The invention discloses a making method for loofah sponge cloth shoes. Making of the loofah sponge cloth shoes can be completed through the steps of early-stage preparation, cloth board making, sole making, sole smoking and upper sewing. The making method has the advantages that the loofah sponge cloth shoes can improve circulation capacity of blood of the feet, dispel pain in the feet, remove fatigue, kill bacteria on the feet, remove dermatophytosis, reduce breeding of bacteria, prevent foot diseases, prevent foot odor, simulate foot acupoints, achieve a massage effect, dredge the channel, improve the organ functions of the body and achieve a healthcare effect; besides, no chemical substance is adopted in the making process, and therefore the loofah sponge cloth shoes are ecological and environmentally friendly, will not harm the body, can protect the health of people and is good in ecology and healthcare effect and easy to popularize.