Preparation method of bacteriostatic sugar-free gel material used for xerostomia

A technology for dry mouth and gel materials, applied in the field of oral materials, can solve the problem of no other medical effects, and achieve the effects of improving sustained release performance and performance, inhibiting complications, and improving oral environment.

Inactive Publication Date: 2019-07-09
冯云菊
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  • Claims
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AI Technical Summary

Problems solved by technology

[0021] The technical problem to be solved by the present invention is to provide a bacteriostatic and sugar-free xerostomia gel material in view of the fact that some saliva substitutes for relieving oral symptoms on the market only have a moisturizing function and have no other medical effects preparation method

Method used

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  • Preparation method of bacteriostatic sugar-free gel material used for xerostomia

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Embodiment Construction

[0041] Take the leaves of aloe vera and wash them with 75% ethanol solution for 3 to 5 times, dry them naturally, peel them and collect the peeled aloe vera, crush them and place them in a homogenizer, and homogenize them at room temperature at 250 to 300r / min Treat for 3-5 hours to obtain a homogeneous liquid and filter it with a 0.25-0.30 μm sieve, collect the filtrate and add hyaluronic acid dropwise to the filtrate at a mass ratio of 1:5, stir and mix, and let stand at room temperature 6-8 hours to obtain the aloe compound solution; weigh 45-50 parts of deionized water, 10-15 parts of citric acid, and 6-8 parts of sodium hypophosphite in a beaker, stir and collect Modified liquid, according to the mass ratio of 1:10, chitosan is added to the modified liquid, stirred and mixed and placed at 45-50 ° C for 1-2 hours, allowed to stand and cooled to room temperature, to obtain the mixed liquid and Ratio 1:1, add 50% ethanol solution dropwise to the mixed solution, control the d...

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Abstract

The invention relates to a preparation method of a bacteriostatic sugar-free gel material used for xerostomia and belongs to the technical field of materials for the oral cavity. According to the technical scheme, propolis is effectively modified, a nano propolis material is extracted and collected, a two-component gel system is more adjustable than a single-component gel system structure when used as a saliva releasing agent for coating citric acid, the citric acid is effectively slowly released, and the saliva secretion capacity of the oral cavity is improved; meanwhile, according to the technical scheme, chitosan is used as a modified material to effectively inhibit complications such as candidiasis albicans and dental caries, and the oral cavity environment is further improved. According to the technical scheme, the citric acid is adopted for modifying the chitosan and then coated for additional modification; since the citric acid is a tricarboxylic acid and carboxyl of the citricacid has strong reaction activity, the citric acid and amino of the chitosan can triger an acylation reaction under a certain condition, so that a hydrophilic group carboxyl is introduced into chitosan molecules to improve the water solubility of the chitosan, and the slow release performance and use performance of the material are further improved.

Description

technical field [0001] The invention relates to a preparation method of an antibacterial and sugar-free xerostomia gel material, belonging to the technical field of oral materials. Background technique [0002] Saliva is a natural fluid whose function is essential to oropharyngeal, digestive and general health. The function of saliva seems simple; however, the complexity of its composition reflects its diverse properties. A number of problems can arise when the quantity or quality of saliva decreases, which is known as xerostomia or "dry mouth" or "burning mouth". [0003] Due to its high incidence, WDF defines it as a "modern human disease". Its percentages have been determined to be 20% in people around the age of 20, 40% in people in their 60s, and higher rates in older people. [0004] Xerostomia, or dry mouth, is a universal problem that can affect anyone regardless of their gender, race, age or other conditions. However, it is more common in women than in men, main...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/98A61K8/73A61K8/365A61Q11/00A61P31/10A61P1/02
CPCA61K8/365A61K8/735A61K8/9794A61K8/987A61K2800/805A61K2800/82A61P1/02A61P31/10A61Q11/00
Inventor 冯云菊
Owner 冯云菊
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