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Application of Chaenomeles speciosa (sweet) Nakai extract in pharmacy

A kind of papaya extract technology, applied in the field of papaya extract

Active Publication Date: 2015-05-06
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, so far there is no relevant report for obtaining the quality controllable raw material medicine of preparation treatment rheumatoid arthritis medicine

Method used

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  • Application of Chaenomeles speciosa (sweet) Nakai extract in pharmacy
  • Application of Chaenomeles speciosa (sweet) Nakai extract in pharmacy
  • Application of Chaenomeles speciosa (sweet) Nakai extract in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Take 50kg of papaya decoction pieces, put them into the extraction tank, add 1.0% cellulase for enzymolysis, control the enzymolysis temperature at 58°C, and enzymolysis for 6 minutes; put the precipitate separated after enzymolysis into the extraction tank , add 500L of 50% ethanol to reflux and extract 3 times, each time for 2 hours, combine the extracts, recover the ethanol under reduced pressure until there is no alcohol smell, put it on a D-3520 macroporous adsorption resin column, and fully elute with water until the effluent is clear and After no reducing sugar reaction, elute with 60%, 70%, and 80% ethanol respectively, collect 60%, 70%, and 80% ethanol eluate, concentrate under reduced pressure and have no alcohol smell, filter, and add 10% hydrogen Sodium oxide solution adjusts the pH value to 9.0, adds 2 times the amount of water-saturated n-butanol to extract twice, combines the n-butanol solution, concentrates under reduced pressure to nearly dryness, and dr...

Embodiment 2

[0041] Take 50kg of papaya decoction pieces, put them into the extraction tank, add 1.0% cellulase for enzymolysis, control the enzymolysis temperature at 55°C, and enzymolysis for 10 minutes; put the precipitate separated after enzymolysis into the extraction tank , add 500L of 70% ethanol to extract 3 times, 2 hours each time, combine the extracts, recover the ethanol under reduced pressure until there is no alcohol smell, put it on the XAD-2 macroporous adsorption resin column, and fully elute with water until the effluent is clear and free of alcohol. After reducing sugar reaction, elute with 60%, 70%, 80% ethanol, collect 60%, 70%, 80% ethanol eluate, concentrate under reduced pressure without alcohol smell, filter, add 10% sodium hydroxide Adjust the pH value of the solution to 8.0, add 1 times the amount of water-saturated n-butanol to extract three times, combine the n-butanol liquid, concentrate under reduced pressure to nearly dryness, and dry under reduced pressure t...

Embodiment 3

[0043] Take 50kg of papaya decoction pieces, put them into the extraction tank, add 1.0% cellulase for enzymolysis, control the enzymolysis temperature at 52°C, and enzymolysis for 15 minutes; put the precipitate separated after enzymolysis into the extraction tank , add 500L 80% ethanol to reflux extraction 3 times, each time for 2 hours, combine the extracts, recover the ethanol under reduced pressure until there is no alcohol smell, put it on the XAD-4 macroporous adsorption resin column, and fully elute with water until the effluent is clear and free of alcohol. After reducing sugar reaction, elute with 60%, 70%, 80% ethanol, collect 60%, 70%, 80% ethanol eluate, concentrate under reduced pressure until no alcohol smell, filter, add 10% potassium hydroxide The pH of the solution is adjusted to be 9.0, add 2 times the amount of water-saturated n-butanol to extract twice, combine the n-butanol solution, concentrate under reduced pressure to nearly dryness, and dry under reduc...

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Abstract

The invention relates to novel application of a Chaenomeles speciosa (sweet) Nakai extract, specifically to application of oleanolic acid, ursolic acid, oleanolic saponins and ursolic saponins in the extract in the pharmaceutical field. The extract has effects on inhibition of DNP-BSA induced RBL-2H3 mast cell degranulation, DNP-BSA induced mBMMCs mast cell degranulation, calcium ionophore A23187 induced RBL-2H3 mast cell degranulation and Thapsigargin induced RBL-2H3 mast cell degranulation and on xylene-induced acute inflammation like ear swelling of mice and has a high medicinal value.

Description

technical field [0001] The present invention relates to the use of papaya extract, in particular to the use of oleanolic acid, ursolic acid, oleanolic acid saponin and ursolic acid saponin in the extract in the pharmaceutical field. Background technique [0002] Papaya comes from the dry and nearly ripe fruit of Chaenomeles speciosa (Sweet) Nakai, a plant belonging to the family Rosaceae. Papaya is a commonly used traditional Chinese medicine, sour in taste, warm in nature, and enters the liver and spleen meridian. It has the effects of calming the liver and relaxing the tendons, harmonizing the stomach and eliminating dampness, and is used for the treatment of damp arthralgia spasm, soreness and pain in the waist and knees, vomiting and diarrhea, and beriberi edema. Modern research shows that papaya contains saponins, organic acids, flavonoids, alkaloids, sugars, tannins, pectin, amino acids, vitamins, minerals, etc. , anti-tumor, immune-enhancing and other pharmacologica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/732A61K31/704A61P29/00A61K31/56
Inventor 李世刚张永琦柳蔚喻玲玲
Owner CHINA THREE GORGES UNIV
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