64 results about "Oxidative metabolism" patented technology

The present invention is generally related to the discovery of the therapeutic benefit of administering gamma-tocopherol and gamma-tocopherol derivatives. More specifically, the use of gamma-tocopherol and racemic LLU-alpha, (S)-LLU-alpha, or gamma-tocopherol derivatives as antioxidants and nitrogen oxide scavengers which treat and prevent high blood pressure, thromboembolic disease, cardiovascular disease, cancer, natriuretic disease, the formation of neuropathological lesions, and a reduced immune system response are disclosed.

The present invention provides methods of using optimal PET tracers for diagnosing head and neck cancer. Non-invasive methods for assessing tumor perfusion and oxidative metabolism for in vivo imaging with PET tracers that are suitable for uses in radiation therapy (RT) in head and neck cancer and evaluation of salivary gland function are provided. A pharmaceutical comprising the PET tracer and a kit for the preparation of the pharmaceutical are provided as well.

The present invention relates to monitoring of oxidative metabolism and is, particularly, directed to a method for the estimation of lipid peroxide load or the consequent inflammatory state of a subject by measuring the concentration of oxidized HDL lipids of said subject. In addition, the invention is also directed to methods for elimination of lipid peroxidation products, and attenuation of the resulting oxidative stress and inflammatory state in human body, by increasing the lipid peroxide transporting capacity of HDL.

The invention relates to mRNA of PTEN genes. The nucleotide sequence is shown as SEQ ID NO.1. The invention further provides PTEN gene overexpression recombinant adenoviral vectors, namely, the mRNA of the PTEN genes is inserted into multiple cloning sites of the adenoviral vectors, and the invention further provides a construction method and purposes of the PTEN gene overexpression recombinant adenoviral vectors. The PTEN gene overexpression recombinant adenoviral vectors constructed through the method can cause overexpression of the PTEN genes, can promote oxidative metabolism of fatty acid, and can effectively increase and determine assembly and secretion of VLDL. Moreover, the PTEN gene overexpression recombinant adenoviral vectors can enhance transport capacity of triglyceride and can be used for treating fatty liver in dairy cows.

The present invention provides methods and kits for determining the metabolic stability of compounds (e.g., stability to oxidative metabolism). In particular embodiments, the invention provides a method of determining the susceptibility of a compound to metabolism by an enzyme. In one representative embodiment, the enzyme is a cytochrome P450 enzyme. The invention is well-adapted for use in high throughput drug screening programs.

The invention provides application of resveratrol in preparing medicines for preventing and curing vessel endothelial injuries caused by organophosphorus pesticides and also provides an application of the resveratrol in preparing medicines for preventing and curing diseases induced by the vessel endothelial injuries caused by the organophosphorus pesticides. Proved by pharmacological tests, the resveratrol can suppress vessel endothelial dependency diastole reaction reduction caused by the organophosphorus pesticides and has better dose dependency. The resveratrol also has the effects of protecting the vessel endothelial cell activity and preventing vessel endothelial permeability increase caused by oxygen and phosphorus and morphologic changes and can also protect the function of endothelial cells for releasing NO and the activity of superoxide dismutase and reduce the content of malondialdehyde which is a lipid peroxided metabolic product.

Alternative cellular energy pigments (ACE-pigments) provide a source of cellular energy other than that provided through the oxidative metabolism of foods, or in the case of plants and certain bacteria, through the process of photosynthesis. In some patients, ACE pigments exist in a form that can be further energized or activated using ultraviolet (UV) light, especially if the reaction is initially triggered by the presence of suitable dyes, such as neutral red. A method is described to further enhance the activation of the ACE pathway in humans and animals deprived of ACE. The method comprises using natural or man-made sources of ACE products (enerceuticals), with or without the inclusion of a suitable dye, such as neutral red; or other activating components, such as magnesium chloride; with the combined mixture being put into a UV transparent container, such as a plastic bag, or placed on some other material, which can be laid onto the skin and illuminated with a UV light source. The process of activating the ACE pathway is evidenced by UV inducible fluorescence seen within areas of the patients' skin and/or mucus membranes. This fluorescence fades as the ACE pathway becomes fully activated. Activating the ACE pathway can have therapeutic benefits in various infectious and non-infectious diseases including illnesses attributed to infections with stealth adapted and conventional viruses and diseases attributed to an inadequacy of the mitochondria and associated metabolic pathways, including states of hypoxia and nutritional deficiencies.

The invention relates to a novel tetrahydronaphthalene derivative and application thereof to preparing a medicine for preventing and/or treating breast cancer osteoporosis. The tetrahydronaphthalene derivative disclosed by the invention is an ideal selective estrogen receptor modulator and can be used for treating or preventing various indications relative to estrogen, in particular breast cancer osteoporosis after menopause. The tetrahydronaphthalene derivative has lower oxidative metabolism and higher effective bioavailability, therefore having the advantages of less application dosage, better tolerance and little side effect.

The invention relates to compounds capable of serving as tyrosine kinase inhibitors and medicinal application thereof in treating malignant tumor. Compared with the prior art, the oxidative metabolism of the compounds provided by the invention is reduced, and the medicinal power performance is improved; and moreover, the compounds have the advantages of less dosage and small side effects.

Alternative cellular energy pigments (ACE-pigments) provide a source of cellular energy other than that provided through the oxidative metabolism of foods, or in the case of plants and certain bacteria, through the process of photosynthesis. In some patients, ACE pigments exist in a form that can be further energized or activated using ultraviolet (UV) light, especially if the reaction is initially triggered by the presence of suitable dyes, such as neutral red. A method is described to assess the energy status of the ACE pathway in an individual or animal and also a method that involves the use of UV light in conjunction with a suitable dye, for activating the pathway in those individuals or animals in which the pathway is not fully charged. Kits for these purposes are also described.

The present invention relates to a method for producing a medium chain aminocarboxylic acid and, more particularly, to a recombinant microorganism in which a fatty aldehyde dehydrogenase gene in ω-oxidative metabolic pathway and a β-oxidative metabolic pathway-related gene are deleted and a ω-transaminase gene is introduced, and a method for producing a medium chain aminocarboxylic acid by culturing the recombinant microorganism. The recombinant microorganism of the present invention can prevent additional oxidation of fatty aldehyde and β-oxidative metabolism and also produce a medium chain aminocarboxylic acid, such as 12-aminodecane, as a raw material of nylon 12 from a substrate such as fatty acid with a high yield by introducing an amine group into a terminal thereof.

The invention discloses a sewage treatment process taking photosynthetic bacteria (PSB for short) as a biochemical core. The technology is as follows: sewage is subjected to a pretreatment/pretreatment process; inoculating a treatment method taking photosynthetic bacteria as a biochemical core; a photosynthetic bacterium biochemical device is specially designed, configured and controlled to operate; the unique growth characteristics (two metabolic pathways of light energy metabolism and oxidative metabolism) of photosynthetic bacteria are utilized to implement growth and proliferation of the bacteria, and the organic pollutants in the sewage are absorbed, converted and degraded by forming advantageous photosynthetic bacteria groups, thereby finally achieving the goal of sewage purificationtreatment.

The present invention provides methods of increasing muscle mass and muscle mitochondrial oxidative metabolism. Additionally, the invention provides treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, muscular dystrophy disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging.

There is provided an ex vivo method for reducing the immunogenicity of a tissue or organ prior to transplantation, comprising:

• • (a) establishing the tissue or organ in a warm perfusion system capable of supporting oxidative metabolism of the tissue or organ;
  • (b) perfusing the tissue or organ with a warm non-blood perfusion solution for at least 1 hour to allow passenger leukocytes within the tissue or organ to migrate from the tissue or organ into the recirculating perfusion solution;
  • (c) isolating the passenger leukocytes from the recirculating perfusion solution to prevent the passenger leukocytes from re-entering the tissue or organ.

The invention provides an anti-aging composition, and relates to the technical field of anti-aging. The anti-aging composition comprises NMN and/or NR. The anti-aging composition provided by the invention has the advantages that the anti-aging composition mainly comprises NMN and/or NR, adjusts a main clock in an organism to a normal state, improves the NAD + level in the organism, maintains the rejuvenation of mitochondria, resists the aging of cells, maintains the regeneration capacity of blood capillaries, prevents and relieves various physiological and pathology processes related to agingin the organism, so that the physiological state tends to be normal young; meanwhile, the muscle state of an organism is also improved, the SIRT1 activity is increased, skeletal muscle oxidative metabolism and energy generation are increased, the endurance and exercise capacity of the organism are improved, sleep is improved, energy resistance and aging resistance are improved, and meanwhile suffering from excessive internal heat is relieved.

A method for preparing for glycoprotein in Chinese yam to enhance the activity of metabolic enzymes of brain mitochondria may include steps of: grinding the Chinese yam into fine powers; adding water into the fine powers and heating up to 50-100° C. to form a mixture, and the amount of water is 2 to 5 times as much as the Chinese yam; extracting the mixture twice, and combining the two extracting solutions; concentrating the extracting solution and adding 95% ethyl alcohol to obtain a first mixed liquid with 60-75% ethyl alcohol concentration and white sediments start to appear; separating the white sediments from a first supernate; adding 95-98% ethyl alcohol in the first supernate to obtain a second mixed liquid with 90-95% ethyl alcohol concentration and brown emplastic sediments start to appear; removing a second supernate; and collecting and drying the brown sediments to obtain brown glycoprotein in Chinese yam.