The invention relates to the fields of composite materials and medical equipment, in particular to a method for preparing high-strength and high-isolation condoms by utilizing a modified graphene / latex composite material. The method comprises the following steps: preparing modified graphene into a stable dispersion liquid, then carrying out direct recombination after latex compounding and prevulcanization curing period, or vulcanization recombination is finished at the same time in the period, and finally a compound rubber emulsion is finally obtained. After the curing of the compound rubber, the condom product is prepared by adopting a mold impregnating method. Compared with existing products, the grapheme compounded condom prepared by the invention has the advantages that the permeance of small-size viruses can be effectively blocked and the performance indexes such as tear resistance, blasting volume and ultimate elongation under same thickness are obviously improved. The method disclosed by the invention has the advantages of scientific principle, obvious characteristics, non-toxicity, innocuity, stable performance, high matching degree with prior art for condom production and the like.