The invention belongs to a low-frequency efficient oral mucosal disease therapy instrument, which comprises a control circuit board, a liquid storage bottle, a water suction pump, a negative pressure pump, a recycling bottle, a handle and a display panel, and is characterized in that the control circuit board is provided with a power supply, a controller, a heater, a refrigerator I, a refrigerator II, a cold circulation controller, an ion output port, a negative pressure port, a temperature sensor, a camera port, a frequency spectrum port and a laser port; the liquid storage bottle is provided with a liquid outlet and a backflow port, the liquid outlet is connected with a liquid transport tube, the handle is connected with a treatment head, the backflow port is connected with a backflow tube, the water is arranged on the backflow tube, cold circulation controller is connected with the water suction pump, the recycling bottle is connected with an absorption tube, the absorption tube is connected to the handle, and the negative pressure pump is arranged on the absorption tube. The low-frequency efficient oral mucosal disease therapy instrument also has the functions of low temperature, low frequency, pulse, frequency spectrum, laser and the like while delivering a medicine, and performs physical treatment on soft tissues of a diseased part of the oral mucosa so as to achieve the effects of inflammation diminishing, swelling diminishing and pain relieving.