Soothing anti-allergy nano-vesicle composition and application thereof

A nanovesicle and composition technology, which is applied in the direction of drug combination, allergic diseases, cosmetic preparations, etc., can solve the problems of active substance retention, limit the use of oily anti-allergic ingredients, and fail to achieve the effect, so as to promote absorption, Effect of reducing vascular permeability and high antioxidant capacity

Active Publication Date: 2022-07-08
上海康华时代生物医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to skin barrier problems, most actives stay on the skin surface and cannot achieve their effect in cell experiments
Moreover, most soothing products suitable for sensitive skin use water as the continuous phase, which limits the use of many oily anti-allergic ingredients with obvious effects

Method used

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  • Soothing anti-allergy nano-vesicle composition and application thereof
  • Soothing anti-allergy nano-vesicle composition and application thereof
  • Soothing anti-allergy nano-vesicle composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Extract stimulation response experiment

[0041] The present invention screened out these three kinds of extracts from dozens of extracts through scientific screening, and the stimulation response degree of the three kinds of extracts was tested as follows:

[0042] Stimulation positive substance: 0.1 wt% SLS aqueous solution, ie, an aqueous solution formed by 99.9 g of water and 0.1 g of sodium lauryl sulfate (Sodium Lauryl Sulfate, SLS), was used as a stimulus model positive substance.

[0043] Test substance: 0.1wt% SLS aqueous solution was added with different concentrations of plant extracts as test substance.

[0044] Experimental method: Place the stimulus-positive substance and the substance to be tested in the patch chamber respectively, apply it to the subject's back, and uncover it after 24 hours, and observe the skin irritation response for 0.5h, 24h and 48h. The sample size was 35 people.

[0045] Result statistics: The number of cases with stim...

Embodiment 2～4

[0049] Examples 2-4 Preparation of soothing and anti-allergic nanovesicle compositions

[0050] Examples 2 to 4 provide the preparation of three different formulations of soothing and anti-allergic nanovesicle compositions. The proportions of the three examples and comparative examples 1 to 3 are shown in Table 2, and the table provides the mass percentage:

[0051] Table 2 embodiment 2~4 and comparative example composition formula summary

[0052]

[0053] The preparation methods of the soothing and anti-allergic nanovesicle compositions provided in Examples 2-4 include the following steps:

[0054] S1, weigh rosemary extract, polyol, PPG-13-decyltetradecanol polyether-24 and PEG / PPG / polytetramethylene glycol-8 / 5 / 3 glycerin by mass ratio;

[0055] S2, the mixture of S1 is heated to 50-60°C, stirred evenly under the condition of 200-1000RPM rotating speed until completely transparent, and then cooled to 20-35°C;

[0056] S3, weigh the magnolia flower extract and the olive...

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Abstract

The invention provides a soothing anti-allergy nano-vesicle composition and application thereof. The soothing anti-allergy nano-vesicle composition is prepared from the following components in percentage by mass: 1-10% of a magnolia flower extract; 0.5-5% of a rosemary extract; 1-10% of an olive leaf extract; 30-60% of an emulsifier; 10-30% of a humectant; and 10-30% of an emulsion stabilizer. The soothing and anti-allergy nano-vesicle composition disclosed by the invention contains water-soluble and oil-soluble active ingredients at the same time, has the effects of quickly soothing and resisting allergy, and has the effects of repairing, conditioning and maintaining the stability of skin for a long time. The soothing and anti-allergy nano-vesicle composition can be used for a conventional emulsification system and a transparent aqueous system, the preparation method is simple and controllable, the repeatability is good, the effect is obvious, and the soothing and anti-allergy nano-vesicle composition can be applied to various cosmetics with anti-allergy and soothing effects.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a soothing and anti-allergic nanovesicle composition and its application in the preparation of corresponding cosmetics. Background technique [0002] Due to the aggravation of environmental pollution, the increase of work and life pressure, the popularity of medical and cosmetic methods, and excessive cleaning, and even frequent cleaning and disinfection in recent years, the skin barrier has been damaged and transepidermal water loss (TEWL) has increased, and skin discomfort symptoms Gradually affecting people's quality of life, it has sparked various discussions and studies on sensitive skin. Sensitive skin (SS) is a sub-health state of the skin. The main feature is that the tolerance threshold of the skin is lowered, and it is easily stimulated by internal or external factors to cause various discomforts, such as itching, burning, stinging, Tightness, etc. In sev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/92A61K8/14A61Q19/00A61P37/08A61P17/00
CPCA61K8/9789A61K8/922A61K8/14A61Q19/005A61P37/08A61P17/00A61K2800/5922Y02P20/54
Inventor 姚敏鲁楠董继英
Owner 上海康华时代生物医学科技有限公司
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