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Preparation method of itching relieving cream for treating seborrheic dermatitis

A technology for seborrheic dermatitis and dry matter, which is applied in the field of preparation of antipruritic ointment, can solve the problems of insignificant use effect and poor transdermal absorption, and achieves inhibition of mast cell degranulation, good oil secretion, and skin reappearance and firmness. smooth effect

Inactive Publication Date: 2018-05-08
CHANGZHOU AMANTE CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a preparation method of antipruritic ointment for the treatment of seborrheic dermatitis in view of the problems of poor transdermal absorption and inconspicuous application effect of the traditional antipruritic ointment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0014] A preparation method of antipruritic ointment for the treatment of seborrheic dermatitis, the preparation method comprising the steps of:

[0015] (1) Grind Sophora sophora to obtain a crushed product, mix the crushed product and ethanol at a mass ratio of 1:10~15, and perform ultrasonic extraction at a temperature of 50~60°C for 15~20 minutes to obtain an extract, and extract Concentrate the liquid under reduced pressure, adjust the pH value to 3~4, let stand for 1~2h, filter to obtain the filtrate, adjust the pH value of the filtrate to 8~9, add petroleum ether 2~3 times the quality of the filtrate to extract 2~3 Second, discard the petroleum ether layer, keep the water phase, adsorb with macroporous adsorption resin, then elute with ethanol, collect the eluent, concentrate the eluent under reduced pressure, and dry to obtain a dry matter. 1:2, recrystallize the dry matter and mixed solvent to obtain crystals;

[0016] (2) In terms of parts by weight, take 20~30 part...

Embodiment 1

[0020] The mixed solvent is obtained by mixing ethanol and petroleum ether evenly at a mass ratio of 1:0.8.

[0021] A preparation method of antipruritic ointment for the treatment of seborrheic dermatitis, the preparation method comprising the steps of:

[0022] (1) Grind Sophora sophora to obtain a crushed product, mix the crushed product and ethanol at a mass ratio of 1:15, and conduct ultrasonic extraction at a temperature of 60°C for 20 minutes to obtain an extract, which is concentrated under reduced pressure, Adjust the pH value to 4, let it stand for 2 hours, filter to obtain the filtrate, adjust the pH value of the filtrate to 9, add petroleum ether with 3 times the weight of the filtrate to extract 3 times, discard the petroleum ether layer, keep the water phase, and use macropore adsorption The resin is adsorbed, and then eluted with ethanol, the eluate is collected, the eluate is concentrated under reduced pressure, and dried to obtain a dry product. The dry produc...

Embodiment 2

[0027] The mixed solvent is obtained by mixing ethanol and petroleum ether evenly at a mass ratio of 1:0.5.

[0028] A preparation method of antipruritic ointment for the treatment of seborrheic dermatitis, the preparation method comprising the steps of:

[0029] (1) Grind Sophora sophora to obtain a crushed product. Mix the crushed product and ethanol at a mass ratio of 1:10, and conduct ultrasonic extraction at a temperature of 50°C for 15 minutes to obtain an extract, which is concentrated under reduced pressure. Adjust the pH value to 3, let it stand for 1 hour, filter to obtain the filtrate, adjust the pH value of the filtrate to 8, add petroleum ether twice the weight of the filtrate to extract twice, discard the petroleum ether layer, keep the water phase, and use macropores to absorb The resin is adsorbed, and then eluted with ethanol, the eluate is collected, the eluate is concentrated under reduced pressure, and dried to obtain a dry product. The dry product and a mi...

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PUM

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Abstract

The invention discloses a preparation method of an itching relieving cream for treating seborrheic dermatitis, and belongs to the field of medicines. According to the preparation method, through extracting a main active component-alkaloid from semen sophorae alopecuroidis, a drug, which has a stabilizing effect on an erythrocyte membrane, of the alkaloid has the stabilizing effect on a lysosome membrane; thus, the release of an inflammatory mediator is reduced; an anti-inflammatory purpose is achieved; meanwhile, the alkaloid also has an antiallergic effect, can be used for suppressing the degranulation of a mast cell, and has favorable effects on balancing grease secretion, relieving pruritus, resisting imflammation and resisting an allergy and immunologic suppression; thus, the use effect of the itching relieving cream is improved; the alkaloid is mixed with distillate prepared from glucose and ethylene glycol; as having multiple hydroxyl groups, the alkaloid has quite high affinitywith water, has a moisturizing effect on skin, and thus, can be also used for retaining moisture for the skin while being used for removing grease on the surface of the skin; a problem that the skin is dry is avoided, and the itching relieving cream is used for solving problems that a current conventional itching relieving cream has poor transdermal absorption and an unconspicuous use effect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method of antipruritic ointment for treating seborrheic dermatitis. Background technique [0002] Seborrheic dermatitis is a chronic inflammatory skin disease that occurs in areas with strong sebum secretion, such as the head, face, chest, and armpits. People who have the initial symptoms of seborrheic dermatitis account for 1 to 3% of the population and 3 to 5% of young people. It affects men more than women, and people aged 30 to 60 can also develop the disease. Seborrheic dermatitis on the face mainly appears on the eyebrows, between the eyebrows, around the forehead, and around the nose, and most of them appear on the hair at the same time; it also occurs in the armpits and crotch. Although the cause of seborrheic dermatitis has not been clarified, excessive fatty secretions produced by sebaceous glands, that is, excessive secretion of sebum, is considered ...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61K9/06A61K47/10A61K47/26A61K47/44A61P17/06A61K31/045
CPCA61K9/06A61K31/045A61K36/489A61K47/10A61K47/26A61K47/44A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 陈兴权乔舍程依
Owner CHANGZHOU AMANTE CHEM CO LTD
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