In-situ cross-linkable polymeric compositions and methods thereof

Abstract

A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or DEAE-Dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying pressure. The biocompatible polymeric composition may further comprise a cross-linking agent such as aqueous calcium chloride. The invention encompasses an initial polymeric composition, the solidified matrix cross-linked and integrated at the wound site, including the methods of using, applying, and cross-linking the composition.

Description

[0001]This application claims the benefit of provisional patent application Ser. No. 61 / 559,110, filed 13 Nov. 2011, the entire disclosure of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates generally to a composition using a biocompatible polymeric formulation and, in particular, to a hemophilic polymeric matrix for use in wound healing, blood coagulation, and cosmetic use.BACKGROUND OF THE INVENTION[0003]Wound healing is an intricate, orchestrated process involving the interactions of various cells and matrix components to first establish a provisional tissue and then remodel this while forming the mature replacement. Initially, the hemostatic platelet plug reestablishes the infection-limiting and desiccation-limiting barrier, and elicits the first wave of cellular infiltrates. This consists mainly of leukocytes that provide both innate and acquired immunity. These cells produce enzymes and biocidal molecules to eliminate microbia...

AI Technical Summary

Benefits of technology

The patent describes a medical gel that can be used to quickly stop bleeding and promote wound healing. The gel can be adjusted to have varying viscosities and functions, and can be used with therapeutics for drug delivery. The formulation can be controlled during preparation and application, and the solidified matrix can have different levels of elasticity or rigidity depending on the patient's needs. The gel can be tailored to different anatomical and physiological measures. Overall, the technical effects of the patent include improved hemostasis, wound healing, and a flexible and customizable gel for medical use.

Problems solved by technology

These cells produce enzymes and biocidal molecules to eliminate microbial contamination; however, these same defense mechanisms are detrimental to the keratinocytes, fibroblasts and endothelial cells required to regenerate the lost tissue.

A particular challenge is offered in the case of skin wound repair, which occurs at a contaminated surface.

However, once hydrated with saline solution, the fibronectin-cellulose dressing does not provide the desired fibrous protective film on the surface of the deepithelialized human skin.

Thus, problems exist in the treatment of acute and chronic wounds, including delayed healing, reduced granulation and epithelialization, and persistent wound inflammation.

Compromised wound healing can result in other complications and problems, such as infection, pain, and development of chronic (non-healing) wounds.

Images