The invention discloses an anti-saccharification moisturizing cream and a preparation method thereof. The cream is prepared from an olive oat emulsifier, cetearyl alcohol, isooctadecyl isooctadecanoate, caprylic acid / capric acid triglyceride, synthetic squalane, polydimethylsiloxane, 2,6-di-tert-butyl-4-methylphenol, disodium EDTA, glycerol, propylene glycol, xanthan gum, carbomer 940, triethanolamine, Inonotus obliquus water extract, Inonotus obliquus alcohol extract, phellinus igniarius alcohol extract, a polysaccharide skin tightening agent, sodium hyaluronate, nicotinamide, panthenol, PCG, water and the like. The product of the invention is an oil-in-water emulsifying system, the novel mild olive oat emulsifier is selected, the Inonotus obliquus water extract and the Inonotus obliquusalcohol extract are used as main anti-saccharification components, and active components such as the phellinus igniarius alcohol extract and the polysaccharide skin tightening agent are compounded, so that the anti-saccharification effect of the product is improved, the effects of moisturizing skins, resisting oxidation, resisting inflammation and the like are enhanced, and the product can make the skin smooth, tender and tight after long-term use and can delay aging. The product of the invention can also be used by people with mild, no irritation and sensitive skin.