Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
31results about How to "Inhibition of degranulation" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Method for preparing atomized liquid for treating infantile asthmatic suffocating pneumonia
ActiveCN102614323APromote secretionCan treat asthmaHydroxy compound active ingredientsAerosol deliveryTreatment effectRed Clover
The invention discloses a method for preparing atomized liquid for treating infantile asthmatic suffocating pneumonia. The atomized liquid comprises gleditsia fruit, loquat leaf, European hop flower, Chinese waxgourd semen, common bluebeard herb, platycodon root, red clover, whiteflower hogfennel root and borneol which serve as raw materials. The method is characterized by comprising the following steps of: (1) extracting the loquat leaf, the European hop flower and the common bluebeard herb by a supercritical fluid extraction method to obtain volatile oil; (2) crushing the gleditsia fruit and the borneol into superfine powder; (3) decocting the red clover, the whiteflower hogfennel root, the Chinese waxgourd semen and the platycodon root in water twice, filtering, mixing filtrates, and concentrating at the temperature of 80 DEG C until the relative density is 1.1 to obtain a water extracting solution; and (4) stirring the volatile oil obtained in the step (1), the superfine powder obtained in the step (2) and the water extracting solution obtained in the step (3) uniformly, standing at normal temperature for 12 hours, and filtering to obtain liquid medicine. Clinical experiments prove that the atomized liquid prepared by the method has an obvious treatment effect, and the hospital stays can be shortened.
Owner:南通东湖国际旅行社有限公司
Human IgE (immunoglobulin E) Fab (fragment ab) against human and coding gene and application thereof
The invention belongs to the technical field of biotechnology and relates to a human IgE (immunoglobulin E) Fab (fragment ab) against human and a coding gene and application thereof. In the invention, a recombined IgE C3-C4 protein is used for screening a natural human immunoglobulin gene library, and a human antibody Fab of IgE against human is screened from the library through ELISA (enzyme-linked immunosorbent assay) sequencing analysis and the like; extensive expression purification and further identification prove that the antibody Fab of human IgE against human is fully human and without Fc (fragment c), has an effect of inhibiting IgE mediated anaphylaxis without activating complements or causing human immune response or other pathological lesions and can be used for preparing antibody drugs for treating allergic diseases caused by IgE.
Owner:FUDAN UNIV
Human monoclonal antibody against IgE, preparation method and purpose thereof
ActiveCN102167745AAntibody affinity is highInhibition of degranulationAntibody ingredientsImmunoglobulinsNucleotideAllergic asthma
The invention relates to the biotechnology field, and more specifically, the invention discloses a human monoclonal antibody against IgE, a preparation method and a purpose thereof. According to the invention, a natural human phage antibody library of large capacity is constructed;; a human antibody 2E19 strain against IgE is obtained through screening from the library; an amino acid sequence of a heavy chain variable region is expressed as SEQ ID NO: 6; and the amino acid sequence of a light chain variable region is expressed as SEQ ID NO: 8. Besides, the invention also discloses the preparation method of the antibody 2E19, as well as a nucleotide sequence for encoding the antibody 2E19 and an expression vector and a host cell comprising the nucleotide sequence. The antibody 2E19 of the invention has a higher antibody affinity, so as to be able to obviously inhibit degranulation caused by the combination of IgE and FC epsilon RI on a cell surface, and the antibody 2E19 does not combine with the IgE combined with the FC epsilon RI on the cell surface. The antibody 2E19 of the invention could be used for the preparation of a medicine for treating hypersensitivity diseases, especially for treating allergic asthma.
Owner:越海百奥药业(绍兴)有限公司
Bifidobacterium longum NX-4 and application thereof in preparing drugs for treating and/or preventing allergic diseases
PendingCN112159784AInhibition of secretionInhibition of degranulationBacteriaMicroorganism based processesDiseaseMicroorganism
The invention discloses bifidobacterium longum NX-4 and application thereof in preparation of drugs for treating and / or preventing allergic diseases, and belongs to the technical field of microorganisms. The invention discloses a bifidobacterium longum NX-4 strain, and the preservation number is CGMCC No. 20112. Bifidobacterium longum NX4 inactivated and non-inactivated fermentation supernatant and bacterial suspension can obviously inhibit Compoud 48 / 80 from stimulating zebra fish to secrete Tryptase in vivo, and have the potential of being applied to relieving or preventing anaphylactic reaction in vivo. The bifidobacterium longum NX-4 disclosed by the invention has a huge potential application prospect in the aspect of relieving and / or preventing allergic reaction.
Owner:FOSHAN LANGSEE BIOTECHNOLOGY CO LTD +1
Compound capable of inhibiting mast cell degranulation and preparation method and application thereof
InactiveCN106632378AInhibition releaseInhibition of degranulationOrganic chemistry methodsRespiratory disorderDiseaseStructural formula
The invention discloses a compound capable of inhibiting mast cell degranulation and a preparation method and application thereof. The molecular formula of the compound is C22H2606, the molecular weight is 386.17, and the chemical structural formula is shown in the description. As proved by research results, the compound can significantly inhibit the release of beta-hexane in mast cells at the inhibition rate of 85.57 percent, has a significant inhibitory effect on mast cell degranulation, is expected to be used as an active ingredient in the preparation of a medicament for inhibiting mast cell mast cell degranulation, can be further used as an active ingredient in the preparation of a mast cell stabilizer medicament and the preparation of a medicament for preventing or / and treating allergic diseases, has a wide application prospect.
Owner:SHANGHAI UNIV OF T C M
Medicinal composition for treating child asthmatic suffocating pneumonia
The invention discloses a medicinal composition for treating child asthmatic suffocating pneumonia. The medicinal composition is characterized by being processed from multiple Chinese medicines in parts by weight: 1-3 parts of Chinese honey locust, 6-9 parts of loguat leaf, 10-15 parts of european hop flower, 10-15 parts of waxgourd seed, 6-9 parts of common bluebeard herb, 6-9 parts of platycodon root, 10-15 parts of red clover flower and inflorescence, 6-9 parts of whiteflower hogfennel root and 1-3 parts of borneol. As proved by clinical experiments, the medicinal composition for treating child asthmatic suffocating pneumonia has the characteristics of good curative effect and high safety, and is worthy of clinical application and popularization.
Owner:JIANGSU SUZHONG PHARM GRP CO LTD
Preparation method and application of phenolic compounds and antiallergic drug
PendingCN110368389AStrong allergic activityInhibition of degranulationOrganic chemistryMicroorganism based processesNatural resourceAntiallergic drugs
The invention discloses application of phenolic compounds. The phenolic compounds are shown in the formulas (I)-(III). The phenolic compounds are used for preparing anti-allergic drugs. Through research, it is found that the three phenolic compounds have strong inhibition effects on degranulation of mast cells, and can be used for preparing anti-allergic drugs, especially anti-food-allergy drugs;through fermentation of deep-sea fungi, namely penicillium chrysanthum which has rich sources, the three substances with strong anti allergic activity are obtained at the same time, compared with directional synthesis during which a variety of by-products are produced, the preparation method is more suitable for industrial production and natural resources are rationally utilized.
Owner:THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES +1
Novel application of dictamnine
InactiveCN108159046ANo obvious side effectsInhibition of activationOrganic active ingredientsImmunological disordersPhosphorylationBiological activation
The invention discloses novel application of dictamnine, in particular to application of the dictamnine in preparing type I hypersensitivity reaction drugs caused by mast cell activation, and belongsto the field of pharmaceuticals. According to the dictamnine disclosed by the invention, by constructing a C48 / 80 induced P815 mast cell in vitro inflammatory model, the dictamnine is found to have the effects of inhibiting the activation of mast cells, effectively inhibiting the degranulation degree of the mast cells in a sensitized state and alleviating the release of beta-hexosaminidase; the expression of inflammatory genes IL-4, IL-6, IL-12 and IL-13 in the mRNA level can be inhibited; in addition, the phosphorylation level of ERK in an intracellular signaling pathway can be significantlyinhibited.
Owner:KUNMING UNIV OF SCI & TECH
Method for preparing atomized liquid for treating infantile asthmatic suffocating pneumonia
ActiveCN102614323BPromote secretionCan treat asthmaHydroxy compound active ingredientsAerosol deliveryMedicineRed Clover
The invention discloses a method for preparing atomized liquid for treating infantile asthmatic suffocating pneumonia. The atomized liquid comprises gleditsia fruit, loquat leaf, European hop flower, Chinese waxgourd semen, common bluebeard herb, platycodon root, red clover, whiteflower hogfennel root and borneol which serve as raw materials. The method is characterized by comprising the following steps of: (1) extracting the loquat leaf, the European hop flower and the common bluebeard herb by a supercritical fluid extraction method to obtain volatile oil; (2) crushing the gleditsia fruit and the borneol into superfine powder; (3) decocting the red clover, the whiteflower hogfennel root, the Chinese waxgourd semen and the platycodon root in water twice, filtering, mixing filtrates, and concentrating at the temperature of 80 DEG C until the relative density is 1.1 to obtain a water extracting solution; and (4) stirring the volatile oil obtained in the step (1), the superfine powder obtained in the step (2) and the water extracting solution obtained in the step (3) uniformly, standing at normal temperature for 12 hours, and filtering to obtain liquid medicine. Clinical experiments prove that the atomized liquid prepared by the method has an obvious treatment effect, and the hospital stays can be shortened.
Owner:南通东湖国际商务服务有限公司
Application of ginkgolic acid in preparation of products for prevention and/or treatment of allergic diseases
ActiveCN107184617ASimple and clearThe chemical composition is simple and clearSalicyclic acid active ingredientsRespiratory disorderDiseaseAllergic asthma
The invention discloses a traditional-Chinese-medicine active compound with the Syk inhibitory activity and its preparation method and application. It is found that the active compound, namely ginkgolic acid C15:1 or ginkgolic acid C13:0, has the spleen tyrosine kinase (Syk) inhibition activity, research further shows that the active compound has the effect of inhibiting mastocyte degranulation, the traditional-Chinese-medicine active compound ginkgolic acid C15:1 is obtained from ginkgo medicinal materials for the first time, and it is verified that the traditional-Chinese-medicine active compound ginkgolic acid C15:1 has the Syk inhibition activity and the mastocyte degranulation inhibition activity. The effective component and chemical component of the active compound ginkgolic acid C15:1 or ginkgolic acid C13:0 are simple, the action target is clear, the Syk activity can be directly inhibited, the mastocyte degranulation is inhibited, the action mechanism of the ginkgolic acid C15:1 or ginkgolic acid C13:0 is easier to illuminate in pharmacological research, and the ginkgolic acid has a potential application value in the prevention and treatment of allergic asthma and provides a new medicine selection for the prevention and treatment of allergic asthma.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Preparation method of itching relieving cream for treating seborrheic dermatitis
InactiveCN107998175AInhibits mast cell degranulationGood oil secretionHydroxy compound active ingredientsAerosol deliveryAnti-inflammatoryDegranulation
The invention discloses a preparation method of an itching relieving cream for treating seborrheic dermatitis, and belongs to the field of medicines. According to the preparation method, through extracting a main active component-alkaloid from semen sophorae alopecuroidis, a drug, which has a stabilizing effect on an erythrocyte membrane, of the alkaloid has the stabilizing effect on a lysosome membrane; thus, the release of an inflammatory mediator is reduced; an anti-inflammatory purpose is achieved; meanwhile, the alkaloid also has an antiallergic effect, can be used for suppressing the degranulation of a mast cell, and has favorable effects on balancing grease secretion, relieving pruritus, resisting imflammation and resisting an allergy and immunologic suppression; thus, the use effect of the itching relieving cream is improved; the alkaloid is mixed with distillate prepared from glucose and ethylene glycol; as having multiple hydroxyl groups, the alkaloid has quite high affinitywith water, has a moisturizing effect on skin, and thus, can be also used for retaining moisture for the skin while being used for removing grease on the surface of the skin; a problem that the skin is dry is avoided, and the itching relieving cream is used for solving problems that a current conventional itching relieving cream has poor transdermal absorption and an unconspicuous use effect.
Owner:CHANGZHOU AMANTE CHEM CO LTD
Lactobacillus gasseri LGV03 and application thereof
ActiveCN113215045AInhibition of secretionInhibition of degranulationBacteriaMicroorganism based processesMicroorganismAnaphylactic reactions
The invention discloses lactobacillus gasseri LGV03 and application thereof, and belongs to the technical field of microorganisms. The preservation number of the lactobacillus gasseri LGV03 is CGMCC No.22010. A fermentation supernatant and a bacterial suspension of the lactobacillus gasseri LGV03 can remarkably inhibit the secretion of Trypase by the zebra fish stimulated by Compound 48 / 80 in vivo, can inhibit in-vivo mast cell degranulation, and have the potential of being applied to in-vivo anaphylactic reaction prevention. The lactobacillus gasseri LGV03 disclosed by the invention has a huge potential application prospect in the aspect of preventing anaphylactic reaction.
Owner:南方医科大学第七附属医院佛山市南海区第三人民医院
Human monoclonal antibody against IgE, preparation method and purpose thereof
ActiveCN102167745BAntibody affinity is highInhibition of degranulationAntibody ingredientsImmunoglobulinsPhage antibodiesNucleotide
Owner:越海百奥药业(绍兴)有限公司
Application of IL-1ra-Fcepsilon fusion gene and coded protein thereof to treatment on allergic rhinitis
InactiveCN102145179BAnti-inflammatory effectInhibition of degranulationGenetic material ingredientsAntibody ingredientsBasophilic GranulocyteNasal Cavity Epithelium
Owner:INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
Use of pseudo-ginseng saponin component for treating septicemia
ActiveCN101327236BSlow downInhibition of degranulationAntibacterial agentsOrganic active ingredientsGynecologyGinsenoside Rb1
Owner:TIANJIN TASLY PHARMA CO LTD
Application of protocatechualdehyde in preparing medicine for preventing and treating bronchial asthma
InactiveCN104274431APromote blood circulationInhibition of degranulationAldehyde active ingredientsRespiratory disorderSide effectVascular endothelium
The invention discloses application of protocatechualdehyde in preparing a medicine for preventing and / or treating bronchial asthma. Specifically, when being applied to early asthma, the protocatechualdehyde not only can remarkably control airway inflammation of the asthma, but also has the effects on protecting vascular endothelial cells of the lung, inhibiting mast cell degranulation, inhibiting fibroblast from secrete collagen, promoting apoptosis and calming by improving blood circulation in lung of asthma, reducing blood viscosity and improving anoxic state of the asthma, so as to relieve or inhibit airway remodeling from various aspects and various links; and inhibiting morphological change of the airway remodeling, effect of the medicine is better than prednisone acetate, and the medicine is free from side effect.
Owner:GUANGDONG MEDICAL UNIV
Application of limonene in preparation of anti-allergic dermatitis drug
InactiveCN111529513AGood treatment effectSuppress allergic reactionsOrganic active ingredientsImmunological disordersDermatitis repensLimonene
The invention discloses application of limonene in preparation of an anti-allergic dermatitis drug, and belongs to the technical field of biological medicines. The limonene can inhibit DNCB acetone solution induced contact dermatitis, and has the effects of inhibiting passive skin allergic reaction and mast cell degranulation; therefore, the limonene can be used for treating allergic dermatitis caused by various reasons, and has a better treatment effect.
Owner:孙东杰
Application of ginkgolic acid in the preparation of products for preventing and/or treating allergic diseases
ActiveCN107184617BThe chemical composition is simple and clearHas anti-mast cell degranulation effectSalicyclic acid active ingredientsRespiratory disorderMedicinal herbsDisease
The invention discloses a traditional-Chinese-medicine active compound with the Syk inhibitory activity and its preparation method and application. It is found that the active compound, namely ginkgolic acid C15:1 or ginkgolic acid C13:0, has the spleen tyrosine kinase (Syk) inhibition activity, research further shows that the active compound has the effect of inhibiting mastocyte degranulation, the traditional-Chinese-medicine active compound ginkgolic acid C15:1 is obtained from ginkgo medicinal materials for the first time, and it is verified that the traditional-Chinese-medicine active compound ginkgolic acid C15:1 has the Syk inhibition activity and the mastocyte degranulation inhibition activity. The effective component and chemical component of the active compound ginkgolic acid C15:1 or ginkgolic acid C13:0 are simple, the action target is clear, the Syk activity can be directly inhibited, the mastocyte degranulation is inhibited, the action mechanism of the ginkgolic acid C15:1 or ginkgolic acid C13:0 is easier to illuminate in pharmacological research, and the ginkgolic acid has a potential application value in the prevention and treatment of allergic asthma and provides a new medicine selection for the prevention and treatment of allergic asthma.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Human IgE (immunoglobulin E) Fab (fragment ab) against human and coding gene and application thereof
ActiveCN102399289BInhibition of degranulationInhibits the release of histamineFungiBacteriaDiseaseSequence analysis
Owner:FUDAN UNIV
New application of paeoniflorin
InactiveCN108159066AInhibition of activationInhibition of degranulationOrganic active ingredientsImmunological disordersSensitizationEccentric hypertrophy
The invention discloses new application of paeoniflorin, particularly relates to application of the paeoniflorin to preparation of a medicine for treating I type hypersensitivity reaction caused by hypertrophy cell activation, and belongs to the field of medicine. Through construction of a C48 / 80 induced P815 hypertrophy cell extracellular inflammation model, the invention discovers that the paeoniflorin has the effect of inhibiting hypertrophy cell activation, can effectively inhibit the degranular degree of the hypertrophy cells under the sensitization state and relieve release of beta-aminophenin, can inhibit expression of inflammatory genes IL-4, IL-6, IL-12 and IL-13 and expression of key receptors PAR2, PAR3 and PAR4 in a hypertrophy cell activation path on the mRNA level, and can obviously limit the phosphorylation level of ERK in an intracellular signal path.
Owner:KUNMING UNIV OF SCI & TECH
Purely-natural woody plant extract as well as preparation method and application thereof
ActiveCN111803410ALight colorImprove performanceCosmetic preparationsToilet preparationsBiotechnologyMast cell
The present invention relates to the related technical field of purely-natural woody plant extraction and in particular provides a purely-natural woody plant extract and an application thereof. In a first aspect, the present invention provides a preparation method of the purely-natural woody plant extract. The preparation method includes the following steps: (1) adding green tea into purified water, and then, performing cooking; (2) after steam is evaporated, retaining a distillate by a condensation pipe. The present invention provides an extraction method for a purely-natural single woody plant which can be used as an allergy relieving agent, and the obtained plant extract is light in color, non-turbid, stable in storage, fragrant, nontoxic, non-irritant to skins and capable of inhibitingthe phenomenon of degranulation of mast cells and has an allergy relieving effect.
Owner:ZHEJIANG FORESTRY UNIVERSITY +2
Soothing anti-allergy nano-vesicle composition and application thereof
ActiveCN114712274AExcellent allergyExcellent anti-inflammatoryCosmetic preparationsToilet preparationsAllergyBULK ACTIVE INGREDIENT
The invention provides a soothing anti-allergy nano-vesicle composition and application thereof. The soothing anti-allergy nano-vesicle composition is prepared from the following components in percentage by mass: 1-10% of a magnolia flower extract; 0.5-5% of a rosemary extract; 1-10% of an olive leaf extract; 30-60% of an emulsifier; 10-30% of a humectant; and 10-30% of an emulsion stabilizer. The soothing and anti-allergy nano-vesicle composition disclosed by the invention contains water-soluble and oil-soluble active ingredients at the same time, has the effects of quickly soothing and resisting allergy, and has the effects of repairing, conditioning and maintaining the stability of skin for a long time. The soothing and anti-allergy nano-vesicle composition can be used for a conventional emulsification system and a transparent aqueous system, the preparation method is simple and controllable, the repeatability is good, the effect is obvious, and the soothing and anti-allergy nano-vesicle composition can be applied to various cosmetics with anti-allergy and soothing effects.
Owner:上海康华时代生物医学科技有限公司
Use of pseudo-ginseng saponin component for treating septicemia
ActiveCN101327236ASlow downInhibition of degranulationAntibacterial agentsOrganic active ingredientsGynecologyGinsenoside Rb1
The invention relates to an application of notoginsenoside for treating septicemia, particularly relates to ginsenoside Rb1 which is the effective component of notoginsenoside, and an application of ginsenoside Rb1 and notoginsenoside R1 in treating and / or preventing septicemia.
Owner:TIANJIN TASLY PHARMA CO LTD
Medicinal composition for treating child asthmatic suffocating pneumonia
ActiveCN102614322BPromote secretionCan treat asthmaRespiratory disorderPlant ingredientsCurative effectGleditsia triacanthos
Owner:JIANGSU SUZHONG PHARM GRP CO LTD
Application of Chaenomeles speciosa (sweet) Nakai extract in pharmacy
ActiveCN103263498AInhibition of degranulationSuppresses swelling and acute inflammatory processesOrganic active ingredientsAntipyreticUrsolic acidThapsigargin
The invention relates to novel application of a Chaenomeles speciosa (sweet) Nakai extract, specifically to application of oleanolic acid, ursolic acid, oleanolic saponins and ursolic saponins in the extract in the pharmaceutical field. The extract has effects on inhibition of DNP-BSA induced RBL-2H3 mast cell degranulation, DNP-BSA induced mBMMCs mast cell degranulation, calcium ionophore A23187 induced RBL-2H3 mast cell degranulation and Thapsigargin induced RBL-2H3 mast cell degranulation and on xylene-induced acute inflammation like ear swelling of mice and has a high medicinal value.
Owner:CHINA THREE GORGES UNIV
A kind of pure natural woody plant extract and its preparation method and application
ActiveCN111803410BLight colorImprove performanceCosmetic preparationsToilet preparationsBiotechnologyWoody plant
The present invention relates to the technical field related to the extraction of pure natural woody plants, more specifically, the present invention provides a pure natural woody plant extract and its application. The first aspect of the present invention provides a kind of preparation method of pure natural woody plant extract, comprises the following steps: (1) green tea is added into pure water, then boils; Keep the distillate. The invention provides an extraction method of a pure natural single woody plant that can be used as a soothing agent. The obtained plant extract is light in color, not turbid, stable in storage, and has a delicate fragrance; it is non-toxic and non-irritating to the skin; and it can inhibit hypertrophy Cell degranulation phenomenon, with soothing effect.
Owner:ZHEJIANG FORESTRY UNIVERSITY +2
Application of Chaenomeles speciosa (sweet) Nakai extract in pharmacy
ActiveCN103263498BInhibition of degranulationSuppresses swelling and acute inflammatory processesOrganic active ingredientsAntipyreticUrsolic acidThapsigargin
Owner:CHINA THREE GORGES UNIV
Application of a compound in the preparation of antiallergic drugs
ActiveCN112915082BInhibition releaseInhibition of degranulationOrganic active ingredientsImmunological disordersAntiallergic drugsMast cell
Owner:SHENZHEN UNIV
Application of compound in preparation of anti-allergic drugs
ActiveCN112915082AInhibition releaseInhibition of degranulationOrganic active ingredientsImmunological disordersAminoglycosideChemical compound
The invention discloses an application of a compound in preparation of anti-allergic drugs, and is characterized in that the molecular formula of the compound is C29H27NO8, and the chemical structural formula of the compound is shown in the specification. The study finds that the compound T-5224 can obviously inhibit release of beta-aminoglycosidase in mast cells, has an obvious effect of inhibiting degranulation of the mast cells, and can obviously inhibit the allergic reaction in mice. Therefore, the T-5224 compound can be used for preparing the anti-allergic drugs and has a wide application prospect.
Owner:SHENZHEN UNIV
Preparation method of non-enzymatic hypoallergenic casein for inhibiting antigen immune presentation
InactiveCN110526963AInhibit bindingInhibition of degranulationPeptide preparation methodsAnimals/human peptidesAntigenFreeze-drying
The invention discloses a hypoallergenic treatment method for chemically modifying casein in milk so as to inhibit the immune presentation process of the casein and reduce the sensitization of the casein. A preparation method comprises the following steps: centrifugally degreasing fresh milk, removing fat-soluble and water-soluble impurities by using absolute ethyl alcohol and ultrapure water, dialyzing with the ultrapure water, and performing freeze-drying; dissolving casein solid obtained by freeze-drying into a maltoheptaose solution containing 1mM of NaHCO3 and 5mM of beta-mercaptoethanol,performing freeze-drying, then putting into a saturated Mg (NO3)2 solution, and performing steps of incubating, dialyzing, and freeze-drying so as to obtain the hypoallergenic casein. The method is low in cost and simple to operate, does not destroy the sensory properties and nutritional quality of the casein, and has the characteristic of remarkably reducing the allergenicity of the casein.
Owner:ZHEJIANG GONGSHANG UNIVERSITY
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com