extracellular restructuring. These identified genes and the proteins they encode can be used as novel biomarkers of brain aging and as targets for developing treatment methods against age-related cognitive decline, Alzheimer's Disease and Parkinson's Disease.
Owner:UNIV OF KENTUCKY RES FOUND

Block chain processing method, bookkeeping node and verification node

ActiveCN108665359AReduce the number and type of bookkeeping nodesSimplify system overheadFinanceUser identity/authority verificationChain networkBlockchain
Embodiments of the invention disclose a block chain processing method, a bookkeeping node and a verification node. The block chain processing method applied to the bookkeeping node comprises the stepsof receiving trading information of at least two trading types; based on a consensus mechanism, forming blocks by the trading information of the at least two trading types passing the verification; and releasing the blocks to a block chain network, wherein the blocks are linked according to a trading time sequence corresponding to the trading information to form a block chain, and the block chaincomprises the trading information of the at least two trading types. According to the block chain processing method provided by the embodiment of the invention, the bookkeeping node can receive the trading information of the at least two trading types, and the trading information of the at least two trading types is fused and recorded in the block chain, so that the quantities of blocks and blockchains are reduced, the number and types of bookkeeping nodes in the block chain network are reduced, and the block chain network and the system overhead are simplified and reduced.
Owner:CHINA MOBILE COMM LTD RES INST +1

Building industrialization concrete horizontal structure prefabricated part application primary design method

The invention discloses a building industrialization concrete horizontal structure prefabricated part application primary design method. A general 'standard superposed beam selection parameter and corresponding number table', various forms of 'bending, shearing and twisting reinforcing bar number combination tables' of superposed floor beams of different concrete grades and section sizes, a 'horizontal prefabricated concrete superposed floor beam standard schematic handbook', a general 'standard superimposed floor slab selection parameter and corresponding number table', a 'horizontal prefabricated superposed floor beam standard graph parameter database', a 'horizontal prefabricated superimposed floor slab standard graph parameter database' and the like are compiled, and are matched with parameters, a software module and a computing result of horizontal structure prefabricated part application primary design software adapted from building structure analysis design software. Through adoption of the method, the design, prefabrication and installation application costs of a novel building industrialization structural part can be lowered, and the bottleneck of the existing industrial assembly type concrete building structure application development can be broken.
Owner:浙江省建筑科学设计研究院有限公司

Power tube gate driving circuit and sectional driving method

The invention provides a power tube gate driving circuit and a sectional driving method. The power tube gate driving circuit comprises a pre-driving stage, an output voltage comparison unit and a tri-state compensation driving stage, wherein the pre-driving stage is used for controlling rising time and falling time of a driving signal, so as to switching on or off an insulated gate power switching device; the output voltage comparison unit is used for comparing voltage of the driving signal output by the pre-driving stage with a set threshold value, and then outputting a switching control signal; and the tri-state compensation driving stage is used for charging or discharging a driving output port in a compensatory manner under the enabling action of a switching control signal and the action of the switching control signal output by the output voltage comparison unit, and accelerating the driving output port to pull up or pull down, so as to fully switching on or off the insulated gate power switching device. The power tube gate driving circuit is simple in structure, requires no resistance and capacitance devices, reduces domain area, and has the advantages that gate charging / discharging speed is less affected by variation of capacitive loads, the efficiency is high, the driving circuit is safe and reliable, and the like. The sectional driving method can reduce EMI effectively and reliably.
Owner:CRM ICBG (WUXI) CO LTD
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