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Vaccine for preventing and/or treating allergic asthma

A technology for allergic asthma and vaccines, which can be used in allergic diseases, respiratory diseases, allergen antigen components, etc., and can solve problems such as Candida albicans infection and hypertension.

Inactive Publication Date: 2008-12-10
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term oral administration of hormones may cause side effects such as obesity, osteoporosis, and high blood pressure; inhalation of hormone sprays may cause Candida albicans infection in the mouth and throat

Method used

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  • Vaccine for preventing and/or treating allergic asthma
  • Vaccine for preventing and/or treating allergic asthma
  • Vaccine for preventing and/or treating allergic asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1, pep323 and pD323 joint immunosuppressive asthma

[0047] experimental method

[0048] Experimental animals: female BALB / c mice (8-10 weeks old) were purchased from the Institute of Experimental Animals, Chinese Academy of Medical Sciences. D011.10 mice (8-10 weeks old) were purchased from Shanghai Slack Experimental Animal Co., Ltd. (SLAC).

[0049] Neutralizing antibodies: various neutralizing antibodies used in the experiment, including anti-CD25, anti-CD4, anti-IL-10, anti-IFN-γ, anti-TGF-β and anti-IL-4, anti-IL -2 were obtained from hybridoma cells purchased from ATCC (Manassas, VA, USA).

[0050] 1. Experimental method

[0051] 1. Asthma model induction: OVA (Sigma, USA; 1 mg / ml dissolved in PBS) was mixed with an equal volume of 10% aluminum salt (Sigma, USA) as an allergic antigen, and oscillated for 2 hours at room temperature. After centrifugation at 750×g for 5 min, the supernatant was discarded and the OVA / aluminum complex was resuspended w...

Embodiment 2

[0093] Example 2, Der p1 protein and pVAX-Der p1 combined immunosuppressive asthma

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PUM

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Abstract

The invention discloses a vaccine for preventing and / or treating allergic asthma. The active ingredients of the vaccine for preventing and / or treating allelgic asthma is as the following: the compound consisting the proteantigen causing allergic asthma or epitope peptides and the recombinant eukaryotic cell expression carrier which inserts proteantigen causing allergic asthma or epitope peptides coding gene thereof in the multiple cloning site. The vaccine can induce to produce immune regulatory T cell, can restrain the activity of allergic T cell of immune animals, thus preventing and / or treating allergic asthma effectively.

Description

technical field [0001] The invention relates to a vaccine for preventing and / or treating allergic asthma. Background technique [0002] Asthma (Asthma) is a chronic airway inflammation involving the participation of various cells such as mast cells, eosinophils and T lymphocytes. The pathogenesis of asthma is mainly type I hypersensitivity (anaphylaxis). [0003] Allergic asthma is more common than childhood onset, and patients often have atopic constitutions that are allergic to certain substances, such as inhaling cold air, pollen, dust mites, etc.; eating fish, shrimp, milk, etc.; or being exposed to certain drugs, such as penicillin. When these allergens enter the patient's body, through a series of reactions, mast cells or basophils release sensitizing active substances, which act on the bronchi, causing extensive narrowing of the small airways, and symptoms of wheezing occur. If not treated in time, asthma Can be fatal. [0004] When the allergen enters the body, it...

Claims

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Application Information

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IPC IPC(8): A61K39/35A61P11/06A61P37/08
CPCA61K39/35A61P11/06A61P37/08
Inventor 王宾金华利靳津康友敏
Owner CHINA AGRI UNIV
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