An iontophoretic patch (20) for transdermal delivery of biologically active agents, comprising: at least two electrodes (8) in contact with respective at least two hydrogel reservoirs (9), wherein atleast one of said hydrogel reservoirs (9) is configured to carry at least one
active agent and, in use of the iontophoretic patch (20), to be disposed on a user's
skin (24) and deliver said at least one
active agent into the user's
skin (24); a
control unit (11) configured to generate a stimulation pattern comprising a plurality of stimulation parameters to be delivered to a plurality of stimuli locations on the
skin; a stimulation unit (6) configured to generate a
time sequence of pulses from said plurality of stimulation parameters generated by the
control unit (11); a demultiplexing unit (10) configured to, from the
time sequence of pulses generated by said stimulation unit (6) and from said stimuli locations generated by said
control unit (11), perform independent spatio-temporal distribution of the electrical pulses comprised in said
time sequence of pulses to at least one
electrode of said at least two electrodes (8); at least one
optical sensing system (3, 12) disposed in at least one of said hydrogel reservoirs (9), for continuously measuring an amount of said at least one
active agent in said at least one hydrogel reservoir (9); a feedback unit (1) configured to estimate an actual delivery profile of said at least one active agent from said measured amount of at least one active agent; said control unit (11) being further configured to continuously modify said stimulation pattern by changing at least one of said plurality of stimulation parameters to be provided to the stimulation unit (6) and / or said stimuli locations to be provided to said demultiplexing unit (10).