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Application of hyaluronic acid and hyaluronate in preparation of composition for treating and alleviating xerostomia

A hyaluronic acid salt and hyaluronic acid technology, applied in the medical field, can solve problems such as poor taste and short action time, and achieve the effect of improving the oral environment and promoting wound healing

Active Publication Date: 2013-11-27
北京泰克美高新技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this kind of artificial saliva alleviates the suffering of patients to a certain extent, its defect is that the mouthfeel is poor and the action time is short.

Method used

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  • Application of hyaluronic acid and hyaluronate in preparation of composition for treating and alleviating xerostomia
  • Application of hyaluronic acid and hyaluronate in preparation of composition for treating and alleviating xerostomia
  • Application of hyaluronic acid and hyaluronate in preparation of composition for treating and alleviating xerostomia

Examples

Experimental program
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Effect test

Embodiment 1

[0055] A composition of the following ingredients is prepared:

[0056] Hyaluronic acid (molecular weight 3000kDa) 0.1wt%

[0057] Distilled water balance

Embodiment 2

[0059] A composition of the following ingredients is prepared:

[0060] Sodium hyaluronate (molecular weight 2000kDa) 1.5wt%

[0061] Distilled water balance

Embodiment 3

[0063] A composition of the following ingredients is prepared:

[0064] Potassium hyaluronate (molecular weight 1000kDa) 2wt%

[0065] Calcium hyaluronate (molecular weight 500kDa) 1wt%

[0066] Distilled water balance

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PUM

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Abstract

The invention provides an application of hyaluronic acid and hyaluronate in preparation of a composition for treating and alleviating xerostomia and the composition for treating and alleviating xerostomia. As hyaluronic acid and hyaluronate thereof are in double helix columnar structures, and massive hydroxyls exist inside the double helix structures, the hyaluronic acid and hyaluronate thereof have a very good water holding effect, so that the hyaluronic acid and hyaluronate thereof have lasting moisturizing effect on oral cavity. Furthermore, the hyaluronic acid and hyaluronate thereof can promote wound healing and have the effects of healing anabrosis and the like. In addition, the hyaluronic acid and hyaluronate thereof are colorless and tasteless and free from toxicity, belong to synthetic substances in human body, and are easy to be compatible with ions such as sodium, potassium, calcium, zinc, ferrum and silver ions, so that the hyaluronic acid and hyaluronate thereof have the taste which is suitable for being accepted by human body.

Description

technical field [0001] The invention belongs to the medical field, and in particular relates to the application of hyaluronic acid and hyaluronate in a composition for treating and alleviating dry mouth. Background technique [0002] A normal person's saliva secretion is about 1500ml a day, so as to moisten the oral mucosa without feeling dry mouth. Dry mouth is a symptom caused by a lack of saliva in the mouth. The production and secretion of saliva is influenced by systemic, local, external and self factors. There are many reasons for dry mouth, including emotional agitation, anxiety, radiation exposure, chemotherapy, salivary gland removal, side effects of certain special drugs (such as diabetes drugs, neuropathy drugs), and no drinking water for 24 hours before and after surgery. [0003] The consequences of dry mouth include chewing, swallowing, and speaking difficulties, interruption of sleep processes, and more seriously, dental disease leading to oral mucosal ulcer...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61P1/02
Inventor 王兵邢艳平范雪张冰月吕伟青
Owner 北京泰克美高新技术有限公司
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