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Device and method for controlled and monitored transdermal delivery of active agents and use thereof

An active agent, bioactive agent technology, applied in the field of transdermal drug delivery products, can solve problems such as difficult integration into wearable or disposable devices

Pending Publication Date: 2020-04-10
技术研究与创新基金会
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Measuring the amount of this drug directly on or in the skin involves very complex research methods that are difficult to integrate into wearable or single-use devices

Method used

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  • Device and method for controlled and monitored transdermal delivery of active agents and use thereof
  • Device and method for controlled and monitored transdermal delivery of active agents and use thereof
  • Device and method for controlled and monitored transdermal delivery of active agents and use thereof

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Embodiment Construction

[0036] In this document, the term "comprise" and its derivatives (such as "comprising", etc.) should not be interpreted in an exclusive manner, that is, these terms should not be interpreted as excluding that what is described and defined may include other elements, Possibility of steps etc.

[0037] In the context of the present invention, the term "approximately" and its cognate terms (such as "approximately", etc.) should be understood as meaning very close to the value accompanying the above term. That is, deviations from the exact values ​​should be accepted within reasonable limits, as those skilled in the art will appreciate that such deviations from the shown values ​​are unavoidable due to measurement inaccuracies, etc. The same applies to the terms "about" and "approximately" and "substantially".

[0038] The following description should not be taken in a limiting sense, but is given for the purpose of describing the broad principles of the invention only. The foll...

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PUM

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Abstract

An iontophoretic patch (20) for transdermal delivery of biologically active agents, comprising: at least two electrodes (8) in contact with respective at least two hydrogel reservoirs (9), wherein atleast one of said hydrogel reservoirs (9) is configured to carry at least one active agent and, in use of the iontophoretic patch (20), to be disposed on a user's skin (24) and deliver said at least one active agent into the user's skin (24); a control unit (11) configured to generate a stimulation pattern comprising a plurality of stimulation parameters to be delivered to a plurality of stimuli locations on the skin; a stimulation unit (6) configured to generate a time sequence of pulses from said plurality of stimulation parameters generated by the control unit (11); a demultiplexing unit (10) configured to, from the time sequence of pulses generated by said stimulation unit (6) and from said stimuli locations generated by said control unit (11), perform independent spatio-temporal distribution of the electrical pulses comprised in said time sequence of pulses to at least one electrode of said at least two electrodes (8); at least one optical sensing system (3, 12) disposed in at least one of said hydrogel reservoirs (9), for continuously measuring an amount of said at least one active agent in said at least one hydrogel reservoir (9); a feedback unit (1) configured to estimate an actual delivery profile of said at least one active agent from said measured amount of at least one active agent; said control unit (11) being further configured to continuously modify said stimulation pattern by changing at least one of said plurality of stimulation parameters to be provided to the stimulation unit (6) and / or said stimuli locations to be provided to said demultiplexing unit (10).

Description

technical field [0001] The present invention relates to the controlled and monitored transdermal administration of biologically active substances and biologically active agents (eg, drugs, prodrugs, tissue growth factors, nanoparticles, biomedical probes (eg, biomarkers or allergen probes)) Transdermal delivery. More particularly, the present invention relates to products and methods for such transdermal administration. Background technique [0002] From wound healing to immune modulation and drug delivery, numerous therapeutic strategies rely on applying electric fields and currents to and through the skin with electronic devices including skin-contacting electrodes. [0003] The primary application for this device today is transdermal drug delivery, which represents an alternative to oral administration and is also poised to provide an alternative to subcutaneous injection. Currently, the transdermal route has emerged as one of the most successful and innovative focal po...

Claims

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Application Information

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IPC IPC(8): A61N1/32A61N1/04A61K9/00G01N9/24G01N9/36G01N21/00G01N33/15A61K9/70
CPCA61N1/0448A61K9/0009A61N1/325A61N1/326A61K9/7053A61K9/7069A61K9/7084A61N1/36034
Inventor 戈兰·比耶利奇曼纽尔·蒙特霍·埃斯特韦兹马蒂亚·什特尔巴茨
Owner 技术研究与创新基金会
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