65 results about "Oxidative metabolism" patented technology

The present invention is generally related to the discovery of the therapeutic benefit of administering gamma-tocopherol and gamma-tocopherol derivatives. More specifically, the use of gamma-tocopherol and racemic LLU-alpha, (S)-LLU-alpha, or gamma-tocopherol derivatives as antioxidants and nitrogen oxide scavengers which treat and prevent high blood pressure, thromboembolic disease, cardiovascular disease, cancer, natriuretic disease, the formation of neuropathological lesions, and a reduced immune system response are disclosed.

A statistical and functional correlation strategy to identify changes in cellular pathways specifically linked to impaired cognitive function with aging. Analyses using the strategy identified multiple groups of genes expressed in the hippocampi of mammals, where the genes were expressed at different levels for several ages. The aging changes in expression began before mid-life. Many of the genes were involved in specific neuronal and glial pathways with previously unrecognized relationships to aging and / or cognitive decline. The processes identified by the strategy suggest a new hypothesis of brain aging in which initially decreased neuronal activity and / or oxidative metabolism trigger separate but parallel genomic cascades in neurons and glia. In neurons, the cascade results in elevations in calcium signaling and reductions of immediate early gene signaling, biosynthesis, synaptogenesis and neurite remodeling. In contrast, glia undergo increased lipid metabolism and mediate a cycle of demyelination and remyelination that induces antigen presentation, inflammation, oxidative stress and extracellular restructuring. These identified genes and the proteins they encode can be used as novel biomarkers of brain aging and as targets for developing treatment methods against age-related cognitive decline, Alzheimer's Disease and Parkinson's Disease.

The invention relates to a novel benzothiophene derivative and application thereof in preventive and / or treatment medicine for breast cancer and osteoporosis. The benzothiophene derivative is an ideal selective estrogen receptor modulator, can be used for treating or preventing various indications related to estrogen functions, and is particularly applicable to treating post-menopause breast cancer and osteoporosis. The compound has the advantages that oxidative metabolism is lowered, effective bioavailability is higher, and accordingly, dosage of the compound is little, tolerance of the compound is fine, and side effects are low.

The invention relates to a novel pyridine androstane derivative and application thereof to preparing a medicine for preventing and / or treating prostatic cancer. The pyridine androstane derivative disclosed by the invention is an ideal selective cytochrome oxidase CYP450c17 inhibitor and can be used for treating or preventing various indications relative to male hormonal functions, in particular prostatic cancer. The pyridine androstane derivative has lower oxidative metabolism and higher effective bioavailability, therefore having the advantages of less application dosage, better tolerance and little side effect.

The invention relates to a sewage treatment device and particularly relates to a biological membrane electrode and UASB (Upflow Anaerobic Sludge Blanket) coupled reactor comprising a reactor cylinder, a biological membrane electrode system, an electrochemical testing system and a cathode potential testing device, wherein the reactor cylinder internally and sequentially comprises a water distribution plate and the biological membrane electrode system from bottom to top; a sludge bed region is arranged between the biological membrane electrode system and a three-phase separator; the biological membrane electrode system comprises an anode and a cathode; the cathode potential testing device comprises a reference electrode, a salt bridge and sealed electrolyte, wherein the salt bridge is used for communicating the sludge bed region near the cathode and the sealed electrolyte, one end of the reference electrode is connected with the sealed electrolyte, and the other end of the reference electrode is connected with the electrochemical testing system. The biological membrane electrode and UASB coupled reactor provided by the invention is used for promoting the oxidative metabolism of microorganisms to organic pollutants and increasing the COD (Chemical Oxygen Demand) removal rate through the coupling effect of a micro electric field and the microorganisms; meanwhile, the micro electric field can be used for promoting the transfer of electrons in the system and increasing the degradation rate of the pollutants.

The present invention provides methods of using optimal PET tracers for diagnosing head and neck cancer. Non-invasive methods for assessing tumor perfusion and oxidative metabolism for in vivo imaging with PET tracers that are suitable for uses in radiation therapy (RT) in head and neck cancer and evaluation of salivary gland function are provided. A pharmaceutical comprising the PET tracer and a kit for the preparation of the pharmaceutical are provided as well.

The present invention relates to monitoring of oxidative metabolism and is, particularly, directed to a method for the estimation of lipid peroxide load or the consequent inflammatory state of a subject by measuring the concentration of oxidized HDL lipids of said subject. In addition, the invention is also directed to methods for elimination of lipid peroxidation products, and attenuation of the resulting oxidative stress and inflammatory state in human body, by increasing the lipid peroxide transporting capacity of HDL.

The invention relates to a novel 2-arylthiazole derivative and medicinal salts thereof, and an application in the preparation of medicaments for preventing and / or treating gout. The compound of the invention is an ideal selective xanthine oxidoreductase inhibitor, is applicable to the treatment and prevention of various indications associated with uric acid synthesis in the body, and is especially applicable to the treatment of gout. The compound has reduced oxidative metabolism and acyl glucuronidation metabolism, reduced first-pass effect, higher effective bioavailability, and less side effect due to its low using amount.

The present invention is generally related to the discovery of the therapeutic benefit of administering gamma-tocopherol and gamma-tocopherol derivatives. More specifically, the use of gamma-tocopherol and racemic LLU-alpha, (S)-LLU-alpha, or gamma-tocopherol derivatives as antioxidants and nitrogen oxide scavengers which treat and prevent high blood pressure, thromboembolic disease, cardiovascular disease, cancer, natriuretic disease, the formation of neuropathological lesions, and a reduced immune system response are disclosed.

The present invention relates to a method for producing a heavy chain aminocarboxylic acid and, more particularly, to a recombinant microorganism in which a fatty aldehyde dehydrogenase gene in [omega]-oxidative metabolic pathway and a [beta]-oxidative metabolic pathway-related gene are deleted and a [omega]-transaminase gene is introduced, and a method for producing a heavy chain aminocarboxylicacid by culturing the recombinant microorganism. The recombinant microorganism of the present invention can prevent additional oxidation of fatty aldehyde and [beta]-oxidative metabolism and also produce a heavy chain aminocarboxylic acid, such as 12-aminodecane, as a raw material of nylon 12 from a substrate such as fatty acid with a high yield by introducing an amine group into a terminal thereof.

The present invention provides methods of using optimal PET tracers for diagnosing head and neck cancer. Non-invasive methods for assessing tumor perfusion and oxidative metabolism for in vivo imaging with PET tracers that are suitable for uses in radiation therapy (RT) in head and neck cancer and evaluation of salivary gland function are provided. A pharmaceutical comprising the PET tracer and a kit for the preparation of the pharmaceutical are provided as well.

The invention relates to mRNA of PTEN genes. The nucleotide sequence is shown as SEQ ID NO.1. The invention further provides PTEN gene overexpression recombinant adenoviral vectors, namely, the mRNA of the PTEN genes is inserted into multiple cloning sites of the adenoviral vectors, and the invention further provides a construction method and purposes of the PTEN gene overexpression recombinant adenoviral vectors. The PTEN gene overexpression recombinant adenoviral vectors constructed through the method can cause overexpression of the PTEN genes, can promote oxidative metabolism of fatty acid, and can effectively increase and determine assembly and secretion of VLDL. Moreover, the PTEN gene overexpression recombinant adenoviral vectors can enhance transport capacity of triglyceride and can be used for treating fatty liver in dairy cows.

The invention relates to an organic molecular probe material with a nucleus-shell structure. A core is transition metal complex; a shell layer is an amphiphilic polymer; metal ion is Ru2+ (ruthenium), Os2+ (osmium) or Re+ (rhenium); the ligands are monosubstitution or polysubstituted morpholine and monosubstitution or polysubstituted 2,2'-bipyridyl; and the amphiphilic polymer is a copolymer formed by polyethylene glycol methacrylate and dimethylamino ethyl methacrylate. The organic molecular probe material has the advantages that the organic molecular probe material has the nucleus-shell structure, wraps a fluorescent material of the transition metal complex in the amphiphilic polymer, is favorable for strengthening the ligand exchange in environment of resisting complex cells by the fluorescent material and rapid oxidative metabolism of cells on the fluorescent material, thereby stabilizing the fluorescence luminous performance of the ligand; and the spherical luminous nano-particles has the function of transfecting implanted fluorescent protein gene plasmid, and realizes dual-marking function of rapid timely trace labeling and long-term trace marking, so the spherical luminous nano-particle has wider application.

The invention relates to an application of Chinese yarn glycoprotein in improvement of the activities of an oxidative metabolism enzymes of mitochondria of a brain cell. Selection and verification are carried out by an animal test so as to prove that the Chinese yarn glycoprotein can obviously improve the activities of key enzymes namely pyruvate dehydrogenase and alpha-oxoglutarate dehydrogenase used for oxidative metabolism in the mitochondria of the brain cell, so that brain cell deterioration and damage diseases, such as senile dementia, vascular dementia, cerebral infarction and cerebral palsy, accompanying with oxidative metabolism efficiency reduction caused by reduction of the activities of the enzymes can be effectively treated.

The invention discloses a solvent for improving the antioxidation metabolic capacity of flue-cured tobacco. The solvent is characterized by being prepared from the following ingredients by weight percent: 0.1-0.5% of betaine, 0.05-0.25% of proline, 0.01-0.05% of nano carbon sol and the balance of water. The application method of the solvent is as follows: the solvent is used for 2-3 times in the early flourishing stage of a tobacco plant and interval time between two times of applications is 3-5 days; and the solvent is uniformly sprayed on the front face and the back face of a tobacco leaf by a sprayer, and the spraying reaches the effect that the leaf face is wet and water does not drop from the leaf. The solvent is based on the antioxidation metabolism characteristic of the tobacco leaf, the activities of superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) of the tobacco leaf can be improved, the content of the important antioxidation metabolic substance, namely proline (Pro) is increased, and the content of membranous maleicdialdehyde (MDA) in the tobacco leaf is reduced. The experiments prove that the spraying of the solvent disclosed by the invention can effectively reduce the adverse effect of drought stress on the flue-cured tobacco, the normal growth and development of the tobacco plant can be maintained, and the yield and output value of the tobacco leaf can be ensured.

The present invention provides methods and kits for determining the metabolic stability of compounds (e.g., stability to oxidative metabolism). In particular embodiments, the invention provides a method of determining the susceptibility of a compound to metabolism by an enzyme. In one representative embodiment, the enzyme is a cytochrome P450 enzyme. The invention is well-adapted for use in high throughput drug screening programs.

Alternative cellular energy pigments (ACE-pigments) provide a source of cellular energy other than that provided through the oxidative metabolism of foods, or in the case of plants and certain bacteria, through the process of photosynthesis. In some patients, ACE pigments exist in a form that can be further energized or activated using ultraviolet (UV) light, especially if the reaction is initially triggered by the presence of suitable dyes, such as neutral red. A method is described to further enhance the activation of the ACE pathway in humans and animals deprived of ACE. The method comprises using natural or man-made sources of ACE products (enerceuticals), with or without the inclusion of a suitable dye, such as neutral red; or other activating components, such as magnesium chloride; with the combined mixture being put into a UV transparent container, such as a plastic bag, or placed on some other material, which can be laid onto the skin and illuminated with a UV light source. The process of activating the ACE pathway is evidenced by UV inducible fluorescence seen within areas of the patients' skin and / or mucus membranes. This fluorescence fades as the ACE pathway becomes fully activated. Activating the ACE pathway can have therapeutic benefits in various infectious and non-infectious diseases including illnesses attributed to infections with stealth adapted and conventional viruses and diseases attributed to an inadequacy of the mitochondria and associated metabolic pathways, including states of hypoxia and nutritional deficiencies.

The invention relates to a novel tetrahydronaphthalene derivative and application thereof to preparing a medicine for preventing and / or treating breast cancer osteoporosis. The tetrahydronaphthalene derivative disclosed by the invention is an ideal selective estrogen receptor modulator and can be used for treating or preventing various indications relative to estrogen, in particular breast cancer osteoporosis after menopause. The tetrahydronaphthalene derivative has lower oxidative metabolism and higher effective bioavailability, therefore having the advantages of less application dosage, better tolerance and little side effect.

The invention relates to compounds capable of serving as tyrosine kinase inhibitors and medicinal application thereof in treating malignant tumor. Compared with the prior art, the oxidative metabolism of the compounds provided by the invention is reduced, and the medicinal power performance is improved; and moreover, the compounds have the advantages of less dosage and small side effects.

The present invention relates to a method for producing a medium chain aminocarboxylic acid and, more particularly, to a recombinant microorganism in which a fatty aldehyde dehydrogenase gene in ω-oxidative metabolic pathway and a β-oxidative metabolic pathway-related gene are deleted and a ω-transaminase gene is introduced, and a method for producing a medium chain aminocarboxylic acid by culturing the recombinant microorganism. The recombinant microorganism of the present invention can prevent additional oxidation of fatty aldehyde and β-oxidative metabolism and also produce a medium chain aminocarboxylic acid, such as 12-aminodecane, as a raw material of nylon 12 from a substrate such as fatty acid with a high yield by introducing an amine group into a terminal thereof.

The invention discloses a sewage treatment process taking photosynthetic bacteria (PSB for short) as a biochemical core. The technology is as follows: sewage is subjected to a pretreatment / pretreatment process; inoculating a treatment method taking photosynthetic bacteria as a biochemical core; a photosynthetic bacterium biochemical device is specially designed, configured and controlled to operate; the unique growth characteristics (two metabolic pathways of light energy metabolism and oxidative metabolism) of photosynthetic bacteria are utilized to implement growth and proliferation of the bacteria, and the organic pollutants in the sewage are absorbed, converted and degraded by forming advantageous photosynthetic bacteria groups, thereby finally achieving the goal of sewage purificationtreatment.

The invention relates to an ultrasonic dredging robot device capable of freely moving in a blood vessel front and back. The ultrasonic dredging robot device comprises a strip-shaped shell, an electricpropelling mechanism, a storage battery and a high-frequency ultrasonic vibration element, wherein the electric propelling mechanism is composed of paddles, an ultra-micro motor and a gear assembly;the high-frequency ultrasonic vibration element and the storage battery are mounted in the strip-shaped shell; the high-frequency ultrasonic vibration element, the ultra-micro motor and the storage battery are electrically connected; and the electric propelling mechanism is mounted at the end part of the strip-shaped shell. The ultrasonic dredging robot device can move in the blood vessel and canbe used for carrying out ultrasonic cavitation on blood, so that fat in the blood can be broken into relatively fine particles by cavitation; under the ultrasonic cavitation effect, blood molecules move in an accelerated manner and the body temperature is raised; and the fine particle fat is subjected to peroxidation metabolism by a main component, namely triglyceride, in the fat under the effectof body hormones, and the triglyceride is decomposed and converted into energy, water and carbon dioxide to be discharged out of a body, so that the treatment effect of treating both principal and secondary aspects of diseases is realized.

The present invention provides methods of increasing muscle mass and muscle mitochondrial oxidative metabolism. Additionally, the invention provides treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, muscular dystrophy disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging.

There is provided an ex vivo method for reducing the immunogenicity of a tissue or organ prior to transplantation, comprising:(a) establishing the tissue or organ in a warm perfusion system capable of supporting oxidative metabolism of the tissue or organ;(b) perfusing the tissue or organ with a warm non-blood perfusion solution for at least 1 hour to allow passenger leukocytes within the tissue or organ to migrate from the tissue or organ into the recirculating perfusion solution;(c) isolating the passenger leukocytes from the recirculating perfusion solution to prevent the passenger leukocytes from re-entering the tissue or organ.

The invention provides an anti-aging composition, and relates to the technical field of anti-aging. The anti-aging composition comprises NMN and / or NR. The anti-aging composition provided by the invention has the advantages that the anti-aging composition mainly comprises NMN and / or NR, adjusts a main clock in an organism to a normal state, improves the NAD + level in the organism, maintains the rejuvenation of mitochondria, resists the aging of cells, maintains the regeneration capacity of blood capillaries, prevents and relieves various physiological and pathology processes related to agingin the organism, so that the physiological state tends to be normal young; meanwhile, the muscle state of an organism is also improved, the SIRT1 activity is increased, skeletal muscle oxidative metabolism and energy generation are increased, the endurance and exercise capacity of the organism are improved, sleep is improved, energy resistance and aging resistance are improved, and meanwhile suffering from excessive internal heat is relieved.

The invention belongs to the technical field of judicial expertise and analytic chemistry, and relates to a method for detecting ethyl alcohol non-oxide metabolins in human whole blood, in particularto a method for simultaneously detecting 4 species of ethyl alcohol non-oxide metabolins (10 kinds in total) in the human whole blood. The method for simultaneously, qualitatively and quantitatively analyzing 4 species of ethyl alcohol non-oxide metabolins with big nature differences is built, has high sensitivity, high specificity and a wide linearity range, can be used for determining the natures and the quantity of the 4 species of ethyl alcohol non-oxide metabolins (10 kinds in total) in 50mu L of human whole blood few examined material, is simple and fast to operate and less in extractionsolvent dosage, can meet the requirements on judicial expertise task urgency and high detection time demand, and can be popularized and applied on a large scale.

A method for preparing for glycoprotein in Chinese yam to enhance the activity of metabolic enzymes of brain mitochondria may include steps of: grinding the Chinese yam into fine powers; adding water into the fine powers and heating up to 50-100° C. to form a mixture, and the amount of water is 2 to 5 times as much as the Chinese yam; extracting the mixture twice, and combining the two extracting solutions; concentrating the extracting solution and adding 95% ethyl alcohol to obtain a first mixed liquid with 60-75% ethyl alcohol concentration and white sediments start to appear; separating the white sediments from a first supernate; adding 95-98% ethyl alcohol in the first supernate to obtain a second mixed liquid with 90-95% ethyl alcohol concentration and brown emplastic sediments start to appear; removing a second supernate; and collecting and drying the brown sediments to obtain brown glycoprotein in Chinese yam.