256 results about "Helix structure" patented technology

A bio-nanowire device includes a substrate having a first surface, a first conductor, a second conductor, and a bio-nanowire. The first and second conductors are disposed on the first surface of the substrate, and are spaced apart from each other. The bio-nanowire has two ends respectively connected to the first and second conductors, and includes a nucleic acid molecule having two nucleotide segments, and a plurality of metal ions bonded between the two nucleotide segments of the nucleic acid molecule. The two nucleotide segments form a double helix structure via base pairs. When a voltage or a current is applied to the bio-nanowire, the oxidation state of the metal ions can be changed such that the non-linear electroconductive characteristic of the bio-nanowire can be controlled.

The invention relates to a compressed storage and construction method of a two-way multi-step de Bruijn graph, and the compressed storage and construction method of the two-way multi-step de Bruijn graph includes compressed storage steps and de Bruijn graph construction steps. The compressed storage and construction method of the two-way multi-step de Bruijn graph includes the steps of (1) carrying out a structure optimization for the de Bruijn graph by combining with the characteristics of the deoxyribonucleic acid (DNA) order complementary double-helix structure, and halving nodes of the graph to be stored by using two-way multi-step de Bruijn graph, (2) using a compressed storage technology of the two-way multi-step de Bruijn graph to enable memory consumption of storing the two-way multi-step de Bruijn graph to be controlled within 100 times size of a reference sequence so that the problem that the sequence-assembled original de Bruijn graph scale is enormous unusually so as to bring a storage pressure to the memory consumption can be solved, and (3) constructing two-way multi-step de Bruijn graph, the DNA sequence assembling problem being capable of being decomposed into the edge fusant problem, and suitable for parallel computing.

The present invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and DNA glycosylase with sufficiently low reactivity with a DNA having an unrelaxed double helix structure (unrelaxed DNA) are bonded, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one strand of the double stranded DNA in the targeted site.

This invention is a kind of auger stem modified structure and the deformed half screw pole body , the auger stem modified structure includes the boring bar, the drill bit, the boring bar , the boring bar has a part to be helix structure at least, the helix part of the boring bar is reverse echelon structure ,it is that it has the outside diameter structure being expanded from downward to upward gradually, it is easy for the helix part leading the whole boring bar drill downward, this structure designs the auger stem structure expanded gradually, it may deter the impact of axial reaction forceto the drill when drilling, diminishing the resisting force when drilling, lightening its work load , improving the work effect of the boring bar. This pole body structure has multilevel structure, the pole body is composed of more than one discontinuous part which have different diameter, the pole body is convenient to enter the soil layer in depth, it can be set to be suitable depth, for example, the bottom of the pole body can arrive at more than 20 meters below the ground, it has forceful supporting effect to the building that it props up.

The invention discloses an anti-caries polypeptide capable of preventing bacteria and promoting remineralization, a polypeptide derivative or a polypeptide pharmaceutical salt thereof. The anti-caries polypeptide contains an amino acid sequence a and an amino acid sequence b; the amino acid sequence a is Xn, wherein X is used for representing S, T, Y, K, R, N, or Q, n is used for representing the amino acid repeat times, and is an integer selected from 5 to 8; the amino acid sequence b is of a alpha double helix structure, is positively charged, and contains 8 to 12 amino acids, and the hydrophilic amino acids and hydrophobic amino acid in the amino acid sequence b appear alternately. The functional anti-caries polypeptide capable of preventing cariogenic bacteria and promoting remineralization is capable of inhibiting growth of streptococcus mutans, inhibiting formation of biological membrane of streptococcus mutans, reducing the metabolism capability of formed biological membrane of streptococcus mutans, killing viable bacteria in the formed biological membrane of streptococcus mutans, promoting remineralization of demineralization tooth enamel, and reducing caries depth and mineral loss of demineralization tooth enamel, and possesses excellent stability, and no obvious cytotoxicity.

The invention discloses a barron device manufactured by using integrated passive component process, which comprises a cardinal plate, a first coplanar helix structure and a second coplanar helix structure; at least two first left semi- coils of the first coplanar helix structure is electrically connected with two corresponding first right semi- coils through a first obliquity structure; at least twain second left semi- coils of the second coplanar helix structure is electrically connected with two corresponding right semi- coils through a second obliquity structure; two ends of the second coplanar helix structure is electrically connected with the second left semi- coil and the second right semi- coil in the most inner circle separately; the first left semi- coil and the second left semi-coil is placed overlapping; and the first right semi- coil and the second right semi- coil are placed overlapping.

The invention discloses a method for eliminating antibiotics resistance gene pollution in water by a hydrogen peroxide coupled ultrasonic method and belongs to the technical field of water treatment. The method provided by the invention is used for solving the problem that the water is polluted by the antibiotics resistance gene. The method is characterized in that the method of feeding hydrogen peroxide into water in combination with ultrasonic radiation is employed so that the antibiotics resistance gene is broken from the point of chemical reaction and basic groups, riboses and phosphoric acids in the antibiotics resistance gene are oxidized by means of strong oxidizing property of the hydrogen peroxide, and consequently, the chemical nature of the antibiotics resistance gene is changed and has no ability of storing and transferring genetic information, on one hand, and on the other hand, many cavitation bubbles are formed in water by means of ultrasonic. When the cavitation bubbles are broken, strong physical destruction effect is generated on the antibiotics resistance gene in water so that the double helix structure of the gene is decomposed and the nucleotide chain of the gen is broken; as a result, the genetic information contained in the nucleotide chain cannot be transferred; therefore, the purpose of eliminating the antibiotics resistance gene pollution is achieved.

The present invention is one kind of symmetric double-spiral resonator and the band-pass filter therewith. The present invention features that the resonator consists of two linearly symmetric microstrip lines in spiral structure and connected into one integral, and the band-pass filter consists of input microstrip, output microstrip and resonator array comprising several double-spiral resonators. The filter of the present invention has the advantages of excellent frequency selectivity, high stop band suppression; and the resonator in symmetric double-spiral structure has reduced size, reduced coupling effect of non-adjacent resonators, and simplified circuit design and regulation. The present invention makes it possible to make traditional planar microstrip filter with common metal material and is suitable for making high temperature superconductive filter with high quality factor.

The present invention provides, for example, a labeling substance that allows the double helix structure of a nucleic acid to be detected effectively. The present invention provides a compound having a structure derived from mononucleoside or mononucleotide, with the structure being represented by the following formula (1), (1b), or (1c), a tautomer or stereoisomer thereof, or a salt thereof.

In the above formulae, B is an atomic group having a nucleobase skeleton, E is an atomic group having a deoxyribose skeleton, a ribose skeleton, or a structure derived from either one of them, or an atomic group having a peptide structure or a peptoid structure, and Z¹¹ and Z¹² each are a hydrogen atom, a protecting group, or an atomic group that exhibits fluorescence and may be identical to or different from each other.

The invention discloses a polarization maintaining double-clad optical fiber having a helical structure and a manufacturing method thereof, and belongs to the technical field of optical fibers. The double-clad optical fiber consists of a fiber core, two stress areas which are symmetrically distributed on two sides of the fiber core, an inner clad layer, an outer clad layer and a coating layer. The technical manufacturing method comprises the steps of: manufacturing a core rod having a clad layer with a certain thickness, two B-doped rods and a plurality of pure quartz rods; selecting a larger-diameter high-purity quartz rod, and helically forming a rectangular groove on the quartz rod along an axial direction; embedding the core rod, the B-doped rods and the pure quartz rod which are softened at high temperature into the helical rectangular groove according to a sequence of a B-doped rod, the core rod, a B-doped rod and the pure quartz rod so as to form a preformed rod of the polarization maintaining optical fiber having the helical structure; and finally, drawing the preformed rod to obtain the polarization maintaining double-clad optical fiber having the helical structure. The optical fiber has a polarization maintaining characteristic and can break a helical effect of pump light, and the absorption efficiency of the optical fiber core on the pump light is improved.

The invention discloses a double-frequency bi-stable liquid crystal display and double-frequency bi-stable liquid crystal composition. The double-frequency bi-stable liquid crystal composition made by mixing double-frequency liquid crystal, chiral composition and nematic phase liquid crystal composition is poured into a liquid crystal box; through the component ratio and chemical features of the double-frequency bi-stable liquid crystal composition, the liquid crystal composition mixed has the features of both the double-frequency liquid crystal and the cholesteric phase liquid crystal, under driving of a frequency modulation mode, two optical statuses, namely focal conic texture and planar texture, can be converted through dielectric anisotropy of the liquid crystal, and an image can be displayed; thus, the double-frequency bi-stable liquid crystal display can be in the two optical statuses without voltage maintaining or decomposing the helix structure of the cholesteric phase liquid crystal through high voltage; dielectric conversion is not related to metastable state conversion, power consumption of the double-frequency bi-stable liquid crystal display is effectively reduced, and conversion time is effectively shortened.

The invention relates to a multifunctional reaction tank for preparing artemisia seed gum/oil. The multifunctional reaction tank comprises a conical cylindrical tank body and is characterized in thata heating jacket is arranged outside the tank body, and a filter screen, a stirrer and a shaft frame are arranged in the tank body which is connected with an upper sealing head and a lower sealing head; the upper sealing head is provided with a feeding port, a condensing port, a pressure relief port and a driver, the lower sealing head is provided with a liquid outlet and an air inlet, and the stirrer is of a single-shaft double-helix structure; a motor drives the stirrer to rotate through a speed reducer and a coupler to quickly mix materials for reaction, solid-liquid separation is performedin the tank body, and filtrate is further refined to obtain the artemisia seed gum/oil; material residues after being degummed and degreased are dried by feeding steam or hot air and discharged aftersolvent recycling. The multifunctional reaction tank has the advantages that the multifunctional reaction tank integrates functions of double-helix stirring, pneumatic stirring, solid-liquid separation, jacket temperature adjustment, material residue drying, solvent recycling, safe pressure relief and the like, and the multipurpose reaction tank is capable of remarkably increasing product yield and lowering solvent consumption and production cost and suitable for the production field of food, medicine and chemical industry using high-material-liquid-ratio reaction.

The invention discloses a mini active microwave and millimeter wave self-loading I/Q variable phase reversal orthogonal filter, which comprises a single-pole double-throw switch chip KD102010040, a low-noise amplifier chip WFD022036-L12, a surface mount 50-ohm impedance input/output interface, a parallel resonance unit module implemented through a strip line structure, a broadside coupled strip line of a double helix structure and a matched load connected to an isolated port, wherein the structures are implemented by adopting a multilayer low-temperature co-fired ceramic technology (LTCC technology). The mini active microwave and millimeter wave self-loading I/Q variable phase reversal orthogonal filter has the advantages of no external load, variability, phase reversal orthogonality, small insertion loss, easiness in debugging, light weight, small volume, high reliability, good electrical property, good temperature stability, low cost, mass production and the like, and is applied to communication, satellite communication and the other occasion at the corresponding millimeter wave frequency band have strict requirements on the volume, the electrical property, the temperature stability and the reliability and corresponding systems.

The invention discloses a barron device manufactured by using integrated passive component process, which comprises a cardinal plate, a first coplanar helix structure and a second coplanar helix structure; at least two first left semi- coils of the first coplanar helix structure is electrically connected with two corresponding first right semi- coils through a first obliquity structure; at least twain second left semi- coils of the second coplanar helix structure is electrically connected with two corresponding right semi- coils through a second obliquity structure; two ends of the second coplanar helix structure is electrically connected with the second left semi- coil and the second right semi- coil in the most inner circle separately; the first left semi- coil and the second left semi-coil is placed overlapping; and the first right semi- coil and the second right semi- coil are placed overlapping.

The invention relates to a PEFC-based self-powered miRNA biosensor and application thereof, belonging to the technical field of biological sensing. One end of a hairpin DNA partially complementary with miRNA is modified with Cds QDs, and the Cds QDs can sensitize a photoelectrochemical material that is g-C3N4. After the target miRNA and a complementary chain thereof form a rigid double helix structure through hybridization and pairing, the Cds QDs is brought far from the surface of the g-C3N4 so that the g-C3N4 sensitizing effect of the Cds QDs is weakened, electrons flowing from an anode to acathode are reduced, and the open-circuit voltage of the PEFC changes, thus achieving miRNA detection. The sensor does not need an extra power supply device during detection and is simple and convenient to assemble, low in cost, high in interference resistance, and high in selectivity because of complementary pairing effects of DNA chains. The sensor can achieve simple, rapid, sensitive and efficient miRNA detection.

An LC composite component capable of reducing an overall size while keeping a Q-value of a resonator at a high level and increasing coupling flexibility of resonators includes two capacitor electrodes and two input/output terminal electrodes extending therefrom provided on a first dielectric layer. A ground electrode and another capacitor electrode are provided on second and sixth dielectric layers, respectively. Two substantially linear line electrodes are provided on a third dielectric layer. Two substantially U-shaped line electrodes are provided on a fourth dielectric layer. Two substantially crank-shaped line electrodes are provided on a fifth dielectric layer. Six via electrodes arranged to connect ends of respective line electrodes are provided on the third, fourth, and fifth dielectric layers. These via electrodes and line electrodes constitute electrodes of a double helix structure.

A development system including a housing, a developer roll mounted in the housing, for depositing marking particles on an imaging surface having an electrostatic latent image thereon, an auger, for mixing and transporting the marking particles and carrier constituents of the developing material and; transferring mixed developer material to the developer roll, the auger comprising an elongate strip of magnetic material having a helix structure; a nonmagnetic sleeve enclosing the elongate strip of magnetic material; and means for rotating the elongate strip of magnetic material within the nonmagnetic sleeve, the elongate strip of magnetic material generates a magnetic field for transporting the developer material axially along an outer surface of the nonmagnetic sleeve when rotated by the rotating means.

A method for designing a protein capable of binding in an RNA base selective manner or RNA base sequence specific manner is provided. The protein of the present invention is a protein containing one or more of PPR motifs (preferably 2 to 14 PPR motifs) each consisting of a polypeptide of 30- to 38-amino acid length represented by the formula 1 (wherein Helix A is a moiety of 12-amino acid length capable of forming an α-helix structure, and is represented by the formula 2, wherein, in the formula 2, A₁ to A₁₂ independently represent an amino acid; X does not exist, or is a moiety of 1- to 9-amino acid length; Helix B is a moiety of 11- to 13-amino acid length capable of forming an α-helix structure; and L is a moiety of 2- to 7-amino acid length represented by the formula 3, wherein, in the formula 3, the amino acids are numbered “i” (-1), “ii” (-2), and so on from the C-terminus side, provided that L_iii to L_vii may not exist), and combination of three amino acids A₁, A₄ and L_ii, or combination of two amino acids A₄, and L_ii is a combination corresponding to a target RNA base or base sequence.

The present invention relates to site-specific labeling of antibodies or fragments thereof with one or more reporter group(s) in a way that does not affect antigen binding. The method for labeling antibodies and/or fragments thereof, comprises the following steps a) providing an IgG binding protein, which comprises α-helix structures, with a photoactivatable group and at least one label; b) forming a mixture of said IgG binding protein and the antibodies and/or fragments to be labeled; and c) UV illuminating said mixture for site-specific labeling of said antibodies and/or fragments thereof. The IgG binding protein is preferably the Z domain of Protein A.