1869 results about "Injury cause" patented technology

A cartilage plug, which is made from a biocompatible, artificial material, that is used to fill a void in natural cartilage that has been resected due to traumatic injury or chronic disease. Alternatively, the plug may be relied upon to anchor a flowable polymer to subchondral bone. The plug is prefabricatable in any size, shape, and contour and may be utilized either singly or in a plurality to fill any size void for any application. The plug may be formed of a laminated structure to match the physiological requirements of the repair site. A plurality of anchoring elements may share a single upper layer.

Devices and methods are disclosed for achieving chest drainage in humans or other animals. Chest drainage is often required following traumatic injury or surgery. The devices and methods disclosed herein are especially useful in the emergency, trauma surgery or military setting. The devices utilize a chest tube with a cutting distal end and a central blunt trocar. The blunt trocar or obturator shields the sharp cutting distal end of the chest tube until controllably retracted. Once the blunt trocar or obturator is retracted, the chest tube is advanced out through its sterile, protective package and into the patient. The blunt trocar is advanced back into its position to shield the sharp tip of the chest tube during patient insertion. The chest tube also includes a hold-down mechanism that is created by an adhesive seal to the patient's chest and ribbons or straps that are wrapped around the chest tube once it is correctly positioned. The straps include adhesive ends to grip the chest tube once the straps are in place.

Disclosed are a method and a corresponding pharmaceutical composition for treating damaged cartilage and subchondral bone. Neurogenic compounds in general and neuropeptides in particular have been found to be highly effective in stimulated repair of cartilage and bone damaged due to traumatic injury, ligament disease, and disuse. Preferred active ingredients for use in the method and corresponding pharmaceutical composition include calcitonin gene-related peptide (CGRP), cholecystokinin (CCK), dynorphin, enkephalin, galanin, neuropeptide Y (NPY), neurotensin, somatostatin, substance P (SP), thyrotropin-releasing hormone (TRH), vasoactive intestinal peptide (VIP).

This invention relates to methods of screening for modulators of mammalian cell injury cause by TRPM7 gene and protein activity, compounds that modulate TRPM7 gene and protein activity and methods of treatment of mammalian cell injury using modulators of TRPM7 gene and protein activity.

A cartilage plug, which is made from a biocompatible, artificial material, that is used to fill a void in natural cartilage that has been resected due to traumatic injury or chronic disease is disclosed. Alternatively, the plug may be relied upon to anchor a flowable polymer to subchondral bone. The plug is prefabricatable in any size, shape, and contour and may be utilized either singly or in a plurality to fill any size void for any application. The plug may be formed of a laminated structure to match the physiological requirements of the repair site. Additionally, ridges may be formed about the periphery of each plug to facilitate its anchoring to surrounding cartilage, bone and / or adjacent plugs. A procedure for resecting damaged or diseased cartilage and for implanting a replacement plug or plugs according to this invention, as well as a set of instruments for effecting the procedure, and a self-contained system for orthopaedic surgeons, which includes a variety of differently sized and shaped plugs, as well as a set of instruments for the procedure are also disclosed.

The invention discloses detumescent and analgesic ointment for curing rheumatism and contusion and a preparation method thereof. The ointment is a pure herbal pharmaceutics, which is composed of monarch drugs, ministerial drugs, adjuvant drugs and conductant drugs. The preparation method comprises the following steps: placing 5kg of tung oil in a pan; grinding all traditional Chinese bug bulk pharmaceutical chemicals (BPC) into refined powder, wrapping the adjuvant drugs and the conductant drugs with gauzes, and placing into a frying pan for boiling; boiling with charcoal fire for 90min, putting the powder in to the frying pan after generating smokes, and boiling the mixture to obtain semi-creamy mixture; placing the ministerial drugs into the pan for even stirring to obtain semi-creamy mixture; taking the pan away from the fire and putting the monarch drugs into ointment for even stirring; placing 2.5kg of rosin into the ointment and evenly stirring to obtain the ointment, and pasting the ointment on kraft papers with 11 centimeters; and pressing the ointment on the kraft papers by a 6-centimeter iron module to obtain the ointment with diameter of 6 centimeters, and placing the obtained ointment on fixed patches. The detumescent and analgesic ointment for curing rheumatism and contusion can be used for stimulating the circulation of the blood and causing the muscles and joints to relax, relieving bruises and pains, and curing traumatic injuries and rheumatoid arthritis.

A fixator for use in the reconstruction of acute, chronic and traumatic injuries to the upper and lower extremities. The fixator has a unique clamping system that allows for the snapping in of pins and rails, and for multi-planar fixation of bones.

A method of producing a homogenous population of homozygous stem (HS) cells pre-selected for immunotype and / or genotype from donor cells is described herein. The invention relates to methods of using immunohistocompatible HS cells for diagnosis, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, traumatic injuries and cancer. The invention further relates to methods for using histocompatible HS stem cells pre-selected for a non-disease genotype for prophylactic and therapeutic intervention including, but not limited to, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, and cancer. Furthermore, the invention relates to a catalogued transplant depository of HS cells derived from multiple donors, each of the HS cells being homozygous for a unique HLA haplotype, for the purpose of having a constant, reliable, comprehensive supply of immunohistocompatible cells for diagnosis, treatment and / or transplantation.

The present invention provides a composition, and a method of use thereof for treating connective tissue damage in man and in animals, which comprises a therapeutically effective amount of chondroitin sulfate, N-acetyl D-glucosamine, and hyaluronan (hyaluronic acid). Particularly, the present invention provides a composition, and a method of use thereof, for treating connective tissue damage including, but not limited to, arthritic disease, osteoarthritis, rheumatoid arthritis, osterochondrosis dessicans, cartilage damage, joint injury, joint inflammation, joint synovitis, degenerative joint disease (DJD), post surgical DJD, traumatic injury, fracture, tendon damage, ligament damage, skeletal damage, musculoskeletal damage, fiber damage, adipose tissue damage, blood cell damage, and plasma damage. Compositions for delivery of the present invention include those for parenteral, oral, and transmucosal delivery and for direct surgical placement onto the affected tissues.

An improved design for a helmet to reduce injuries caused by helmet-to-helmet collisions. The helmet has a thin layer of padding added onto the hard shell of the helmet. The padding may be textured to add “crumple zones.” A thin, rugged, low-friction exterior cover is affixed to the padding. In one embodiment of the helmet, the cover is separated slightly from the padding to provide air space. The air space, combined with the textured padding, provides a substantial reduction in peak acceleration resulting from a helmet-to-helmet collision.

The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and / or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.