Application of protocatechualdehyde in preparing medicine for preventing and treating bronchial asthma

A technology for bronchial asthma and protocatechuic aldehyde, applied in the field of medicine, can solve the problems such as the use of protocatechuic aldehyde that is not reported

Inactive Publication Date: 2015-01-14
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of protocatechualdehyde in the treatment of asthma has not been reported

Method used

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  • Application of protocatechualdehyde in preparing medicine for preventing and treating bronchial asthma
  • Application of protocatechualdehyde in preparing medicine for preventing and treating bronchial asthma
  • Application of protocatechualdehyde in preparing medicine for preventing and treating bronchial asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The preparation of embodiment 1 protocatechualdehyde

[0049] Take 50kg of Danshen medicinal material, remove impurities, cut into 3cm-5cm sections, rinse with drinking water and distilled water successively. Drain and dry, and pulverize into 10-18 mesh powder. Put the salvia miltiorrhiza powder into the extraction tank, add 10 times the amount of distilled water, decoct for 2 hours, filter, and save the first decoction; add 8 times the amount of distilled water to decoct for 1.5 hours, filter, and save the second decoction liquid; dregs plus 8 times the amount of distilled water decocted for 1.5 hours, filtered, and retain the third decoction. Remove the dregs, and then combine three decoctions. The decoction was adjusted to neutral with hydrochloric acid, and adsorbed by an adsorption column filled with weakly basic macroporous adsorption resin D301M. After the adsorbent was saturated, it was eluted with 50% ethanol solution and 0.4% sodium hydroxide aqueous solutio...

Embodiment 2

[0050] The preparation of embodiment 2 protocatechuic aldehyde tablet

[0051] Weigh 100.0 g of protocatechualdehyde prepared in Example 1, 35.0 g of powdered sugar, 40.0 g of lactose, and 23.0 g of sodium carboxymethyl starch, mix well, pass through a 100 mesh sieve, add an appropriate amount of 3% PVP aqueous solution to make soft material, 20 Mesh sieve for granulation. Dry at 60°C for 3 hours, sieve through a 18-mesh sieve, add 2.0 g of magnesium stearate, mix well, and then punch tablets with dimples to adjust the weight of the tablets to about 200 mg (including 100 mg of protocatechualdehyde).

Embodiment 3

[0052] Example 3 Preparation of Protocatechuic Aldehyde Capsules

[0053] Weigh 100.0 g of protocatechualdehyde prepared in Example 1, 35.0 g of powdered sugar, 40.0 g of lactose, and 23.0 g of sodium carboxymethyl starch, mix well, pass through a 100 mesh sieve, add an appropriate amount of 3% PVP aqueous solution to make soft material, 20 Mesh sieve for granulation. Dry at 60°C for 3 hours, sieve through a 18-mesh sieve, add 2.0 g of magnesium stearate, and fill capsules with about 200 mg per capsule (including 100 mg of protocatechuic aldehyde).

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PUM

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Abstract

The invention discloses application of protocatechualdehyde in preparing a medicine for preventing and / or treating bronchial asthma. Specifically, when being applied to early asthma, the protocatechualdehyde not only can remarkably control airway inflammation of the asthma, but also has the effects on protecting vascular endothelial cells of the lung, inhibiting mast cell degranulation, inhibiting fibroblast from secrete collagen, promoting apoptosis and calming by improving blood circulation in lung of asthma, reducing blood viscosity and improving anoxic state of the asthma, so as to relieve or inhibit airway remodeling from various aspects and various links; and inhibiting morphological change of the airway remodeling, effect of the medicine is better than prednisone acetate, and the medicine is free from side effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the use of protocatechualdehyde in the preparation of medicines for preventing and treating bronchial asthma. Background technique [0002] Bronchial asthma (hereinafter referred to as asthma) is a major chronic respiratory inflammatory disease that seriously threatens public health worldwide. According to the current international medical theory, the pathogenesis of asthma is caused by the imbalance of T helper cells TH1 and TH2, the strain inflammation of the respiratory tract is the basis, and the airway hyperresponsiveness is caused by the infiltration of inflammatory mediators in the respiratory tract. At present, there are many kinds of western medicines for the treatment of asthma, including glucocorticoids, β2 receptor agonists, theophylline and some antiallergic drugs. In the past 20 years, the focus of asthma treatment has been on chronic anti-inflammatory treatment i...

Claims

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Application Information

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IPC IPC(8): A61K31/11A61P11/06A61K36/537
CPCA61K31/11
Inventor 覃冬云张剑凯邬永富彭锦赵智丽许卫铭
Owner GUANGDONG MEDICAL UNIV
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