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Application of resveratrol in preparing medicines for preventing and curing vessel endothelial injuries caused by organophosphorus pesticides

A technology of organophosphorus pesticides and resveratrol, which is applied in drug combinations, cardiovascular system diseases, active ingredients of hydroxyl compounds, etc., can solve problems such as body damage, achieve life extension, good dose dependence, and block vascular endothelium The effect of increased cell permeability

Inactive Publication Date: 2010-08-25
XINXIANG MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although most farmers have paid attention to the prevention of acute organophosphate poisoning, they have not pa

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  • Application of resveratrol in preparing medicines for preventing and curing vessel endothelial injuries caused by organophosphorus pesticides
  • Application of resveratrol in preparing medicines for preventing and curing vessel endothelial injuries caused by organophosphorus pesticides
  • Application of resveratrol in preparing medicines for preventing and curing vessel endothelial injuries caused by organophosphorus pesticides

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Abstract

The invention provides application of resveratrol in preparing medicines for preventing and curing vessel endothelial injuries caused by organophosphorus pesticides and also provides an application of the resveratrol in preparing medicines for preventing and curing diseases induced by the vessel endothelial injuries caused by the organophosphorus pesticides. Proved by pharmacological tests, the resveratrol can suppress vessel endothelial dependency diastole reaction reduction caused by the organophosphorus pesticides and has better dose dependency. The resveratrol also has the effects of protecting the vessel endothelial cell activity and preventing vessel endothelial permeability increase caused by oxygen and phosphorus and morphologic changes and can also protect the function of endothelial cells for releasing NO and the activity of superoxide dismutase and reduce the content of malondialdehyde which is a lipid peroxided metabolic product.

Description

technical field The invention relates to the application of resveratrol, in particular to the application of resveratrol in the preparation of medicines for preventing and treating vascular endothelial damage caused by organophosphorus pesticides. Background technique my country is a large agricultural country, and it is also one of the countries in the world where organophosphorus pesticides are widely used and organophosphorus pollution is relatively serious. Organophosphorus (OPs) pesticides (such as paraoxon, triazophos, phoxim, profenofos, etc.) It is widely used in rural areas of our country. Although most farmers have paid attention to the prevention of acute organophosphate poisoning, they have not paid enough attention to the damage to the body caused by long-term low-dose exposure to organophosphate pesticides. At present, studies abroad have pointed out that the activity and concentration of paraoxonase-1 (PON1) in the body of flower workers who spray organophosph...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P9/00A61P9/10A61P9/12A61P3/10
Inventor 李鹏尹雅玲詹合琴卢光洲梁金英朱茉莉赵繁荣张玉林
Owner XINXIANG MEDICAL UNIV
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